🚨 PI position in dept. of Neuroscience with lab located the @crchum.bsky.social Hiring at assistant/associate prof level in the fields of neural regeneration, stem cells and spinal-associated pathologies can-acn.org/professor-re...

We identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth. Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...

New Year, new paper from our lab. Emily Kramer used 3D light-sheet imaging and tissue clearing to examine the spatial architecture of mouse amygdala engram ensembles. onlinelibrary.wiley.com/doi/10.1002/...

“Basic neuroscience hasn’t produced new drugs.” 💊 Not true - zuranolone (PPD), suzetrigine (pain), gepants (migraine), and more... were born out of a long arc of studies in the lab. I wrote a Perspective on why this matters. @thetransmitter.bsky.social www.thetransmitter.org/drug-develop...

Alicia Pietramale et al. discovered a disconnection between microglial processes that surveil or respond to acute damage and those that contain mitochondria. Cytoskeletal components and metabolic enzymes underlie these differences. Final version just published! www.nature.com/articles/s41...

Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41... This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)

If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal! Date: Monday, Nov 17th Time: 9PM till close Location: The Smoking Gun SD, 555 Market St. All welcome, please free to spread the word!

If you’re interested in the roles of glia in stroke and TBI, kick off #SfN2025 with a minisymposium on Saturday afternoon in room 6B! @droligo.bsky.social and I are also hosting a glia get-together Monday night, sponsored by Avantor and @plasmidsaurus.bsky.social - all glia-inclined are welcome!

The Gowrishankar lab will be opening its doors @neuro_MUSC on Dec 1, 2025! We will be hiring at all levels. I will also be at @SfNtweets presenting my lab's vision on Wednesday, Nov 19, 8AM-12PM at poster board GG7. If you're interested, please reach out! www.raajgowrishankarlab.org

Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com www.nature.com/articles/s41...

In How to Change a Memory, neuroscientist @okaysteve.bsky.social shares his disarmingly personal account of the new science of memory manipulation.⁠ ⁠ 🎧️📔 The #audiobook, read by the author himself, is out now! Add it to your #audio library: press.princeton.edu/books/audio/...

Meet our 2025 cohort of Next Generation Leaders! For the next 3 years, they will network with other rising stars, participate in professional development, and share their ideas for future research directions.

Important article from @marymunson4.bsky.social @joann-trejo.bsky.social @needhibhalla.bsky.social

Our latest paper is out! While the circadian photoentrainment circuit has been extensively studied, the mechanisms regulating its development remain poorly understood. Here we show that retinal Müller glia play a key role in this process. Check it out! www.sciencedirect.com/science/arti...

Excited to share the latest from the lab on the molecular mechanisms of silencing and un-silencing a hippocampal engram ensemble. Was fun using a variant of the EPSILON technique developed by Adam Cohen's lab. (1/2) www.sciencedirect.com/science/arti...

If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal! Date: Monday, Nov 17th Time: 9PM till close Location: The Smoking Gun SD, 555 Market St. All welcome, please free to spread the word!

Fantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...

I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene. Read our two companion papers: 🔹 www.biorxiv.org/content/10.1... 🔹 www.biorxiv.org/content/10.1... 🧵 Highlights below!

New paper from the lab 🚨 Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age: authors.elsevier.com/a/1lzT-3BtfH...

In the desert of tools to manipulate oligodendrocytes in the brain, we built an OASIS. 🌿 Pun intended. I’m still in awe every time I spot an amazing-looking cell. The beauty of OL and myelin never fails me! Hope this tool helps more people see it too.

Just out in Nature! “The astrocytic ensemble acts as a multiday trace to stabilize memory.” We identified astrocytic ensembles that link experiences across days to stabilize memory nature.com/articles/s41.... New astrocyte tools are openly available at Addgene: addgene.org/Jun_Nagai/. 1/8

Thrilled to share this work from my postdoc with Tom Carmichael, available online @ Neuron! Long story short: we find even more evidence that all reactive astrocytes are not equal, and we can take advantage of those differences to improve repair after stroke. www.sciencedirect.com/science/arti...

Huge congrats @amygleichman.bsky.social on this phenomenal study, demonstrating regional differences in astrocyte responses to stroke and a key role for astrocytes in post-stroke angiogenesis and repair! (see also - gorgeous astrocytes for fluorescence Friday) www.sciencedirect.com/science/arti...

Come join us at @westernu.ca: Chair, Department of Medical Biophysics: www.uwo.ca/facultyrelat...

PhD / Postdoc in Neuroscience – University of Montreal - Seeking a highly motivated PhD student or Postdoctoral Fellow to join an exciting collaborative project between the laboratories of Dr. Antonio Nanci and Dr. Ravi Rungta at the Université de Montréal. can-acn.org/phd-postdoc-...

Patch clamp friends, anyone have experience with the Digidata HumSilencer feature? Does it do anything?

Interview with @pegmccarthy.bsky.social on the *evidence* related to Tylenol and pregnancy nam.edu/news-and-ins...

