@lyons-lab.bsky.social
๐ค 498
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reposted by
Julia van de Korput
4 days ago
Thrilled that our paper is now published. Itโs been a real privilege to work on this project together with co-first author
@ara-donia.bsky.social
, under the supervision of
@lyons-lab.bsky.social
, and with such an outstanding team in Edinburgh and internationally!
www.science.org/doi/10.1126/...
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Myelin sheaths in the central nervous system can withstand damage and dynamically remodel
Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...
https://www.science.org/doi/10.1126/science.adr4661
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26
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reposted by
6 days ago
I am delighted to see this work published. A big thanks to everyone, particularly the excellent supervision of
@lyons-lab.bsky.social
, the work of co-first author
@juliavdkorput.bsky.social
and wonderful collaborators in Amsterdam and Oregon.
www.science.org/doi/10.1126/...
loading . . .
Myelin sheaths in the central nervous system can withstand damage and dynamically remodel
Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...
https://www.science.org/doi/10.1126/science.adr4661
1
49
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Latest from the lab, led by
@ara-donia.bsky.social
and
@juliavdkorput.bsky.social
Huge team effort, with immense contributions by friends from nearby and around the globe.
www.science.org/doi/10.1126/...
loading . . .
Myelin sheaths in the central nervous system can withstand damage and dynamically remodel
Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...
https://www.science.org/doi/10.1126/science.adr4661
7 days ago
5
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reposted by
Jenn Orthmann Murphy
28 days ago
alert! fundamental myelin biology - led by the amazing Yevgeniya Mironova and Dwight Bergles
www.science.org/doi/10.1126/...
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Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors
Oligodendrocytes form myelin sheaths around axons to enable rapid signaling within neural circuits. The generation of new oligodendrocytes through differentiation of oligodendrocyte precursor cells (O...
https://www.science.org/doi/10.1126/science.adu2896
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6
reposted by
UK Dementia Research Institute
3 months ago
Very excited to share the news today that Professor Baljit Khakh will become the new Centre Director of the UK DRI at Cardiff University! Read our full announcement ๐
www.ukdri.ac.uk/news-and-eve...
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Led by Marcus Keatinge "Mislocalisation of TDP-43 to the cytoplasm of either neurons or oligodendrocytes causes axonopathy and dysmyelination"
www.biorxiv.org/content/10.1...
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https://www.biorxiv.org/content/10.1101/2025.11.17.688801v1
3 months ago
0
6
1
reposted by
Institute for Regeneration and Repair
5 months ago
ยฃ70 million investment in IRR spinout Trogenix to tackle aggressive cancers. The funding will enable the rapid advancement of its pipeline of potentially curative cancer therapies across multiple treatment-resistant cancers
regeneration-repair.ed.ac.uk/ps70-million...
@edinnovations.bsky.social
0
4
2
www.nature.com/articles/s41...
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FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult central nervous system - Nature Communications
The homeostasis of myelin in the central nervous system is highly regulated, but the underlying mechanisms are unclear. Here, the authors show that the FBXW7 protein has a role in constraining myelin ...
https://www.nature.com/articles/s41467-025-62715-9
6 months ago
0
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8
reposted by
MariaEichelVogel.bsky.social
6 months ago
Brilliant Kick off day
#ISNASN2025
@neurochemistry.org
with the best conference views ever ๐ Glad to be part of it
#TogetherForScience
If you wanna know more about my work on axons & zebrafish in the
@lyons-lab.bsky.social
join me during the poster session tmr evening (LBA45) or just reach out ๐
0
5
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For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker
www.nature.com/articles/s41...
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Activity-driven myelin sheath growth is mediated by mGluR5 - Nature Neuroscience
Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...
https://www.nature.com/articles/s41593-025-01956-9
9 months ago
1
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26
reposted by
Steffen Scholpp
10 months ago
The LSI Exeter invites you to join the first UK Zebrafish Meeting, 10/ - 12/9/
@lsiexeter.bsky.social
. We are looking for motivated PhD students/ECRs to present their work - as talks and posters.
www.exeter.ac.uk/research/ins...
. The deadline for the early bird registration is 15/5/. So, be quick!
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Fun to have contributed a little to this, led by the team of the incomparable Guoqiang Yu. Suspect that this will prove to be an immensely popular image analysis platform for interrogation of dynamic signallingl!
www.sciencedirect.com/science/arti...
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Fast, accurate, and versatile data analysis platform for the quantification of molecular spatiotemporal signals
Optical recording of intricate molecular dynamics is becoming an indispensable technique for biological studies, accelerated by the development of newโฆ
https://www.sciencedirect.com/science/article/pii/S0092867425002855
11 months ago
0
3
2
reposted by
Philip Hasel
12 months ago
Our paper on the superficial glia limitans is now published - huge thank you to all co-authors that helped getting this work across the finish line!
www.cell.com/cell-reports...
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Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates
Hasel etย al. show that molecularly and morphologically specialized astrocytes make up the brain and spinal cord surface, thereby creating the glia limitans superficialis. These astrocytes selectively ...
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00115-9
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Two new opportunities in Edinburgh: Research technician in our lab
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
Senior research technician to support the Zebrafish Imaging and Screening Facility
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
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https://em3.oraclecloud.com
12 months ago
0
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One week to go before application deadlines... 1. Postdoc, investigating how neurons respond to demyelination. 2. Research assistant, investigating how conduction properties are established in neural circuits
elxw.fa.em3.oraclecloud.com/hcmUI/Candid..
.
elxw.fa.em3.oraclecloud.com/hcmUI/Candid..
.
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https://elxw.fa.em3.oraclecloud.com/hcmUI/Candid..
about 1 year ago
1
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Couple of opportunities up to join the group! One at postdoc level, but open to senior support path. One research assistant role. Please share, or drop a line if you want to learn more! Or just apply! Thanks!
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
about 1 year ago
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First post at this side. Latest axon diameter action led by Jenea Bin, in collaboration with Nolan, Mobius, Monk, Werner, and Emery labs.
www.biorxiv.org/content/10.1...
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Developmental axon diameter growth of central nervous system axons does not depend on ensheathment or myelination by oligodendrocytes
Myelination facilitates the rapid conduction of action potentials along axons. In the central nervous system (CNS), myelinated axons vary over 100-fold in diameter, with conduction speed scaling linea...
https://www.biorxiv.org/content/10.1101/2025.01.10.632348v1
about 1 year ago
2
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