🧠 Metabolic #Tau Toxicity Drives Neuronal Death: This study shows how reduced brain glucose metabolism and pathological phosphorylated Tau cooperate to trigger neuronal #necroptosis. 🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...

Advanced Clinician Scientist Program for Comprehensive Neuroscience (PROMISE) www.med.lmu.de/de/wissensch...

🧠 Engineered Human Neurons Model Late-Stage #Tauopathy. This study presents a human induced pluripotent stem cell ( #iPSC )–based neuronal model that reproduces key features of late-stage tauopathies. 🔗Read a summary of the study on our website: synergy-munich.de/news-events/...

🧠Single-synapse mechanisms shape #visualperception. This study reveals how thalamic inputs to the #primaryvisualcortex operate at individual #synapses 🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...

Please Repost: @genecenter-lmu.bsky.social @synergy-munich.bsky.social @enardhellmannwg.bsky.social @dickmerrill.bsky.social @lifescimunich.bsky.social @evobiolmu.bsky.social

🧠Constitutive neuronal expression and disease-associated upregulation of #chitinases in #amyotrophiclateralsclerosis 🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...

🧠 #CSF #proteomics sharpens #multiplesclerosis diagnosis. 🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...

New paper out: TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism.: Feiten, Astrid Feentje; Dahm, Kilian; Schlepckow, Kai; et al. Nature Communications Vol. 17, no. 1, p. 2002 | Thanks for sharing #dzne #papers

🧠 Synaptic #Dopamine Storage Defect Uncovered as Key Mechanism in #Parkinson’s Disease Neurons. 🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...

🧠CD38 Shields #CNS Tregs From Post-Inflammatory Stress. The study shows that regulatory #Tcells persist in the CNS after the acute phase and are essential to prevent local relapses. 🔗Read a summary of the study on our website: www.synergy-munich.de/aktuelles/ne...

🧠 TREM2 Levels Shape Microglial Metabolic Fitness. This study shows that microglial #TREM2 is not an on/off signal but a graded axis that tracks with microglial state and function. 🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...

Outstanding work! – Congratulations to SyNergy member Fabian Theis!

Congratulation to SyNergy member Mikael Simons!

🧠 Zebrafish compass neurons learn visual anchoring. Using panoramic virtual reality and two-photon imaging, we show that larval #zebrafish head-direction neurons track complex visual scenes. 🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...

🧠✨ Dive into #neurodegeneration at the SyNergy #ScienceDay on February 3, 2026! (in German) Medical students get inspiring talks, expert discussions, and an emotional #Alzheimer film through Cineducation. Curious? Join the journey from lab to clinic! #MedicalStudents #TranslationalTeaching

🧠New blood test shows the extent of brain injury after #stroke – and reveals treatment effects. Bood #biomarker brain-derived #tau (BD-tau) can track acute brain injury after ischemic stroke over time. 🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...

Neuer Kurs: Die #Alzheimer-Erkrankung – Dieser Kurs richtet sich an alle, die sich für das Thema Alzheimer interessieren: an Sie als Betroffene, Angehörige, interessierte Laien oder medizinische Fachkräfte. In Zusammenarbeit mit dem SyNergy Cluster. www.synergy-munich.de/aktuelles/ne...

🧠 Fully human #iPSC - derived 3D #BBB model with perfusable vessels and key BBB functions. #FOXF2 deletion causes BBB dysfunction, rescued by lipid-nanoparticle delivery of Foxf2 mRNA. 🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...

🧠 ApoE4 lowers the p-tau217 #tauopathy threshold. In two independent cohorts spanning preclinical and symptomatic #Alzheimer’s disease, the study tested where #ApoE4 accelerates the amyloid-to-tau transition. 🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...

