New preprint 🥳 Gamma secretase isnt a single enzyme, multiple GSEC exist depending on which subunits are incorporated into the complex. We made PSEN1 & PSEN2 knockouts to study the impact of different GSEC in neurons & microglia Led by @celarber.bsky.social www.biorxiv.org/content/10.6...

Excited to share new work led by Sam Swift in the lab identifying NINL as a modifier of tau seeding

Beyond excited to share new work using super resolution microscopy to reveal how a tau mutation drives early changes in the autophagy lysosome pathway led by the amazing Dr Mirfakhar

Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition: Neuron www.cell.com/neuron/fullt...

UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration www.nature.com/articles/s41...

Transgender rights = human rights. In many countries around the world, the rights of trans people are under attack. This International Transgender Day of Visibility, we continue to work for a world where all people can enjoy their rights fully.

Latest preprint from our lab reports that the distinct pH of anterograde (less acidic) and retrograde (more acidic) lysosomal vesicles in the axon depends on assembly of the V1 and V0 domains of the vacuolar H+ ATPase, mediated by the metazoan RAVE complex www.biorxiv.org/content/10.6...

Guidelines for T cell nomenclature www.nature.com/articles/s41...

NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...

Our first Family Social Hour is today at 8PM! Join us to meet other #MAPTFTD families ❤️ #cureMAPTFTD #FTD us06web.zoom.us/meeting/regi...

Thank you Alzforum for featuring our new preprint identifying regulators of disease states of #microglia. Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs. Alzforum www.alzforum.org/news/researc... Preprint www.biorxiv.org/content/10.1...

Excited to share new work from the lab showing that FTD causing mutations in tau cause widespread defects in microglia function www.nature.com/articles/s41...

Excited to share new work from the lab showing that loss of AD risk gene Ms4a4a promotes abeta clearance and protects against amyloid plaque accumulation in a mouse model 🧠🐭 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Should PIs at institutions where NIH funds have been frozen still agree to participate in NIH study sections?

www.alz.org/news/2025/ke...

Dear immune/glia lovers of brain, gut and beyond… We’re looking for a lab tech/manager to join our team! Pls see details for application here ucl.ac.uk/work-at-ucl/se… @ukdri.ac.uk @uclqsion.bsky.social - pls help circulate among networks who’d be of interest, thank you!

LipidCruncher: An open-source web application for processing, visualizing, and analyzing lipidomic data

Everyone should contact their us congress members and tell them not to cut SNAP (food stamps). secure.everyaction.com/lmBv70YdQkCu...

New TYP lab paper out today in @cp-neuron.bsky.social led by PhD student @alexlish.bsky.social! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read! www.cell.com/neuron/abstr...

Great article featuring pioneering work from the Frost lab along with promising clinical trial data @bessfrost.bsky.social

Join us on Monday, April 21st for our next #ZoomYourCareer webinar, "The Future of #AI in Research “Is #ChatGPT Smarter than Me?” with #CCAD alumni speakers Shea Andrews and @trajnp.bsky.social! Registration 🔗 us02web.zoom.us/meeting/regi... #NewVisionResearch #ProfessionalDevelopment

Zoom your career 🤓🧠🧬https://us02web.zoom.us/meeting/register/tIp9vIuwSF2LJydcdpDIxQ#/registration

1/ Why do patients with late-stage cancer lose motivation & sink into apathy? 🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵 🔗 doi.org/10.1126/scie...

Excited to share our findings on how APOE genotype impacts cell responses to AD using human brain snRNAseq. Huge thanks to the team for all the hard work! @drneurochic.bsky.social @mayoclinic.org @cp-neuron.bsky.social

When educators, students, families, and community members come together, there is nothing we cannot achieve. Join us to protect students and families on March 19 by attending or hosting a “walk-in” at your local school: nea.org/March19

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇

NfL beats GFAP in a head-to-head FTD biomarker competition. Gendron et al. show plasma GFAP and NfL correlate with FTD disorder severity; however, NfL outperforms GFAP as a prognostic biomarker and potential susceptibility marker. molecularneurodegeneration.biomedcentral.com/articles/10....

Endothelial TDP-43 depletion disrupts core blood–brain barrier pathways in neurodegeneration www.nature.com/articles/s41...

Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum: Neuron www.cell.com/neuron/fullt...

Our proximity proteomics study introducing Probe‑dependent Proximity Profiling (ProPPr) and applying it for profiling tau pathology‑associated proteins in tauopathies + @drneurochic.bsky.social & others is out now! @cziscience.bsky.social molecularneurodegeneration.biomedcentral.com/articles/10....

🤩Preprint alert👇 Excited to introduce the concept of transformative neuropathology, a term we use to describe the integration of foundational descriptive pathology with advanced technologies and methodologies 🔬🏛️🧬🧪🖥️🔬 🧠📊🤖 @cshlnews.bsky.social www.preprints.org/manuscript/2...

Results from our AntiRetroviral Therapy for Alzheimer's Disease (ART-AD) clinical trial are available online today and will be included in the inaugural issue of npj Dementia. rdcu.be/edfwq

PTPσ-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD: Neuron www.cell.com/neuron/fullt...

If you are in St Louis this weekend, join MO Jobs with Justice to support federal workers

@michellemonje.bsky.social at @stanfordmedicine.bsky.social and Frank Winkler at Heidelberg University have won the 2025 @brainprize.bsky.social from the Lundbeck Foundation for their work in cancer neuroscience. By @sydneywyatt.bsky.social #neuroskyence www.thetransmitter.org/community/20...

Nice to see this finally published! Congratulations @jack-humphrey.bsky.social www.nature.com/articles/s41... (Collaborative work with Panos Roussos and his team! ) Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing

CLEC16A in astrocytes promotes mitophagy and limits pathology in a multiple sclerosis mouse model @NatureNeuro www.nature.com/articles/s41...

In honor of #RareDiseaseDay and the mom of an amazing kiddo with one, I want to highlight the amazing organization working to improve the lives of people and families with RASopathies (like ours). (Full disclosure, I am lucky enough to be a Board member of this organization too).

Happy to share this new #glycotime work with collaborator Tony Wyss-Coray, led by grad student Sophia Shi, mucin loss at the BBB is associated with aging and cognitive decline, can be reversed by restoration with with gene therapy. Aging is a mucinopathy! www.nature.com/articles/s41...

If you have a chance and allowed - call your #Program #Officers and #Scientific #Review #Officers, say thank you🙏. They are working under pressure, trying to #reschedule #study #sections when possible. Please accept if they ask you to review in coming months! It will take a village to get through!