loading . . . A PI(3,5)P2/CHMP4B axis on lysosomes is essential for microautophagic degradation of STING - Nature Communications Inhibition of Pikfyve, a kinase generating PI(3,5)P2, abolishes CHMP4B (an ESCRT-III subunit) recruitment to lysosomes, and leads to an accumulation of STING vesicles and sustained signaling. Our resu... https://www.nature.com/articles/s41467-026-72828-4