Online now! Online now! GLP-1R and GIPR crosstalk modulates insulinotropic signaling pathways #chembiol

Online now! Online now! XPO1 inhibition induces NCOR1-Dependent oxidative stress to suppress hepatocellular carcinoma #chembiol

Online now! Online now! Mechanism and regulation of programmed cell death in aging-related diseases #chembiol

Online now! Online now! Mechanistic dissection of SMARCA2/4 molecular glues reveals programmable switching between DCAF16 and FBXO22 #chembiol

Online now! Online now! Beyond the veil of cell death #chembiol

Online now! Online now! Assessment of mitochondrial lipid peroxidation in cells and zebrafish using a targeted mass spectrometry probe #chembiol

Online now! Online now! Lysine methylation as a bidirectional switch #chembiol

Online now! Online now! Quantitative profiling of RNA modifications enriched in non-membrane-bound cellular structures using APEX-RNA-MS #chembiol

Optogenetic control of plasma membrane O-GlcNAcylation regulates WNK1 condensates and cellular signaling

Covalent PPARγ inverse agonism by FX-909 reveals mechanistic insights into therapeutic targeting of PPARγ/RXRα-activated urothelial carcinoma

Structure-based design of Sec61 translocon targeting prodrugs minimize off-target toxicity

Small-molecule inhibitors of the protein kinase DYRK as potential therapeutic candidates in cancer

The molecular basis for nuclear pore destruction by a proximity-inducing molecular glue

Giredestrant immobilizes the estrogen receptor to exert potent antitumor efficacy against ER-active breast cancers

Mechanisms and interventions of epigenetic aging

A defense-like route to gene transfer agent release

S-acylation of TDP-43: PALMing down aggregation?

SpsB is a target of SOS-response inhibitor OXF-077 and regulates quinolone resistance emergence

Intercepting the SOS message: SpsB inhibition by OXF-077 stalls the evolution of antibiotic resistance

An extracellular, optogenetic antibody platform for stimulus-gated antigen recognition and modulation of cell behavior

Extrabody: An optogenetic remote for extracellular antigen-driven cell behaviors

The cytotoxic effect of prexasertib is a consequence of dual inhibition on both CHK1 and AMPK

Dangerous liaisons: Promiscuous inhibition of CHK1 and AMPK is a lethal affair for cancer cells

The June issue of Cell Chem Biol is now live! This month features molecular glues, optogenetic control of cell signaling, epigenetic aging, targeted protein degradation, cancer therapeutics, antibiotic resistance, and more. Explore the full issue: http://dlvr.it/TT63ys

Cell Symposia is now Cell Press Symposia. Our meetings have always been shaped by Cell Press editors—this name simply makes that connection clearer. Read more: http://dlvr.it/TSr7FK

Online now! Online now! Signaling of glycoRNAs to Siglec-11 protects neurons by suppressing NF-κB #chembiol

Online now! Online now! Pyroptosis across species and its potential impact on host defense against zoonotic pathogens #chembiol

Online now! Online now! Small-molecule inhibitors of the protein kinase DYRK as potential therapeutic candidates in cancer #chembiol

Online now! Online now! Structure-based design of Sec61 translocon targeting prodrugs minimize off-target toxicity #chembiol

Online now! Online now! Chemical modulation of Miro1 alleviates cell-type-specific vulnerabilities in Friedreich’s ataxia #chembiol

Online now! Online now! Optogenetic control of plasma membrane O-GlcNAcylation regulates WNK1 condensates and cellular signaling #chembiol

Online now! Online now! Licensed to pore: Gasdermins in action #chembiol

Online now! Online now! Covalent PPARγ inverse agonism by FX-909 reveals mechanistic insights into therapeutic targeting of PPARγ/RXRα-activated urothelial carcinoma #chembiol

Online now! Online now! The molecular basis for nuclear pore destruction by a proximity-inducing molecular glue #chembiol

Online now! Online now! Chemical biology tools for studying histone post-translational modifications #chembiol

SpsB is a target of SOS-response inhibitor OXF-077 and regulates quinolone resistance emergence #chembiol

Structural insights into inhibition mechanism of the helicase-primase complex from human herpesvirus 1

NEK7 Cys298 is important for NLRP3 inflammasome and targetable by dimethyl fumarate

CryoSeek identification of glycofibrils with diverse compositions and structural assemblies

Genetically encoded manipulation of ATP/ADP ratio in human cells uncovers proteomic and physiological signatures of energy stress

Engineered pistol ribozymes selectively target KRAS G12V with enhanced efficacy by capping modification

Control of the signaling of RAS proteins by modulating their palmitoylation

Mechanism by which a linoleic acid metabolite suppresses cancer cell growth by inhibiting mTOR

ER-localized ceramide accumulation contributes to replicative senescence

Identification of an STING inhibitor targeting the allosteric transmembrane domains

Programmable living therapeutics for cancer immunotherapy

Drosha Dice(r)ing lipid metabolism in the liver

“SelO”ective NAD+ hydrolysis regulates mitochondrial NAD+ and homeostasis

Engineering NRas palmitoylation to hook zDHHC inhibitors

Pain in the NEK: Dimethyl fumarate inactivates the NRLP3 inflammasome by covalent inhibition of NEK7