This is one of the most beautiful cross sections of cilia I've ever seen in our data, found by @csigulinsky.bsky.social. It is perfectly perpendicular to the plane of imaging which brings up an important point ~ connectomics. You gotta have enough resolution to see the important things. 2nm/px FTW!

Had a lot of fun writing this primer with @elisagalliano.bsky.social! If you've ever been transported back to childhood by the smell of a familiar scent, you might enjoy this. We unpack a new study revealing how neurons generated around birth help encode these lifelong olfactory memories.

want one

One chemical to rule them all🔥

"I still love what I do,” she said. “But it’s time to step aside and make resources available for the up-and-coming junior people who want to do what I do, especially right now" news.harvard.edu/gazette/stor...

MIT Professor Susumu Tonegawa, renowned molecular biologist and Nobel laureate, dies at 86 news.mit.edu/2026/mit-pro... #neuroscience

PV interneuron-targeted CRISPRa rescue of SCN1A haploinsufficiency in Dravet syndrome https://www.biorxiv.org/content/10.64898/2026.07.12.737793v1

Really enjoyed reading this great review paper by @shoheifurutachi.bsky.social and @sonjahofer.bsky.social www.annualreviews.org/content/jour...

The 2026 volume of the Annual Review of Neuroscience is now online 🧠 The most read article is "Planning in the Brain: It's Not What You Think It Is" by @marcelomattar.bsky.social and @nathanieldaw.bsky.social

The Queen's mate feeds her a sunflower seed. 📷: Northern Cardinals

Are you a senior postdoc with a complete scientific story to tell? Apply for our Yale Molecular Psychiatry MAPS program and tell us about your work at our weekly neuroscience seminar series. PLEASE REPOST!

Thrilled to share: we show that neuronal hyperactivity drives C1q-mediated synapse loss via brain-recruited B cell/IgM, revealing unexpected neuroimmune crosstalk in the adult brain. Congrats to Gerard Crowley who led this w/ resilience & creativity & our whole team! www.science.org/doi/10.1126/...

🎉 New/updated preprint! From 🌟 GS Kirsten Judge + Most neuronal cilia form during development. Can adult neurons rebuild damaged cilia? Are functions restored? Does regrowth use different pathways from ciliogenesis? Answers (in C. elegans): Yes, yes, and partly. 1/6 www.biorxiv.org/content/10.6...

Beautiful work and what a stunning image!

That single dynamical property being criticality

I joined the Sohal lab with one major hypothesis: psychedelic drugs can be powerful psychiatric treatments, depending on underlying neurobiology. Indeed, psilocybin restored cognitive flexibility in one circuit model of dysfunction, but not another! Then, we had to find out how! 🧠🍄🧪

Cool dissection of basal forebrain PV's role in attention! I wonder similar modulation exists in V1? Another source of disinhibition other than cortical VIPs? (didn't find any in literature although BF-PVs project to V1 more than to A1) www.cell.com/cell/fulltex...

New paper out! We used MEG to catch the brain learning hidden patterns buried in noise and found two separate mechanisms at play: fast predictive activity (up to 500ms before a stimulus!) followed by slower representational change that tracks actual learning. www.nature.com/articles/s41...

Our paper "Neural timescales from a computational perspective" is finally out in @natneuro.nature.com: www.nature.com/articles/s41... We discuss how computational models and methods can distill empirical observations on neural timescales into quantitative, testable theories of brain computation.

Rhythmic beating of a transgenic zebrafish embryo’s heart. Credit to @helenevignes.bsky.social, @cvagenapantoula.bsky.social & @vermotlab.bsky.social. #ZebrafishZunday 🧪

Our new preprint is out!! The human brain runs on ~20 watts. Computers and modern AI systems require vastly higher energy. This gap raises a fundamental question: how does the brain compute so efficiently? In our new study, we take a critical step toward measuring and understanding this directly 1/3

UPDATE: We learned that the folks behind Project 2025, are encouraging their base to write comments in favor of the rule. This suggests our efforts are working and they are shaken. IT ALSO MEANS WE NEED TO GO OUT WITH A BANG. MAKE YOUR COMMENT TODAY!!!

During sleep, neurons in the hippocampus 'replay' past activity patterns. This is thought to underlie memory consolidation 🧠 After a busy day, how does the brain sort out what is worth replaying? 🤔 Check out this preprint 📃 from Tirole, Duvelle and Bendor for answers! doi.org/10.64898/202...

Paper: www.nature.com/articles/s41... Huge thanks to my collaborators, mentors @irinadudanova.bsky.social and @takakikomiyama.bsky.social , and funders (DFG, NIH, ERC, Joachim Herz Fndt., CZI, Simons Fndt.) who made this possible. It’s been a long, exciting road and there’s more ahead. Onward!

