Meera Sundaram
@meera-sundaram.bsky.social
📤 1238
📥 437
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Worms, Tubes, Matrix. In Philly
#Celegans
#aECM
Editor at GENETICS
pinned post!
#aECM
(apical extracellular matrix) is a subset of
#ECMatrix
that is distinct from stromal matrices or basement membranes. Anybody out there studying
#mucins
#ZPproteins
#cuticle
#glycocalyx
#surfactant
or the like? We need to find each other and start talking!
12 months ago
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Genetics Society of America
3 days ago
We’re excited to expand our partnership with
@reviewcommons.org
in a new collaborative model reshaping scientific publishing to streamline peer review, reduce redundancy, and improve the author and reviewer experience. Read more:
buff.ly/h6SfMXF
And meet our Editorial Board! 👋
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ELECTION DAY
#Philly
billypenn.com/2025/10/29/p...
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Procrastinator’s Guide to the 2025 general election in Philly
Election Day is Tuesday, Nov. 4. Judicial candidates — especially retention votes for state Supreme Court justices — have drawn extraordinary attention.
https://billypenn.com/2025/10/29/procrastinators-guide-2025-general-election-philly/?mc_cid=53bc27a871&mc_eid=df0de6fd0b
4 days ago
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Meera Sundaram
Mark A. Hanson
7 days ago
Just tried q.e.d. by
@odedrechavi.bsky.social
et al. with a few papers including by myself & others where I knew a claim within was flawed based on a misunderstanding of the signal. 1) it was impressive. I see what the hype is about. 2) it hallucinated.
www.qedscience.com
Overly long
#SciPub🧵
1/n
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q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
https://www.qedscience.com/
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Meera Sundaram
Nature
7 days ago
Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake
go.nature.com/3X5lbUg
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From MRI to Ozempic: breakthroughs that show why fundamental research must be protected
Nature - In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.
https://go.nature.com/3X5lbUg
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Oof, Richard Scarry was a formative part of my youth and this is brutal. There is an election on Tuesday Nov 4. Vote to change this.
7 days ago
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Cory Booker
8 days ago
Thank you Congressman Neguse for laying it plain.
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Cells & Development
9 days ago
From the lab of Maxwell Heiman discussing the interesting topic of apical ECM and the function of sensing organs and how these ECM proteins can both mechanically and biochemically modulate the organ's functions.
doi.org/10.1016/j.cd...
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Cells & Development
9 days ago
The ECM is no longer in the back seat when it comes to development. Check out our special issue "Dynamics of the extracellular matrix in development, cell physiology and disease" with 8 selected articles to learn more: A 🧵
www.sciencedirect.com/special-issu...
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Cells & Development | Dynamics of the extracellular matrix in development, cell physiology and disease. | ScienceDirect.com by Elsevier
Extracellular matrices (ECMs) are everywhere in our body– from the sheet-like basement membranes that line epithelia and other tissues - to the loose stromal arrays of mesenchyme - to the rigid struct...
https://www.sciencedirect.com/special-issue/1057HJ3N6V3
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VOTERS, There’s an important Election Day coming up on Tues Nov4, including here in
#Philly
billypenn.com/2025/10/29/p...
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Procrastinator’s Guide to the 2025 general election in Philly
Election Day is Tuesday, Nov. 4. Judicial candidates — especially retention votes for state Supreme Court justices — have drawn extraordinary attention.
https://billypenn.com/2025/10/29/procrastinators-guide-2025-general-election-philly/?mc_cid=53bc27a871&mc_eid=df0de6fd0b
9 days ago
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Meera Sundaram
Bucks County Beacon
10 days ago
A Rutgers University report released Monday reveals that corporate investors are gobbling up about 25% of all residential units in predominantly Black and Hispanic neighborhoods in Philadelphia, raising concerns about increased evictions, higher rents, and reduced homeownership.