Welche Prinzipien der Intelligenz verbinden Mensch, Tier und Roboter? Hört rein in die nächste Folge des #Podcast #exzellenterklaert – Spitzenforschung für alle! Das Cluster Science of Intelligence erklärt. warum Grundprinzipien von Intelligenz wichtig sind. exzellent-erklaert.podigee.io #Wisskomm

🧠 In vivo #CRISPR screening approach identifies cytokine networks that control #macrophage function in #neuroinflammatory lesions, offering new insights into immune regulation in diseases such as #multiplesclerosis 🔗Read a summary of the study on our website: www.synergy-munich.de/aktuelles/ne...

👏 Our member Qihui Zhou, has received a grant of 100,000 Swiss francs from the Frick Foundation. Zhou and her team will take a closer look at the role of the immune system in the most common genetic form of ALS. 🔗https://www.dzne.de/en/im-fokus/meldungen/2025/funding-for-munich-als-researcher/

🏆 👏 Congratulations to our member Arthur Liesz @isd-research.bsky.social for receiving an ERC consolidator grant for his project: TRAINED - The Role of Trained Immunity in Brain-Body Communication and Secondary Organ Dysfunction. 🔗 Read more on our website: synergy-munich.de/news-events/...

My research at @isd-research.bsky.social, @lmumuenchen.bsky.social, @synergy-munich.bsky.social focused on more physiological, human-based models that better reflect actual disease processes - and thus contribute to the global effort towards more effective dementia treatments tinyurl.com/3thjnvzs

Congratulations @angelikadannert.bsky.social 👏

You can currently find us at #SfN25 Neuroscience 2025 in San Diego (Society for Neuroscience) as part of Neurocenters in Germany. If you're there too, let's connect - join us at booth 3917!

👃 A reduced sense of smell can be one of the first signs of Alzheimer's disease. Researchers discovered that the brain's immune system plays a significant role, indicating that it may attack neuronal fibers essential for the sense of smell. 🔗Summary on our website: synergy-munich.de/news-events/...

🏆 Our member Mikael Simons receives US$500,000 for a project to investigate disease mechanisms involving tau proteins. The funding is part of the international program „Tauopathy Challenge Workshop 2025“. 🔗 Read more at @dzne.science: www.dzne.de/en/im-fokus/...

👇Meet our member Angelika Harbauer @harbauerlab.bsky.social

🧠 A team of researchers led by Monika Leischner-Brill and Thomas Misgeld discovered that tubulin polyglutamylation plays an important role in synaptic remodeling by tagging microtubules for severing. 🔗Read a summary of the study on our website: synergy-munich.de/news-events/...

💭 “The most important thing for an early career researcher is to have good mentors. Ideally, this kind of a mentoring relationship is something that will naturally develop between the doctoral researcher and their supervisor." 👉 Interview w/ @haasslab.bsky.social at UEF: www.uef.fi/en/article/c...

🏆 👏 Congratulations to our members Dieter Edbauer, Thomas Korn, and Christian Weber who each received the prestigious ERC Advanced Grant from the European Research Council (ERC)! 🔗 Read more on our website: synergy-munich.de/scrivito/new...

👏Congratulations Arthur Liesz! Liesz was awarded the prestigious ESO Scientific Excellence Award for his contributions to the understanding of stroke and neurovascular disease. The award was presented during the Presidential Session at the ESO Conference in Helsinki. @isd-research.bsky.social

Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration @janos-groh.bsky.social @tum.de @synergy-munich.bsky.social @dzne.science www.nature.com/articles/s41...

👏 With our member Lisa-Ann Gerdes 👇

🏃‍♂️‍➡️🏃‍♀️‍➡️ A team of 19 researchers, along with our managing director and Team Captain, Tobias Niemann, participated in the largest running event to raise funds for spinal cord injury research—the Wings for Life World Run. More: synergy-munich.de/news-events/...

Great to be at #Tau2025 in London, where @angelikadannert.bsky.social from the lab presents our human #iPSC model of Tauopathies in a packed poster session

A study led by Anna-Sophia Wahl (@isd-research.bsky.social) reveals that the survival of place cells with stable coding for spatial information can be a strong predictor of positive cognitive outcomes following a #stroke. 🔗Read a summary on our website: synergy-munich.de/news-events/...

