Soyon Hong
@soyonhonglab.bsky.social
š¤ 633
š„ 137
š 15
I study neuro-glia-immune interactions in brain and gut with my wonderful lab in UKDRI at UCL
Weāre looking for a postdoc to join us
@ukdri.ac.uk
@uclqsion.bsky.social
! Strong immunology background to study neuroimmune interactions along gutābrain axis in Parkinsonās, supported by
@wellcometrust.bsky.social
. Collegiality & team spirit are a must. Info:
lnkd.in/eZSyHjND
. Please help share š
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LinkedIn
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https://lnkd.in/eZSyHjND
2 months ago
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Soyon Hong
Mitchell Bijnen
4 months ago
So great that this paper is finally out! Happy that I was able to contribute to this important study. Congratulations
@seppedeschepper.bsky.social
,
@soyonhonglab.bsky.social
, Tim Bartels and all co-authors!
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Soyon Hong
UCL News
4 months ago
New research has revealed how Parkinsonās spreads from the gut to the brain, with the help of immune cells ā offering a new potential therapeutic strategy ā in a study in mice co-led by Dr
@soyonhonglab.bsky.social
& Dr Tim Bartels
@ukdri.ac.uk
@uclqsion.bsky.social
@uclbrainscience.bsky.social
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Targeting the gut's immune system could tackle early stages of Parkinson's
New research reveals how Parkinsonās spreads from the gut to the brain, with the help of immune cells ā offering a new potential therapeutic strategy ā in a study in mice led by scientists at the UK D...
https://www.ucl.ac.uk/news/2026/jan/targeting-guts-immune-system-could-tackle-early-stages-parkinsons
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Soyon Hong
James Conway
4 months ago
Our paper is finally out! We position intestinal muscularis macrophages as early initiators of α-synuclein pathology and dopaminergic neurodegeneration in Parkinsonās models. They also drive local CD4āŗ T cell expansion, which subsequently migrates from gut to brain
www.nature.com/articles/s41...
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Intestinal macrophages modulate synucleinopathy along the gutābrain axis - Nature
Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinsonās disease, and understa...
https://www.nature.com/articles/s41586-025-09984-y
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šš to entire team esp co-lead Tim Bartels. So proud of
@seppedeschepper.bsky.social
brilliant first postdoc who now leads his own at VIB. šššto
@chanzuckerberg.bsky.social
for supporting the project from early pilot phase. Contact us if u want to explore next steps in PD gut/brain neuroimmunology!
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4 months ago
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Absolutely thrilled & grateful to be awarded this prestigious ERC grant. None of this would have been possible without the remarkable team in my lab, past & present! Excited for the next steps of this important project.
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6 months ago
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Very excited and honored to join the Warsaw glia symposium- canāt wait to learn more about and discuss together the beauty and the complexity of glia with the community!
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10 months ago
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Dear immune/glia lovers of brain, gut and beyond⦠Weāre looking for a lab tech/manager to join our team! Pls see details for application here
ucl.ac.uk/work-at-ucl/seā¦
@ukdri.ac.
u
k @uclqsion.bsky.soci
al - pls help circulate among networks whoād be of interest, thank you!
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https://ucl.ac.uk/work-at-ucl/seā¦
about 1 year ago
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Soyon Hong
John Lukens
about 1 year ago
Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity.
@cp-immunity.bsky.social
All credit to Kristine Zengeler, who was the brainsš§ and musclešŖ behind this project and is a wonderful collaborator.
www.cell.com/immunity/ful...
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Inflammasome signaling in astrocytes modulates hippocampal plasticity
The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler etĀ al. find that the inflammasome complex, typically associated with immune responses, is involved in memory...
https://www.cell.com/immunity/fulltext/S1074-7613%2825%2900170-0
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Soyon Hong
Mariko Bennett
about 1 year ago
Our lab's 1st paper, led by
@fchrisbennett.bsky.social
&
@waisenberg.bsky.social
. A decade thinking how to directly assess the impact of microglia replacement. Yrs of hard work. This kind of work is needed to expand brain disease care for kids & the vision for safer, more effective cell therapy.
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Soyon Hong
Will Aisenberg
about 1 year ago
Check out this paper from the Movahedi lab! Itās a great companion to ours - showing the populations of brain macrophages that monocytes can replace. Congrats to first author Jonathan Bastos!
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Soyon Hong
Beth Stevens
about 1 year ago
Excited to share this new work led by the talented Mike Dolan @dolan in collaboration with Evan macosko See below for details and preprint
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šŖšŖšŖ
@blurtonjoneslab.bsky.social
sooo cool!
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about 1 year ago
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Super fascinating!! Congrats, TomƔs!!!
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about 1 year ago
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Soyon Hong
Darragh O'Brien
over 1 year ago
I've
#justsponsored
Selina Wray, who's fundraising for Alzheimer's Research UK on @JustGiving. Donate now:
www.justgiving.com/page/selina-...
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Selina's fundraiser for Alzheimer's Research UK
Help Selina wray raise money to support Alzheimer's Research UK
https://www.justgiving.com/page/selina-wray-1727162622101
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Soyon Hong
Steven Sloan
over 1 year ago
Hi
#neuroscience
community! This is one of my favorite posts ever. In close collaboration with
@liddelowsa.bsky.social
and Ye Zhang, we've built a new tool that we are eager to share!
www.webseq.net
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WEBseq
share freely
https://www.webseq.net
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Soyon Hong
Prof Malú GÔmez Tansey
over 1 year ago
Day 2 Session 7
#ImmuneDynamics
at
#BarrierTissues
#gut_brain
in
#neurodegeneration
with Michal Schwartz Soyong Hong Sandro Da Mesquita Elizabeth Bradshaw & Ryan Hobson
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Soyon Hong
BrunetLab
over 1 year ago
Thrilled to see this paper out!! š§Ŗ Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with
@jameszou.bsky.social
!
rdcu.be/d33uQ
š§µ
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Spatial transcriptomic clocks reveal cell proximity effects in brain ageing
Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...
https://rdcu.be/d33uQ
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Soyon Hong
Lance Johnson
over 1 year ago
new preprint!
www.biorxiv.org/content/10.1...
a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!) first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon,
@cohenlaboratory.bsky.social
@morganti.bsky.social
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Soyon Hong
Priya Prakash
over 1 year ago
Happy to share our review on how different lipids shape microglial biology in
#GLIA
journal. š«
onlinelibrary.wiley.com/doi/full/10....
šš½with Gaurav Chopra, Caitlin Randolph, and
@katherinewalker.bsky.social
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Lipids: Emerging Players of Microglial Biology
Lipids are crucial in mediating microglial metabolism and function. The microglial lipidome is vast and complex, with over 10,000 lipid species. We discuss key lipid classes and their roles in m...
https://onlinelibrary.wiley.com/doi/full/10.1002/glia.24654
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Soyon Hong
Shane Liddelow
over 1 year ago
it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease
www.nature.com/articles/s41...
led by Michael Heneka, published in
@natrevimmunol.bsky.social
today (MANY more authors listed and linked below)
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Neuroinflammation in Alzheimer disease - Nature Reviews Immunology
This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...
https://www.nature.com/articles/s41577-024-01104-7
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