New #MolTherapy paper: AUF1 therapy blocks atrophy, promotes regeneration, re-innervation and strength for severe muscle injury. #Myoblue tinyurl.com/3bmnxr8d

Molecular and phenotypic blueprint of human #hematopoiesis links proliferation stress to #StemCell #aging. From Emanuele Lettera et al. @dimiccolab.bsky.social: rupress.org/jem/article/... 📘 In Hematopoiesis and #Myeloid Cells collection: rupress.org/jem/collecti... #KSMyeloid26 #KSHemato26

Really happy to see this one out: www.sciencedirect.com/science/arti... Alibek's drive & great coll w/ friends @gekaragoz.bsky.social & E. Hallacli resulted in a cool story that starts with our beloved #Marchantia and ends with iPSC-derived neurons 🤩🤪 A short 🧵

Researchers led by Dr. César Nombela-Arrieta at the University of Zurich have demonstrated a central role of #hepatoblasts in the regulation of fetal liver hematopoiesis and stem cell maintenance. 1️⃣ Read the study: https://bit.ly/46FF8Gr 2️⃣ Hear the discussion: https://bit.ly/3O6oN7s

In this week's episode, Daylon and Arun discuss a new @cp-cellstemcell.bsky.social study identifying a #SleepDeprivation-responsive neural circuit that controls intestinal stem cell function. 📔: https://bit.ly/4ttyYTz 🎧: https://bit.ly/3O6oN7s

A new study from Drs. Peter Friend, Abraham Shaked, Alex Sagar, and Peter Reese explores extracorporeal liver cross-circulation using transgenic xenogeneic pig livers with brain-dead human decedents. 📄: https://go.nature.com/4cpmztI 🎧: https://bit.ly/3O6oN7s

A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated #macrophages in #lupus #nephritis. From Hoover, Hacohen, Davidson & colleagues: rupress.org/jem/article/... 📘 In #Hematopoiesis & #Myeloid Cells collection: rupress.org/jem/collecti... #KSMyeloid26 #KSHemato26

📢 New in @natcomms.nature.com! Scientists show that human #cytomegalovirus infection induces epithelial–mesenchymal transition in cholangiocytes. 📄 Read the paper: https://go.nature.com/3O2zRSS 🎧 Hear the discussion: https://bit.ly/3O6oN7s

We are very happy to see our study finally appear online @nature.com! This has been work of nearly 10 years in collaboration with the National Institute of Genome Medicine 🇲🇽, the National Cancer Institute 🇲🇽, the @sangerinstitute.bsky.social and others ⬇️ www.nature.com/articles/s41...

🎙️ We've got a special episode out for you now! We chat with Drs. Fiona Doetsch and Nozomu Yachie about what to expect at the upcoming #ISSCR2026 meeting. 🎧 Check it out: https://bit.ly/3O6oN7s

New research from Leiden University Medical Center! A simplified co-culture reveals altered cardiotoxic responses to doxorubicin in hPSC-derived cardiomyocytes in the presence of endothelial cells, and highlights how AI can scale assessment of drug-induced cardiotoxicity. https://ow.ly/Z2R450Yeymp

☕Donahue et al. show that #aging is associated with changes in ER morphology. ER-phagy drives age-associated ER remodeling through tissue-specific factors. #autophagy #longevity bit.ly/40dNHEE

📢 Remember to submit your abstract for #ISSCR2026 by February 25th! Join nearly 3,500 scientists from across the world at ISSCR 2026 for a 4-day event highlighting the most important breakthroughs in the field. @isscr.org#ISSCR2026 https://bit.ly/3ObQGeg

Wounds on the face heal with less scarring than wounds elsewhere on the body. The Longaker lab at @stanfordsurgery.bsky.social developed a strategy to promote facial-like reduced fibrosis at scar-prone sites. #WoundHealing #Fibrosis 📃 https://bit.ly/4qfAuWB 🎙️ https://bit.ly/4thHuVG

Dr. Avi Samelson and a team in Dr. Martin Kampmann's lab used #CRISPR screening to study tau proteostasis in human #neurons. Read the @cellcellpress.bsky.social paper: https://bit.ly/4qikdQM Listen to the discussion: https://bit.ly/4thHuVG @samelsonlab.bsky.social @kampmann.bsky.social#CRISPR

This week: A team at the @molgen.mpg.de used high-content screening to identify compounds that affect pancreatic #organoid differentiation or morphology. 📍: https://bit.ly/4qnMW6B 🎧: https://bit.ly/4thHuVG

The latest @nature.com paper from Drs. @sergiuppasca.bsky.social and Daniel Geschwind's labs uses cortical #organoids to model #AutismSpectrumDisorder, and identifies how genetic risk can impact neurodevelopment. 🖇️ https://go.nature.com/4qZUzkS 🗨️ https://bit.ly/4thHuVG

Earlier this week, our Co-Founder, Dr. Joseph C. Wu, was featured as a guest on the @stemcellpodcast.com, discussing his work with iPSCs, vaccine-induced myocarditis, and New Approach Methodologies (NAMs). You can listen to the full episode here: stemcellpodcast.com/ep-313-cardi...

