Now online! Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle

Congrats (again) to Julia and Abby for their collaborative effort asking when and why cells use the TCA cycle. TLDR; it's not just about ATP or making nutrients-- the TCA cycle is also important to remove nutrients!

HUGE congratulations to our very own Julia Brunner for her paper describing cell-state dependent engagement of the malate-aspartate shuttle, out today!! Many thanks to all lab members, funders, and colleagues who supported the work, and stay tuned for more from Julia very soon!

We are hiring a postdoc! The group has a funded opening to join our amazing team on the NCI's Frederick, MD campus. This is an opportunity to train in cutting-edge chemical & RNA biology methods with a supportive, tight-knit group. Link to posting below. Please share! jobrxiv.org/job/national...

📣 First preprint from the TeSlaa lab 📣 We investigated how methyl-rich nutrient, choline, is used in the body and how systemic one-carbon metabolism responds to dietary methyl-donor deficiency. www.biorxiv.org/content/10.6...

🍰Read also the Research Briefing here: 👉https://rdcu.be/e3tiZ bit.ly/404rclA

☕Yashinskie, Zhu et al show that #p53 activation triggers increased synthesis and accumulation of phospholipids, with enhanced activation of #autophagy and lysosomal catabolism programmes and increased reliance on lipid headgroup recycling. @lydiafinley.bsky.social bit.ly/4asbwO3

Lab’s 1st preprint! Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate. @cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation. He is on the job market!

Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

Just out in @science.org: Together with the lab of @johanneszuber.bsky.social, we used sequential in-vitro/in-vivo screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

Check out the symposium organized by our CoE, excited to have Marcia Haigis, @lydiafinley.bsky.social, Matthias Hebrok and Tom MacVicar over in Helsinki in November. Sign up by October 22nd 👇

Happy to share the most recent preprint from the lab, the thesis work of Dr. Adam Krebs and a collaboration with many, including the Geissmann lab @mskcancercenter.bsky.social Here is a short paper thread. #tuberculosis #macrophages 🦠 www.biorxiv.org/content/10.1...

Super excited to share new review on metabolic stress and adaptations in pancreatic cancer to these stresses from @cssheehan.bsky.social jci.org/articles/vie... 1/6

Proudly presenting Simon’s @simonsterson.bsky.social‬ paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism @naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8

Our paper on regulation of BCAA catabolism by mitochondrial calcium signaling is out! Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...

ICYMI:

I'm excited to share our latest story from the @lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/

Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com A thread 🧵 1/9

Showcase your research! Submit your poster abstract by April 16 (11:59pm MST) to join speakers @lydiafinley.bsky.social, Ralph J. DeBeradinis, & Keynote Navdeep Chandel. Apply now: keysym.us/KSMetabDev25. Can't attend? Access insights On Demand for 6 months post-conference! #KSMetabDev25 #cellfate

2 weeks to go to the annual NYAS cancer metabolism symposium, April 8 at NYU Langone! www.nyas.org/shaping-scie... Register now using code CancerMetabolism10 for a 10% discount. And hurry! Last year we sold out! cc: @lyssiotislab.bsky.social @marcusgon.bsky.social

www.quantamagazine.org/how-metaboli... Seems like a good time to remind you of an upcoming meeting on this exact topic: www.keystonesymposia.org/conferences/...

We are 2 weeks out from the @NYASciences Cancer Metabolism meeting - still time to register! Join us for: Exciting science ✅ Awesome speakers ✅ Great camaraderie ✅ Science jokes⚠️ Celebrity appearances‼️ (probably not) Please circulate 🔁 events.nyas.org/event/16a78a...

Unlock $200 in savings on Metabolic and Nutritional Control by registering before 11:59 PM MST on March 20! Don't miss the chance to hear from @lydiafinley.bsky.social this May in Beverly, MA, USA. Secure your spot now: keysym.us/KSMetabDev25. #KSMetabDev25 #metabolism youtu.be/le7D7qpo4sM

1/Happy to share a new paper reporting a metabolic approach to radiosensitization in lung cancer, from Rachel Chiang, Faith Zhang and colleagues at UT Southwestern Radiation Oncology and @cri-utsw.bsky.social www.science.org/doi/10.1126/...

New preprint time!! This one has been brewing in the lab for ~8 years describes a strategy for tumor selective WNT suppression. It was led by an amazing (then) grad student, Jill Zimmerman, with help from a host of lab members and collaborators along the way. www.biorxiv.org/content/10.1...