For his research project “Reprogrammed microglial cells as a therapeutic approach against Alzheimer's Disease” Dominik Paquet receives funding from the Alzheimer Forschung Initiative 🙌 @afi-ev.bsky.social www.alzheimer-forschung.de/forschung/fo...

Interested in cellular mechanisms of cognitive decline after stroke? Check out this work in Nature communications: Anna-Sophia Wahl lab track the fate of individual neurons involved in spatial memory before + after multiple, distributed microstrokes using chronic 2photon imaging in-vivo. 👍

A study led by @nfranzme.bsky.social and published in Molecular Neurodegeneration reveals that α-synuclein co-pathology is more prevalent in advanced #alzheimersdisease and that it accelerates amyloid-related tau accumulation. 🔗Find a summary on our website: synergy-munich.de/scrivito/new...

Join "Was Wissen schafft" next week for an exciting presentation by our member Jovica Ninkovic (@bmc-lmu.bsky.social) 🗓️8 April 2025, 7 PM 📍Hybrid: Campus Martinsried or Zoom 🎤"Gehirn in Bestform: Stammzellen für Plastizität und Regneration des Gehirns" 🔗 more info: www.bi.mpg.de/2739077/2025...

🧠 🏆 Congrats DZNE scientist Christian Haass @haasslab.bsky.social On a recent gala in Paris, he was awarded the "Grand Prix Européen 2024" by the "Fondation Recherche Alzheimer" for his research on #Alzheimer's. 👉 youtu.be/kDe8nuGkn2E?...

A team led by Jürgen Bernhagen & Omar El Bounkari (@isd-research.bsky.social) improves our understanding of how inflammation in blood vessels is connected to liver problems in atherosclerotic diseases and suggests potential treatment pathways. 🔗More insights: synergy-munich.de/news-events/...

Prof. Dr. Paquet (@paquetlab.bsky.social) von der LMU München und sein Team züchten Mikrogliazellen mit neuen Rezeptoren, die schädliche Eiweiße wie Amyloid-beta besser erkennen und beseitigen sollen. Mit dieser Strategie könnten die neuen Alzheimer-Therapien ergänzt werden. Mehr Infos im Video!

💭 Our PhD & Postdoc reps initiated visits to our Technology Hubs for our researchers and kicked off with a visit to our Single-Cell and Spatial Transcriptome Hubs last week. 👋 Thanks Arek Kendirli, Janos Groh, Clara de la Rosa del Val, and Simon Frerich for hosting the first event of the series!

👋 Meet our PhD and Postdoc Representatives 💭 The voice of our PhD students and Postdocs. A point of contact for feedback, questions, criticism, and improvements. And they organize extracurricular activities! Meet @angelikadannert.bsky.social, Clara, Lis and Nathalie. 🔗 Read more: lnkd.in/dKtzshqr

Die nächste Folge des Podcast “#exzellenterklaert – Spitzenforschung für alle” ist online. Dieses Mal erzählen Forschende des Münchner #Exzellenzcluster SyNergy etwas zu dem Thema „Neurowissenschaften: Reparaturmechanismen im Gehirn“. Hört rein: 👉 exzellent-erklaert.podigee.io

A team of researchers led by @nfranzme.bsky.social studied the connection between amyloid and tau buildup. They show that amyloid drives the spread of tau by evoking neuronal hyperconnectivity. 🔗More insights on our website: synergy-munich.de/scrivito/new...

🎧Our member Anna-Sophia Wahl (LMU) and speaker Thomas Misgeld (@tum.de) are featured in the newest episode of the German podcast #exzellenterklaert: Spitzenforschung für alle - talking about repair mechanisms in the brain. Listen to the podcast here👇 exzellent-erklaert.podigee.io/54-neurowiss...