Check out our latest episode! Dr. Joseph Wu from @stanfordcvi.bsky.social talks about disease models, mentorship, and more. 📌 https://bit.ly/45H0ZNq

📢 We can't wait to chat with Dr. Joseph Wu from @stanfordcvi.bsky.social! Tune in tomorrow to learn about his early #iPSC work, his team's research on drug screening and translation, and promoting his trainees' success!

Dr. Volker Busskamp's lab at @unibonn.bsky.social used #endothelial cells to induce transient vascular support in retinal #organoids. At later stages, these organoids displayed photoreceptor-driven light responses! 💡 📃 https://bit.ly/49x2UoK 🗨️ https://bit.ly/3ZjiWxM

Check out this neat paper from Dr. Qi Gu's lab! They developed NEAT, a nanoengineered extrusion-aligned tract that promotes axonal reconnection, synapse formation, and locomotor recovery after #SpinalCordInjury. 📄 @cp-cellstemcell.bsky.social#SpinalCordInjury- https://bit.ly/45oXDhM 🗣️ - https://bit.ly/3ZjiWxM

Federico Midena and a team in Dr. Raffaella Di Micco's lab developed "nichoids," a new 3D system that improves HSPC multi-lineage differentiation and engraftment capacity. Article: https://bit.ly/4r5P4kj Discussion: https://bit.ly/3ZjiWxM

🔔 This is a reminder to submit your abstract for #ISSCR2026 by February 25th! Join nearly 3,500 scientists, clinicians, and industry leaders for 4 days at the frontiers of stem cell science, regenerative medicine, and engineering biology. 🗓️ July 8-11 📍 Montréal https://bit.ly/4pOzEzT @isscr.org#ISSCR2026

This week, we cover the latest work from Gameto! Their Fertilo platform improved the in vitro maturation of human #oocytes. 🥚 Article: https://bit.ly/4sSEmPN Discussion: https://bit.ly/3ZjiWxM

We're starting 2026 on a high note! 🚀 Dr. Pinar Mesci from Axiom Space discusses how #microgravity affects biological research, and the future of #LowEarthOrbit research. 🛰️ Listen now: https://bit.ly/3ZjiWxM

🌌 Make space in your schedule for next week's episode! Dr. Pinar Mesci from Axiom Space is joining us to talk about #biomanufacturing in #LowEarthOrbit. 🛰️

Dean's POV 📸 I'm blown away by this photo of a lab-grown human kidney assembloid from the Li Lab at USC Stem Cell and was thrilled to hear it was selected by @nature.com as Image of the Year. Incredible! (Image by Pedro Medina/Li Lab/USC Stem Cell) #StemCell #Science 🧪

Drs. Komal Makwana, Louise Tilley, and the @nmoris.bsky.social lab at the @crick.ac.uk developed human trunk-like structures to model somite and #neural tube co-development. 🔖 @natcellbio.nature.com#neural- https://go.nature.com/4qsAmUd 🎙️ - https://bit.ly/4p3izlj

#Sunitinib is an effective cancer treatment, but can cause #hypertension & #HeartFailure. Drs. Amit Manhas, Yu Liu, & Dr. Nazish Sayed at @stanfordcvi.bsky.social#Sunitinib#hypertension#HeartFailurestored #PIEZO1 expression to reverse sunitinib-induced #endothelial dysfunction. 🔖 https://bit.ly/4s9xrBG 🗨️ https://bit.ly/4p3izlj

The @merihuchlab.bsky.social at @mpi-cbg.de developed patient-specific human periportal liver #assembloids. Read the @nature.com#assembloidsarticle: https://go.nature.com/4qpL7Xw Get the breakdown in this week's episode: https://bit.ly/4p3izlj

New in @cp-cellstemcell.bsky.social! Researchers at ShanghaiTech developed sympathetic ganglion #organoids and heart-forming organoids to study inter-tissue crosstalk. 🗣️ Article: https://bit.ly/4pHS9GX Discussion: https://bit.ly/4p3izlj

Tune in to our latest episode! Dr. Deepak Srivastava from @gladstoneinst.bsky.social talks about his lab's recent work investigating heart defects in Down syndrome, and strategies for delivering therapies to the heart. 🫀 Listen now: https://bit.ly/4p3izlj

