#Medsky🧪 #neurosky #publichealth #pedsky #IDsky @brainbehavimm.bsky.social Higher CRP concentrations in cord blood are associated with greater ADHD symptom severity at age 5. These findings support the hypothesis that early-life inflammation may contribute to the developmental origins of ADHD

I wonder if HIF-2α can linger postnatally in humans? "The above data can be reconciled by proposing that HIF-2α is required for maintaining the supply of astrocyte progenitors by slowing down their differentiation into non-proliferative mature astrocytes."

OUT NOW from Steve Feldon & Collynn Woeller: Metformin inhibits PDGFβ signaling to suppress hyaluronan and cytokine production in thyroid eye disease in Experimental Eye Research. doi.org/10.1016/j.ex... #URochesterResearch @flaumeye.bsky.social

Our First Accepted Manuscript is Live on Cambridge Core! "Hyaluronic acid-coated polymer-siRNA nanovectors for evading macrophage uptake and STAT3 gene silencing in breast cancer cells" by Harini Nagaraj, Aarohi Gupta, Anil Cicek, et al. Read open access: https://cup.org/4cBOcOO

Hyaluronic acid: biological functions, production strategies, and clinical applications

Feeling like learning about a secret astrocyte network in the brain? Check out the latest from @melcooperphd.bsky.social in @nature.com. www.nature.com/articles/s41... (take two because I'm out of action on the socials!)

Eusocial Reproduction Selects for Longevity https://www.biorxiv.org/content/10.1101/2025.03.25.645350v1

A reciprocal glial circuit calibrates injury information and governs the tissue response balance

I just realised that humans have high cortical folding amongst primates, sort of like shar pei dog skin. Are there any other species with similar cortical folding?

This is interesting from “Matters of size: roles of hyaluronan in CNS aging and disease”. Rodent data shows a strong postnatal HA surge followed by decline. But in humans? I can’t find much data, If HA plays a role in development and regeneration, this seems like an area worth looking into!

Matrix composition modulates cancer cell phenotypes and secretions in a blood–brain barrier organ-on-a-chip model: Comparison of collagen and hyaluronic acid

CD44-mediated meningeal monocyte activity enhances immune surveillance in the central nervous system after traumatic brain injury

"Although HA, CSA, and CMC supported comparable numbers of adherent cells, HA exhibited significantly higher adhesion strength. These results demonstrate that cellular adhesion mediated by CD44 displays a nonlinear relationship between adhesion strength and the number of attached cells"

Survey research is often interpreted as showing that belief in conspiracy theories can be surprisingly widespread, including belief in conspiracy theories that would be astonishing if true. For example, in The Atlantic we learn that “12 million Americans believe lizard people run our country”

A movie couple that would definitely have a podcast

Ridiculous.. "Mr Robinson — a former defence force member who served in Afghanistan — told the jury he was "utterly horrified" by the incident, which resulted in the girl's front teeth being knocked out."

"receptor CD44 enables astrocytes to respond to extracellular signals and decipher them into intracellular signaling pathways, to maintain and modulate their morphology. This mechanism can underlie the morphological changes associated with many physiological and pathological processes in the CNS"

ONLINE NOW: Targeting the hyaluronic acid–CD44 axis in hepatocellular carcinoma

"the hyaluronan degradation enzyme HYAL2 was found to be required for BBB integrity throughout life"

Check out 2 papers and a related Perspective on tissue regeneration in @science.org this week Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration | Science www.science.org/doi/10.1126/...

Awakening latent regeneration in mammals | Science www.science.org/doi/10.1126/...

Non-canonical roles for Hif-1α in interneuron progenitor proliferation and cortical circuit maturation

"These pathways converge on the HA–CD44 signaling axis, which safeguards centrosome clustering and mitotic fidelity, integrating metabolic and structural adaptations that ensure the survival of genomically unstable CA cells"

Glycobiology: How enzymes make the right choice during biosynthesis

"Our findings identify ECM composition and mechanics as a primary mechanism governing mammalian regeneration. By demonstrating that the ECM acts as a mechanochemical signalling hub, we show that “retuning” the physical environment from a stiff, collagenous state to a soft, HA-rich state can.."

