New paper from @uwe689.bsky.social ! Muscle and #ECM remodeling during fly metamorphosis is still poorly understood. Why? Pupae are really hard to work with. Uwe took on the challenge and explored how Mmp2 contributes to this amazing morphogenetic process. www.nature.com/articles/s41... #cellbio

Youthful antics predict lifespan? Using machine learning & continuous recordings of #killifish behavior from adolescence until death, @brunetlab.bsky.social & @deisseroth.bsky.social find early-life behavior predicted future lifespan! Now published @science.org: www.science.org/doi/10.1126/... 🧪 1/2

Super stoked to share that I’m starting my lab at UHN @dkjei-uhn.bsky.social / @kbi-uhn.bsky.social and the University of Toronto! If you’re interested in neuron-myelin interactions in circuit maturation and cognition, please reach out - we are hiring! www.oligodendrocyte.org 1/

Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties. @cp-neuron.bsky.social www.cell.com/neuron/fullt...

Excited to share our new study using engineered immune proteins to quench inflammation in aged brains!! Congratulations to Paloma Navarro and the entire team! Fantastic collaboration with Chris Garcia's lab, Tony Wyss-Coray's lab, and Saul Villeda's lab! www.cell.com/immunity/ful...

Fintastic meeting as always, for those interested! #ZebrafishMeeting

🐟👀 SFSU Biology seminar — Thu Mar 5 2–3pm | SEC 116 Dr. Patricia Schneider (LSU): “Split Screens: Exploring Vision through the Eyes of the Four-Eyed Fish.” Student time: 3–3:30pm. Come by!

Endogenous retrovirus-derived RNA-DNA hybrids induce microglial synaptic pruning in autism models @cp-neuron.bsky.social www.cell.com/neuron/fullt...

🧠 SFSU Biology Special Seminar Dr. Biswa Ramani, MD, PhD (UCSF) — neurodegeneration + neuropathology + physician-scientist career path 📅 Wed 2/25/2026 • 🕙 10:00–11:40 • 📍 Hensill Hall 233 Hosted by @nicholasjsilva.bsky.social All welcome!

Axolotls can completely rebuild their thymus, a key immune organ

Latest from the lab, led by @ara-donia.bsky.social and @juliavdkorput.bsky.social Huge team effort, with immense contributions by friends from nearby and around the globe. www.science.org/doi/10.1126/...

#fluorescencefriday distribution of microglia in the whole brain

I am SO incredibly excited to announce the launch of a global list of Inspiring Black Scientists. You can use this list to nominate and connect with researchers. Please share and join us in highlighting these outstanding scientists for #BlackHistoryMonth and beyond! www.wiley.com/en-us/resear...

A lifelong passion for writing helped rising star @doctheagrif.bsky.social land a book deal and publish 15 chapter books for early readers, covering topics ranging from what the cerebellum does to how a cake bakes. By @avaskham.bsky.social www.thetransmitter.org/craft-and-ca...

Our paper is (finally) out in Cell today! CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis www.cell.com/cell/fulltex... Great collaborative effort - read more from first author @asamelson.bsky.social below:

A landmark discovery in cancer neuroscience! Why is the incidence of Alzheimer’s disease (AD) lower in patients with a history of cancer? CELL: Peripheral cancer attenuates amyloid pathology in Alzheimer’s disease via cystatin-c activation of TREM2 www.cell.com/cell/fulltex...

We’re delighted to see this out today! Latest work from the lab reveals insights into the evolution of brain immunity and the developmental and evolutionary plasticity of lymphatic endothelial cells. www.nature.com/articles/s41...

Ageing promotes microglial accumulation of slow-degrading synaptic proteins @nature.com www.nature.com/articles/s41...

Proud to announce our collaboration with @blurtonjoneslab.bsky.social & the Paz lab showing that transplanted human iPSC-derived microglia in a PGRN KO mouse model restores progranulin in microglia and rescues pathology, circuitry, and behavior. Preprint out now: www.biorxiv.org/cgi/content/...

IFN-brite: A new interferon reporter from our lab designed by Dr. Sarah Anderson is bright and pan cellular

New discoveries are reshaping how scientists understand the molecular connections between the extracellular matrix and lysosomes—and the resulting implications for research and therapeutics for neurodegenerative disorders. Learn more in this #ScienceSignaling Review: https://scim.ag/3Yi2sFS

Maspardin/SPG21 controls #lysosome motility and TFEB phosphorylation through RAB7 positioning, say Thomas Jacqmin, Marielle Boonen and colleagues (University of Namur): rupress.org/jcb/article/... #Trafficking #Organelles #Disease

Great time to be a new PI 🤦🏾‍♀️ www.statnews.com/2025/12/18/n...