We're wrapping up 2025 with none other than Dr. Deepak Srivastava from @gladstoneinst.bsky.social! His lab recently identified HMGN1 as a key contributor to congenital heart defects associated with Down syndrome. 🫀 Learn more: https://go.nature.com/49ovtpT

New paper out today at @natneuro.nature.com in collab. with DichgansLab @isd-research.bsky.social @lmumuenchen.bsky.social: We developed a fully #iPSC-derived human model of the #BBB #blood-brain-barrier and applied it to study neurovascular disease (NVD)! #OA PDF here: rdcu.be/eUIl3 Thread👇 1/10

New work from the lab of Dr. Saghi Ghaffari has shown that reversing #lysosomal dysfunction restores youthful state in aged #hematopoietic stem cells. 📘 Read it in @cp-cellstemcell.bsky.social#lysosomal#hematopoietichttps://bit.ly/4pv1S2X 🎙️ Listen to the episode: https://bit.ly/4q05JW4

We're bringing you a new study from friend-of-the-show Dr. Cat Jamieson! It shows the results of HSPC functionally organized multi-omics aging and resilience analyses in 9 astronauts before, during, and after 3 short-duration ISS missions. 🚀 🗒️: https://bit.ly/3YgAs5c 🎧: https://bit.ly/4q05JW4

From cell fate to The Fate of Ophelia, our listeners have good taste. Thanks for keeping it 100 in 2025. 💯 See you next year! #SpotifyWrapped

This looks like an excellent read from @cellysally.bsky.social I think that looking at cell cooperation/synchronization from the lens of clones/phylogenies is something super interesting.

In this week's episode, we discuss a new study in which researchers developed a #BloodVesselOrganoid model from #HutchinsonGilford progeria syndrome-mutant human embryonic stem cells. 🔬 Read the @cp-devcell.bsky.social#BloodVesselOrganoid#HutchinsonGilfordtudy: https://bit.ly/44BDMvB Listen to the episode: https://bit.ly/4q05JW4

📢 New in @natneuro.nature.com! A team led by Dr. Tal Sharf (@talsharf.bsky.social) has shown that structured neuronal firing sequences appear in spontaneous activity of human and murine #BrainOrganoids. 🗒️: https://go.nature.com/4rlnpgc 🎧: https://bit.ly/4q05JW4

📢 Our next episode is out! We chat with the Father of Organoids, Dr. Hans Clevers (@hansclevers.bsky.social) about transitioning from academia to industry, the challenges of creating a #CellTherapy, and creating #organoids of snake guts and lungs. 🔊 Listen now: https://bit.ly/3Mne9IB

📢 You won't want to miss our next episode with Dr. @hansclevers.bsky.social! Learn about his return to the @hubrechtinstitute.bsky.social and his experience running the Institute of Human Biology at Roche: https://bit.ly/48sIRIV

Researchers at the University of Basel developed #BoneMarrow #organoids that recapitulate molecular and cellular features of native endosteal niches, enabling the study of pathophysiological interactions with HSCs. 📝 https://bit.ly/48mU0cH 🗨️ https://bit.ly/48dmghX

Great to see this published: Fitting dynamical landscape models to single-cell data, creating interpretable maps of cell decision making & developmental logic Applied to neural tube patterning, we show how morphogen signals reshape landscapes and drive fate decisions www.pnas.org/doi/10.1073/...

Meet Dr. Mingxia Gu, a stem cell biologist who engineers miniature human organs like hearts and lungs to develop personalized treatments. Read our Q&A to learn about her mission to reverse aging, how her father inspired her and the silver lining to living with face blindness. tinyurl.com/MingxiaGu

A new @cp-cellstemcell.bsky.social paper reveals a cardio-immune mechanism whereby Clusterin+ #cardiomyocytes reprogram #macrophages to resolve inflammation. Read the paper: https://bit.ly/3Kn8GR9 Listen to the discussion: https://bit.ly/48dmghX

🩸 Dr. Lucrezia della Volpe and a team in Dr. Vijay Sankaran's lab (@bloodgenes.bsky.social) discovered that ferroptosis is a key barrier to HSC survival during ex vivo culture. Read their @natcellbio.nature.com paper: https://go.nature.com/4ib4Ln6 Listen to the discussion: https://bit.ly/48dmghX

What a story! 🤯 A team at @ucsandiego.bsky.social grafted ESC-derived spinal cord #neural stem cells into non-human primates with #SpinalCordInjury, improving their hand function. 📎 - https://go.nature.com/3LOQsbG 🎧 - https://bit.ly/48dmghX

Don't miss this episode! Dr. @tvierbuchen.bsky.social from @mskcancercenter.bsky.social discusses his work direct reprogramming #fibroblasts into neurons, and PSC models of #neurodevelopment. Check it out: https://bit.ly/48dmghX