@fchrisbennett.bsky.social
📤 512
📥 176
📝 2
Microglia biologist
reposted by
Waggoner Lab
about 2 months ago
Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells
www.cell.com/molecular-th...
www.cell.com/molecular-th...
@moltherapy.bsky.social
@fchrisbennett.bsky.social
@blurtonjoneslab.bsky.social
@ucirvine.bsky.social
@upenn.edu
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reposted by
Kelsey Nemec
about 2 months ago
📄🚨: Building off a stellar 2023 pub that engineered an hCSF1R variant, Sonia et al. now show how an mCSF1R variant not only confers inhibitor resistance and allows for efficient & non-toxic microglia replacement, but does so after vascular delivery into immunocompetent mice! 👏🧠
tinyurl.com/3wvmm8v3
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Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells
Microglia replacement holds great promise for the study and treatment of neurological diseases. We previously achieved high-efficiency replacement by …
https://tinyurl.com/3wvmm8v3
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reposted by
Deborah Kronenberg-Versteeg
3 months ago
✨ It's happening again! 🚀 Registration for Stem Cells in Neuroscience 2026 has officially opened! 🧠 Don't miss your chance to attend this exciting event with great keynote speakers, thought-provoking workshops and ample networking opportunities 👉🏼
www.stemcelltuebingen.com
#neuroscience
#stemcells
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reposted by
Alice Mosberger
7 months ago
🚨🚨🚨 OPEN POSTDOC POSITION 🚨🚨🚨 in my lab! Are you interested in understanding how the brain moves our arms? Reach to your computer and apply!
www.mosbergerlab.com/open-positions
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Open Positions — Mosberger Lab
https://www.mosbergerlab.com/open-positions
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reposted by
Aakanksha Singhvi
7 months ago
Happy to present a single cell atlas of ALL glia, in BOTH sexes of an animal (in vivo validated!)! Fab work by postdoc
@glia-maria.bsky.social
, team, & collaboration with
@manusetty.bsky.social
. Find insights into glia, new analytics and ML models, and browse our companion website (
wormglia.org
)
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React App
Web site created using create-react-app
https://wormglia.org
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reposted by
The Freducator
7 months ago
www.cell.com/cell/fulltex...
Check out this new paper on Leaf Cutter Ants The Berger lab has published in cell! This story is super cool and provides new insights into conserved mechanisms in eusocial societies!
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Neuropeptides specify and reprogram division of labor in the leafcutter ant Atta cephalotes
We identify specific neuropeptides mediating worker division of labor in the leafcutting ant A. cephalotes, finding two neuropeptides associated with characteristic behaviors of leafcutting and of bro...
https://www.cell.com/cell/fulltext/S0092-8674(25)00573-2
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reposted by
Lucie Van Emmenis
7 months ago
My first meeting in a long time, and it's going to be a good one! 🧠🇨🇦 Let me know if you want to chat, and don't miss the Meet the Editors session on Tuesday afternoon!
#ksneuroimmune25
#ksneurodegen25
add a skeleton here at some point
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reposted by
⚡️GREG_CORDER⚡️
8 months ago
🧠 🍄 ⚡️🐭 Now published in
@natneuro.nature.com
Psilocybin enhances fear extinction by reshaping retrosplenial cortex ensembles—suppressing fear neurons, recruiting extinction neurons + boosting plasticity to enable behavioral flexibility
nature.com/articles/s4159…
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reposted by
Immunity
8 months ago
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Interleukin-34-dependent perivascular macrophages promote vascular function in the brain
The niche signals critical for the homeostasis and functions of the brain border-associated macrophages (BAMs) are not well understood. Van Hove et al. demonstrate that BAMs require IL-34 derived from mural cells and perivascular fibroblasts for their maintenance in adulthood. They show that BAMs are required to promote normal vascular function in the brain.
http://dlvr.it/TKnl5Z
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reposted by
Immunity
8 months ago
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Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease
Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated macrophages (globoid cells) and demonstrate that brain-specific high-efficiency macrophage replacement in the twitcher model of Krabbe disease improves neuropathology, macrophage dysfunction, and survival.
http://dlvr.it/TKndDW
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reposted by
Immunity
8 months ago
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Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1+ microglia
Replacing brain macrophages holds substantial therapeutic promise but remains challenging. Bastos et al. uncover the requirements for monocytes to replace microglia and border-associated macrophages. They show that monocyte ontogeny shapes brain macrophage identity, with fetal monocytes acquiring a true microglial state. Using xenotransplantation and Alzheimer’s patient data, they identify human monocyte-derived microglia. These findings are important for microglia replacement therapies.
