News from our CoE by @htyynismaa.bsky.social and Ruben Torregrosa Munumer labs. Mitochondrial ATP synthase deficiency results in Metabolic trade-offs and vulnerabilities in stem cell derived motor neurons www.nature.com/articles/s42... @helsinki.fi @stemmprogram.bsky.social

Next MetaStem PhD defense in two days, go Hien! 🎩

Still time today to sign up and submit an abstract for this excellent symposium

Next MetaStem PhD defense coming up on Tuesday, go Simon 👏@simonsterson.bsky.social

Tomorrow, welcome!

Excited to announce our Stem Cell Metabolism Symposium organized in Helsinki on November 12th. Fantastic invited speakers Marcia Haigis, Lydia Finley, Matthias Hebrok and Tom MacVicar. Sign up by Oct 22nd, free of charge, welcome! @hilife-helsinki.bsky.social @helsinki.fi @stemmprogram.bsky.social

Welcome to the Stem Cell Seminar next week Friday Oct 3rd at 9-11, ☕️🍪 at 8:30. Exciting science on embryo development, ECM, cancer and stem cells by Juha Kere and @johannaienglund.bsky.social labs. See you there! @hilife-helsinki.bsky.social @helsinki-biotech.bsky.social @stemmprogram.bsky.social

#CFM_MolCellAging: The third session will deal with the regulation of aging processes, with talks by @pekka-katajisto.bsky.social  @metastem.bsky.social  @helsinki.fi and Salvador Aznar @irbbarcelona.org   Registration: http://bit.ly/4kOyYch   🤝With support of @caixaresearch.bsky.social

Welcome to the Metabolism seminar tomorrow in Viikki. Excited to have @nunuping.bsky.social and @sirakarvinen.bsky.social groups present their research

News from our CoE by @katajistolab.bsky.social @simonsterson.bsky.social found that intestinal stem cells with old mitochondria make Paneth cells faster due to higher aKG levels and aKG improves regeneration in old animals by renewal of Paneth cells. www.nature.com/articles/s42... @helsinki.fi

News from our CoE by @otonkoskit.bsky.social lab, Eliisa Vähäkangas et al show that upon engraftment into mice stem cell derived pancreatic islets become insensitive to pyruvate, correlating with down regulation of the pyruvate/lactate transporter MCT1. link.springer.com/article/10.1... @helsinki.fi

Proudly presenting Simon’s @simonsterson.bsky.social‬ paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism @naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8

News from our CoE by @htyynismaa.bsky.social group characterize the role of mitochondrial intermembrane space protein CHCHD10 in metabolism and spinal muscular atrophy Jokela type (SMAJ) actaneurocomms.biomedcentral.com/articles/10.... Congratulations Sandra! @helsinki.fi @stemmprogram.bsky.social

Hien’s peroxisome story is out! Amazing effort starting from description of a new phenomenon, building in vivo tools, and describing how sub-cellular localization of metabolic activities can guide stem cell fate. Congrats Hien and thank you to the great collaborators!

Last Friday Pooja Manjunath successfully defended her thesis on Mitochondrial proteostasis and structure. Well done Dr Pooja 🎩👏 @htyynismaa.bsky.social @stemmprogram.bsky.social

A new study from our CoE finds that stem cells can control whether they self-renew or differentiate by localizing certain metabolic reactions differently www.helsinki.fi/en/faculty-b... @helsinki.fi @helsinki-biotech.bsky.social #stemcell #metabolism #peroxisome

News for our CoE by @katajistolab.bsky.social show how tissue stem cells can metabolically regulate tissue renewal and differentiation by providing daughter cells with peroxisomes of different age and metabolic properties nature.com/articles/s41... @helsinki.fi @helsinki-biotech.bsky.social

Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com A thread 🧵 1/9

Glad to be highlighted as FutureLeaders in Cancer research by Cancer Grand Challenges @cancergrand.bsky.social. Thank you! @fimm-uh.bsky.social, @helsinki-biotech.bsky.social, @metastem.bsky.social, @cruk-si.bsky.social. features.cancerresearchuk.org/cancergrandc...

Tomorrow, welcome!

MetaStem PhD defence 🎩 April 25th at 12 Pooja Manjunath from @htyynismaa.bsky.social lab will defend her thesis Preserving Mitochondrial Proteostasis and Structure-The Roles of Mitochondrial Co-Chaperones GRPEL1, GRPEL2, and Small Protein NERCLIN in Porthania PIII. Opponent Prof Kostas Tokatlidis 👏

Welcome to the Stem Cell Seminar April 23rd. Stem cell metabolism of both tissue and pluripotent stem cells on the menu with exiting presentations from @rafabolism.bsky.social and @rutorregrosa.bsky.social @stemmprogram.bsky.social @helsinki.fi @helsinki-biotech.bsky.social @fimm-uh.bsky.social

Welcome to the Stem Cell Seminar April 23rd. Stem cell metabolism of both tissue and pluripotent stem cells on the menu with exiting presentations from @rafabolism.bsky.social and @rutorregrosa.bsky.social @stemmprogram.bsky.social @helsinki.fi @helsinki-biotech.bsky.social @fimm-uh.bsky.social

The @katajistolab.bsky.social modeled #epithelial regeneration using small intestinal scaffolds and identified #asporin is a mediator of fetal-like reprogramming. Read the @cp-cellstemcell.bsky.social article: bit.ly/41LJbhn Listen to the conversation: bit.ly/4kTt36a

Tomorrow, welcome! 👇

Welcome to the next Metabolism seminar, March 18th at 9-11 am in Meilahti. Excellent speaker lineup with Kirsi Pietiläinen and Robin Cristofari groups presenting about #obesity #adiposetissue #diet #aging in humans and penguins @helsinki.fi @stemmprogram.bsky.social @helsinki-biotech.bsky.social

News from our CoE by @katajistolab.bsky.social @sharifiqbal.bsky.social shed light on how the intestinal epithelium is repaired after injury, with implications for aging and chemotherapy-induced damage www.sciencedirect.com/science/arti... @helsinki.fi @helsinki-biotech.bsky.social Congratulations 🎉

1/6 Proudly presenting Sharif’s @sharifiqbal.bsky.social paper on the role of Asporin in intestinal regeneration through TGF-B-dependent fetal-like reversion www.sciencedirect.com/science/arti... out in @cp-cellstemcell.bsky.social @pekka-katajisto.bsky.social @helsinki.fi @metastem.bsky.social 🧵

Congratulations Dr Hossam Montaser! 🎩 Great discussion with Professor Evans-Molina yesterday @stemmprogram.bsky.social @otonkoskit.bsky.social

Next MetaStem PhD defense this Friday Feb 21st when Hossam Montaser from @otonkoskit.bsky.social lab takes the stage discussing his work on Modelling ER stress-induced Diabetes Using stem cell-derived islets with opponent Professor Carmella Evans-Molina 🎩 👏@stemmprogram.bsky.social @helsinki.fi

Excited that Pekka is presenting at @CellSymposia Metabolites: Organellar Communication in Health and Disease this May 11–13, 2025, in Sitges, Spain! The abstract submission deadline has been extended until Feb 14th. Hope to see you at #CSMetabolites2025 cell-symposia.com/metabolites-...