In this Opinion piece, Rachel Turn, Mohammad Ovais Aziz-Zanjani, Anushweta Asthana & Peter Jackson highlight strategies for multiplexing diverse approaches to map transient phosphorylations driving ciliary function & G0 in health versus disease. #JCSciliaSI journals.biologists.com/jcs/article/...

Wut. A.I. is to intelligence what a scarecrow is to a human. Sure, some birds might confuse them, but that does not make them the same.

How many (active) C. elegans labs are there?

I thought the "most dangerous animal in the world" was us!

From the lab of Maxwell Heiman discussing the interesting topic of apical ECM and the function of sensing organs and how these ECM proteins can both mechanically and biochemically modulate the organ's functions. doi.org/10.1016/j.cd...

The ECM is no longer in the back seat when it comes to development. Check out our special issue "Dynamics of the extracellular matrix in development, cell physiology and disease" with 8 selected articles to learn more: A 🧵 www.sciencedirect.com/special-issu...

Excited to share our latest work on a new cilia disassembly pathway and a link between this pathway and the neurological disorder focal cortical dysplasia: www.science.org/doi/10.1126/... Brief summary: we used a genome-wide CRISPRa GOF screen to identify negative regulators of ciliary signaling...

Micropublication @micropub7n.bsky.social is peer reviewed and PubMed indexed. A great way to get the data out in uncertain times 👇🏼

🔊New preprint from our lab! Zygotene cilia regulates meiosis, germ cell development, and fertility in zebrafish, mice, and humans www.researchsquare.com/article/rs-7...

US citizens, if you can please donate to help Paul Maddox run for Congress in his home district in Western NC.

A microscopist with a vision! Go Paul!

Jensen, @peiferlabunc.bsky.social et al. @unclineberger.bsky.social reveal that the intrinsically disordered region of Canoe is critical for its role in linking cell–cell adherens junctions to the #cytoskeleton. rupress.org/jcb/article/... #Development #Adhesion #Drosophila

Despite the mess, we are grateful to be funded, have exciting science happening, and have an opening for a postdoc! If you are interested in sensory biology and esp in cilia, thermosensation, or interoception, and would like to join an interactive & supportive group - please email. Please RT 🙏

Excited to finally share this pre-print on the eve of my viva: ‘C. elegans septins regulate a subset of sensory neuronal cilia via cell-non autonomous mechanisms in supporting glia’ www.biorxiv.org/content/10.1...

We pulled this out of a (pre-CRISPR era) EMS screen for CHX resistance around 2008 but never followed through with it! Happy to see others do it, a little sad we never did. Our idea was to use it to make CHX sensitivity in single neurons/glia, to test role of protein synthesis in sensory adaptation.

I am thrilled to share our latest story led by the incredibly talented Brooke D’Arcy and Camila Musso. We discover a rich world of local gene expression in radial glia, essential neural and glial precursors, and develop a new method for sub-cellular mRNA manipulation. www.biorxiv.org/content/10.1...

Paper alert! doi.org/10.1038/s443... - "A scheduler for rhythmic gene expression". We show how 9 txn factors suffice for rhythmic gene expression of thousands of genes with any phase or amplitude in #Celegans larvae (and also look at the tissues where oscillations happen) 1/n

Saturday morning, waiting for kid's soccer game, is a great time to indulge in the lowest form of humor: LAB HAIKU! 1. Does anyone know whose PCR is in there? BEEP. BEEP. BEEP. BEEP. BEEP.

🚨 New preprint! We profile the transcriptome of the C. elegans distal tip cell: a persistent leader cell that invades basement membrane to shape the gonad. Our dataset defines the molecular signature of invasive leader cells & uncovers new regulators of collective cell invasion.

Cilia and aECM, what more could you want? www.biorxiv.org/content/10.1...

Thomas Hunt Morgan, born 159 years ago #OTD in 1866. Happy 1.59 centiMorgans. en.m.wikipedia.org/wiki/Thomas_...

Please join us! sundaramlab.com/blog/aecm-cl...

The 2025-2026 #aECM club schedule is now posted on our website, where you can also find the link to sign up for access. I’m looking forward to lots of great talks and discussions! sundaramlab.com/blog/aecm-cl...

Will today's digital lab notebooks feel like this in 30 years?

New preprint! How are developmental cycles coordinated across cell types? It turns out that, like Geppetto's cuckoo clocks in the GIF below, individual cell types are each performing their own little crazy routine, but all in sync with each other.