Metabolic & Nutritional Control of Development and Cell Fate is just around the corner. Register by March 20 (11:59pm MST) and snag a $200 discount! Don't miss our incredible speaker lineup! 👉 keysym.us/KSMetabDev25. #KSMetabDev25 youtu.be/CSto4rJv40I @lydiafinley.bsky.social @rjdlab.bsky.social

📢3 weeks left to submit your abstract for the Cancer Metabolism Showcase and Workshop!📢 We already have over 150 registrants! Sign up for free today at www.cancermetabolismshowcase.org

Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside: A broadly applicable serum-free media, Quantitative lipid uptake characterization, Evidence lipid scavenging > synthesis for cancer cell proliferation.

Happy to share our new #NIHfunded study! Led by Kath Oñate + crew of #WomenInSTEM 💪🏽💪🏻💪, we ID potential of normal mesenchyme to restrain #inflammation, epithelial identity, & #pancreaticcancer via KITL, a cue lost in transition to a CAF state. Now at Cancer Discovery aacrjournals.org/cancerdiscov...

We are soliciting poster and short talk abstracts for the NYASciences Cancer Metabolism meeting. Just around the corner - join us for awesome metabolism in the Big Apple 🍎 Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White

Massive work from Jess Spinelli's lab at UMASS demonstrating a SECOND electron carrier in the mammalian ETC: www.cell.com/cell/fulltex...

The Cancer Metabolism and Signaling in the Tumor Microenvironment *Abstract Deadline* is rapidly approaching 2/4/25. Don't miss this star-studded event! @nyasciences.bsky.social @nyulangonepccsm.bsky.social events.nyas.org/event/16a78a...

Our latest preprint identifies (targetable!) metabolic programs intrinsic to different cancer cell states in rhabdomyosarcoma, out just in time for @katrinaparas.bsky.social's thesis defense tomorrow!

I hope you will join @lydiafinley.bsky.social and me for two days of great science on metabolic support of development and cell fate. Deadline for scholarships and short talk abstracts is Feb. 6.

There is an amazing lineup of metabolism talks at this meeting. Chicago is going to be THE place to be for all things cell metabolism. Would tag people if I could figure out who's on here 🧐 🤗

HUGE congratulations to @paigearnold.bsky.social for being named a @hhmi.bsky.social Hanna Gray Fellow! A well-deserved recognition for all of your accomplishments and promise: I can't wait to see what you do next!!

⏰ Deadline is approaching (Feb 6!) to apply for scholarships + short talks for the Keystone meeting on metabolism in development! keysym.us/KSMetabDev25 The meeting is May 7-9 in Beverly, MA and will be a unique forum for discussing the role of metabolites in development. Hope to see you there!

Congratulations @seanjmorrison.bsky.social 👏! Catch DR. Morrison at the @keystonesymposia.bsky.social meeting on "Metabolic and Nutritional Control of Development and Cell Fate." Learn more and register today at keysym.us/KSMetabDev25.

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

Applications for the 2025 Bioorganic GRC are now live! Here is the link where you can check out the current line-up: grc.org/bioorganic-c...

Here's some new additions to this #Cancer #Research 🧪🔬⚕️🩺 starter pack! @marinelab.bsky.social @leilaakkari.bsky.social @carolynbertozzi.bsky.social @lydiafinley.bsky.social @ibcradiation.bsky.social and many more.. I also included some starting #PIs - welcome to you all & do give them a follow!

www.annualreviews.org/content/jour... —>this one? (Hoping link works…)

Clear and comprehensive new go-to review from #NoTwitterNav (we're gonna need a new hashtag) delineating how mitochondria have distinct and context-specific roles in proliferation and fate determination www.annualreviews.org/content/jour...

Join us in May, 2025 for a conference on Metabolic and Nutritional Control of Development and Cell Fate - one of the most interesting and fast-moving areas in cellular metabolism, with great relevance to disease: www.keystonesymposia.org/conferences/.... -RJD

Kicking off my migration here with a re-post of my greatest contribution to science: a follow-the-emoji TCA cycle, here to help you follow your friendly carbons as they spin through metabolic pathways

Registration is open for the NYAS Cancer Metabolism Symposium! Submit your abstract for consideration for a short talk/poster prize 🏆 or just join us for a day of amazing science in NYC 🗽 events.nyas.org/event/44e2c3...