This is an interesting one.

Altered Brain Extracellular Matrix Structure and Sex-Specific Learning/Memory Dysfunction in Mice Lacking the Functional Amyloid Cystatin-Related Epididymal Spermatogenic (CRES) https://www.biorxiv.org/content/10.64898/2026.05.27.728219v1

Professor Richard Scolyer dies aged 59 leaving behind legacy of revolutionary brain cancer research

New #RepFertDev #EditorChoice article 📢 'Formation of the hyaluronan–serum-derived hyaluronan-associated protein complex during cumulus expansion contributes to in vitro maturation of porcine oocytes' By Masaki Yokoo, Naoko Kimura Read it in @repfertdev.bsky.social: doi.org/10.1071/RD26...

An interesting paper from 2007.

This preprint suggests: LMW-HA - stress MMW-HA - metabolic and cytoskeletal signaling HMW-HA - stabilizing

Extracellular matrix-derived matrikines as emerging modulators of neuroinflammation and central nervous system signaling

Spatially confined niches support hypoxia-associated transcriptional plasticity contributing to malignant progression in IDH-mutant gliomas https://www.biorxiv.org/content/10.64898/2026.05.31.729105v1

"In OA, chondrocytes exhibit reduced mitochondrial respiration and increased glycolysis, a metabolic shift thought to contribute significantly to OA progression.. Interestingly, in our study, HK2 deficiency in chondrocytes accelerated OA progression.."

Reduced sperm binding capacity to hyaluronic acid is associated with ultrastructural sperm abnormalities

Beyond a passive coating: The cancer glycocalyx as a dynamic biophysical and immune interface www.hh.um.es/Abstracts/Vo...

Preprint: Telomere Dysfunction and Extracellular Matrix Remodeling "telomere dysfunction is not only a marker of tissue aging but it is also an active driver of persistent ECM remodeling and fibrosis, while signals from the ECM can in turn influence telomere maintenance and cellular senescence"

Sliding into Place: The Lymphatic Vessel Endothelial Hyaluronan Receptor LYVE-1 and Its Role as a Mediator of Cell Entry and Trafficking in the Lymphatics www.mdpi.com/2218-273X/16...

A post-inflammatory C3-high astrocyte state persists after inflammatory stimulus withdrawal and is attenuated by JAK inhibition https://www.biorxiv.org/content/10.64898/2026.05.26.725945v1

Modeling Prenatal Immune Activation in Human Brain Organoids Uncovers IL-6-Dependent Interneuron Dysmaturation https://www.biorxiv.org/content/10.64898/2026.05.26.728058v1

4-methylumbelliferone attenuates amyloid pathology and learning deficits in the APP/PS1 mouse model #NeuroDegeneration 🧪🧠 https://www.biorxiv.org/content/10.64898/2026.05.21.726929v1

Interestingly they use HA oligosaccharides to disrupt HA signalling

YAP/TAZ inhibition refines TGF-β signaling to prevent laryngeal fibrosis https://www.biorxiv.org/content/10.64898/2026.05.18.726086v1

LMW-HA/TLR4 has been debated because of possible LPS contamination, but HA fragments are widely reported as DAMPs, especially via TLR2 and in some contexts TLR4. So could dysregulated HA turnover activate TLR4?

Hyaluronan Regulates Vascular Smooth Muscle Cell Osteogenic Differentiation and Vascular Calcification www.mdpi.com/2218-273X/16...

Intracellular pH dynamics promotes zebrafish larval tail regeneration https://www.biorxiv.org/content/10.64898/2026.05.14.724960v1

Check out fascinating insights on nature’s most abundant polymers in our latest blog post. 🌱 Cellulose 🦀 Chitin (found in insects & fungi) 💪 Hyaluronan 🍚 Starch 🦠 Peptidoglycan Read research.bidmc.org/ncfg/blog/27... #Glycobiology #Science #Biochemistry #Nature #CellBiology #Glycotime

ADAM17-Mediated Cleavage of CD44 Impairs Hyaluronan-Dependent Shear Stress Mechanotransduction

Hyaluronan-Collagen balance dictates regenerative vs non-regenerative fate of adult🐭digit regeneration🤠 Soft matrix confers a pro-regenerative, HA-building (HAPLN1+) Blastema Fibroblast state Force mapping of wounded digits (stiffness fluidity) #Science 2026 www.science.org/doi/10.1126/...

Spectroscopic Analysis of the Extracellular Matrix Hierarchical Structure in Naked Mole-Rat Skin www.mdpi.com/2310-2861/12...

This is interesting, when CD44 pulls in hyaluronan, it can also bring in bound iron, increasing intracellular iron, which may then reinforce CD44 expression.

The naked mole-rat microbiome is associated with healthy aging and social structure www.cell.com/cell-reports...

I reframed the project into a neuro-dev context, the idea is that sustained postnatal HMW-HA driven by diet/metabolic changes across our evolution could act as a drag on maturation. The Hyaluronan Terrain Hypothesis: Molecular Weight and Turnover in Developmental Timing osf.io/sd5g4/wiki?w...

Early fibrotic niches establish tumour-permissive microenvironments www.nature.com/articles/s41...

More mad thoughts: In naked mole rats, a tuber-based diet and protected subterranean life may interact with hypoxic signalling. In humans, increased starch consumption and better shelter/safety occurred without chronic hypoxia, but phytochemicals may have provided mild pseudohypoxia-like signals.

Mild perinatal hypoxia uncouples excitatory-inhibitory circuit maturation and reprograms neocortical organization https://www.biorxiv.org/content/10.64898/2026.05.07.723460v1

High prevalence of CNS-directed autoantibodies in patients with schizophrenia https://www.biorxiv.org/content/10.64898/2026.05.04.722731v1

This is hilarious 🫠

www.cell.com/iscience/ful... Recovering damaged heart by reprogramming extracellular matrix after myocardial infract with hipsc derived cardiomyocyte patch @cpi-exstra.bsky.social

An agent-based model suggests how senescent cell behavior and matrix mechanics drive pulmonary fibrosis in aged mice https://www.biorxiv.org/content/10.64898/2026.05.01.722023v1

question: What are we calling a manuscript that never moves past the preprint stage to peer reviewed publication? A terminal preprint? something else you prefer?

Review: Epigenetic Regulation of Hyaluronan-Associated Genes in the Brain: Identifying Key Regulatory Sites www.mdpi.com/2075-4655/10...

Neuronal Toll-like Receptor-4 regulation of Matrix Metalloproteinase-9 Activity Mediates Dentate Circuit Dysfunction after Traumatic Brain Injury https://www.biorxiv.org/content/10.64898/2026.01.09.698505v1

How do epithelial cells integrate mechanical and biochemical signals to control their behavior? I am @ronjahoutekamer.bsky.social, and in this thread, I’ll show you how force transduction connects to biochemical signaling, and how it activates ERK by inducing biochemical ligand shedding.

Mad thought: We have similar hydration patterns to seedlings. Seedlings prefer moist soil while they grow, with alterations in hydration causing stress and altered growth, then as they mature they prefer wet/dry cycles. We may be the same!