New preprint from the lab by Dennis Feigenbutz et al.: Using #snRNA-seq, we explore vulnerability profiles of cortical cell types in #HuntingtonsDisease mice and identify ER-phagy as a new pathway in HD pathogenesis. www.biorxiv.org/content/10.1...

Job Alert! The Institute for Neuro- and Behavioural Biology at the Faculty of Biology @uni-muenster.de invites applications for a Full Professorship (W3) in “Systems Neuroscience” - Highly attractive research environment at the Multiscale Imaging Center. Apply by January 5th. See shorturl.at/VczFp

We are hiring a postdoc to work @istaresearch.bsky.social on an @erc.europa.eu funded project, investigating the control of behavior and physiology by the hypothalamus. Please apply and share! ist.ac.at/en/job/postd...

Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...

Congratulations to Cole Sitron et al. from Ulrich Hartl's group @mpibiochem.bsky.social on this beautiful study exploring the interaction of α-synuclein aggregates with the ESCRT-III complex, now out in @cp-molcell.bsky.social - it was a pleasure to contribute to the project.

Trilled to share our new work🥳We show that age-related hyperactivation of the EPS8/RAC signaling pathway drives protein aggregation and neurodegeneration — hallmarks of Huntington’s disease and ALS. #proteostasis #aging #neurodegenerativediseases

New lab preprint: Leveraging the updated AutoGaitA toolbox, we revealed distinct species-specific mechanisms to generate propulsion during walking and the conserved pattern of age-related propulsive decline from flies to humans. www.biorxiv.org/content/10.1...

Apply now for a fully funded #PhD position at the Cologne Graduate School of Ageing Research and become part of our vibrant #AgingResearch commmuny. 🗓️ Deadline: November 3, 2025. ℹ️ More info: www.ageing-grad-school.de 📣 Spread the news!

We have a 4-year postdoc position open in our Research Unit on proteostasis! The project explores inter-tissue regulation using advanced proteomics approaches. Collaborative & interdisciplinary environment. More details & application here: jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...

New work from our lab;)

🚨 Scholarship Alert! 🚨 Pursue your Master studies in Biology or Biochemistry with our #CGA Master Fellowship programme. 🧬👩🏽‍🔬💰 Explore ageing research at the Cologne Ageing Campus! Apply by July 15! 📅 🔗 Learn more: www.ageing-grad-school.de/master/maste...

Delighted to be part of the new Research Unit on Organismal Proteostasis. Thanks to @thevilchezlab.bsky.social for all the hard work on putting together this consortium, and to the #DFG for funding our research!

Happy to share our new preprint, where we find that anle138b reduces Huntingtin inclusions and improves disease phenotypes in #Huntington’sDisease models, showing its potential as an HD treatment. Great work by Miguel Padilha and several wonderful collaborators including thevilchezlab.bsky.social

Mitochondria a safe haven for aggregation-prone proteins? #neurodegeneration. #Parkinson. Find our latest manuscript in @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

Interested in the molecular mechanisms of neurodegeneration? 📢 We are looking for a PhD student interested in studying the role of TDP-43 in genome stability and the DNA damage response! Apply via this fantastic PhD Programme until April 3 👇

Our new paper shows that targeted stimulation of a subtype of cortical inhibitory neurons can ameliorate motor deficits in Huntington’s disease mice. A great collab with @irinadudanova.bsky.social www.biorxiv.org/content/10.1...

How do different cortical neuron types contribute to circuit dysfunction in #Huntington’s disease? Check out our new collaborative study with @takakikomiyama.bsky.social, spearheaded by Sonja Blumenstock, now out as a preprint. www.biorxiv.org/content/10.1...