Drs. Komal Makwana, Louise Tilley, and the @nmoris.bsky.social lab at the @crick.ac.uk developed human trunk-like structures to model somite and #neural tube co-development. 🔖 @natcellbio.nature.com#neural- https://go.nature.com/4qsAmUd 🎙️ - https://bit.ly/4p3izlj

#Sunitinib is an effective cancer treatment, but can cause #hypertension & #HeartFailure. Drs. Amit Manhas, Yu Liu, & Dr. Nazish Sayed at @stanfordcvi.bsky.social#Sunitinib#hypertension#HeartFailurestored #PIEZO1 expression to reverse sunitinib-induced #endothelial dysfunction. 🔖 https://bit.ly/4s9xrBG 🗨️ https://bit.ly/4p3izlj

The @merihuchlab.bsky.social at @mpi-cbg.de developed patient-specific human periportal liver #assembloids. Read the @nature.com#assembloidsarticle: https://go.nature.com/4qpL7Xw Get the breakdown in this week's episode: https://bit.ly/4p3izlj

New in @cp-cellstemcell.bsky.social! Researchers at ShanghaiTech developed sympathetic ganglion #organoids and heart-forming organoids to study inter-tissue crosstalk. 🗣️ Article: https://bit.ly/4pHS9GX Discussion: https://bit.ly/4p3izlj

Tune in to our latest episode! Dr. Deepak Srivastava from @gladstoneinst.bsky.social talks about his lab's recent work investigating heart defects in Down syndrome, and strategies for delivering therapies to the heart. 🫀 Listen now: https://bit.ly/4p3izlj

We're wrapping up 2025 with none other than Dr. Deepak Srivastava from @gladstoneinst.bsky.social! His lab recently identified HMGN1 as a key contributor to congenital heart defects associated with Down syndrome. 🫀 Learn more: https://go.nature.com/49ovtpT

New paper out today at @natneuro.nature.com in collab. with DichgansLab @isd-research.bsky.social @lmumuenchen.bsky.social: We developed a fully #iPSC-derived human model of the #BBB #blood-brain-barrier and applied it to study neurovascular disease (NVD)! #OA PDF here: rdcu.be/eUIl3 Thread👇 1/10

New work from the lab of Dr. Saghi Ghaffari has shown that reversing #lysosomal dysfunction restores youthful state in aged #hematopoietic stem cells. 📘 Read it in @cp-cellstemcell.bsky.social#lysosomal#hematopoietichttps://bit.ly/4pv1S2X 🎙️ Listen to the episode: https://bit.ly/4q05JW4

We're bringing you a new study from friend-of-the-show Dr. Cat Jamieson! It shows the results of HSPC functionally organized multi-omics aging and resilience analyses in 9 astronauts before, during, and after 3 short-duration ISS missions. 🚀 🗒️: https://bit.ly/3YgAs5c 🎧: https://bit.ly/4q05JW4

From cell fate to The Fate of Ophelia, our listeners have good taste. Thanks for keeping it 100 in 2025. 💯 See you next year! #SpotifyWrapped

This looks like an excellent read from @cellysally.bsky.social I think that looking at cell cooperation/synchronization from the lens of clones/phylogenies is something super interesting.

In this week's episode, we discuss a new study in which researchers developed a #BloodVesselOrganoid model from #HutchinsonGilford progeria syndrome-mutant human embryonic stem cells. 🔬 Read the @cp-devcell.bsky.social#BloodVesselOrganoid#HutchinsonGilfordtudy: https://bit.ly/44BDMvB Listen to the episode: https://bit.ly/4q05JW4

📢 New in @natneuro.nature.com! A team led by Dr. Tal Sharf (@talsharf.bsky.social) has shown that structured neuronal firing sequences appear in spontaneous activity of human and murine #BrainOrganoids. 🗒️: https://go.nature.com/4rlnpgc 🎧: https://bit.ly/4q05JW4

📢 Our next episode is out! We chat with the Father of Organoids, Dr. Hans Clevers (@hansclevers.bsky.social) about transitioning from academia to industry, the challenges of creating a #CellTherapy, and creating #organoids of snake guts and lungs. 🔊 Listen now: https://bit.ly/3Mne9IB

📢 You won't want to miss our next episode with Dr. @hansclevers.bsky.social! Learn about his return to the @hubrechtinstitute.bsky.social and his experience running the Institute of Human Biology at Roche: https://bit.ly/48sIRIV

Researchers at the University of Basel developed #BoneMarrow #organoids that recapitulate molecular and cellular features of native endosteal niches, enabling the study of pathophysiological interactions with HSCs. 📝 https://bit.ly/48mU0cH 🗨️ https://bit.ly/48dmghX

Great to see this published: Fitting dynamical landscape models to single-cell data, creating interpretable maps of cell decision making & developmental logic Applied to neural tube patterning, we show how morphogen signals reshape landscapes and drive fate decisions www.pnas.org/doi/10.1073/...