Did you know the last common ancestor of #zebrafish and humans was ~450 million years ago? A whole genome duplication event (3R) occurred early in the teleost fish phylogeny. Despite this event, zebrafish and humans have about the same number of chromosomes. #ZebrafishFunFacts 🧪

Dravet Syndrome is a genetic form of epilepsy caused by mutations in SCN1A. Researchers screened a library of compounds on loss-of-function scn1Lab (Nav1.1) #zebrafish and found clemizole (EPX-100) rescued the phenotype. This drug is now in Phase 3 Clinical Trials to treat seizures. #KnowYourZDM 🧪

Time-lapse movie of mitochondria (blue) transport within neurons (green) in the tail of a transgenic #zebrafish larva. Credit to @paquetlab.bsky.social. #ZebrafishZunday 🧪

Two-photon imaging of pulsating brain activity in a #zebrafish larva that's having a seizure. Credit to Dr. Dominic Burrows. #ZebrafishZunday 🧪

“The only reason I don’t have this funding is because my last name is Rodriguez.” MOSAIC checked many of the boxes of the administration — but that didn't matter. It was terminated, and left grantees scrambling Next installment of American Science, Shattered: www.statnews.com/2025/12/08/t...

“By performing longitudinal live imaging of intubated adult fish we observe vascular regrowth and immune responses to [meningeal cerebrovascular injuries] over time in the same animal with unprecedented resolution” New work from #WeinsteinLab at NIH

#ZebrafishFunFacts: Known to hobbyists as the leopard Danio, TL or Tüpfel longfin #zebrafish consist of two alleles (leo and lof). leo is a gap junction protein (ncbi.nlm.nih.gov/pmc/articles...), while lof is caused by upregulation of a K+ channel (journals.biologists.com/dev/article/...). 🧪 1/2

Slow-mo video of zebrafish mating. Credit to @zebrafish007.bsky.social. #ZebrafishZunday 🧪

Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed. She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.

Applications for the Neuroscience Scholars Program close tomorrow! Don't miss the opportunity to join a growing network that provides guidance for today's challenges & connections for your future. 🚨Deadline: Tuesday, October 21, 5 p.m. EDT Apply now: vist.ly/4b3np

Congrats to Mary Brunkow from @isbscience.org on winning the Nobel Prize in Physiology or Medicine! Brunkow was honored with collaborators Ramsdell and Sakaguchi for their groundbreaking work on immune system regulation. A proud moment for science and Seattle! 🔗 www.nytimes.com/2025/10/06/h...

Celebrating #PostdocAppreciationWeek2025 🎉Meet Amanda Iglesias, Ph.D., postdoc in the Fioravante Lab at CNS. She investigates the neural circuits underlying motivated behavior and reward-related psychopathologies. Learn more about research in the Fioravante Lab: www.fioravantelab.ucdavis.edu

I just sent this email to Director Bhattacharya and am sending him a hard copy by registered mail. 1/14

SCOTUSBlog story about NIH Grant Termination case www.scotusblog.com/2025/08/supr...

Really important article in the NY Times today about cuts to NIH diversity grants, featuring a profile of Ashley Albright @aralbright.bsky.social who is an amazing and super inspiring cell biology postdoc whose K99 was prematurely terminated.

We're now appreciating how the immune and nervous systems communicate across body & brain, and there's still more to explore! Had a fun time co-writing this with some amazing immunologists and neuroscientists @nickmroz.bsky.social @arimolofskylab.bsky.social @annamolofskylab.bsky.social 😎🧠

Calling all @apsphysiology.bsky.social members: let’s help raise some money to support ABRCMS student presentation awards! Goal is $1200/discipline to support 12 awards by Sept 30th! 🧪 abrcms.org/donate/stude...

Please RT: Published today, a super fun collaboration w/ @fanjumeng.bsky.social and Marnie Halpern's lab to establish methods for transgene mapping in zebrafish - TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation: Cell Reports Methods www.cell.com/cell-reports...

MOSAIC scholars: Sharing again in case anyone missed this. Less than an hour left in this deadline 👇🏾

Trump, who said last year that he had “saved” historically Black colleges, has canceled $140 million in grants to them since March. Agencies told HBCUs “to change the language in grant applications that explicitly focus on Black people — or lose federal funding.” www.chronicle.com/article/hbcu...

So important! Please contact your Republican senators, especially Sen. Susan Collins (R-ME), Sen. Shelley Moore Capito (R-WV), Sen. Bill Cassidy (R-LA), Sen. Katie Britt (R-AL), and Sen. Dave McCormick (R-PA). 🙏 amplify!

🧬🌽 Happy Transposon Day! 🌽🧬 Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025

Many w current R16s are also waiting on renewals and those planning on submitting for the May deadline had it cancelled last minute. These are the R01 like grants for unis w >$6M NIH funding that serve >25% Pell students. Lots of fear this mechanism would be permanently cancelled

I’ve warned that this was only a matter of time, but it’s still shocking to see in person. Here AI generated content is being used to create a fake news ecosystem, disparaging a professor who has been critical of unscientific bullshit in the form of deextinction hype.

Powerful statement by Sen. Alex Padilla. Please notice that anytime senators or representatives try to conduct oversight, they’re blocked. In this case, a sitting US senator was tackled to the ground and handcuffed—for asking a question. Where the hell has Chuck Schumer been on this?

If they can do it to a United States senator, what do you think they’ll do to you?

$160 billion in new spending on building jails, hiring more ICE 'agents' to carry out kidnappings & flying people to torture prisons. For comparison, the 2024 NIH budget, which funds essentially all US medical research, was $47.1 billion. Funding racism instead of research.