🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

I was Chair of @biologists.bsky.social when we started this initiative, the brainwave of the @stevenkelly.bsky.social It was an imaginative idea and I am thrilled to see this landmark Remember: @biologists.bsky.social are the goodies in scientific publishing!

🔬 Congratulations to Sarah Cohen (@cohenlaboratory) (@UNC) on receiving ASCB’s 2025 WICB Junior Award for Excellence in Research! This honor celebrates exceptional early-career contributions to cell biology and strong potential for continued leadership. #ASCB #CellBiology

Les désinformateurs continuent leur harcèlement en bande organisée... Apparemment l'Inspecteur Gadget enquête. Ca va être brillant... Cela ne pourra pas bien se terminer, tout ça...

poke @elodie-lafont.bsky.social

Out in @febsj.bsky.social, comment written with @tonyavril.bsky.social from @csignaling.bsky.social. https://doi:10.1111/febs.70259 The SARS-CoV-2 spike protein interacts with HAX1 to modulate cellular stress responses through activation of the UPR

Little Trump aping what Big Trump is doing. Sewing hate and division

Here are the highlights for the most recent computational and analytical methods for small molecule analysis coupled to mass spectrometry. biomed.news/bims-metlip/... A collaboration with @biomednews.bsky.social

This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

It’s literally the only way we will find out!!

Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou

Our work @benschulz.bsky.social on the specificity and the mechanism of activation of the eukaryotic oligosaccharyltransferase is now on Glycopedia ⬇️🎉🥳, the largest repository of #glycotime news and educational material online! Thank you Serge Perez 🤓❤️ glycopedia.eu/2025/09/09/r...

This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation www.sciencedirect.com/science/arti...

and last but not least two cancer neuroscience papers on small cell lung cancer. 1. www.nature.com/articles/s41...

Après avoir fait fi des vies de personnes âgées pendant le Covid, nos désinformateurs se moquent des décès de bébés pour poursuivre leur sinistre business.

Transmembrane protein export in developing axons, via axonal ERES and Golgi bypass

Allosteric Disulfide Bridges in Integrins: The Molecular Switches of Redox Regulation of Integrin-Mediated Cell Functions www.mdpi.com/2076-3921/14...

This is a critical piece - how widespread disinformation is a direct threat to human survival: www.theguardian.com/commentisfre...

Great perspective by @dereklowe.bsky.social on recent advances in cell surface #glycoRNA biology, including new work from @raflynn5.bsky.social and collaborators identifying an immune silencing effect of N-glycans on activation of TLRs by Acp3U-RNA (www.nature.com/articles/s41...)

Membrane protein export in developing axons, via axonal ERES and Golgi bypass #ER_Literature

Hope for diabetes: CRISPR-edited cells pump out insulin in a person – and evade immune detection Edits create cells that don’t trigger an immune response, allowing implant recipient to forego immune-suppressing drugs. Nature www.nature.com/articles/d41... NEJM article www.nejm.org/doi/10.1056/...

Looking forward to 2 days of proteostasis talks and discussions, especially in chairing today’s pm ‘medical implications’ session I’ll try to keep you updated (but possibly not when I’m meant to be chairing 😏) @royalsociety.org @cambup-lifesci.cambridge.org royalsociety.org/science-even...

Thank you for including our Paper as a highlight! for anyone interested in the accompanying blog post: go.nature.com/4mFNYdb

'Using genetically distinct mouse models of glioblastoma, we found that deletion of Adar1 consistently reduced tumor growth and extended survival, suggesting that disrupting ADAR1 activity could overcome the genetic heterogeneity of glioblastomas.'

This week selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation www.nature.com/articles/s42...

Ceux qui savent savent... Les camions frigorifiques...quand vous arrivez sur le parking le matin, et que vous voyez un camion frigorifique garé devant le funérarium. Quelle horreur... La vaccination d'une masse critique de la population a strictement coïncidé temporellement avec la diminution

Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!

🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS. The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch 🧵 www.nature.com/articles/s43...

Epstein Survivor Lisa Phillips: “Together as survivors, we will confidentially compile the names we all know who were regularly in the Epstein world.”

La Floride annonce son intention de mettre fin à toutes les obligations vaccinales L’État serait le premier à supprimer l’obligation pour les enfants d’être vaccinés pour aller à l’école. share.google/H59ghhyvMZaz...

L'histoire se répète, encore et toujours. Aujourd'hui, Nicolas Sarkozy adoube le RN. Comme nous le rappelait l'historien Johan Chapoutot aux Journées d'Été des Écologistes, le soutien des droites est essentiel pour que l'extrême-droite accède au pouvoir. www.mediapart.fr/journal/poli...

Epstein & Maxwell explicitly threatened their victims with death if they spoke out.

Exciting preprint on organelle mechanoadaptation from Stephanie Miserey and Felix Campelo @felixmendu.bsky.social! Extracellular forces modulate Golgi secretory output by tuning carrier biogenesis via microtubule acetylation, DAG, and PKD. Golgi is a mechanoregulator! www.biorxiv.org/content/10.1...

Excited to share our new work "Dissecting the Cdc37 Co-chaperone Code: Functional Roles in Chaperone-Mediated Stress Adaptation" in press at the Journal of Biological Chemistry www.jbc.org/article/S002...

He vaccinated his own kids

Nature methods: Co-profiling of in situ RNA-protein interactions and transcriptome in single cells and tissues www.nature.com/articles/s4...

1/11 Et maintenant Didier Raoult qui se positionne en expert de la nutrition ! Un interview pitoyable à la gloire de Trump et de Kennedy qu’il considère comme ayant fait une révolution dans le domaine de la nutrition pour lutter contre la malbouffe… Voir fil dessous: www.youtube.com/watch?v=U59T...

The era of ASIs is slowly dawning www.nejm.org/doi/full/10.... (Yeah spironolactone is just as good and cheaper) Disclosure: we recruited patients for this one

During surgical treatment for pancreatic cancer, pre-malignant lesions often go unnoticed and can later cause recurrence. MD Anderson researchers investigated whether a fluorescent imaging agent could better identify these areas for removal. Read more: spr.ly/6016ffOKM #EndCancer

BTW I wrote that. (It was approved by and reflects the mandate of the search committee). Drop me a line if you have any questions about the opening.

(1,2) Since @JDVance is spreading all kinds of opinion and bullshit on root causes of gun violence and talking about "research" perhaps he ought to start with my book American Carnage if facts are what he wants. He should include my co author @tomgabor.bsky.social as an expert on this topic.

Take a look at this picture and ask is the problem: 1. The drivers? 2. The cyclist? The secret answer is… 3. The urban planners who refuse to protect vulnerable cyclists and thus make cycling a potentially fatal activity and the highly vocal but tiny minority of toxic car heads who oppose bike lanes

GMail Breach Affecting 2.5 Villion Users "Google confirmed a massive security breach affecting 2.5 billion Gmail users after hackers successfully compromised a corporate Salesforce database through sophisticated social engineering tactics." www.perplexity.ai/page/google-...

Now online! Hepatocyte metabolic adaptations during pregnancy and lactation

Quantitative imaging of lipid transport in mammalian cells www.nature.com/articles/s41... (with a bit of #ER_literature)