Online now! @thevilchezlab.bsky.social @sedakoyuncu.bsky.social identify age-related hyperactivation of EPS8/RAC signaling in C.elegans as a driver of pathological protein aggregation, highlighting EPS8 and its regulators as potential therapeutic targets. www.nature.com/articles/s43...

Trilled to share our new work🥳We show that age-related hyperactivation of the EPS8/RAC signaling pathway drives protein aggregation and neurodegeneration — hallmarks of Huntington’s disease and ALS. #proteostasis #aging #neurodegenerativediseases

Happy to have contributed to this exciting work in collaboration with Prof. Dr. Irina Dudanova’s group! If you're interested in learning more about the role of Anle138b in regulating pathological phenotypes in mouse and cellular models of #Huntington’sDisease, check it out!