Now published: doi.org/10.1002/cne.... Our fan letter to Ward et al., J. Comp. Neuro. 1975 -- the first EM reconstruction of the C. elegans nervous system -- is now out in the same journal 50 years later.

easily readable history of C. elegans drug screening - great resource pedantic point: "26 sensory neurons... are exposed to the environment through cuticular holes and readily take up hydrophobic molecules" 8x2 AM, 2x2 PH, 1x6 IL2 = 26, but AWB takes up FITC = 28 and I'd count AWA, AWC, IL1 = 38

More new science from the lab! Led by @nathancsharris.bsky.social (now at GA State) and PD Priya Dutta. We describe how experience tunes the ratios of functional receptors in a single sensory neuron via coordinating transcriptional and post-transcriptional mechanisms to drive response plasticity.

In this 1892 lecture, the poet A. E. Housman advocates for basic curiosity-driven discovery research: www.chiark.greenend.org.uk/~martinh/poe... I've copied some of my favorite parts below. 1/10

Snails with human-like eyes?! Published in @natcomms.nature.com, the @planaria1.bsky.social & @accorsi-alice.bsky.social Labs have established apple snails as a novel model for studying vision restoration. They have complex camera-type eyes & the ability to regrow them in 28 days: bit.ly/4mvaxkq

Chitin. It's what's for dinner.

trick question, dev bio is movies not static images. correct answer is this wild-type C. elegans embryo from Bob Goldstein @bob-goldstein-art.bsky.social youtu.be/vxeBWwr4310

My fabulous colleague (and ex-postdoc) @inechipurenko.bsky.social and I (mostly Inna!) wrote a review extolling the many virtues of C. elegans for the study of cilia biology. A really interactive and collaborative community of people working in this field too. www.sciencedirect.com/science/arti...

Great GRC, great chair. This was the first GRC that I ever attended (2001), getting to speak on yeast "fertilization". I remember the meeting vividly, including the chair (Harvey Florman) who was super welcoming. These early interactions had a big impression on me as a student!

Our recent study exploring the mechanisms behind hybrid incompatibility in Caenorhabditis Elegans nematodes is now available at @currentbiology.bsky.social! Many thanks to my collaborators at UCSD - @odlab.bsky.social @greenbeegreen.bsky.social and the Rifkin Lab! www.cell.com/current-biol...

Huge thanks to Cathy Savage-Dunn @cswormlab.bsky.social and Baris Tursun @baristursun.bsky.social for an amazing #worm25 !! I want to call out the OUTSTANDING meeting they created! Talks and posters were A+++. Most of all they brought us together in one of the most challenging times we've had.

Rachel Swope opens the ECM workshop saying it's a great time to study ECM! #worm25

And then after lunch, the trainee-organized ECM workshop Khaira, 1:15 PM - 2:45 PM Extracellular Matrix: A New Era of Tools and Discovery

#aECM at #worm25: Talk this morning (Cell Bio session) by Prioty Sarwar from my lab A role for the spectrin cytoskeleton in cuticle alae patterning 9:06 AM - 9:18 AM Program Number: 66

#aECM at #worm25 Development session: Rachel Swope described how sensory cilia that are embedded in cuticle deal with the molt cycle

Kicking off #Worm25 with the parasitic nematode workshop organized by the great Astra Bryant and Elissa Hallem!

The Oegema/Desai labs are heading to #Worm25! Mark your calendars and check out the talks/posters from our current lab members @greenbeegreen.bsky.social @nehavarshney.bsky.social @aleesaschlientz.bsky.social and Wanying Tian!

Tursun lab en route to Davis for #worm25 after a stop in San Francisco.

Is this OUR M. Maduro? #worm25

WormAtlas will have a booth at the Worm Meeting during the poster sessions. Please stop by to see what is new and to enter our t-shirt giveaway. We have some free pens as well! #worm25

Good early morning #worm25!!! The Lee lab is en route to California for grad students Tahreem & Marybeth's first-ever worm meeting 🪱🪱🪱 Are we completely awake? No! Are we super excited to see worm friends very soon? You betcha! 🥳

I am excited (as usual) about attending #Worm25. But I am also sad that so many friends and colleagues can't be there. Because you know....insane policies and war and such. Hoping the science will provide at least a temporary distraction from the unending chaos.

Just what you want the morning of #worm25 - get in the shower, low pressure, almost no hot water. Something's wrong. Go downstairs, hear loud rushing water. Both kids still asleep. Broken pipe? Flooded house? Cancel trip? Nope - just the cats learned to turn the bathtub hot water on full blast.

Starting my pilgrimage to #Worm25 ✈️

Attending #Worm25 in Davis? Go talk to Clover at Poster 271C in the Cell Biology section on Tuesday to learn more about this approach and get some practical tips straight from the expert!