Pioneer work from the Frank Kooy lab published today in The Lancet eBioMedicine. Congratulations to Claudio D’Incal and all co-authors. Proud to have contributed to this study on ADNP-related neurodevelopmental mechanisms and Wnt signalling. www.thelancet.com/journals/ebi...

The Hoffman Lab at Yale is hiring! We’re currently recruiting for a Lab Manager and Post-Graduate Research Associate positions. If you're interested in understanding the function of neurodevelopmental disorder genes in the developing brain using #zebrafish, we'd love to hear from you! #researchjobs

⏰ Reminder: the abstract submission deadline for the Network Glia Satellite Event at FENS 2026 is today, 30 April! SE07 – Emerging roles of glial cells in brain function and disease 📍 Barcelona 📅 5 July 2026

My paper is finally out in @natcomms.nature.com ! 🐟🐭🧠 Thankful to the contributors and @annamolofskylab.bsky.social for the support! How does the developing brain clear millions of dying neurons? Read below, if interested. #zebrafish #neuroscience #microglia #devbio @zebrafishrock.bsky.social 1/5

Astrocytes do so much more than any of us thought - they even communicate among specific brain regions across hemispheres! The journey to this paper spanned nearly a decade, but I'm most excited to see what everyone else does with the tools we've built. There's so much for all of us to explore!

Lovely highlight of a new fascinating study by @ehoffmanlab.bsky.social 🐟💊 For those interested, 🔗 to original research: www.pnas.org/doi/10.1073/...

Happy to share our new paper published in Nature Communications! www.nature.com/articles/s41... We developed CaMPARI-seq to link neural activity with molecular profiles and revealed how the brain distinguishes optic flow to guide behavior. Congratulations to our postdoc Koji Matsuda!

🚨 Turning on heart regeneration through immune modulation? Led by @kcinc.bsky.social, we show that activating pro-regenerative macrophages induces Granulin, a key driver of cardiomyocyte proliferation and scar resolution in medaka, now published in @pnas.org 💔➡️❤️ www.pnas.org/doi/10.1073/...

New work from @ehoffmanlab.bsky.social 🐟 🔗 to original research: www.pnas.org/doi/10.1073/...

I created this collection of common brain models in neuroscience, all to scale Across species, brains share fundamental principles and many homologous regions But as size increases, complexity and connectivity change. We need the full spectrum, from flies to rodents, non-human primates, and humans

Very happy to share this study from our group and colleagues now out in Science! We found that in zebrafish, before the immune system is mature, gut epithelial cells perform immune functions by producing the cytokine IL-22 to shape the microbiota to promote early life gut function #Zebrafish #Gut

A transcriptomic microglia taxonomy across mouse and human pathologies www.nature.com/articles/s41...

I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.

“Here we present ZMAP (Zebrafish Meta Atlas Project), a harmonized reference integrating 8 published whole-embryo zebrafish scRNA-seq datasets comprising 798,790 cells across 15 developmental time windows.” 🐟 🧪 New work from @danwagnerlab.bsky.social 🔗 to WebApp: wagnerlabucsf.github.io/zmap/

It's #GatorGivingDay and we're almost at our goal! Every $$ supports our wonderful students and community here at @sfstatebio.bsky.social Thank you for your support! giving.sfsu.edu/schools/SanF...

Undergraduate student Alexandra Jose shares “SFSU has provided me with such amazing opportunities to let me pursue my academic goals, contribute to research that inspires me, and be part of an incredible community!” Your gift makes such research opportunities possible. #GatorsGiveDay

“Here, we combined inducible lineage tracing, single-cell RNA sequencing and morphological analysis to define the molecular and structural features of Muller glia derived neurons in the adult zebrafish retina [following injury]” New work from Thanh Hoang et al. at University of Michigan 🐟 👁️

New paper from @uwe689.bsky.social ! Muscle and #ECM remodeling during fly metamorphosis is still poorly understood. Why? Pupae are really hard to work with. Uwe took on the challenge and explored how Mmp2 contributes to this amazing morphogenetic process. www.nature.com/articles/s41... #cellbio

Youthful antics predict lifespan? Using machine learning & continuous recordings of #killifish behavior from adolescence until death, @brunetlab.bsky.social & @deisseroth.bsky.social find early-life behavior predicted future lifespan! Now published @science.org: www.science.org/doi/10.1126/... 🧪 1/2

Super stoked to share that I’m starting my lab at UHN @dkjei-uhn.bsky.social / @kbi-uhn.bsky.social and the University of Toronto! If you’re interested in neuron-myelin interactions in circuit maturation and cognition, please reach out - we are hiring! www.oligodendrocyte.org 1/

Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties. @cp-neuron.bsky.social www.cell.com/neuron/fullt...

Excited to share our new study using engineered immune proteins to quench inflammation in aged brains!! Congratulations to Paloma Navarro and the entire team! Fantastic collaboration with Chris Garcia's lab, Tony Wyss-Coray's lab, and Saul Villeda's lab! www.cell.com/immunity/ful...

Fintastic meeting as always, for those interested! #ZebrafishMeeting

🐟👀 SFSU Biology seminar — Thu Mar 5 2–3pm | SEC 116 Dr. Patricia Schneider (LSU): “Split Screens: Exploring Vision through the Eyes of the Four-Eyed Fish.” Student time: 3–3:30pm. Come by!

Endogenous retrovirus-derived RNA-DNA hybrids induce microglial synaptic pruning in autism models @cp-neuron.bsky.social www.cell.com/neuron/fullt...

