🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

1993 gilson pipettes!!! 😭😭😭😭

I am ready for the apocalypse, got my sequence of pPD95.75 and others right here #celegans

if anyone wants a billion cardboard freezer boxes, hmu.

today in I’m Not Crying, You’re Crying, original reprints from the CGC (1976, 1977) #celegans

got the keys to my office today - I’m not crying you’re crying

The chromatin remodeller CHD4 controls both nucleosome integrity and transcription factor binding to promote activity of active regulatory elements and to prevent activation of silent enhancers https://www.biorxiv.org/content/10.1101/2025.08.29.672645v1

our department @zoology.ubc.ca has a tenure-track faculty position opening at the level of Assistant Professor of Teaching in the educational stream with a focus on Neuroscience! please share! academicjobsonline.org/ajo/jobs/30389

New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...

heck yeah ethan!

Worms love flies! Please consider donating to FlyBase. Model organisms unite! #celegans

thank you so much @celjauebel.bsky.social for the warm send off poster, been a pleasure to organize the Stanford Superworm seminar series. also #celegans has 300 neurons, don’t fight me

Important new piece by Indigenous scholars—including ecologists @1nativesoilnerd.bsky.social and @niiyokamigaabaw.bsky.social (who is here at #ESA2025 this week)—who set out eight steps to stop marginalization in academia and to enable a shared Indigenous agenda in science.

nice new pape out on autism-associated genes and experience-dependent neuron remodeling! congrats @michaelphart1.bsky.social and lab squad! pubmed.ncbi.nlm.nih.gov/40795403/

found my old FACS gating notes 😭; worm flow back in 2016 was so hard (still is hard)

Studying subjects that motivate you to develop as a person is going to make you much more generally competent, self-efficacious, and ultimately employable than any checklist of learning outcomes or button-pushing skills from undergrad syllabi. And happier. And better at life.

I just got the notice that all the FlyBase people at Harvard, including me, will be laid off on October 12. I'm devastated.

a new lab photo, finally. last lab meeting ever for me in the shen lab!

A longtime colleague and friend is shutting down her research program; there is no hope. I’m crushed on her behalf, just no words to do this justice. She started a gofundme to finish the last study so their findings can be published - please consider donating gofund.me/8bf0f53f

So let me get this straight. In the last *week* a praying mantis jumped on me, a possum made a house out of my trash can, and I encountered a mouse eating an ice cream cone. I feel like the Disney Princess of Philly Trash Girls 🥹

Well, none of us may ever get funded again but in the meantime, here's some new science! Led by recent PhD Anjali Pandey w/ex-UG Maya Katz. Here we identify an asymmetric molecular mechanism that underlies symmetric context-dependent sensory plasticity in the AWC olfactory neuron pair in C. elegans

my baymate xing gave me the wildest worm farewell gift, made in biorender and printed on a bag

My fabulous colleague (and ex-postdoc) @inechipurenko.bsky.social and I (mostly Inna!) wrote a review extolling the many virtues of C. elegans for the study of cilia biology. A really interactive and collaborative community of people working in this field too. www.sciencedirect.com/science/arti...

cellular jazz hands

In light of today’s news about the National Cancer Institute announcing a 4% payline, it’s really important to communicate to people that the previous 10% payline was still effectively a lottery and the result of decades of underfunding the NIH. Paylines used to be 25%.

A beautifully written piece on a terrible time www.science.org/content/arti...

How do chromatin remodelers use #IDRs to find TF binding partners? In our new Molecular Cell paper, we show that β-catenin is an adaptor that links SWI/SNF (cBAF) subunit ARID1A with binding partners via IDR-domain interactions. www.cell.com/molecular-ce...

A study in Scientific Reports suggests that the way dogs engage with TV may depend on their personalities. Excitable dogs were more likely to follow on-screen objects while fearful or anxious dogs were more likely to respond to stimuli such as cars or a doorbell. go.nature.com/4eQKDVy 🧪

This thread is incredible.

As requested - A Starter Pack of PIs in Biology (or related fields) who are recruiting PHD STUDENTS! If you would like to be added, feel free to ask! go.bsky.app/Bf4DRFm

submitted my NSERC NOI! with all the genetic screens I am proposing...I can't wait to isolate my first lfg alleles 🤣

Hey 🧪 I’m looking for a sci-savvy illustrator to build a cartoon-style schematic for a paper about summer research experiences. HMU if this describes you or your side gig.

new preep by the templeman lab at uvic!

Come join us in Vancouver! Exciting opportunity for a more senior investigator researching new regenerative medicine approaches for Type 1 diabetes. $8M in funding for successful candidate research.ubc.ca/media/file/j...

portland rules

Congestion pricing by the # ‘s 6 months in: * 67k fewer drivers entering zone daily * Delays in Holland Tunnel down 65% * Traffic deaths down 32% so far in 2025 * $500m projected this year for MTA capital improvements * B’way attendance +12% * Subway ridership +7% So yes this program is a SUCCESS.

still riding the high from #worm25. highlight for me was meeting a student who did one of my papers for his qualifying exam 🥺🥺🥺

A wormy tradition is the trading of meeting badges at the last night party 🪱🎉 I know I've made it as a PI bc #worm25 is the first time a trainee specifically asked for mine! Meet @ahnaskop.bsky.social (aka Kareem in @drohsopretty.bsky.social lab) & @rnareylab.bsky.social (aka @giosg.bsky.social)

“if david says it is a synapse, it is a synapse” 🕵️ #worm25

As it’s my first time joining Worm Meeting, I was excited to participate in Worm Art show as well. This year’s topic is resilience. In times of scarcity, worms gather holding one another to reach new grounds. Alone - they are fragile, together - they rise. Even the sky yields in unity. #worm25

c. elegans, ba-ba-bah #worm25

Crystal Rogers’ Genetics course changed her life! The difference of an engaging teacher 👍 #worm25

tots this AM at the dorms #worm25. 7/10, would tater again.

Anne starting off by really showcasing the awesome work by @celjauebel.bsky.social 🥰

Fantastic Nobel Moment at #worm25 with Victor Ambros and Gary Ruvkun.

First up, Shelby Lauzon and Audrey Gilbert will present on behalf of #TeamCocaine (also including Prince Mosley, Elizabeth Eason and Ian Shen) their work using 🪱 to understand conserved mechanisms of acute cocaine exposure (500B), in collaboration with @csybio.bsky.social

I think we just witnessed the first ever nematode ménage a trois! #worm25

learning the deets on deet #worm25

Fed up with having to reconcile comments from Reviewer 1 and #Reviewer2? At eLife, editors and reviewers discuss their reviews with each other before reaching a consensus, letting you focus on how to improve.

I will be opening my new lab in September at UBC! if you’re coming to #Worm25 and are looking for graduate studies or a postdoc position, let’s meet! Vancouver + worms = perfect vibes. www.zoology.ubc.ca/~yeecs/labsi... Please share! 🙌