New paper out today at @natneuro.nature.com in collab. with DichgansLab @isd-research.bsky.social @lmumuenchen.bsky.social: We developed a fully #iPSC-derived human model of the #BBB #blood-brain-barrier and applied it to study neurovascular disease (NVD)! #OA PDF here: rdcu.be/eUIl3 Thread👇 1/10

Congratulations! 🏆 The European Research Council has awarded the prestigious ERC Consolidator Grant to support TRAINED, a project led by Arthur Liesz (ISD) that investigates how maladaptive trained immunity drives systemic inflammation and multimorbidity after stroke and myocardial infarction.

German Research Foundation (DFG) has approved funding of a new CRC on “Compartmentalized Cellular Networks in Neurovascular Diseases”. Thanks to everyone involved!🙏 www.lmu.de/en/newsroom/...

Synaptic density and tau pathology in Alzheimer’s disease: a dual role in susceptibility and degeneration url: academic.oup.com/brain/articl...

Happy to find Martin Dichgans on the list of Highly Cited Researchers™ once more 🎉 clarivate.com/highly-cited...

Key risk factors for post-stroke dementia uncovered: results from DEMDAS study identify metabolic syndrome + reduced HDL cholesterol as novel, modifiable risk factors for post-stroke dementia... www.thelancet.com/journals/lan...

Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer’s disease url: academic.oup.com/brain/articl... #tao @nfranzme.bsky.social

Marios Georgakis and team showed IL6 genetic perturbation mimicking IL-6 inhibition is associated with lower cardiometabolic risk www.nature.com/articles/s44...

Mikael Simons receives $500,000 for a project to investigate disease mechanisms involving tau proteins. The funding is part of the international program „Tauopathy Challenge Workshop 2025“, supporting research projects aimed at understanding and treating tau-associated diseases such as AD. 🎉

Annual ISD Research Retreat 🎆 Great talks, project presentations, poster session, games, guest talks and an amazing LLM workshop by Rainer Malik 🙏

Arthur Liesz received the prestigious ESO Scientific Excellence Award for his contributions to the understanding of stroke and neurovascular disease. The award was delivered in the Presidential Session at the European Stroke Organisation Conference (ESOC 2025) in Helsinki. @arthurliesz.bsky.social 👏

The Munich Cluster for Systems Neurology (SyNergy) has been awarded a third funding period (2026-2032) by the DFG. 🎆 👏 @synergy-munich.bsky.social

Die Europäische Kommission hat den Wirkstoff Lecanemab (Handelsname: Leqembi) zur Behandlung der Alzheimer-Krankheit im frühen Stadium zuzulassen. Damit wird es erstmals in Deutschland eine Alzheimer-Behandlung geben, die ursächlich an einer der möglichen Krankheitsursachen angreift.

Interested in cellular mechanisms of cognitive decline after stroke? Check out this work in Nature communications: Anna-Sophia Wahl lab track the fate of individual neurons involved in spatial memory before + after multiple, distributed microstrokes using chronic 2photon imaging in-vivo. 👍

For his research project “Reprogrammed microglial cells as a therapeutic approach against Alzheimer's Disease” Dominik Paquet receives funding from the Alzheimer Forschung Initiative 🙌 @afi-ev.bsky.social www.alzheimer-forschung.de/forschung/fo...

Alpha-synuclein co-pathology promotes tau accumulation in Alzheimer’s disease - findings by ISD investigators published in Molecular Neurodegeneration 👏 rdcu.be/ed0Su @nfranzme.bsky.social @springernature.com

An atypical chemokine that links atherosclerosis and metabolic disease - A new study led by ISD staff identifies D-dopachrome tautomerase (D-DT/MIF-2) as an atypical chemokine that promotes both atherosclerosis and hepatic lipid accumulation. (...) read: 👉 www.isd-research.de/scrivito/isd... 👏

Open #Postdoc position @isd-research.bsky.social @lmumuenchen.bsky.social to develop an #iPSC-derived #BBB model. Fully funded and embedded in our international Foundation Leducq Network of Excellence www.brenda-leducq.de Experience in vascular biology or related field required. Please RP and apply

Finally printed: ISD Annual Report 2023/2024: Nice overview about the last years of research life and events at the institute. Thanks to everyone who contributed.🫶 www.isd-research.de/about-us/med...

Prof. Dr. Paquet (@paquetlab.bsky.social) von der LMU München und sein Team züchten Mikrogliazellen mit neuen Rezeptoren, die schädliche Eiweiße wie Amyloid-beta besser erkennen und beseitigen sollen. Mit dieser Strategie könnten die neuen Alzheimer-Therapien ergänzt werden. Mehr Infos im Video!

👋 Meet our PhD and Postdoc Representatives 💭 The voice of our PhD students and Postdocs. A point of contact for feedback, questions, criticism, and improvements. And they organize extracurricular activities! Meet @angelikadannert.bsky.social, Clara, Lis and Nathalie. 🔗 Read more: lnkd.in/dKtzshqr

www.cell.com/immunity/ful... - 👉ISD investigators now defined a mechanism whereby HDAC9 regulates activation of the NLRP3 inflammasome and developed a targeted anti-inflammatory approach for treating atherosclerosis. #HDAC9 #cell #immunity

A study led by ISD researchers suggests a key mechanistic link between Aβ and tau accumulation in Alzheimer’s disease, showing that Aβ induces neuronal hyperconnectivity, thereby promoting the spread of tau pathology across interconnected brain regions. 👍 www.science.org/doi/10.1126/...