Online now! Online now! A nature-inspired nanoplatform for multi-protein targeted degradation via the autophagy-lysosome pathway #chembiol

Online now! Online now! Assessing the suitability of deubiquitylases as substrates for targeted protein degradation #chembiol

Our Editor-in-Chief, Mishtu Dey, is in Suzhou, China for the Cold Spring Harbor Asia meeting: Ubiquitin Family, Autophagy and Diseases. If you’re attending, find her and share your latest research!

Online now! Online now! IAP-based biodegraders can convert necroptosis to apoptosis and eliminate cancer driving protein complexes #chembiol

Online now! Online now! ER-localized ceramide accumulation contributes to replicative senescence #chembiol

Online now! Online now! Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins #chembiol

Online now! Online now! Too much of a good thing: Promotion of tumor progression and metastasis by apoptotic cells #chembiol

Online now! Online now! Receptor-ubiquitination-targeting antibody-drug conjugates for enhanced endocytosis and lysosomal delivery #chembiol

Online now! Online now! Engineered pistol ribozymes selectively target KRAS G12V with enhanced efficacy by capping modification #chembiol

Online now! Online now! Control of the signaling of RAS proteins by modulating their palmitoylation #chembiol

Intracellular cyclization-coupled peptide library screening yields potent transcription factor antagonists

De novo design of Ras isoform selective binders

Discovery of MARK2 as a physiological kinase for PER2 in the mammalian clock

Cytoplasmic tail diversity determines the effector bias of the adhesion GPCR ADGRL2

A small molecule PTER-selective inhibitor reduces food intake and body weight

Advances in degradomics technologies to assess proteolytic cleavage events

De novo protein assembly enables drug-controlled cellular functions

Influenza A virus polymerase co-opts distinct sets of host proteins for RNA transcription or replication

Divide and conquer: Dissecting the host machinery underlying influenza virus transcription and replication

Law-NQO1 redox boosts the pentose phosphate pathway to confer stem-like properties and antitumor durability in effector CD8+ T cells

Oxidizing to optimize stemness and antitumor immunity

Mechanosensation promotes broad-spectrum antiviral defense through membrane remodeling

The membrane strikes back: A mechanical force awakens antiviral defense

The March issue of Cell Chemical Biology is now online! Explore the latest research, reviews, and insights in chemical biology. Check it out here: http://dlvr.it/TRb66p

Online now! Online now! Transcending cell death – The diverse roles of necroptosis signal adaptors in pathogen infection #chembiol

Online now! Online now! De novo design of Ras isoform selective binders #chembiol

Online now! Online now! Discovery of MARK2 as a physiological kinase for PER2 in the mammalian clock #chembiol

Online now! Online now! A small molecule PTER-selective inhibitor reduces food intake and body weight #chembiol

Online now! Online now! Cytoplasmic tail diversity determines the effector bias of the adhesion GPCR ADGRL2 #chembiol

Online now! Online now! Influenza A virus polymerase co-opts distinct sets of host proteins for RNA transcription or replication #chembiol

Online now! Online now! Intracellular cyclization-coupled peptide library screening yields potent transcription factor antagonists #chembiol

Online now! Online now! Law-NQO1 redox boosts the pentose phosphate pathway to confer stem-like properties and antitumor durability in effector CD8+ T cells #chembiol

Systematic cysteine scanning identifies a druggable pocket in oncogenic KRAS

Structural basis for NONO-specific modification by the α-chloroacetamide compound (R)-SKBG-1

Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO

Systematic cysteine scanning identifies a druggable pocket in oncogenic KRAS

Exporter Mdr1 as an importer is an achilles’ heel for combating drug-resistant Candida

Aerobic glycolysis promotes NLRP3 inflammasome activation via NLRP3 lactylation

Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis

The HEAT repeat protein MROH7 regulates the inflammatory macrophage response via LBP acetylation

Deciphering phosphorylation TACtics: Advances in phosphorylation targeting strategies and bifunctional modalities

Decoding E1-E2 specificity: How UBA6 prioritizes BIRC6 for ubiquitin conjugation

Beyond a degrader: VHL reprograms hypoxic metabolism

Discovery of bioactive peptidoglycan fragments from Lactobacillaceae that confer intestinal protection in hosts

What’s the good word? Lactobacilli produce peptidoglycan fragments with the right structure to induce tolerance during colitis

New issue alert! The February edition of Cell Chemical Biology is here with must-read studies and a review. Which article will you read first? Tell us after you check it out: http://dlvr.it/TR3DfM #ChemicalBiology

Online now! Online now! Lysosome-targeting chimeras enable targeted protein degradation #chembiol

Online now! Online now! Systematic cysteine scanning identifies a druggable pocket in oncogenic KRAS #chembiol

Online now! Online now! Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis #chembiol

Online now! Online now! Discovery of bioactive peptidoglycan fragments from Lactobacillaceae that confer intestinal protection in hosts #chembiol