Meet Dr. Mingxia Gu, a stem cell biologist who engineers miniature human organs like hearts and lungs to develop personalized treatments. Read our Q&A to learn about her mission to reverse aging, how her father inspired her and the silver lining to living with face blindness. tinyurl.com/MingxiaGu

A new @cp-cellstemcell.bsky.social paper reveals a cardio-immune mechanism whereby Clusterin+ #cardiomyocytes reprogram #macrophages to resolve inflammation. Read the paper: https://bit.ly/3Kn8GR9 Listen to the discussion: https://bit.ly/48dmghX

🩸 Dr. Lucrezia della Volpe and a team in Dr. Vijay Sankaran's lab (@bloodgenes.bsky.social) discovered that ferroptosis is a key barrier to HSC survival during ex vivo culture. Read their @natcellbio.nature.com paper: https://go.nature.com/4ib4Ln6 Listen to the discussion: https://bit.ly/48dmghX

What a story! 🤯 A team at @ucsandiego.bsky.social grafted ESC-derived spinal cord #neural stem cells into non-human primates with #SpinalCordInjury, improving their hand function. 📎 - https://go.nature.com/3LOQsbG 🎧 - https://bit.ly/48dmghX

Don't miss this episode! Dr. @tvierbuchen.bsky.social from @mskcancercenter.bsky.social discusses his work direct reprogramming #fibroblasts into neurons, and PSC models of #neurodevelopment. Check it out: https://bit.ly/48dmghX

Our next episode features Dr. @tvierbuchen.bsky.social from @mskcancercenter.bsky.social Tune in tomorrow to hear about his work on next-generation models of #BrainDevelopment. 🧠

Registration & abstract submission are NOW OPEN for #ISSCR2026, July 8-11 in Montréal! Join global leaders in stem cell science & regenerative medicine to advance the field together. @stemcell.com will co-sponsor the hallmark event, continuing a valued partnership. 👉 isscr2026.org @isscr.org#ISSCR2026

Check out the Image of the Month! Human intestinal #organoids or ‘mini-guts,’ provide a laboratory model to study human intestinal epithelial biology and the processes leading to intestinal disease. Courtesy of S Blutt lab, F Sawyer. blogs.bcm.edu/2025/11/20/f... @bcmhouston.bsky.social

Dr. Lu Wang and a team in the @gleesonlab.bsky.social at @ucsandiego.bsky.social generated a brain #organoid atlas from patients with neurodevelopmental disorders. 🗺️ Read the article in @cp-cellstemcell.bsky.social#organoid: https://bit.ly/49hIEsK Learn more in this week's episode: https://bit.ly/4qTwoVL

Save the date! @isscr.org, @alleninstitute.org & @socdevbio.bsky.social are collaborating to present a 3-day scientific symposium led by early-career scientists. The Stem Cell & Developmental Biology Early Career Symposium will be held September 23-25, 2026 in Seattle, WA. Learn more: bit.ly/4p98dkv

This week: Colin O'Hern and a team in Dr. Aitor Aguirre's lab at Michigan State University made heart-macrophage #assembloids that allow them to model heart #arrhythmias. 🫀 @cp-cellstemcell.bsky.social#assembloids#arrhythmiasaper - https://bit.ly/447iUf7 Discussion - https://bit.ly/4qTwoVL

Check out our latest episode with Dr. @sumrubayin.bsky.social from the @gurdoninstitute.bsky.social! Learn about her research on neural regeneration in the neonatal mouse #cerebellum. 🧠

We're very excited to welcome Dr. @sumrubayin.bsky.social from the @gurdoninstitute.bsky.social onto the next episode of the podcast! 🎉 Her lab studies the mouse #cerebellum to better understand the regulation of #neural stem cell behavior. 🧠

In a new study, Drs. Christoph Kuppe, Michael Schaub, Rafael Kramann, and Ivan Costa present PHLOWER. 🖥️ This new Hodge Laplacian model infers complex #CellDifferentiation trajectories from single-cell multimodal data. 📔: https://go.nature.com/4hqMim0 🎧: https://bit.ly/4qwoGke

The Spiralian Organiser (enriched with dpERK1/2) 🪱🎃🪱🎃🪱 #DevBio #EvoDevo #SciArt

🍹Grab a glass of OJ! In this week's episode, Daylon and Arun review a new Cell Stem Cell (@cp-cellstemcell.bsky.social ) study suggesting that oral #VitaminC protects against #OvarianAging in primates. 🗒️: https://bit.ly/4hFnTcD 🎧: https://bit.ly/4qwoGke