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Corporate Investors Are Gobbling Up Philadelphia’s Single-Family Homes at an Unprecedented Rate, New Report Shows - Bucks County Beacon
The Rutgers University report released Monday reveals that about 25% of all residential units are purchased as nameless, faceless individuals as investors in LLCs.
https://buckscountybeacon.com/2025/10/corporate-investors-are-gobbling-up-philadelphias-single-family-homes-at-an-unprecedented-rate-new-report-shows/
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eric lai
10 days ago
🪰 folks! Despite Harvard lawsuit outcome, FlyBase NIH grant was not released. FlyBase now runs on the public, like NPR, PBS etc. If we don't step up, it can go away! Donations site on
flybase.org
homepage. Note: it links to IU stock center, but its for FlyBase, see instructions. pls give+share! 2/2
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FlyBase Homepage
FlyBase: a database for drosophila genetics and molecular biology
https://flybase.org/
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Cool Halloween events happening in the dead
#Philly
Macy’s
www.operaphila.org/whats-on/eve...
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Silent Classic Horror - Silent Classic Horror
Free 1920s horror films with live organ accompaniment at the Wanamaker.
https://www.operaphila.org/whats-on/events/other/2025/silent-classic-horror/?mc_cid=76543198b7&mc_eid=df0de6fd0b
10 days ago
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Meera Sundaram
Conrad Benner
14 days ago
PHILLY/ PA: Vote on November 4, and vote YES on all three PA Supreme Court judicial retentions! 🗳️✅
#PACourtsMatter
#PAVotes
#StayInformed
#ProtectPACourts
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Beware
#Philly
bike commuters: Problems on the Schuylkill river trail
www.phillyvoice.com/schuylkill-r...
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A 10-foot long, 8-foot deep sinkhole has caused part of the Schuylkill River Trail to temporarily close
Repairs on the section between Race Street and JFK Boulevard could take months after a large crater formed under the asphalt.
https://www.phillyvoice.com/schuylkill-river-trail-closed-sinkhole-repairs/?mc_cid=6e5d63b768&mc_eid=df0de6fd0b
16 days ago
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Meera Sundaram
Joshua Weitz
17 days ago
Abandoning Merit for Compliance: Unpacking The Compact for Higher Education
substack.com/@joshuasweit...
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Abandoning Merit for Compliance: Unpacking The Compact for Higher Education
How the Dept. of Education’s proposed “Compact” for higher education would undermine merit-based review in exchange for fealty.
https://substack.com/@joshuasweitz/note/p-176800037?utm_source=notes-share-action&r=fjyhw
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Meera Sundaram
Daniel Gorelick
16 days ago
Eliminating DEI & hiring your friends
www.science.org/content/arti...
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JD Vance officiated the wedding of new head of NIH environmental institute
Unusual hiring process raises fears of political favoritism
https://www.science.org/content/article/jd-vance-officiated-wedding-new-head-nih-environmental-institute
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Meera Sundaram
David Ho
17 days ago
We were all relieved that this didn’t happen on 9/11.
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jon ben-menachem
18 days ago
Wow. Harvard nuking its PhD programs - Science PhD admissions reduced by more than 75% - Arts & Humanities reduced by about 60% - Social Sciences by 50–70% - History by 60% - Biology by 75% - The German department will lose all PhD seats - Sociology from six PhD students to zero
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Harvard FAS Cuts Ph.D. Seats By More Than Half Across Next Two Admissions Cycles | News | The Harvard Crimson
The Faculty of Arts and Sciences slashed the number of Ph.D. student admissions slots for the Science division by more than 75 percent and for the Arts & Humanities division by about 60 percent for th...
https://www.thecrimson.com/article/2025/10/21/fas-phd-admissions-cuts/
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Meera Sundaram
Grosshans Lab
19 days ago
And the next one:
dx.doi.org/10.1038/s44318-025-00585-z
. Super-fun collaboration with
@partchlab.bsky.social
&
@gotworms.bsky.social
to find similarities between developmental and circadian clocks – supported by
@fmiscience.bsky.social
Facilities and, financially,
@snsf.ch
and
@erc.europa.eu
. 1/n
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Latin American worm meeting in beautiful Merida Mexico, February 24-28, 2026. Abstract deadline is October 31.
meetings.embo.org/event/26-worm
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𝘊. 𝘦𝘭𝘦𝘨𝘢𝘯𝘴 Biology
This EMBO Workshop on C. elegans Biology is the IV Latin American Worm Meeting. It will convene in Merida, Mexico. The overall mission of this meeting is to create an inclusive environment that pro…
http://meetings.embo.org/event/26-worm
20 days ago
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Meera Sundaram
Bucks County Beacon
20 days ago
Photo Essay: Millions of Americans Join No Kings Demonstrations Across the County to Protest Trump | “Big rallies like this give confidence to people who have been sitting on the sidelines but are ready to speak up,”
@chrismurphyct.bsky.social
told
@apnews.com
. MORE PHOTOS:
bit.ly/475cEoQ
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Meera Sundaram
Bucks County Beacon
20 days ago
Photo Essay: Thousands of Democracy Defenders Protest Trump at
#NoKings
Rallies Throughout Bucks County | Doylestown, Morrisville, Perkasie and New Hope were among the locations where local residents protested Saturday because they love their country.
