Textbooks said neurons don’t burn fatty acids for energy🤔. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation. Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com

I was featured on The Scientist as a part of their 'Postdoc Portraits' series where I spoke about my scientific career path and ongoing work on oligodendrocyte dysfunction in neurodegeneration. Check it out! www.the-scientist.com/postdoc-port...

PREPRINTS ON THEIR WORK: Priya - www.biorxiv.org/content/10.1... and www.biorxiv.org/content/10.1... (press - www.npr.org/2024/10/07/n...) Melissa - www.biorxiv.org/content/10.1... (press - www.thetransmitter.org/astrocytes/a...)

#SfN #SocietyForGlia STARTING NOW! Ending strong with the last www.liddelowlab.com presentations of the week. @pryprk.bsky.social talking about a world first mouse model for XDP... and OLIGODENDROCYTES! @melcooperphd.bsky.social presenting on astrocyte networks in the mouse forebrain.

IT'S A BUSY AFTERNOON FOR THE LAB! @mrodea.bsky.social - astrocyte chromatin in reactive astrocytes across the forebrain Nick Kathman - COCKROACH BRAIN ALERT! (is this the largest single cell atlas of an insect brain?) @liddelowsa.bsky.social - multiomic approaches to study astrocyte reacitivity

Congrats to our very own Ipshita Zutshi on being awarded the Peter & Patricia Gruber International Research Award in Neuroscience!! #SfN25

Very happy to have contributed to this new review on Lewy body dementia in @thelancetneuro.bsky.social led by Sonja W. Scholz. We highlight the latest advances in genetics and pathology. @liddelowsa.bsky.social Check it out! www.sciencedirect.com/science/arti...

Looking forward to presenting our work on oligodendrocyte dysfunction in a rare neurodegenerative movement disorder X-linked Dystonia Parkinsonism. Come say hi if you're around on Tuesday, Nov 18 between 1-5 pm! @sfn.org #SfN2025 #SfN25

(1/2) preprints: @melcooperphd.bsky.social - astrocyte networks pubmed.ncbi.nlm.nih.gov/40777296/ @mrodea.bsky.social - single cell analysis & diversity www.biorxiv.org/content/10.1... @pryprk.bsky.social - XDP www.biorxiv.org/content/10.1..., www.biorxiv.org/content/10.1... See you in San Diego

@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below. Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social. (1/2)

Liver-brain axis in neuroinflammation. Hepatic acetyl-CoA metabolism modulates neuroinflammation and depression susceptibility via acetate. www.cell.com/cell-metabol...

Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com www.nature.com/articles/s41...

Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke www.nature.com/articles/s42...

Heartbreaking, well crafted thread from an immigrant scientist who’s decided being in the US isn’t worth the struggle anymore.

After 13 years in the US, I’ve made the difficult decision to leave. Having packed up everything and rethought about priorities, rather painstakingly, while I’m sad to leave the life I’ve made here, I’m also relieved that I won’t have to plan my life around immigration policies anymore.

Oligodendroglial fatty acid metabolism as a central nervous system energy reserve www.nature.com/articles/s41...

We're thrilled to publish 2 exciting preprints today on the molecular pathology of X-linked Dystonia Parkinsonism! biorxiv.org/content/10.1... AND biorxiv.org/content/10.1... @nyulangone.bsky.social

We've been doing some amazing stuff outside the astrocyte realm. Check out our latest Oligo investigation led by @pryprk.bsky.social !

I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene. Read our two companion papers: 🔹 www.biorxiv.org/content/10.1... 🔹 www.biorxiv.org/content/10.1... 🧵 Highlights below!

Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis www.nature.com/articles/s41...

Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD mice www.nature.com/articles/s41...

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...

PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia www-nature-com.ezproxy.med.nyu.edu/articles/s41...

Huntington's disease successfully treated for first time www.bbc.com/news/article...

Mitochondrial transfer www.nature.com/articles/s42...

Happy to share that I have been awarded an @alzassociation.bsky.social grant to advance our work on astrocyte lipids in tau-mediated neurodegeneration. Important gaps remain in understanding glial lipid metabolism in AD and related diseases, and I’m excited to drive this work forward! #ALZFunded

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

Postdoc paper submitted! Venturing into a completely new research direction with incredible collaborators and a fascinating finding. Excited to see how it all pans out! 🚀

'Amyloid Beta Impairs Microglia Function in Alzheimer’s Disease' the-scientist.com/amyloid-beta... Our work on microglial lipid droplets in Alzheimer's disease featured on The Scientist by Shelby Bradford.

