Bringing some more ExM to #FluorescenceFriday with what appears to be a frustrated cell division in fibroblasts. More details in Alt-text.

The brain is incredibly densely connected. Human cerebral cortex may have as many as *one trillion* connections. Most of those cortical connections are recurrent, inside each area. What do they do? New paper from me in Annual Reviews: 🧪 🧠📈 1/ www.annualreviews.org/content/jour...

🚨Our preprint is online!🚨 www.biorxiv.org/content/10.1... How do #dopamine neurons perform the key calculations in reinforcement #learning? Read on to find out more! 🧵

A far-red dopamine sensor unlocks multiplex views of in vivo neuromodulation — a Tools of the Trade article by Yu Zheng #neuroscience #neuroskyence www.nature.com/articles/s41...

Finding correlates of the same signal in different brain areas is not evidence against specialisation, it is evidence for interconnection. When I flush my toilet, the level in the tank and the flow rate in the supply pipe become perfectly correlated. Yet these toilet areas have distinct functions.

super cool. another crack in the genome-centric paradigm,& a great example of Alfonso Martinez Arias’s argument in “The Master Builder." I look forward to anything @philipcball.bsky.social might write about this! (Disclaimer: all posts represent personal views only) www.nature.com/articles/s41...

When neurons change, but behavior doesn’t: Excitability changes driving representational drift New preprint of work with Christian Machens: www.biorxiv.org/content/10.1...

Check out the latest volume of the Annual Review of Neuroscience 🧠 Take a look at the table of contents arevie.ws/44K8QJZ

1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social @wellcometrust.bsky.social

Children are incredible language learning machines. But how do they do it? Our latest paper, just published in TICS, synthesizes decades of evidence to propose four components that must be built into any theory of how children learn language. 1/ www.cell.com/trends/cogni... @mpi-nl.bsky.social

🚨 New opinion piece written with Tara Keck 𝘐𝘯𝘵𝘦𝘳𝘢𝘤𝘵𝘪𝘰𝘯𝘴 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 𝘩𝘰𝘮𝘦𝘰𝘴𝘵𝘢𝘵𝘪𝘤 𝘱𝘭𝘢𝘴𝘵𝘪𝘤𝘪𝘵𝘺 𝘢𝘯𝘥 𝘴𝘵𝘢𝘵𝘪𝘴𝘵𝘪𝘤𝘢𝘭 𝘭𝘦𝘢𝘳𝘯𝘪𝘯𝘨: 𝘈 𝘳𝘰𝘭𝘦 𝘧𝘰𝘳 𝘪𝘯𝘩𝘪𝘣𝘪𝘵𝘪𝘰𝘯 rb.gy/m862ik It's part of a special issue born from an unforgettable science extravaganza hosted by @kitp-ucsb.bsky.social in Santa Barbara🌴🧠 1/🧵

I read about embryonic patch clamp this morning and I'm still thinking about and being amazed by that work🤯

We began a pilot experiment. Lots of sciencey excitement! Then, (pole)catastrophe. Something weaseled into the barn and started killing mice. It kept coming back until it was caught and ID'd: a polecat with a rude demeanor, an appetite for small mammals, and exceptionally bad scientific timing 8/11

The phenomenon you're seeing here is sometimes called a "fire rainbow", which is a misnomer, but beautifully descriptive of a cloud on fire with color. This is actually the result of light passing through flat, hexagonal plates of ice suspended in clouds. Let's talk about circumhorizontal arcs.

Why is brainstorming always so much more fun than actually writing up research strategies (I should call it a day since I just spelled "homeostatic" wrong the third time🤦‍♀️

#neuroskyence folks: as my postdoc grant is running out soon, I am looking for new opportunities in systems neuroscience! Keywords: patch clamp ephys, opto, mouse behavior, (in vivo) voltage imaging. Would love to return to the Basal Ganglia. Sharing appreciated, and happy #FluorescenceFriday !

Genetic material shed by tumors can be detected in the bloodstream three years before cancer diagnosis, according to a study led by investigators at Johns Hopkins University. That study was made possible with federal funding. Now, many studies like this are canceled. hub.jhu.edu/2025/06/04/...

