Lydia Finley
@lydiafinley.bsky.social
📤 2198
📥 143
📝 17
cell biologist with an interest in pretty much everything ski.edu/finley
reposted by
Lydia Finley
Kara McKinley
3 months ago
Lab’s 1st preprint! Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social
made menstruating mice + used them to discover early events in menstruation. He is on the job market!
add a skeleton here at some point
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Lydia Finley
Johannes Zuber
3 months ago
Just out in
@science.org
: Together with the lab of
@wilhelmpalm.bsky.social
, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience.
www.science.org/doi/10.1126/...
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Lydia Finley
Wilhelm Palm
3 months ago
Just out in
@science.org
: Together with the lab of
@johanneszuber.bsky.social
, we used sequential in-vitro/in-vivo screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience.
www.science.org/doi/10.1126/...
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reposted by
Lydia Finley
KatajistoLab
3 months ago
Check out the symposium organized by our CoE, excited to have Marcia Haigis,
@lydiafinley.bsky.social
, Matthias Hebrok and Tom MacVicar over in Helsinki in November. Sign up by October 22nd 👇
add a skeleton here at some point
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reposted by
Lydia Finley
Michael Glickman
5 months ago
Happy to share the most recent preprint from the lab, the thesis work of Dr. Adam Krebs and a collaboration with many, including the Geissmann lab
@mskcancercenter.bsky.social
Here is a short paper thread.
#tuberculosis
#macrophages
🦠
www.biorxiv.org/content/10.1...
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Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in M. tuberculosis host defense
M. tuberculosis must survive within multiple macrophage populations during infection, including alveolar macrophages (AM) and recruited inflammatory macrophages. In mice, itaconate, produced in macrop...
https://www.biorxiv.org/content/10.1101/2025.07.23.664455v1
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reposted by
Lydia Finley
Muir Lab
6 months ago
Super excited to share new review on metabolic stress and adaptations in pancreatic cancer to these stresses from
@cssheehan.bsky.social
jci.org/articles/vie...
1/6
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JCI - What’s on the menu?: metabolic constraints in the pancreatic tumor microenvironment
https://jci.org/articles/view/191940
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reposted by
Lydia Finley
KatajistoLab
6 months ago
Proudly presenting Simon’s
@simonsterson.bsky.social
paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism
@naturemetabolism.bsky.social
www.nature.com/articles/s42...
@helsinki.fi
@metastem.bsky.social
🧵1/8
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Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism
Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.
https://www.nature.com/articles/s42255-025-01325-7
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reposted by
Lydia Finley
Yasemin Sancak
7 months ago
Our paper on regulation of BCAA catabolism by mitochondrial calcium signaling is out! Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances
www.science.org/doi/10.1126/...
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Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma
Mitochondrial Ca2+ signaling regulates branched-chain amino acid catabolism in an adolescent liver cancer.
https://www.science.org/doi/10.1126/sciadv.adu9512
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reposted by
Lydia Finley
Nature Metabolism
8 months ago
ICYMI:
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Intracellular metabolic gradients dictate dependence on exogenous pyruvate
Nature Metabolism, Published online: 28 April 2025; doi:10.1038/s42255-025-01289-8Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a key metabolite in central carbon metabolism.
https://bit.ly/3F2s5nP
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reposted by
Lydia Finley
Ben Jackson
8 months ago
I'm excited to share our latest story from the
@lydiafinley.bsky.social
lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in
@naturemetabolism.bsky.social
:
rdcu.be/ejFTs
1/
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Intracellular metabolic gradients dictate dependence on exogenous pyruvate
Nature Metabolism - Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a...
https://rdcu.be/ejFTs
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reposted by
Lydia Finley
KatajistoLab
8 months ago
Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells
www.nature.com/articles/s41...
@metastem.bsky.social
@helsinki.fi
@ki.se
@helsinki-biotech.bsky.social
out now in
@natcomms.nature.com
A thread 🧵 1/9
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Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications
Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...
https://www.nature.com/articles/s41467-025-58752-z
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reposted by
Lydia Finley
Keystone Symposia
9 months ago
Showcase your research! Submit your poster abstract by April 16 (11:59pm MST) to join speakers
@lydiafinley.bsky.social
, Ralph J. DeBeradinis, & Keynote Navdeep Chandel. Apply now:
keysym.us/KSMetabDev25
. Can't attend? Access insights On Demand for 6 months post-conference!
