Takaki Komiyama
@takakikomiyama.bsky.social
📤 1774
đź“Ą 152
đź“ť 26
UCSD professor of neurobiology and neurosciences
reposted by
Takaki Komiyama
Simons Foundation
about 1 month ago
A new
@nature.com
study from Simons Collaboration on the Global Brain investigator
@takakikomiyama.bsky.social
finds that as mice learn a complex movement, the pathway from the motor thalamus to the motor cortex rewires itself to drive the movement:
www.simonsfoundation.org/2025/08/11/h...
#science
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How a Tiny Brain Region Helps You Learn Complex Movements, One Neuron at a Time
How a Tiny Brain Region Helps You Learn Complex Movements, One Neuron at a Time on Simons Foundation
https://www.simonsfoundation.org/2025/08/11/how-a-tiny-brain-region-helps-you-learn-complex-movements-one-neuron-at-a-time/
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Our new paper is out in Science. We identified a subgroup of cholinergic neurons that mediate sensory modality-specific attention. They change their funcitonal properties within secs of behavioral context change. Congrats to Bin for the great thesis, and the team!
www.science.org/doi/10.1126/...
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Cholinergic feedback for modality- and context-specific modulation of sensory representations
The brain’s ability to prioritize sensory information is crucial for adaptive behavior, yet its mechanisms remain unclear. We investigated basal forebrain cholinergic neurons modulating olfactory bulb...
https://www.science.org/doi/10.1126/science.ads9152
3 months ago
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In June 2001, I arrived in SFO with a suitcase, a student visa, and disproportionate dreams. My life since has been nothing but a dream. My heart is with the international students in the US today.
4 months ago
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Our paper is out in Nature. By examining various inputs to the motor cortex during learning, we found that thalamic inputs learn to activate the cortical neurons encoding the movement being learned. Tour de force by Assaf in collab with Felix and Marcus. Congrats!
www.nature.com/articles/s41...
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Motor learning refines thalamic influence on motor cortex - Nature
Imaging and optogenetics in mice provide insight into the interplay between the primary motor cortex and the motor thalamus during learning, showing that thalamic inputs have a key role in the executi...
https://www.nature.com/articles/s41586-025-08962-8
5 months ago
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A very thoughtful Perspective on our recent paper by Ayelén Groisman and Johannes Letzkus. Thank you!
www.science.org/doi/10.1126/...
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Dendritic arbors structure memories
Synapses on different dendritic domains store distinct types of information
https://www.science.org/doi/10.1126/science.adx0640
5 months ago
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Our new paper is out in Science. What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons. Congrats Jake!
www.science.org/doi/10.1126/...
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Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning
Synaptic plasticity underlies learning by modifying specific synaptic inputs to reshape neural activity and behavior. However, the rules governing which synapses will undergo different forms of plasti...
https://www.science.org/doi/10.1126/science.ads4706
5 months ago
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reposted by
Takaki Komiyama
Irina Dudanova
8 months ago
How do different cortical neuron types contribute to circuit dysfunction in
#Huntington’s
disease? Check out our new collaborative study with
@takakikomiyama.bsky.social
, spearheaded by Sonja Blumenstock, now out as a preprint.
www.biorxiv.org/content/10.1...
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Optogenetic restoration of neuron subtype-specific cortical activity ameliorates motor deficits in Huntington′s Disease mice
Huntington′s disease (HD) is a devastating movement disorder without a current cure. Although the monogenic basis of HD is well-defined, the complex downstream effects that underlie behavioral symptom...
https://www.biorxiv.org/content/10.1101/2025.02.07.637155v1
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Our new paper shows that targeted stimulation of a subtype of cortical inhibitory neurons can ameliorate motor deficits in Huntington’s disease mice. A great collab with
@irinadudanova.bsky.social
www.biorxiv.org/content/10.1...
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Optogenetic restoration of neuron subtype-specific cortical activity ameliorates motor deficits in Huntington′s Disease mice
Huntington′s disease (HD) is a devastating movement disorder without a current cure. Although the monogenic basis of HD is well-defined, the complex downstream effects that underlie behavioral symptom...
https://www.biorxiv.org/content/10.1101/2025.02.07.637155v1
8 months ago
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663 days since the senseless tragedy that took An, we present a manuscript that reports some of the discoveries that she left us.
www.biorxiv.org/content/10.1...
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Targeted stimulation of motor cortex neural ensembles drives learned movements
During the execution of learned motor skills, the neural population in the layer 2/3 (L2/3) of the primary motor cortex (M1) expresses a reproducible spatiotemporal activity pattern. It is debated whe...
https://www.biorxiv.org/content/10.1101/2025.01.06.631504v1
9 months ago
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IMO one of the most exciting studies I’ve seen recently. Trial-level unmasking of memory-specific functional connectivity
www.nature.com/articles/s41...
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Intermittent rate coding and cue-specific ensembles support working memory - Nature
By recording large populations of neurons in behaving monkeys using newly developed silicon probes, we show that intermittent periods of memorandum-specific spiking coexist with synaptic mechanis...
https://www.nature.com/articles/s41586-024-08139-9
9 months ago
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Our new paper out in Science Advances. A population code in the retrosplenial cortex explains the discrepancy between animal behavior and standard RL models.
www.science.org/doi/10.1126/...
almost 2 years ago
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Our new paper out in @NatureNeuro. We uncovered the roles of orbitofrontal cortex in distinct aspects of meta-reinforcement learning.
www.nature.com/articles/s41...
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Meta-reinforcement learning via orbitofrontal cortex - Nature Neuroscience
The authors show that neural activity and synaptic plasticity in the orbitofrontal cortex mediate multiple timescales of reinforcement learning (RL) for meta-RL, which parallels a form of meta-RL in a...
https://www.nature.com/articles/s41593-023-01485-3
almost 2 years ago
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PSA to SfN attendees— the metro now goes between Dulles and downtown DC
almost 2 years ago
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Our recent collab paper. Reanalysis of our previous data from a functional connectome perspective identified hub neurons that remain the center of functional reorganization during learning. Congrats Saber, Rudi et al.!
www.tandfonline.com/doi/full/10....
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Rewiring Dynamics of Functional Connectomes during Motor-Skill Learning
The brain’s functional connectome continually rewires throughout an organism’s life. In this study, we sought to elucidate the operational principles of such rewiring in mouse primary motor cortex...
https://www.tandfonline.com/doi/full/10.1080/26941899.2023.2260431
almost 2 years ago
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Excited to be speaking at this SfN satellite meeting on Saturday evening
mbns.bruker.com/acton/fs/blo...
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https://mbns.bruker.com/acton/fs/blocks/showLandingPage/a/9063/p/p-03b1/t/page/fm/12
almost 2 years ago
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Wrote a little intro to the BICCN package that just dropped:
www.science.org/doi/full/10....
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Science | AAAS
https://www.science.org/doi/full/10.1126/sciadv.adl0650
almost 2 years ago
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Our recent collab paper-- an attempt at spike estimation from calcium imaging data with temporal superresolution (i.e. faster than the frame rate), congrats to Pulak and Piya:
ieeexplore.ieee.org/abstract/doc...
almost 2 years ago
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Please smack me if I become a billionaire and start acting like Elon Musk.
almost 2 years ago
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