Thrilled to share our new paper @cp-cell.bsky.social: “Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.” This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling. 🔗 www.cell.com/cell/fulltex... Faust et al., Cell 2025

If you're interested in trafficking of #myelin constituents in #oligodendrocytes, and of course you are, you may want to check out our new preprint. It's very nice PhD work by @sophiesiems.bsky.social, and we're grateful to all who contributed! www.biorxiv.org/content/10.1...

We are looking for a new coordinator to join the Education & Engagement team at @alleninstitute.org! This person will support the full breadth of our efforts here in the program, including administrative support, participant communications, helping with field trips, and much more. 1/2

Excited to share our new preprint from my graduate work, a collaboration between the Brown lab and @srirams433.bsky.social and others in the Kolodkin lab! Our study investigated how patterned excitatory connectivity is generated in the development of the cerebral cortex (1/7)

Ever wanted to do a CRISPR screen directly in the mammalian brain? While perturbing thousands of genes in parallel? All while targeting specific cell types? Check out our latest paper describing CrAAVe-seq, a powerful new functional genomics tool for massively parallel neuroscience research

🚨Another PI job opening in the Neuroscience dept. at @umontreal.ca ! 🚨 www.nature.com/naturecareer...

Join me in donating to ABRCMS. For many of us early in our careers (and for many of us now), this is THE conference. Let’s make sure future generations get the same experience. I was told if each poster judge donated $25, their goal would be quickly met, but I think we can do better! 🙏🏾💪🏾

Here you go..." Why strong mentorship was essential for my career success in science" JoAnn Trejo has turned mentoring into an evidence-based science, driven by her own exposure to inspiring mentors. www.nature.com/articles/d41...

As chair of the @acnporg.bsky.social Global Outreach Committee, I am happy to answer any questions about the Global Scholarship! Please share with your networks! Excellent opportunity to attend what might be the best science meeting in this space!

In the battle against brain disease, researchers can now rely on a new arsenal of genetic tools – The Armamentarium. Together with scientists from across the NIH BRAIN Initiative, we’ve created and published over 1000 new enhancer AAV vectors. 🧠📈

🇨🇦 🧠 Are you a #Postdoc in #Canada or #Canadian abroad? We are selecting #speakers for the (second round of the) 2025 Canadian #Neuroscience #Seminars: Postdoctoral Series. Apply by July 6th, 2025 @ 23:59PT. Find more details here: tinyurl.com/56m946jh Apply through this form: tinyurl.com/42cwhae3

For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker www.nature.com/articles/s41...

Come join us at @westernuresearch.bsky.social as a Canada Excellence Research Chair! DM me with questions/interest about theme 2! Be a part of a strong and well-equipped (e.g., imaging, behaviour) neuroscience community! uwo.ca/research/cer... @westernuwin.bsky.social @westernubrainscan.bsky.social

Open call for Next Generation Leaders! Our NGL program recognizes early career scientists with fresh and innovative perspectives. For 3 years, NGLs contribute to ongoing research and initiatives at the Allen Institute. Apply by June 3. alleninstitute.org/about/people...

Thrilled to announce that my lab is now open at Ohio State! We study astrocytes as gene therapy targets for brain repair after ischemic stroke and in vascular dementia, developing new viral tools along the way. If you're interesting in joining or collaborating, please reach out! gleichmanlab.com

1/11 Though it's personal, I’m sharing this analogy if it helps others: In the last few weeks, I’ve been thinking a lot about my past journey with cancer. Years ago, I found out in the worst way. My doctor accidentally released the biopsy results to my online patient portal. 🧵 Thread

ATTENTION If you are someone (or know someone) who is enrolled in an NIH-funded clinical trial that has been disrupted by grant uncertainties or terminations, please DM me. THANK YOU!

KEEP CALLING. PEEL OFF ALL DEM SENATORS YOU CAN. ☎️: (202) 224-3121 Tell them to vote NO on Cloture and NO on CR. Vote is pushed to after 1:15ish for now. Situation is fluid. The only public YES votes are Schumer and Fetterman. They need 7-8 total. KEEP CALLING. Call retiring Senators too!

This is what we are hearing from lots of federal employees right now: white-hot anger at Senate Democrats. From ppl across the country too. @schumer.senate.gov @kirstengillibrand.bsky.social @fetterman.senate.gov @bennet.senate.gov You are risking the ends of your political careers. Will you act?

Jay Bhattacharya’s committee vote in the Senate is tomorrow at 10am. Tell your Senators you want them to vote no. And tell your Stanford colleagues they can still speak out against Bhattacharya. His full Senate vote is likely next week.

Last year, I was overjoyed to receive an NIH NRSA fellowship to study toddler brains and caregiving effects on memory at Columbia. Last night, my grant was terminated.

We need to organize--let’s help each other. NIH is cancelling grants, but it's not clear exactly what they're cancelling and why. Without this information, we can't respond. I've started a Google Sheet to track grant cancellations. Please add any canceled grants you know of and spread the word!

This. Universities, this is not going away. The Trump administration is going to continue to attack academia and higher education. You have to fight. For your lives.