ER stress tolerance is regulated by copper-dependent PERK kinase activity ft. S. Newton (@BB_UPenn), @bradylabupenn.bsky.social (@penncbio.bsky.social), X. Shi, N. Beratan, J. Arya, M. Bond, C. Akay-Espinoza & @KJSsci (Dental) @cp-cellreports.bsky.social www.cell.com/cell-reports...

🚨 Our 4th example of metalloallosteric regulation of kinase activity. Out today in @CellReports with @KJSsci. The ER stress sensor kinase PERK needs copper to work. Without copper, PERK can’t protect cells under stress. cell.com/cell-reports/p…

Thank you @pennmedicine.bsky.social for highlighting my journey and this recognition.I'm honored to received the 2026 @asbmb.bsky.social Ruth Kirschstein Award for Maximizing Access in Science. — rooted in a vision to remove barriers and ensure everyone has the opportunity to contribute to science.

Congratulations to the Brady Lab!

Join us in celebrating the #ASBMB26 Award Winners! • @abu-remaileh.bsky.social • Suzanne Barbour • @bradylabupenn.bsky.social • George Carman • Joseph Cotruvo • Roger Davis • @rolanddunbrack.bsky.social • Pamela Mertz • @olzmannlab.bsky.social • Kim Orth • Margaret Phillips ow.ly/x05f50WSbax

Congratulations to @bradylabupenn.bsky.social (@penncbio.bsky.social/ @rtaatpennmed.bsky.social), recipient of the 2026 @asbmb.bsky.social Ruth Kirschstein Award for Maximizing Access in Science! tinyurl.com/6w7n3uzx

🎉Brady Lab is 10! A decade of discovery & growth. This milestone belongs to the incredible trainees, collaborators, colleagues, & steadfast friends & family who’ve fueled our journey every step. On to the next chapter @pennmedicine.bsky.social @penncbio.bsky.social @rtaatpennmed.bsky.social 💙

As Faculty Director of @rtaatpennmed.bsky.social, I’m proud to affirm our values that shape our education, training & outreach commitments. Juneteenth reminds us that progress is ongoing—and our work must be rooted in respect, access, & opportunity for all. #Juneteenth

My buddy hard at work on his experiments! There’s nothing quite as pure as the excitement he feels learning through play.

Check out the first preprint from @drariav.bsky.social lab!

Hey y'all! My department is conducting a search for an assistant or associate professor in bacteriology. It's pretty broadly defined. If you know anyone who's looking for a great department that does awesome science - please send them our way! You can DM me with any questions you have 😀

Proud to see ASBMB joining other scientific societies in support of the MOSAIC programs!

#RedoxBio25 Announcement! 🚨 Exciting opportunity for early career researchers! 🎉We have complimentary registrations available! Don't miss out - apply now! ➡️ bit.ly/4cSV0qZ

Please help spread the word: @ishahjain.bsky.social @bradylabupenn.bsky.social @naama-kanarek.bsky.social @liron1bar-peled.bsky.social @lydiafinley.bsky.social

For the upcoming #ASBMB25 symposia on oncogenic hubs, organizers Cigall Kadoch and Greg Wang selected a diverse array of speakers who study the role of molecular condensates, extrachromosomal DNA, chromatin regulatory machinery, epigenetics and more in #cancer. www.asbmb.org/asbmb-...

New #lipidmetabolism research is shedding light on crucial lipid–protein interactions, revealing promising therapeutic targets for both metabolic and neurodegenerative diseases. Discover the latest breakthroughs in lipid science at the ASBMB Annual Meeting: http://ow.ly/qUPE50V...#lipidmetabolism

Several months ago, I was honored to be invited by JMB Editor-in-Chief Mike Summers to write a Perspective for the Pioneers in Molecular Biology special issue. It was a chance to reflect on the journey that led me here. You can read the pieces here: tinyurl.com/2pb967u9 & tinyurl.com/kkwfynt2

The #ASBMB2025 meeting will feature 11 scientific symposia. Meet the organizers for each symposia & topics here: www.asbmb.org/annual-meeti...

In 7 days @asbmb.bsky.social #ASBMB25 will start in Chicago. Check out the scientific symposia @Pagliarini_Lab I have put together for the biochemistry & molecular biology communities as the co-chairs of #ASBMB25! Let me know if you’ll be there to join us! www.asbmb.org/annual-meeti...

We're exhibiting at #ASBMB2025! Visit us at stand 333 to chat about our publishing model and pick up some exclusive eLife goodies. See you in Chicago! @ASBMB

🦠Unraveling the battle between hosts & pathogens is key to fighting infectious diseases. #ASBMB25's new session will explore breakthroughs in immune evasion, host defenses, & disease progression. ➡️Learn more & add it to your schedule: www.asbmb.org/asbmb-today/.... #Immunology

ASBMB is deeply dismayed and saddened about the termination of the NIH MOSAIC program. We are proud of our scholars, will welcome them to #ASBMB25 and remain dedicated to cultivating and tapping all available talent to pursue scientific progress. bit.ly/4iWtJGq

As a result of Trump’s slashes to research funding, dozens of graduate programs have announced reductions and cancellations of graduate admissions slots. If you are an impacted applicant, please fill out this survey: docs.google.com/forms/d/e/1F... 🧪🧠🧬🔬🥼👩🏼‍🔬🧑‍🔬

Diversity is our greatest asset, even if the government disagrees… They not like us! POC in STEM are here to stay. They tried to rig the game but you can’t fake influence! Mustard on the [Be][At] bro. Happy Black History Month!

Pretty sad. Just got the email that CZI is canceling the second round of Diversity Leadership Awards. Private industry will definitely not fill the hole that NIH and NSF are leaving. 😢💔

I maxed out my credit card, emptied my savings account, and took out a loan to move from Alabama to Bethesda, MD. I don’t even qualify for unemployment since I’ve only worked at NIH for a month. I will be financially and medically devastated. Seeking suggestions for anywhere that’s hiring!!

Leading Edge is celebrating a milestone: 100 (actually 102!) new assistant professors!!! 🎉🥳🎊 Learn more about them: www.leadingedgesymposium.org/fellows/ Applications are now open for the 2025 Leading Edge cohort! (Deadline Feb 3). You do NOT need to be ready for the job market to apply.

I just reached out to my senators about the NIH situation. If you need to find out how much impact NIH has in your state in terms of dollars in and their economic impact here's a link: www.unitedformedicalresearch.org/nih-in-your-...

If you’ve been directly impacted by a pause or cancellation of an NIH study session, we @forbes.com would like to talk to you

Congratulations to @ginadenicola.bsky.social and @christhechang.bsky.social labs on their latest @pnas.org paper revealing context-dependent sensitivity to copper chelation! Thrilled to have collaborated with such amazing friends on the first manuscript of 2025.

Excited to co-chair #ASBMB2025 with the incredible Dave Pagliarini! This year’s ASBMB meeting promises to showcase cutting-edge science, foster dynamic collaborations, & inspire new ideas. Don’t miss your chance to be part of it—register & submit your late breaking abstracts. t.co/UwgMdxBo15

Sundays experiment by Trainee Barnett Brady! Hypothesis: If I pour the water from my cups, it’ll only be in the cups! Results: When I poured more than the cup would hold, it went all over the table and on top the floor. Conclusions: I should only pour what is enough for the cup to hold.

Big news about this paper soon!

The Brady Lab is part of the Department of Cancer Biology and the Abramson Family Cancer Research Institute in the Perelman School of Medicine at the University of Pennsylvania. Our research program at Penn explores two key areas in cancer biology to understand what fuels cancer cells!