📢 New in @natbiotech.nature.com! Via live imaging of late-stage preimplantation human #embryos, Dr. Kathy Niakan at @loke-ctr.bsky.social#embryoshas shown that abnormalities can arise at a later stage of development than previously thought. 🗒️: https://go.nature.com/4oIQj80 🎧: https://bit.ly/4qwoGke

In our latest episode, we discuss a new study from Dr. Deepak Srivastava ( @ncndgroup.bsky.social ) at the Gladstone Institutes. It identifies HMGN1 as a key contributor to #Trisomy21-related congenital #HeartDefects. 🗒️: https://go.nature.com/49ovtpT 🎧: https://bit.ly/4qwoGke

📢 A new episode is out! We chat with Dr. Juan Melero-Martin (@meleromartinlab.bsky.social about how #VascularNetworks are formed and the mechanisms by which the vasculature modulates the engraftment and activity of various human stem cells. 🔊 Listen now: https://bit.ly/4qwoGke

Intussusceptive angiogenesis: bridging in vivo and in vitro observations link.springer.com/article/10.1... Thanks, Dr. Steven Mentzer and Dr. Maximilian Ackermann🙏 for this insightful highlight of our recent PNAS paper on #IntussusceptiveAngiogenesis😁 www.pnas.org/doi/abs/10.1...

This week’s round-up spans species from birds to sheep, and now, fittingly, to dogs! We dive into a new study from Japanese researchers, who have successfully established culture conditions for #canine iPSCs. 🐕 Article: https://bit.ly/4gA5zkC 🐩 Discussion: https://bit.ly/4qfiME4

Do sarcomeres disassemble when a cardiac myocyte (heart muscle cell) enters mitosis as the literature suggests? Not completely. Here is a cardiac myocyte in metaphase. There are plenty of stacks of myosin II filaments (the core of each sarcomere) hanging about. #CellBiology

New work from Dr. Shamil Sunyaev at @harvard.edu shows that as men age, harmful genetic mutations in #sperm not only accumulate but are favored during sperm production, giving them a reproductive advantage. 📑 Nature study: https://go.nature.com/3WCZ736 🎙️ Podcast episode: https://bit.ly/4qfiME4

Less than 3 weeks before scientists and clinicians convene in Los Angeles, CA for @CellSymposia #CSStemCells2025. Check out the scientific program and register today: http://dlvr.it/TNkn4M

By popular demand — the next edition of our hands-on @Stanford @BrOrganogenesis course is coming in 2026! This year, the focus turns to neural #assembloids, reflecting the growing movement toward modeling circuit-level and complex cell-cell interactions in brain disease. 🧠 Deadline: mid-December

Researchers at @keck.usc.edu, led by Dr. Qi-Long Ying, have succeeded in deriving and maintaining authentic #ESCs from chickens and seven other #bird species. 🪶 🦆 Read the article: https://go.nature.com/4gSwzvZ 🦜 Listen to the discussion: https://bit.ly/4qfiME4

The Burnette Lab did well this year in the Nikon Small World contest! Way to go James and Zach! 🔬 www.nikonsmallworld.com/galleries/20...

📢 New in @natbiotech.nature.com! Scientists have successfully derived #haploid androgenetic #ESCs from cattle and sheep and developed a novel method to generate offspring from these cells. 📖 Read the article: https://go.nature.com/48XR600 🎧 Listen to the discussion: https://bit.ly/4qfiME4

📢 Our newest episode is out! Daylon and Arun chat with Dr. Carole LaBonne from Northwestern University about her work understanding the genesis of #NeuralCrest stem cells at the level of signaling pathways and transcription factors. 🎧 Listen now: https://bit.ly/4qfiME4

For #FluorescenceFriday, α-spectrin (red) and lipid droplets (green) are shown in adipocytes 🔬 #Microscopy #CellBiology

Paper Alert!! Our collaborative work with Giger Lab at UMich is out now in #ScienceTranslationMedicine Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury | Science Translational Medicine @science.org www.science.org/doi/10.1126/...

This week: Khristian Bauer-Rowe and a team in Drs. Jeong Hyun's and Michael Longaker's labs showed how 'creeping fat' can trigger scarring in the intestines of people with #CrohnsDisease. 📰 - https://stan.md/48cdgeG 🗣️ - https://bit.ly/48I9olK

How do hearts recover after #MyocardialInfarction? ❤️‍🩹 A collaborative paper from Drs. Shengshou Hu, Yu Nie, and Hui Zhang's labs found that inhibiting lysosomal degradation improves recovery. @cp-cellstemcell.bsky.social#MyocardialInfarctionpaper - https://bit.ly/4nHwI7J Discussion - https://bit.ly/48I9olK