🧠 SFSU Biology Special Seminar Dr. Biswa Ramani, MD, PhD (UCSF) — neurodegeneration + neuropathology + physician-scientist career path 📅 Wed 2/25/2026 • 🕙 10:00–11:40 • 📍 Hensill Hall 233 Hosted by @nicholasjsilva.bsky.social All welcome!

Axolotls can completely rebuild their thymus, a key immune organ

Latest from the lab, led by @ara-donia.bsky.social and @juliavdkorput.bsky.social Huge team effort, with immense contributions by friends from nearby and around the globe. www.science.org/doi/10.1126/...

#fluorescencefriday distribution of microglia in the whole brain

I am SO incredibly excited to announce the launch of a global list of Inspiring Black Scientists. You can use this list to nominate and connect with researchers. Please share and join us in highlighting these outstanding scientists for #BlackHistoryMonth and beyond! www.wiley.com/en-us/resear...

A lifelong passion for writing helped rising star @doctheagrif.bsky.social land a book deal and publish 15 chapter books for early readers, covering topics ranging from what the cerebellum does to how a cake bakes. By @avaskham.bsky.social www.thetransmitter.org/craft-and-ca...

Our paper is (finally) out in Cell today! CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis www.cell.com/cell/fulltex... Great collaborative effort - read more from first author @asamelson.bsky.social below:

A landmark discovery in cancer neuroscience! Why is the incidence of Alzheimer’s disease (AD) lower in patients with a history of cancer? CELL: Peripheral cancer attenuates amyloid pathology in Alzheimer’s disease via cystatin-c activation of TREM2 www.cell.com/cell/fulltex...

We’re delighted to see this out today! Latest work from the lab reveals insights into the evolution of brain immunity and the developmental and evolutionary plasticity of lymphatic endothelial cells. www.nature.com/articles/s41...

Ageing promotes microglial accumulation of slow-degrading synaptic proteins @nature.com www.nature.com/articles/s41...

Proud to announce our collaboration with @blurtonjoneslab.bsky.social & the Paz lab showing that transplanted human iPSC-derived microglia in a PGRN KO mouse model restores progranulin in microglia and rescues pathology, circuitry, and behavior. Preprint out now: www.biorxiv.org/cgi/content/...

IFN-brite: A new interferon reporter from our lab designed by Dr. Sarah Anderson is bright and pan cellular

New discoveries are reshaping how scientists understand the molecular connections between the extracellular matrix and lysosomes—and the resulting implications for research and therapeutics for neurodegenerative disorders. Learn more in this #ScienceSignaling Review: https://scim.ag/3Yi2sFS

Maspardin/SPG21 controls #lysosome motility and TFEB phosphorylation through RAB7 positioning, say Thomas Jacqmin, Marielle Boonen and colleagues (University of Namur): rupress.org/jcb/article/... #Trafficking #Organelles #Disease

Great time to be a new PI 🤦🏾‍♀️ www.statnews.com/2025/12/18/n...

Did you know the last common ancestor of #zebrafish and humans was ~450 million years ago? A whole genome duplication event (3R) occurred early in the teleost fish phylogeny. Despite this event, zebrafish and humans have about the same number of chromosomes. #ZebrafishFunFacts 🧪

Dravet Syndrome is a genetic form of epilepsy caused by mutations in SCN1A. Researchers screened a library of compounds on loss-of-function scn1Lab (Nav1.1) #zebrafish and found clemizole (EPX-100) rescued the phenotype. This drug is now in Phase 3 Clinical Trials to treat seizures. #KnowYourZDM 🧪

Time-lapse movie of mitochondria (blue) transport within neurons (green) in the tail of a transgenic #zebrafish larva. Credit to @paquetlab.bsky.social. #ZebrafishZunday 🧪

Two-photon imaging of pulsating brain activity in a #zebrafish larva that's having a seizure. Credit to Dr. Dominic Burrows. #ZebrafishZunday 🧪

“The only reason I don’t have this funding is because my last name is Rodriguez.” MOSAIC checked many of the boxes of the administration — but that didn't matter. It was terminated, and left grantees scrambling Next installment of American Science, Shattered: www.statnews.com/2025/12/08/t...

“By performing longitudinal live imaging of intubated adult fish we observe vascular regrowth and immune responses to [meningeal cerebrovascular injuries] over time in the same animal with unprecedented resolution” New work from #WeinsteinLab at NIH

#ZebrafishFunFacts: Known to hobbyists as the leopard Danio, TL or Tüpfel longfin #zebrafish consist of two alleles (leo and lof). leo is a gap junction protein (ncbi.nlm.nih.gov/pmc/articles...), while lof is caused by upregulation of a K+ channel (journals.biologists.com/dev/article/...). 🧪 1/2

Slow-mo video of zebrafish mating. Credit to @zebrafish007.bsky.social. #ZebrafishZunday 🧪

Zara Weinberg passed away earlier this week. She joined my lab earlier this year when her postdoc lab formally closed. She was a brilliant scientist, supportive mentor, dear friend, avid music fan, rabid believer in public transit, open science champion, and above all just an amazing human.

Applications for the Neuroscience Scholars Program close tomorrow! Don't miss the opportunity to join a growing network that provides guidance for today's challenges & connections for your future. 🚨Deadline: Tuesday, October 21, 5 p.m. EDT Apply now: vist.ly/4b3np