A base editor facilitates simultaneous purine and pyrimidine substitutions for ex vivo and in vivo mutagenesis screens http://dlvr.it/TN9vP8

Pharmacologic interrogation of USP28 cellular function in p53 signaling http://dlvr.it/TN9tBM

A covalent inhibitor targeting Cys16 on RhoA in colorectal cancer http://dlvr.it/TN9rgP

Structural basis of adenosine 2A receptor-balanced signaling activation relies on allosterically mediated structural dynamics http://dlvr.it/TN9qTx

A potent NLRP3 inhibitor effective against both MCC950-sensitive and -resistant inflammation http://dlvr.it/TN9p5R

BLOC-1 and BORC: Complex regulators of endolysosomal dynamics http://dlvr.it/TN9mpn

Disruption to the gut microbiome by non-antibiotics is linked to infection risk http://dlvr.it/TN9lNG

tRNA-derived RNA promotes autophagy for kidney protection http://dlvr.it/TN9jxt

Sweet signaling for ferroptosis http://dlvr.it/TN9h9s

Activation primes GPCRs for versatile coupling http://dlvr.it/TN9fWv

Meet the authors: Raffaella De Pace, Chad Williamson, and Juan Bonifacino http://dlvr.it/TN9cVw

Meet the authors: Canyong Guo and Kurt Wüthrich http://dlvr.it/TN9Zvp

The September issue of Cell Chemical Biology is live! Click here to read more: http://dlvr.it/TN9Yd1

Online now! A potent NLRP3 inhibitor effective against both MCC950-sensitive and -resistant inflammation #chembiol

Online now! Structural basis of adenosine 2A receptor-balanced signaling activation relies on allosterically mediated structural dynamics #chembiol

Online now! A covalent inhibitor targeting Cys16 on RhoA in colorectal cancer #chembiol

Online now! A base editor facilitates simultaneous purine and pyrimidine substitutions for ex vivo and in vivo mutagenesis screens #chembiol

Online now! Pharmacologic interrogation of USP28 cellular function in p53 signaling #chembiol

Online now! BLOC-1 and BORC: Complex regulators of endolysosomal dynamics #chembiol

An adjuvant database for preclinical evaluation of vaccines and immunotherapeutics http://dlvr.it/TMdVqb

Inhibiting cancer metastasis with water-solubilized membrane receptor CXCR4QTY-Fc as a molecular trap http://dlvr.it/TMdRlQ

Engineering affinity-matured variants of an anti-polysialic acid monoclonal antibody with superior cytotoxicity-mediating potency http://dlvr.it/TMdNRC

A method for the detection and enrichment of endogenous cereblon substrates http://dlvr.it/TMdKHq

Robust antitumor treatment driven by lock-and-key biorecognition of dynamic cyclic diselenide-guided chiral prodrug self-assembly http://dlvr.it/TMcgcg

Targeting the MYC oncogene with a selective bi-steric mTORC1 inhibitor elicits tumor regression in MYC-driven cancers http://dlvr.it/TMcdJZ

RENBP inhibition amplifies metabolic glycan labeling efficiency of antigen-presenting cells in vitro and in vivo http://dlvr.it/TMcZly

The August issue of @CellChemBiol is now live! Read it here: http://dlvr.it/TMcT2j

Online now! Targeting the MYC oncogene with a selective bi-steric mTORC1 inhibitor elicits tumor regression in MYC-driven cancers #chembiol

Online now! Robust antitumor treatment driven by lock-and-key biorecognition of dynamic cyclic diselenide-guided chiral prodrug self-assembly #chembiol

Online now! An adjuvant database for preclinical evaluation of vaccines and immunotherapeutics #chembiol

Online now! A method for the detection and enrichment of endogenous cereblon substrates #chembiol

Online now! RENBP inhibition amplifies metabolic glycan labeling efficiency of antigen-presenting cells in vitro and in vivo #chembiol

The July issue of @cp-cellchembiol.bsky.social‬ is live. Read the full issue here: http://dlvr.it/TLzFLF

Attend the 2025 Bringing Chemistry to Medicine Symposium to learn from leading experts in transcription, chromatin regulation, computational biology and chemical biology. Registration is free and available both in-person and virtually.

Online now! #chembiol

Online now! #chembiol

Online now! #chembiol

Online now! #chembiol