Live a little, comfort a little, cheer thyself a little.

Excited to share our Science paper on HaloDA1.0-the first genetically encoded far-red dopamine sensor! 🥳It enables powerful multiplex imaging in neurons, brain slices, and live animals.🧠🔬 #GRABsensors #Dopamine www.science.org/doi/10.1126/...

Feels nice when authors have addressed my comments exactly how I would've done! (Also making the re-review much easier to write haha)

Very happy that this work is finally out in ‪@pnas.org‬! We show that synaptic and intrinsic forms of homeostatic plasticity sense distinct aspects of network activity, and can thus be independently recruited by distinct network functions. A thread: www.pnas.org/doi/10.1073/...

Actin sun.

More evidence for altered sensory processing in ASD- great story! www.nature.com/articles/s41...

Some beautiful IPSCs for your Friday! #patchclamp

Happy to share our new preprint! We show how cell-type-specific synaptic scaling mechanisms shape memory representations during associative learning and highlight a critical role of top-down inputs in modulating this process. www.biorxiv.org/content/10.1...

I love everything about this paper

Super cool- it has an immune system!

Our latest work extends ketamine’s antidepressant action and highlights the importance of a specific form of synaptic plasticity in the effects www.science.org/doi/10.1126/...

Besides the gorgeous journal cover, the article it links to uses 724 classic Chinese poems to estimate the range contraction of the Yangtze finless porpoise over 1400 years. These animals are threatened by human activity, have intelligence comparable to a gorilla & are critically endangered.

As a cortex person, I keep forgetting pyramidal neurons in dentate gyrus are inhibitory...

On Friday, my son stayed home from school because he had a sore throat and wasn’t feeling well. He went with my husband to his office for the morning while I handled our daughter. When he came back at lunch, he was not interested in eating, saying his throat hurt too much. 1/n

People are patching bees now?! Super cool🤯

“In a time of destruction, create something. A poem. A parade. A community. A school. A vow. A moral principle. One peaceful moment.” -Maxine Hong Kingston (from the book she wrote from scratch after her home burnt down and she lost all her drafts in the Oakland forest fires of 1991)

If you're a grad student or an undergrad interested in research I need to you listen to me very carefully. You cannot learn to write good research papers if you do not read good research papers. Stop asking LLMs to summarize papers for you.

Seems like the playback times of my Mozart playlist positively correlates with the amount of stress in my life… If there’s one thing that can lift my spirit under any circumstance, it’s that.

I first did research as an undergraduate in an NSF-funded lab - without that experience I would not have known about science careers, let along gotten into grad school. NSF also provided the first funding for my lab and helped me make important discoveries that launched my career #WithoutNSF

Breaking: President Trump said his administration will strip Harvard of its tax exempt status. www.reuters.com/world/us/tru...

Well, fuck! Just got a message from my university that we can no longer spend money on our NSF-funded grants. This is as good as having the grants taken away from us.

Love inhibitory synaptic scaling in interneurons!

Just got mine. Totally expected, but it still sucks. Probably the most for all the work that so many of us put in on behalf of US taxpayers that is now wasted and will never come to fruition.

Like his scientific heroes before him, Rafael Yuste thinks science progresses through new methods. By @shaena.bsky.social, Brady Huggett #neuroskyence www.thetransmitter.org/neural-netwo...

It's really hard to overstate how hugely favored conservatives were up until two months ago. Here's the graph of Canadian polling between March 2023 and March 2025. (Reminder: blue is conservative.) Those are months and months of 20+ point leads for Tories.

The equivalent of ~60 multi year research grants just fell overboard

🫩🫩🫩

It’s that time of the year again when you struggle to keep the bath solution at the right temp because of the blasting AC🤦‍♀️

NEWS: After canceling thousands of foreign students' immigration records — threatening their ability to study and live in the US — the Trump administration has reversed course and restored them all. It follows intense pushback from courts across the country. Details TK

I am teaching my phd writing workshop course this quarter, question: are there any words/phrases said to you by an advisor/mentor that stuck with you, were memorable, or particularly helpful? If so please reply below!

The first draft is where you explain it to yourself. The second draft is where you explain it to your readers