New online: Structural mechanism for noncanonical GPCR signaling in the Hedgehog pathway

Now online in @natsmb.nature.com - - We combine AlphaFold, structural, and biochemical approaches to show that SMO directly inhibits PKA via a pseudosubstrate mechanism—revealing a new mode of #GPCR signal transduction in the #Hedgehog pathway. Big thanks to everyone who contributed!

Posted also on linkedin - where it's all one post (why linkedin is better than bluesky for science, frankly). www.linkedin.com/feed/update/... Not posting on Xitter, because I get called the f-word, the q-word, woke, and other things there. 🏳️‍🌈

Excited to share our latest work on a new cilia disassembly pathway and a link between this pathway and the neurological disorder focal cortical dysplasia: www.science.org/doi/10.1126/... Brief summary: we used a genome-wide CRISPRa GOF screen to identify negative regulators of ciliary signaling...

Univ. of Utah & Huntsman Cancer Institute are seeking tenure-track faculty in cancer biology (broadly defined), especially in combining experimental & computational structural approaches (incl. AlphaFold & other AI/LLM tools) to study cancer-relevant signaling. utah.peopleadmin.com/postings/189...