Glia-derived noncanonical fatty acid binding protein modulates brain lipid storage and clearance www.science.org/doi/10.1126/... Fly glia secrete Obp44a, a fatty acid binding protein, that binds long-chain fatty acids and shuttles between glia and neurons.

If I have to read one more 'single cell atlas' paper... 😑

Brain myelin as a deficient energy source in aging and disease www.cell.com/trends/endoc... Excellent discussion on how myelin fatty acid reserves may be reallocated during aging and neurodegeneration

Lipid metabolism and neuroinflammation: What is the link? rupress.org/jem/article/... Another nice review covering lipid metabolism in the CNS, including discussion of interferon pathways and their connection to lipid regulation

Triglycerides are an important fuel reserve for synapse function in the brain www.nature.com/articles/s42...

Excited to share @thehindu.com coverage of our research: “Immune cells’ fat blocks brain’s ability to clean Alzheimer’s plaques” -- now out in print and online! Grateful to Manjeera Gowravaram for the thoughtful and clear storytelling. www.thehindu.com/sci-tech/sci...

How this image is #notthecover? It's the coolest one I've seen in a while! All praise to M, our microglia savior, for destroying amyloid and rescuing neurons!

Meet M, our microglia superheroine 🦸‍♀️💥 After chugging the magical DGAT2-Stop! Kool-Aid 💊🧃, she breaks free from her lipid droplet shackles 💥💪 Supercharged, she lifts the amyloid beams 🧱 trapping neurons and saves the city of Brain 🧠🏙️! Our cover submission for @cp-immunity.bsky.social. #notthecover

#notthecover, but it’s beautiful and captures the science so well! Thank you for sharing your creative vision with us!

Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...

Tremendously grateful to an amazing team of lab members and collaborators including @pryprk.bsky.social , @evipaouri.bsky.social , Palak Manchanda and Gaurav Chopra and pretty much all Chopra and Davalos Lab members for the smooth teamwork @clevelandclinic.bsky.social @purdueuniversity.bsky.social

Why do the brain’s professional phagocytes stop clearing amyloid in Alzheimer’s disease? Can we restore microglial superpowers & rescue dying neurons in AD? YES, by stopping DGAT2-mediated lipid droplet formation! Checkout our latest manuscript @cp-immunity.bsky.social 👇🏼 www.cell.com/immunity/abs...

#GliaPapers #GliaSpecialIssue SPECIAL COVER SPECIAL ISSUE: Glial omics: unraveling mechanisms in health and disease onlinelibrary.wiley.com/toc/10981136... Editorial Unboxing “Omics” in Glial Biology to Understand Neurological Disease here - onlinelibrary.wiley.com/doi/10.1002/...

Wrapping up the last experiment before the holiday break! Grateful for all that 2024 brought and excited for what’s ahead in 2025. Thankful for my family, friends, lab, and my pup. Wishing everyone happy holidays! 🎄💫

I love how complimentary our review is with the one from @pryprk.bsky.social and colleagues!! I think it points to how important and growing this area of research is and how much there is still left to research!! onlinelibrary.wiley.com/doi/10.1002/...

Timely and elaborate review that highlights role of little-known phospholipids in glial biology!

Happy to share our review on how different lipids shape microglial biology in #GLIA journal. 💫 onlinelibrary.wiley.com/doi/full/10.... 👉🏽with Gaurav Chopra, Caitlin Randolph, and @katherinewalker.bsky.social

Lipids are a big deal in #microglia, and can tell us much about their mood! Read Priya Prakash’s and Gaurav Chopra’s team’s review below to learn more about them! 👇

congratulations to @pryprk.bsky.social for her recent review article in #GLIA on the role of lipids in microglial function. onlinelibrary.wiley.com/doi/full/10....

In an interview for @natureportfolio.bsky.social NatureMethods @kerrylimberg.bsky.social talks about her first time experience at @societyforneuro.bsky.social #SfN in Chicago earlier this year. www.nature.com/articles/s41...