Going for a rollercoaster ride on the spinal cord! 🤩

Slick-H/M83 mice injected with alpha synuclein preformed fibrils. Magenta pS129 and yellow for eGFP driven by the Thy-1 promoter. blue nuclei #fluorescencefriday courtesy of Vlad Novikov. Shaz and Nadia from the @mind-western.bsky.social

One of my favorite jokes ever: What did Watson and Crick discover? Rosalind Franklin's notebooks

Slick-H/M83 mice injected with alpha synuclein preformed fibrils. Magenta pS129 and yellow for eGFP driven by the Thy-1 promoter. blue nuclei #fluorescencefriday courtesy of Vlad Novikov. Shaz and Nadia from the @mind-western.bsky.social

Our paper using endoscopic in vivo calcium imaging to uncover how neuronal population dynamics in the prelimbic cortex track attention and task engagement during the rodent continuous performance test (rCPT) is now online www.nature.com/articles/s41...

Just published in Nat. Neurosci. Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression. @erzimmer.bsky.social @natureportfolio.nature.com www.nature.com/articles/s41...

Great to be in Toronto for the Second AG meeting for @tridentpct.bsky.social where our 🐁 molecular and cognition core will show what we are up to in the last 2 years facilitated by @touchscreencog.bsky.social and we will continue to learn about our organoid and marmoset models.

Bottom line of systematic assessment of studies on Covid vaccinations/boosters: ~50% reduction of hospitalization, across all adults (not just older) who are not immunocompromised Real data on vaccine-induced myocarditis: occurred in 1-3 per 100,000 male adolescents www.nejm.org/doi/full/10....

Hippocampus masquerading as a 🦇 for Halloween 🎃 #FluorescenceFriday Image credit to the @lieberinstitute.bsky.social Microscopy and Spatial Biology Core 🧠🔬🧪

Forbidden gummy 🎃

Women experience delayed diagnoses, more adverse drug effects, and spend 25% more time in poor health than men. Yet only 4.5% of CIHR-funded projects over 15 yrs addressed major health burdens affecting women. 📚 Learn more: ow.ly/Cqjx50XkANC

More necessary awareness: yes, parliament has the legal authority to do this. There are many reasons they should not. That it is legal does not mean it is ethical, necessary, non-destructive, or appropriate. It DEFINITELY doesn't mean it shouldn't be publicly opposed (👀 @u15ca.bsky.social )... /1

I see the face!!!!! 😱 😬 🧠 🎃 #FluorescenceFriday imaging from the Lightsheet Microscopy team at Western.

Love it! Now I want to carve a pumpkin as a mouse brain, but I think it's too late.

and another 👻 entry for #fluorescencefriday courtesy of Nadia Haghbin and Shaz

👻 #fluorescencefriday weird microglia (yellow) in a model of synucleinopathy courtesy Anoosha Attaran

👻 #fluorescencefriday. plaque ghosts attacked by red (astrocytes) and cyan (microglia) Globins

And it took me 20 min to get the two shots tonight. Freely available in Ontario.

Thrilled that our paper is out today in Nature! www.nature.com/articles/s4...

Double posting for #FluorescenceFriday today, because I am in love w/ this particular astrocyte (marked w/ GFAP in 🔴) that is sitting in dorsal anterior cingulate cortex in the human 🧠. Image credit to Staff Scientist/image analyst Maddy Tippani and JHU grad student @shkwon-bcmbneuro.bsky.social 🔬🧪

For #FluorescenceFriday - projection neurons from the mouse prefrontal cortex to the locus coeruleus 🔴 with Fos labeling activated cells 🟢. Image credit to the Circuits team in the Translational Neuroscience Division @lieberinstitute.bsky.social 🧠🔬🧪

Some of SpaceX’s biggest breakthroughs began in government labs. As the US retreats from science funding, the next American tech startup may not be so lucky.

Was great to attend the @gairdnerawards.bsky.social Gala representing @westernu.ca @schulichmeddent.bsky.social last night! Great to celebrate basic science and meet old friends and make new ones!

Is it candy? Nope, it is a spooky 👻 cleared mouse 🧠 used for #fluorescencefriday movies

#fluorescencefriday Side by side comparison of alpha synuclein S129 (magenta), a marker of #parkinson’s , in M83 hemyzigous mice injected with human pre formed fibrils @shahrzadbahrampour.bsky.social Vlad Novikov clearing with SHIELD @lifecanvastech.bsky.social imaged at MIND platform @westernu.ca

Brazilian-born Tiago Splitter named interim coach of Trail Blazers reut.rs/4qnWuzJ

Trump slammed for demolishing White House before Canadians could burn it down again

Happy to share a new peer-reviewed study on PubMed. Blessing eggs creates bigger and tastier chickens (p < 0.001). pubmed.ncbi.nlm.nih.gov/41035978/

This is @nytpitchbot.bsky.social level

The G2G rail trail is one of the best for colours this time of year

We see a #TRIDENT spotight in the CIHR Faces of Health Research storybook, among other stories about the life-changing research happening right here in Canada! #NFRF #impact #neuroscience. Check it out, below! 🇨🇦🔬🌍🤩👀👇 cihr-irsc.gc.ca/e/54163.html

Had a great time at the @mind-western.bsky.social Lightsheet Meeting Series this week, an amazing, interactive talk led by Christopher Pfeiffer-Kelly of LifeCanvas Technologies Inc. @braincanada.bsky.social @maximoprado.bsky.social🔬🖥️🤩

New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org. rdcu.be/eKKz1 🇨🇦

The truth of autism will continue to be found in science, not myth. Canadian research needs to lead the world forward, by Stephen Scherer and Evdokia Anagnostou www.theglobeandmail.com/opinion/arti... via @theglobeandmail.com

Peter Howitt, @westernualumni.bsky.social, has won the #NobelPrize in #Economics. He earned his master’s at #WesternU, spent nearly 25 years on our economics faculty and remains closely connected to our academic community as an Honorary Professor. buff.ly/J5qFeSh #PurpleAndProud

In honor of spooky month, share a 4-word horror story that only someone in your profession would understand: Comments from reviewer 3

I am delighted to share our new paper! nature.com/articles/s41... Lizzie Kleeman & our Florey Institute team, with WEHI, UoM & others, found that paternal COVID-19 (SARS-CoV-2 infection) can alter sperm & offspring phenotypes, including anxiety. This discovery has major (brain) health implications!

Great music at the Distillery district today

A reminder for the unenlightened.

Reads like the National Post! In a country with negative birth rate that seems like a huge problem 🤷🏼‍♂️.

Who knew the Nobel Peace Prize is awarded to those fighting to change dictatorships to democracies and not the other way around?

@sfn.org please consider hosting your next meeting outside of the 🇺🇸

Just incredible findings, and a beautifully written paper: www.nature.com/articles/s41... Get your shingrix vaccine! You do not want peripheral neuropathy, and as a bonus you get substantial protection from later development of dementia.