New paper out! We systematically compared how ATN biomarker changes track cognitive decline in AD: Tau-PET, plasma ptau217 & cortical thickness changes track cognition, amyloid-PET does not. Ptau217 = cost-effective proxy for monitoring cognitive changes in AD doi.org/10.1002/alz....

I'm thrilled that our paper "Personalised regional modelling predicts tau progression in the human brain" is finally published in PLoS Biology! Here's a short thread about the main findings of the paper...

🚨Postdoc position open at @BarcelonaBeta🚨 We're looking someone to work on a project at the intersection of cardiovascular and neurodegenerative research 🫀🧠 Fully funded position!!! More details: www.imim.cat/media/upload... Please share! #Alzheimer's #ENDALZ

I have just dropped a new version of my academicdb project, which helps prolific researchers generate a CV automatically. Now with a web interface! If you are interested, please try it out and let me know what you think - it takes a bit of setup work but then runs easily using Docker.

Out now in Brain: Our new study shows that tau deposits in Alzheimer’s disease not affect gray matter but also drive degeneration of connected white matter tracts, offering mechanistic insight into how tau disrupts brain networks academic.oup.com/brain/articl...

🔥Recent advances in #neuroimaging of #Alzheimers disease 🧠✨ dx.doi.org/10.1002/alz.... ➡️ Valuable resource for both researchers & clinicians! ➡️ ATNIV biomarkers, staging, connectomics & more ➡️ Plus: how are sex & country represented in first/last authorship? @istaart.bsky.social Neuroimaging PIA

Very happy to share our 2nd paper today, led by Lukas Frontzkowski: We developed a novel data driven reference region for PI-2620 PET tailored to assess 4R tauopathies, improving i) PSP vs. control separation and ii) PET associations with clinical scores doi.org/10.1007/s002...

Happy to share our new work by Carla Palleis in Movement Disorders showing that brain networks shape neurodegeneration patterns in PSP => This suggests that grey matter atrophy expands across connected brain regions, potentially following tau accumulation in PSP doi.org/10.1002/mds....

Alzheimer's disease drug development pipeline: 2025 - Cummings - 2025 - Alzheimer's & Dementia: Translational Research & Clinical Interventions - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

“I would like to cure brain cancer. I think that's not particularly controversial.” Be that as it may, the NIH terminated that scientist's grant. Here's a huge survey of the 2,500 grants that NIH has killed or delayed...so far. Gift link: nyti.ms/43Jz1yJ

This is a well done study! congrats www.cell.com/cell-reports...

Hiring! We're looking for a postdoc to join my lab at the @ukdri.ac.uk @ucl.ac.uk We’re investigating neuronal and circuit dysfunction in Alzheimer's, and developing innovative new treatments. Apply here👇 shorturl.at/LpCAq

Our latest work, published in @cellpress.bsky.social, identifies a rare soluble #tau species in human #Alzheimer’s brain that suppresses CA1 complex-spike bursting, a hippocampal neuronal firing pattern that is critical for learning and memory. www.cell.com/cell/fulltex...

Super excited to announce a PhD position on polypathology in the medial temporal lobe at the Paris Brain Institute together with @nvillain-alz.bsky.social and @robindeflores.bsky.social! offres.institutducerveau-icm.org/fr/jobs/1935... Please repost!

When I was a student, I dreamed of one day publishing in Trends In Neurosciences. So I'm proud that we had the opportunity to write an invited review on BIN1, a major genetic determinant of Alzheimer's disease that we've been working on for over 10 years. www.sciencedirect.com/science/arti...

Just out in JAMA Neurol blood biomarkers are powerful—but without cognitive phenotyping, we risk more noise than signal. Plasma p-tau217 needs clinical context or we’ll end up in a false-positive factory! Clinico-biological AD is a reality! 👉🏻 jamanetwork.com/journals/jam... bsky.app/profile/vinc...

We are HIRING!! Postdoc for multimodal imaging lab at Yale. If you get excited about preclinical and prodromal states, atypical Alzheimer’s, graph theory, predictive modeling, and/or baked goods at lab meetings, come join us: postdocs.yale.edu/postdoctoral... Please share with your circles!

Also out today in EJNMMI, led by @matthiasbrendel.bsky.social and Johannes Gnörich: Ever wondered about the strong PI-2620 tau-PET signal in the vermis and superior cerebellum? We found that this signal is driven by leptomeningeal melanozytes rather than tau deposits. doi.org/10.1007/s002...

Excited to share our new work in Molecular Neurodegeneration, showing that α-synuclein co-pathology is common in Alzheimer’s and accelerates amyloid-related tau accumulation, supporting its role as a tau co-aggregation factor. doi.org/10.1186/s130...