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Photo Essay: Thousands of Democracy Defenders Protest Trump at 'No Kings' Rallies Throughout Bucks County - Bucks County Beacon
Doylestown, Morrisville, Perkasie and New Hope were among the locations where local residents protested Saturday because they love their country.
https://buckscountybeacon.com/2025/10/photo-essay-thousands-of-democracy-defenders-protest-trump-at-no-kings-rallies-throughout-bucks-county/
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Meera Sundaram
Minor Spear Carrier
21 days ago
PHILLY I stepped out to walk across Philly last night and get a sense of things. City Hall always captures me here, Philadelphia has maintained its European layout and much of its early architecture.
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Indivisible ❌👑
20 days ago
This is what democracy looks like.
#NoKings
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20 days ago
#Philly
#NoKings
#AntiFascist
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Buck’s county PA
#nokings
20 days ago
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Meera Sundaram
Grosshans Lab
26 days ago
Watch Lucas' amazing artistic/musical rendition of C. elegans larval development and our work on developmental timing and molting here
youtu.be/-hGHYRvw87w
and read on his inspiration and challenges below
add a skeleton here at some point
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Meera Sundaram
HHMI
26 days ago
🎉Congrats to Freeman Hrabowski Scholar
@ishmailsaboor.bsky.social
on receiving the NIH Director’s Pioneer Award! His research will explore how sense of touch contributes to communal behaviors.
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Meera Sundaram
David Ho
25 days ago
Nobel Prize given for showing the importance of investing in science for innovation and long-term economic growth. Basically the opposite of what the US is doing. 😭
add a skeleton here at some point
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Ishmail Abdus-Saboor
25 days ago
We were just having this conversation
@meera-sundaram.bsky.social
! Using C.elegans as a model in your lab as a PhD student, I learned to think about biological systems as integrated networks. This has shaped my approach to studying the nervous system, attempting to link the body and brain.
add a skeleton here at some point
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Basic, curiosity driven, sometimes very exploratory, research is the seed corn that leads to the biggest scientific advances
www.nytimes.com/2025/10/09/s...
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Nobel Prizes This Year Offer Three Cheers for Slow Science
https://www.nytimes.com/2025/10/09/science/nobel-prizes-science-basic-research.html?unlocked_article_code=1.s08.5PyZ._yrfmoCC0gta&smid=url-share
27 days ago
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Reaffirming the value of model organisms in training scientific minds
@ishmailsaboor.bsky.social
exactly what we were talking about re your
#Celegans
background setting you up for creative work in other systems!
www.nature.com/articles/s41...
add a skeleton here at some point
28 days ago
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For those in
#Philly
share.inquirer.com/uMddWX
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The house where ‘American hero’ Paul Robeson lived until 1976 is reopening as a museum
A ribbon cutting ceremony is set for the Walnut Hill house that tells the story of the Black Renaissance man who was born in Philadelphia.
https://share.inquirer.com/uMddWX
29 days ago
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Meera Sundaram
Craig Kaplan
about 1 month ago
I think the R01 is basically a non-starter at NIGMS now. Data from NIH Reporter for new and competing awards, comparing number of R01s issued relative to R35s (MIRA). This has major ramifications for basic science and basic science investigators that are not yet in the MIRA pool
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Rick Steves
29 days ago
Thread: A year ago yesterday was a very happy day for me. I had lost my prostate. It was good riddance, as it was riddled with cancer. I’m now cancer-free — and thankful for the tax-funded technology that saved my life.
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The Onion always has the best headlines
add a skeleton here at some point
30 days ago
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cc: University presidents
add a skeleton here at some point
about 1 month ago
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Meera Sundaram
Chrystal Starbird
about 1 month ago
The title says it all ⬇️
add a skeleton here at some point
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Meera Sundaram
Jeremy Berg
about 1 month ago
Hear! effing Hear! [Gift link]
www.nytimes.com/2025/10/02/o...