The study provides a concept of proof of benefit of use of hyaluronan enriched media as a novel minimally invasive add-on intervention to facilitate the enhancement of success rates of IUI treatment.

Seed and soil… but what about water? The Hyaluronan Terrain Hypothesis: Molecular-Weight Dynamics in Development, Ageing, and Disease osf.io/sd5g4/wiki?w...

Stable metabolism allows long chain HA, while disruption leads to shorter chains, potentially shifting ECM signalling.

Human placental matrix hydrogel: A biomaterial for modulating inflammation and promoting repair of refractory diabetic wounds 🤢

In HaCaT keratinocytes, ATP caused a rapid and strong but transient activation of HAS2 expression

Pathological accumulation of extracellular-matrix components, including hyaluronan and sGAGs, has been suggested to sustain advanced atherosclerotic plaques by altering tissue architecture and transport. D016 is a recombinant dual-active hyaluronidase designed to cleave both substrates

"CD44 emerges as a key network node with potential relevance in PCOS pathophysiology"

This paper shows CREB and retinoic acid receptor signalling converge on HAS2. In development, multiple pathways are active at once, I wonder whether HIF signalling might also feed into this broader regulation of hyaluronan production.

This preprint suggests ECM stiffness regulates ovarian aging and follicle function

Would be interesting to see whether lutein metabolites affect placental HAS2 or hyaluronidase. HAS2 is RA responsive but likely more context dependent. Carotenoid intake is also linked to reduced preeclampsia risk.

The astrocyte clock controls circadian perineuronal net remodeling, synapse strength and learning behavior https://www.biorxiv.org/content/10.64898/2026.04.04.716486v1

I wonder if ECM hydration, particularly HMW-HA, influences amyloid aggregation or clearance. Aging tissues become stiffer and less hydrated, which may create conditions that favour retention and build-up.

After ischemia, ECM components like CSPGs, fibronectin and hyaluronan inhibit remyelination.

The non-scaffold effects of natural polysaccharides in promoting organ regeneration: a review

Interesting that miR-23a-3p can inhibit HAS2 in some contexts

The production and accumulation of aberrant proteins can have serious pathological consequences. In a new #ScienceReview, researchers explore how organisms maintain the extracellular proteome. https://scim.ag/4tdEB7B

Perineuronal nets reflect a continuum of fast-spiking specialization in adult parvalbumin interneurons https://www.biorxiv.org/content/10.64898/2026.03.31.715401v1

"Obesity induces renal HA accumulation and CD44 and RHAMM expression, which activates the TGF-β1/Smad2/3, P38/JNK MAPK, and ROCK2/ERK/Akt pathways, promoting transcription of profibrotic.." A Novel Role of Hyaluronan and Its Membrane Receptors, CD44 and RHAMM, in Obesity-Related Kidney Pathology

Microbial Hyaluronidases: From Obscure Virulence Factors to Promising Therapeutic Targets www.mdpi.com/2218-273X/16...

Changes in hyaluronan could have big functional effects

Here is our paper on diffusion of neurotransmitters in the perisynaptic extracellular space, just out in Fluids and Barriers of the CNS rdcu.be/fbkFx #Neuroskyence

"HA shows the most rapid decline after birth, decreasing by 50% in the first 3 days of life, attaining levels present in adult rat tissues (28% of peak HA values) by 18 days of age"

Yay! Our paper is now out @emboreports.org! I posted about it a while back (tinyurl.com/yc7td3px) but the work really improved thanks to the wonderful feedback from three anonymous reviewers 🙏 (1/4)

An Integrated Network Biology and Molecular Dynamics Approach Identifies CD44 as a Promising Therapeutic Target in Multiple Sclerosis www.mdpi.com/1424-8247/19...