#KSMetabDev25
#cellfate
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2 weeks to go to the annual NYAS cancer metabolism symposium, April 8 at NYU Langone!
www.nyas.org/shaping-scie...
Register now using code CancerMetabolism10 for a 10% discount. And hurry! Last year we sold out! cc:
@lyssiotislab.bsky.social
@marcusgon.bsky.social
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Cancer Metabolism and Signaling in the Tumor Microenvironment - NYAS
April 8, 2025 | 9:00 AM – 5:00 PM ET Join leading experts at the forefront of cancer metabolism research for a one-day event on April 8, 2025, in New York City. The New York Academy of Sciences invite...
https://www.nyas.org/shaping-science/events/cancer-metabolism-and-signaling-2025/
10 months ago
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reposted by
Lydia Finley
DeBerardinis Lab at UT Southwestern Medical Center
10 months ago
www.quantamagazine.org/how-metaboli...
Seems like a good time to remind you of an upcoming meeting on this exact topic:
www.keystonesymposia.org/conferences/...
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How Metabolism Can Shape Cells’ Destinies | Quanta Magazine
A growing body of work suggests that cell metabolism — the chemical reactions that provide energy and building materials — plays a vital, overlooked role in the first steps of life.
https://www.quantamagazine.org/how-metabolism-can-shape-cells-destinies-20250321/
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reposted by
Lydia Finley
Lyssiotis Lab
10 months ago
We are 2 weeks out from the @NYASciences Cancer Metabolism meeting - still time to register! Join us for: Exciting science ✅ Awesome speakers ✅ Great camaraderie ✅ Science jokes⚠️ Celebrity appearances‼️ (probably not) Please circulate 🔁
events.nyas.org/event/16a78a...
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reposted by
Lydia Finley
Keystone Symposia
10 months ago
Unlock $200 in savings on Metabolic and Nutritional Control by registering before 11:59 PM MST on March 20! Don't miss the chance to hear from
@lydiafinley.bsky.social
this May in Beverly, MA, USA. Secure your spot now:
keysym.us/KSMetabDev25
.
#KSMetabDev25
#metabolism
youtu.be/le7D7qpo4sM
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KSQA: Dr. Lydia Finley (Metabolic and Nutritional Control)
YouTube video by KeystoneSymposia
https://youtu.be/le7D7qpo4sM
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reposted by
Lydia Finley
DeBerardinis Lab at UT Southwestern Medical Center
10 months ago
1/Happy to share a new paper reporting a metabolic approach to radiosensitization in lung cancer, from Rachel Chiang, Faith Zhang and colleagues at UT Southwestern Radiation Oncology and
@cri-utsw.bsky.social
www.science.org/doi/10.1126/...
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Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair
Genetic screen finds lipoylation as a target to improve radiation success in lung cancer by blocking DNA damage repair.
https://www.science.org/doi/10.1126/sciadv.adt1241?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
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reposted by
Lydia Finley
Dow Lab
10 months ago
New preprint time!! This one has been brewing in the lab for ~8 years describes a strategy for tumor selective WNT suppression. It was led by an amazing (then) grad student, Jill Zimmerman, with help from a host of lab members and collaborators along the way.
www.biorxiv.org/content/10.1...
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A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression
Hyperactive WNT signaling is a potent cancer driver, but clinical translation of WNT inhibitors has been hampered on-target toxicities. WNT signaling can be constrained through inhibition of the PARP ...
https://www.biorxiv.org/content/10.1101/2025.03.04.641305v1
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reposted by
Lydia Finley
Keystone Symposia
10 months ago
Metabolic & Nutritional Control of Development and Cell Fate is just around the corner. Register by March 20 (11:59pm MST) and snag a $200 discount! Don't miss our incredible speaker lineup! 👉
keysym.us/KSMetabDev25
.