New in PLOS Comp Bio, cool work from @timothyoleary.bsky.social showing that representational "drift" (lol, sorry for the scare quotes, Tim!), follows non-Gaussian statistics that can be beneficial for adaptive decoding: journals.plos.org/ploscompbiol... #neuroscience 🧪

My department, Neurobiology and Biophysics at the University of Washington (nbio.uw.edu), is hiring a new tenure-track Assistant Professor, application deadline 09/30/26. It's a broad search — molecular to organismal, all of neuroscience/physiology/biophysics welcome. apply.interfolio.com/187735

Don't laugh, just read! "Behavioral and clinical evidence distinguish two major forms of human laughter: spontaneous, emotionally driven vocalizations and volitional expressions used in social communication." 🧪 #Science #Biology #Neuroscience The neural basis of laughter www.cell.com/trends/neuro...

Mind-blowing🤯

🔔 Our new preprint is out! Here we asked whether sleep spindles - a hallmark NREM rhythm linked to plasticity and memory - changes how well latent working memory representations can be accessed after a nap.

Excited to share this preprint from @ianoldenburg.bsky.social . To evoke movement with holo stim, you need the right pattern at the right time! Interestingly, the preparatory state before spont motion is not the same as the state permissive for evoked motion. Dig in! www.biorxiv.org/content/10.6...

Finally someone addresses the elephant in the culture room

Wow. I love papers like this where you start off thinking “what? Sounds fishy” and then the data are so convincing and the paper so well written that is all so clear that you are blown away. Cells have a little aerial to allow them to move toward the anode!!! Galvanin! #PureScience #biophysics

More reporting from @maxkozlov.bsky.social on the political screening process that is slowing public investment in science to a crawl www.nature.com/articles/d41...

We got a big bump in traffic yesterday when people learned about us on NPR. Thank you to @npr.org for covering our launch and bringing our story to people's attention! And thank you to all our new followers. We can do this together! 🌍️🧪💪 #ClimateAction #ClimateForUs #ProtectScience

I was a bit skeptical (unsure about the relationship btw sleep pressure and synaptic strength…), but the validation with that memory consolidation task is pretty convincing!

Excited to share our first red ACh sensor! 🔴 We developed GRAB_rACh1h, the first genetically encoded red fluorescent sensor for recording acetylcholine dynamics in vivo. (1/3)

Really cool🤯

Calling all computational neuroscientists! Our department is recruiting two new lecturers/associate profs. Application deadline 10th July. tinyurl.com/4wnzvjc2 #sciencejobs @uclnpp.bsky.social

Triple-N dataset: large-scale fMRI-guided dense recordings of nonhuman primate neural responses to natural scenes Yipeng Li, Xieyi Liu, Wanru Li, Jia Yang, Baoqi Gong, Wei Jin, Zhengxin Gong, Kesheng Wang, Jingqiu Luo, Zishuo Zhao & Pinglei Bao www.nature.com/articles/s41...

One of my favorite photographers, Duane Michals, passed away this week, age 94. I came across a postcard print of "This Photograph is My Proof" when I was 18 and decided that the hand-written insistence - "It did happen, she did love me!” was both the height and depth of all love. Safe travels -

The GSA gave me the opportunity to write an article in GENETICS reflecting on my journey as an immigrant in the USA and how those experiences have shaped my life and career. Thank you to all of my mentees, friends, and family who have supported me along the way 🙏 academic.oup.com/genetics/adv...

Some personal news: I've joined Communications Biology (@commsbio.nature.com) as an Associate Editor! I'm incredibly honored and excited for this opportunity to serve the scientific community that I hold so dearly in my heart. Look forward to connecting with you and hearing about your work!

The absence of food activates the brain's "hunger neurons" even before there is an energy deficit! We discovered a new hypothalamic circuit that enables the brain to predict and prevent deviations from homeostasis. Published in @cp-neuron.bsky.social www.cell.com/neuron/abstr...

Important new work from Chia-Hsiang Chang, @nachury.bsky.social and colleagues identifying the composition of neuronal cilia in an unbiased way. Lots of surprises herein: www.science.org/doi/10.1126/...

Some very cool simulations, look at those little guys climb that ladder! #MolecularNodes

A hackathon reveals that disagreement in neuroscience runs deeper than most researchers suspect—even in electrophysiology, a field that prides itself on hard data, write @mattiachini.bsky.social and Gaelle Chapuis. #neuroskyence www.thetransmitter.org/reproducibil...

If Big Brother doesn’t like your science topic you won’t be funded and if Big Brother doesn’t like your results you will be defunded. A recipe for backwardness that seems to be designed by people who want America to humiliate itself and collapse. elizabethginexi.substack.com/p/summary-of...

Neuropixels + Optogenetics = Neuropixels Opto Combining high-resolution electrophysiology and optogenetics. 960 sites, 28 emitters, 2 colors. Today in @natmethods.nature.com doi.org/10.1038/s415... Thanks to @wellcometrust.bsky.social, @alleninstitute.org, @hhmijanelia.bsky.social & team.

Interested in super-resolution microscopy? Come to Bordeaux next October for a workshop, a meeting, or both! This @france-bioimaging.bsky.social initiative will foster exchange between scientists from France, China and everywhere thanks to @cnrs.fr support: france-bioimaging.org/news-events/...

You don’t need the best gears to take great shots, just go out there and find the views that resonate with you.