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Opinion | Trump’s ‘Compact’ With Universities Is Just Extortion
https://www.nytimes.com/2025/10/02/opinion/trump-compact-universities-constitution.html?unlocked_article_code=1.qk8.k1Ht.fAKa364Chn1q&smid=url-share
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The 2025-2026
#aECM
club schedule is now posted on our website, where you can also find the link to sign up for access. I’m looking forward to lots of great talks and discussions!
sundaramlab.com/blog/aecm-cl...
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aECM Club Seminars
A virtual seminar series to highlight work on apical ECM across different systems Organizers: Meera Sundaram, UPennMax Heiman, Boston Children’s, Harvard U.Nathalie Pujol, U. Aix MarseilleJor…
https://sundaramlab.com/blog/aecm-club-online-seminar-series/
about 2 months ago
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Meera Sundaram
Carl Zimmer
about 2 months ago
This year's Lasker Awards went to scientists who studied the wiring diagram of life, a new state of biological matter, and a potent treatment for cystic fibrosis. Here's my story with Gina Kolata. Gift link:
nyti.ms/4mZlH1F
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https://nyti.ms/4mZlH1F
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Meera Sundaram
bioRxiv Developmental Biology
2 months ago
Apical extracellular matrix regulates fold morphogenesis in the Drosophila wing disc
https://www.biorxiv.org/content/10.1101/2025.09.06.674631v1
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Meera Sundaram
Max Heiman
2 months ago
New preprint! How are developmental cycles coordinated across cell types? It turns out that, like Geppetto's cuckoo clocks in the GIF below, individual cell types are each performing their own little crazy routine, but all in sync with each other.
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TanentzapfLab
3 months ago
The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard.
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If you liked this article, you might be interested in the new
#aECMClub
starting Fall2025 -a virtual seminar series to highlight work on
#aECM
across different organisms. 🪱🪰🐟🐁👳♀️🌱🦠 Sign up here: 👉https://forms.gle/Y6UjbnXPH1pDHAE97
3 months ago
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Meera Sundaram
Max Heiman
3 months ago
In this 1892 lecture, the poet A. E. Housman advocates for basic curiosity-driven discovery research:
www.chiark.greenend.org.uk/~martinh/poe...
I've copied some of my favorite parts below. 1/10
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Introductory Lecture
https://www.chiark.greenend.org.uk/~martinh/poems/introductory.html
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Meera Sundaram
Cells & Development
3 months ago
Maybe it's time we rethink the idea that development is a cell centric process? In this beautiful review, María-del-Carmen and
@stramerlab.bsky.social
discussed how the ECM underlies and influences many morphogenesis processes from wing unfolding to mammary gland development.
doi.org/10.1016/j.cd...
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Meera Sundaram
Meital Oren
3 months ago
highlight of two recent fantastic comparative inter-species single-cell atlases, by
@live-large.bsky.social
from
@jisaacmurray.bsky.social
, and Itai Toker from Oliver Hobert's lab
www.sciencedirect.com/science/arti...
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Evolution of nervous systems: Molecular divergence in a conserved body plan
Comparative inter-species single-cell atlases of Caenorhabditis whole embryos and larval nervous systems reveal deep conservation of cell type identit…
https://www.sciencedirect.com/science/article/pii/S0960982225007572?dgcid=author#bib2
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Meera Sundaram
PLOS Biology
3 months ago
More than a billion tons of
#chitin
are produced on Earth each year. This study shows that the soil
#bacterium
#Streptomyces
venezuelae thrives on chitin from
#insect
#exoskeletons
, using a potent mix of chitinases and a dedicated chitobiose importer
@plosbiology.org
🧪
plos.io/45sg4S5
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This is the first manuscript I am choosing to have reviewed by Review Commons. It’s an experiment!
www.biorxiv.org/content/10.1...
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Opposing roles for lipocalins and a CD36 family scavenger receptor in apical extracellular matrix-dependent protection of narrow tube integrity
All exposed epithelial surfaces, including the walls of internal tubes, are lined by a lipid and glycoprotein-rich apical extracellular matrix (aECM) that helps shape and protect the apical domain. Se...
https://www.biorxiv.org/content/10.1101/2025.07.25.666821v1
3 months ago
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