#KSMetabDev25
youtu.be/CSto4rJv40I
@lydiafinley.bsky.social
@rjdlab.bsky.social
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Metabolic and Nutritional Control Meeting Promo
YouTube video by KeystoneSymposia
https://youtu.be/CSto4rJv40I
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reposted by
Lydia Finley
Isaac Harris
10 months ago
📢3 weeks left to submit your abstract for the Cancer Metabolism Showcase and Workshop!📢 We already have over 150 registrants! Sign up for free today at
www.cancermetabolismshowcase.org
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9:30 AM - 3 PM EST, May 5th and 6th, 2025
https://www.cancermetabolismshowcase.org/
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reposted by
Lydia Finley
Lucas Sullivan
11 months ago
Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside: A broadly applicable serum-free media, Quantitative lipid uptake characterization, Evidence lipid scavenging > synthesis for cancer cell proliferation.
add a skeleton here at some point
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reposted by
Lydia Finley
Mara Sherman
11 months ago
Happy to share our new
#NIHfunded
study! Led by Kath Oñate + crew of
#WomenInSTEM
💪🏽💪🏻💪, we ID potential of normal mesenchyme to restrain
#inflammation
, epithelial identity, &
#pancreaticcancer
via KITL, a cue lost in transition to a CAF state. Now at Cancer Discovery
aacrjournals.org/cancerdiscov...
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Stromal KITL/SCF maintains pancreas tissue homeostasis and restrains tumor progression
Abstract. Components of normal tissue architecture serve as barriers to tumor progression. Inflammatory and wound-healing programs are requisite features of solid tumorigenesis, wherein alterations to...
https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-24-1079/751664/Stromal-KITL-SCF-maintains-pancreas-tissue
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reposted by
Lydia Finley
Lyssiotis Lab
11 months ago
We are soliciting poster and short talk abstracts for the NYASciences Cancer Metabolism meeting. Just around the corner - join us for awesome metabolism in the Big Apple 🍎 Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White
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Massive work from Jess Spinelli's lab at UMASS demonstrating a SECOND electron carrier in the mammalian ETC:
www.cell.com/cell/fulltex...
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Rhodoquinone carries electrons in the mammalian electron transport chain
Valeros et al. identify rhodoquinone (RQ), an electron carrier present in mammalian mitochondria, that can deliver electrons to fumarate instead of O2 as the terminal electron acceptor. The authors de...
https://www.cell.com/cell/fulltext/S0092-8674(24)01420-X
11 months ago
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reposted by
Lydia Finley
Marcus Goncalves
12 months ago
The Cancer Metabolism and Signaling in the Tumor Microenvironment *Abstract Deadline* is rapidly approaching 2/4/25. Don't miss this star-studded event!
@nyasciences.bsky.social
@nyulangonepccsm.bsky.social
events.nyas.org/event/16a78a...
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Cancer Metabolism and Signaling 2025
https://events.nyas.org/event/16a78ab1-f658-4260-acd8-31a78071dac3/summary?_gl=1*ktfvj0*_gcl_au*MTQ0NjU5Mjc4OS4xNzM2MzcwNTU4*_ga*MTcwOTkxMDUzMC4xNzM2MzcwNTU5*_ga_FL3407S79M*MTczNjM3MDU1OC4xLjEuMTczNjM3MDYwMi4wLjAuMTE4NDg4ODQ3NQ..*_fplc*UjFxYnA4c1pDNlRiRU0lMkJJS1dQWTEySTd0Nlp5T3MzM0ExZ0VFa0poeWhaYjdtWjRnR0RnajN2Ykt0QmZNUTIzTmh0TFhKTmMzVVdScDR2RXhDSkMzTFU3clRnOThDVktiaiUyQkhEeTRQSTA4Z3RNeXRpR3M0bm4zanFybkpWQSUzRCUzRA
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Our latest preprint identifies (targetable!) metabolic programs intrinsic to different cancer cell states in rhabdomyosarcoma, out just in time for
@katrinaparas.bsky.social
's thesis defense tomorrow!
add a skeleton here at some point
12 months ago
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reposted by
Lydia Finley
DeBerardinis Lab at UT Southwestern Medical Center
12 months ago
I hope you will join
@lydiafinley.bsky.social
and me for two days of great science on metabolic support of development and cell fate. Deadline for scholarships and short talk abstracts is Feb. 6.