Great working with Sujala Ghatamaneni, Val Lowe, and colleagues on this high resolution autoradiography study of MK-6240 and flortaucipir🧠🖥️ link.springer.com/article/10.1... @drchristinamoloney.bsky.social @davidjonesbrain.bsky.social

Open #Postdoc position @isd-research.bsky.social @lmumuenchen.bsky.social to develop an #iPSC-derived #BBB model. Fully funded and embedded in our international Foundation Leducq Network of Excellence www.brenda-leducq.de Experience in vascular biology or related field required. Please RP and apply

Why academia is sleepwalking into self-destruction. My editorial @brain1878.bsky.social If you agree with the sentiments please repost. It's important for all our sakes to stop the madness academic.oup.com/brain/articl...

Zelensky is a wartime leader watching his people suffer and die under Russian attacks every day. To be lectured and lied to by Trump and Vance, as they defend the war criminal dictator committing these atrocities, is unimaginable agony. An everlasting shame for America.

We did it and now it is published: A highly Lewy-fold selective and quantitative Synuclein Aggregate Amplification Assay (SAA). Huge thanks to the amazing teams at MODAG GmbH, LMU Munich, and Bologna University! rdcu.be/eaISM

Overview of all our locus coeruleus studies presented at HAI2025 - by Alzforum 💙 . Proud of our team!! Thank you @leatgrinberg.bsky.social and @drneurochic.bsky.social ! ow.ly/mGaZ50V0LBu

WOMEN and FEMALE are red flag words. (Men, male are not on the list). Let that sink in.

Huge thanks to alzforum for covering our most recent work! Great summary! www.alzforum.org/news/researc...

Incredibly happy and proud to share our newest work in Science Transl Med showing that Aβ promotes neuronal hyperconnectivity, thereby driving tau spread across connected brain regions. Many thanks to first authors @sebroemer.bsky.social and Fabian Wagner! science.org/doi/10.1126/... Thread below

It's #FluorescenceFriday! Here goes one image showing pathological Tau🟢 spreading in the monkey hippocampus. Neurons in 🟢 are dying, and healthy neurons in 🟣. Pathology spreads in a prion-like manner in this novel monkey model of Alzheimer we developed. How do we know that?

Happy to share our new preprint led by Johannes Gnörich and @matthiasbrendel.bsky.social, showcasing a full ATN staging approach using a single dynamic PI-2620 scan, leveraging advanced kinetic modelling techniques www.medrxiv.org/content/10.1...

Happy to share Davina Biels newest work in @embomolmed.bsky.social, showing stronger Aβ-dependent p-tau increases in women, potentially driven by elevated sTREM2-related microglial activation and stronger effects of ApoE4 carriership in women Many thanks also to co-senior Matthias Brendel!

Happy to share our new work led by Johannes Gnörich and Matthias Brendel, suggesting a visual read algorithm for PI-2620 in 4R taupathies. Early imaging windows, kinetic modelling and basal ganglia are key! doi.org/10.1016/j.ne...

With so many great tau researchers like @leatgrinberg.bsky.social @lucbuee.bsky.social @sjorsscheres.bsky.social @selinawray.bsky.social @karchlab.bsky.social on #SciSky could not help but put together my 1st starterpack⤵️ We are all fighting for you @curemaptftd.bsky.social 💙 go.bsky.app/KHno2VG

Paper alert: We performed a prognostic validation of the MDS PSP criteria, showing most patients with possible/suggestive PSP show an increase in diagnostic certainty over time. Increase in diagnostic certainty could be used as an endpoint in trials doi.org/10.1002/mds....

Very happy to share the first PhD work by Hannah de Bruin, showing that traumatic brain injury is not linked to higher fibrillar amyloid and tau per se, but to altered patterns of tau deposition preferentially in TBI vulnerable regions doi.org/10.1093/brai... @rikossenkoppele.bsky.social

Many thanks to the @alzassociation.bsky.social for funding our project on ApoE4s role in accelerating pathophysiological disease trajectories in AD via the 2025 AD Strategic Fund. Awesome Christmas present!!! Congrats also to Co-PIs Matthias Brendel and Anna Steward!

it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease www.nature.com/articles/s41... led by Michael Heneka, published in @natrevimmunol.bsky.social today (MANY more authors listed and linked below)

it’s not as simple as just “activating microglia” to produce benefits in neurodegenerative disorders. Multiple glial states coexist and should be strategically targeted. ⭐️🌟 Press release from TREM2 antibody trial in Alzheimer’s 👇👇👇 investors.alector.com/news-release...

Massive paper alert: We performed extensive profiling of PI-2620 for 4R tauopathies. PI-2620 tau PET signals in PSP stem from neuronal and oligodendroglial tau, not astrocytes. Signals correlate with fibrillary tau, autoradiography, and autopsy data in PSP doi.org/10.1007/s004...

New paper alert: A two-cutoff CSF Aβ42/40 approach improves Aβ detection in real world clinical settings. CSF Aβ42/40≥7.1 rules out amyloid, while ratios~5.5–7.1 benefit from Aβ PET. Key for Lecanemab stratification. #Alzheimers #Biomarkers 📄read more: doi.org/10.1002/dad2...