Online now! Online now! Structure-based design of Sec61 translocon targeting prodrugs minimize off-target toxicity #chembiol

Structure-based design of Sec61 translocon targeting prodrugs minimize off-target toxicity: Cell Chemical Biology www.cell.com/cell-chemica...

Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...

Fantastic !!

Thermo Fisher now has a page up in response to our observations. They flatly deny that images were manipulated or fabricated while repeating that images were "optimized for presentation and clarity on the website", no lie, six times. www.thermofisher.com/us/en/home/l...

Hey y'all, let's make Thermo Fisher and their "optimization" famous🧪

Misguided Brushes of a Pen Continue to Dismantle and Destroy Biomedical Research in the United States: We Can No Longer Afford Complacency and Fear. We Must All Act Now! diabetesjournals.org/care/article...

Good morning! This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: Prevalent gut phages encode modular adhesins mediating epithelial binding and endoplasmic reticulum trafficking www.nature.com/articles/s41...

Scientific Streisand Effect

Good job editors for being clear this is happening under Censorship Jay.

Remember the current NIH director going on about protecting researchers from government censorship? Today his people called the police in to forcibly remove my colleagues from their own society meeting for sharing an editorial published in their flagship journal that was critical of him. Gift link

We are moving into a new scary era as scientists www.nytimes.com/2026/06/05/w...

Sad news - Persepolis is one of the great graphic novels, if you haven't read it, get a copy (I believe it has been translated into English)

#ESR Succès total dans l'offensive contre l'Université: le privé "hors Parcoursup" continuera ses arnaques; les gros prédateurs comme Galileo, à l'origine du texte de loi, se sont fait ouvrir les portes de la diplomation et de la reconnaissance par l'Etat. www.mediapart.fr/journal/poli...

Bonsoir, La semaine dernière, j'ai fait une série de posts sur Linkedin au sujet de la désinformation concernant les scénarios réactualisés pour les projections climatiques. Vous les trouverez ici, à partir de celui-ci, www.linkedin.com/posts/val%C3...

Another great collection of #autophagy and #mTOR papers from the past two weeks, can’t be missed if you’re into these topics! biomed.news/bims-auttor/... biomed.news/bims-auttor/...

Good morning! This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: Mechanism of RACK1-dependent ZAKα activation at stalled and collided ribosomes www.sciencedirect.com/science/arti...

Really looking forward to this and can’t wait to visit @livuni-ismib.bsky.social !!

Wu and Hegde annotate and analyze the topology of 4,863 human endoplasmic reticulum–inserted membrane proteins and their 20,546 transmembrane domains, showing that transmembrane domains inserted by different pathways can tolerate different biophysical properties. rupress.org/jcb/article/...

Gina Simon, Doris Hellerschmied @hellerschmiedlab.bsky.social and colleagues @unidue-zmb.bsky.social dissect stress-induced proteome remodelling at the Golgi–endosome interface. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

The was a straight up awesome talk. Beautiful work, @mads100tist.bsky.social , congratulations!

How to determine the proteome of cellular compartments? We established a method to do just that, published n @eLife.bsky.social: SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection doi.org/10.7554/eLif...

New paper from the Yasin Dagdas (@plantophagy.bsky.social) group, this time in @science.org, on how plant cells cope with viral infection and how selective autophagy delays cell death to give plants a chance to survive. Chapeau and congratulations to all the authors! www.science.org/doi/10.1126/...

Tomorrow! Come hear me rambling for an hour about neurons, dev bio, transcription factors, colorful dots and fun speculations of galactic proportions 🧪

Single molecule studies from Arda Mizrak in the Farese/Walther @msk & Harper Labs @harvardcellbio.bsky.social shows how lipid droplet proteins track through ER networks to ultimately partition into nanodomains on droplets, dependent upon Trp-containing hairpin motifs www.nature.com/articles/s41...

UK-based cell biologist? Interested in membrane trafficking? Want to find a conference? Looking for a job (PI, postdoc...)? Do link to www.ukmembranetraffic.com, where @jezcarlton.bsky.social and Chris Stefan (not here?) do sterling work

Reminder I will be in Paris and that, if you are, too, I'd love to see you there and chat and maybe plot a bit 👀🧪

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Good morning! This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: Nitric oxide drives proteomic diversity through alternative splicing www.sciencedirect.com/science/arti...

Good morning! This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: Biomolecular Condensates as Protein Degradation Tools for Intracellular Targets www.nature.com/articles/s41...

Good morning! This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: Impaired collagen deposition in the absence of ERp44 www.cell.com/iscience/ful...

France has a record number of presidential hopefuls. Will any of them be able to hold back the far right?

Early fibrotic niches establish tumour-permissive microenvironments www.nature.com/articles/s41...

Congrats @tonyavril.bsky.social and team 🤩 ... well done 👏

Désinformation en santé. Les fans de Didier Raoult, prix Nobel du harcèlement

#Autophagy and #mTOR papers from last week, enjoy! biomed.news/bims-auttor/...

#ESR L'habituelle clique trumpiste financée par Stérin s'engouffre dans les dysfonctionnements réels et récurrents des commissions disciplinaires locales, pour mettre leurs chimères et délires identitaires en scène.

#ESR Voilà la raison pour laquelle la loi de privatisation Galileo-Baptiste doit être combattue au profit d'une loi interdisant tout financement public du supérieur privé, et mettant fin à ce qu'a engendré la loi Pénicault. bsky.app/profile/agor...

#ESR Pourquoi pas mais alors quid pour les formations privées ? Les GE à moins qu'on considère qu'elles sont toutes "intégrées ds ces nouveaux conglomérats des EPE ou leurs dérivés 😉 @pvandeweghe.bsky.social www.aefinfo.fr/depeche/7499...

#ESR Pendant ce temps, sur le réseau du cauchemar corporate permanent et du branding de soi le plus aliéné, cette infographie IA dont on se demande si elle n'a pas été prise… pour un programme de politiques publiques par les réformateurs français depuis un quart de siècle.

#ESR La trésorerie des universités publiques est en faux semblant: l'essentiel des "ressources propres" sont en réalité des contrats de recherche qu'elles ne peuvent pas mobiliser. Ce passe-passe a servi de prétexte à un tour de plus d'austérité. www.lemonde.fr/societe/arti...

Good morning!! This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: A network-based map of the chemical exposome connects molecular interactions to public health www.nature.com/articles/s41...

#ESR Le financement par appel à projets conduit à une double perte de budget, comme nous l'expliquions dans un récent billet. Une première fois parce que les dépenses se font au gré des besoins. Et une seconde parce que Bercy y trouve prétexte à coupure budgétaire. bsky.app/profile/agor...

www.biorxiv.org/content/10.1... In situ cryo-ET defines the ultrastructure of ER exit sites in human cells

The most corrupt family in American history. www.bloomberg.com/news/article...

Deux mois après le début du conflit, ce montant comprend les patrouilles de Rafale, les équipages ou encore le kérosène utilisé par ces avions, a appris France Télévisions de source gouvernementale.

New online: Direct roles of long non-coding RNAs in transcription activation

charliehebdo.fr/2026/04/scie...

#ESR Faudra-t-il en arriver là pour financer la recherche ? youtu.be/x2XMfjfG2ug?...