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Metabolic and Nutritional Control of Development and Cell Fate | Keystone Symposia
Join us at the Keystone Symposia on Metabolic and Nutritional Control of Development and Cell Fate, May 2025, in Beverly, with field leaders!
https://www.keystonesymposia.org/conferences/conference-listing/meeting/T52025
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There is an amazing lineup of metabolism talks at this meeting. Chicago is going to be THE place to be for all things cell metabolism. Would tag people if I could figure out who's on here 🧐 🤗
add a skeleton here at some point
12 months ago
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HUGE congratulations to
@paigearnold.bsky.social
for being named a
@hhmi.bsky.social
Hanna Gray Fellow! A well-deserved recognition for all of your accomplishments and promise: I can't wait to see what you do next!!
add a skeleton here at some point
12 months ago
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⏰ Deadline is approaching (Feb 6!) to apply for scholarships + short talks for the Keystone meeting on metabolism in development!
keysym.us/KSMetabDev25
The meeting is May 7-9 in Beverly, MA and will be a unique forum for discussing the role of metabolites in development. Hope to see you there!
12 months ago
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Lydia Finley
Keystone Symposia
about 1 year ago
Congratulations
@seanjmorrison.bsky.social
👏! Catch DR. Morrison at the
@keystonesymposia.bsky.social
meeting on "Metabolic and Nutritional Control of Development and Cell Fate." Learn more and register today at
keysym.us/KSMetabDev25
.
add a skeleton here at some point
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reposted by
Lydia Finley
Anna Obenauf
about 1 year ago
1/23 Big news for the
#ObenaufLab
! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇
www.nature.com/articles/s41...
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reposted by
Lydia Finley
Jordan Meier
about 1 year ago
Applications for the 2025 Bioorganic GRC are now live! Here is the link where you can check out the current line-up:
grc.org/bioorganic-c...
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reposted by
Lydia Finley
Johanna Joyce
about 1 year ago
Here's some new additions to this
#Cancer
#Research
🧪🔬⚕️🩺 starter pack!
@marinelab.bsky.social
@leilaakkari.bsky.social
@carolynbertozzi.bsky.social
@lydiafinley.bsky.social
@ibcradiation.bsky.social
and many more.. I also included some starting
#PIs
- welcome to you all & do give them a follow!
add a skeleton here at some point
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reposted by
Lydia Finley
Linda Sinclair
about 1 year ago
www.annualreviews.org/content/jour...
—>this one? (Hoping link works…)
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Distinct Essentiality of the Mitochondrial Respiratory Chain in Proliferating Cells in Vivo | Annual Reviews
Mitochondrial respiratory chain (RC) activity is essential for in vivo cell proliferation, particularly in cancer, CD4+ and CD8+ T cells, and endothelial cells involving ATP production and biosynthesi...
https://www.annualreviews.org/content/journals/10.1146/annurev-cancerbio-061424-125611
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Clear and comprehensive new go-to review from
#NoTwitterNav
(we're gonna need a new hashtag) delineating how mitochondria have distinct and context-specific roles in proliferation and fate determination
www.annualreviews.org/content/jour...
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https://www.annualreviews.org/content/journals/10.1146/annurev-cancerbio-061424-125611A
about 1 year ago
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reposted by
Lydia Finley
DeBerardinis Lab at UT Southwestern Medical Center
about 1 year ago
Join us in May, 2025 for a conference on Metabolic and Nutritional Control of Development and Cell Fate - one of the most interesting and fast-moving areas in cellular metabolism, with great relevance to disease:
www.keystonesymposia.org/conferences/...
. -RJD
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Conferences | Keystone Symposia
https://www.keystonesymposia.org/conferences/conference-listing/meeting?eventid=7116
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Kicking off my migration here with a re-post of my greatest contribution to science: a follow-the-emoji TCA cycle, here to help you follow your friendly carbons as they spin through metabolic pathways
about 1 year ago
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Registration is open for the NYAS Cancer Metabolism Symposium! Submit your abstract for consideration for a short talk/poster prize 🏆 or just join us for a day of amazing science in NYC 🗽
events.nyas.org/event/44e2c3...
about 2 years ago
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