http://dlvr.it/TKnJwR
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reposted by
Kavitha Scranton
8 months ago
Excited to see this collection out! Thank you to all the authors and reviewers who contributed!
add a skeleton here at some point
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reposted by
Immunity
8 months ago
May issue is online! Explore reviews on the
#neuroimmune
axis! The beautiful cover was designed by Ella Marushchenko, working with
@jonykipnis.bsky.social
. A brain encased in a walnut shell that is cracking open symbolizes our growing understanding of
#neuroimmunology
www.cell.com/immunity/iss...
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reposted by
Amy Gleichman
8 months ago
Thrilled to announce that my lab is now open at Ohio State! We study astrocytes as gene therapy targets for brain repair after ischemic stroke and in vascular dementia, developing new viral tools along the way. If you're interesting in joining or collaborating, please reach out!
gleichmanlab.com
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The Gleichman lab
https://gleichmanlab.com
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reposted by
Immunity
8 months ago
Online now: Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease
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Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease
Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated macrophages (globoid cells) and demonstrate that brain-specific high-efficiency macrophage replacement in the twitcher model of Krabbe disease improves neuropathology, macrophage dysfunction, and survival.
http://dlvr.it/TKTJQF
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reposted by
Will Aisenberg
8 months ago
Thrilled that
@chopresearch.bsky.social
highlighted our latest work published today in
@cp-immunity.bsky.social
www.chop.edu/news/preclin...
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Preclinical Study from Children’s Hospital of Philadelphia Highlights Innovative Approach to Replacing Brain Cells in the Treatment of Leukodystrophies
Researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania announced the first ever direct approach to the depletion and replacemen...
https://www.chop.edu/news/preclinical-study-childrens-hospital-philadelphia-highlights-innovative-approach-replacing
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reposted by
Mariko Bennett
10 months ago
In this
#rarediseaseday2025
we cannot remain silent. We must fight on the beach and the bench. Share. Tell your stories. Call your elected officials. Call your unelected officials.
#fightonthebench
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We are looking to hire a research assistant - posting will be available soon but please DM if you have interest, thank you
11 months ago
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reposted by
Alice Mosberger
11 months ago
Super stoked to announce 📣 The *Mosberger lab* is officially open and hiring! We're looking for Research Associates and Postdocs interested in uncovering how the brain makes us move 🧠👋🏻 Learn more and find out how to apply here:
mosbergerlab.com
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Mosberger Lab
https://mosbergerlab.com
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reposted by
Nick Silva
12 months ago
Excited to share that our lab website is live!
nicholassilvalab.org
Please reach out if you are interested in studying neuroimmune mechanisms using the zebrafish model. 🐟🧠🥼🔬
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Silva Lab – Neuroimmune mechanisms in health and disease
https://nicholassilvalab.org
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reposted by
Steven Sloan
12 months ago
Hi
#neuroscience
community! This is one of my favorite posts ever. In close collaboration with
@liddelowsa.bsky.social
and Ye Zhang, we've built a new tool that we are eager to share!
www.webseq.net
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WEBseq
share freely
https://www.webseq.net
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reposted by
Steven Sloan
about 1 year ago
First 🦋 post! Very excited to share our lab's latest work exploring the shared and divergent aspects of human astrocyte development and glioblastoma. This effort spans many fields from developmental
#glial
biology to
#stem
cells and
#tumor
biology.
rdcu.be/d5ADz
A 🧵
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Mapping the developmental trajectory of human astrocytes reveals divergence in glioblastoma
Nature Cell Biology - Sojka et al. analyse the transcriptomic and epigenomic landscape of human astrocyte maturation and identify an epigenetically regulated intermediate state associated with...
https://rdcu.be/d5ADz
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reposted by
Kelsey Nemec
about 1 year ago
My thesis paper is out in
@elife.bsky.social
! We look forward to making it even better as we respond to our (very kind) reviewer comments. Till then, see how we created a novel microglia replacement system & showed that brain macs can drive brain interferonopathy!
elifesciences.org/reviewed-pre...
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Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutières Syndrome neuropathology
https://elifesciences.org/reviewed-preprints/102900
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Any tips or tricks to improve cd45.1 vs 2 staining in the brain by flow?
about 1 year ago
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