Yulong Li Lab
@yulonglilab.bsky.social
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📥 33
📝 29
Yulong Li lab at Peking University
Glad to see Yu Zheng PhD
@zheng-yu.bsky.social
highlighting the far-red dopamine sensor for multiplex imaging of in vivo neuromodulation. Happy to share these probes to the community.
add a skeleton here at some point
7 days ago
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1/ Excited to share a new preprint! Our latest study uncovers how serotonin precisely controls the “time window” for fear learning, ensuring that our brains link cues (CS) & threats (US) only when it’s adaptive.
#Neuroscience
#FearLearning
www.biorxiv.org/content/10.1...
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Serotonin shapes the temporal window for associative fear learning
Fear learning is a critical adaptive mechanism that enables the association of an environmental cue (the conditioned stimulus, CS) with a potential threat (the unconditioned stimulus, US), even when t...
https://www.biorxiv.org/content/10.1101/2025.08.06.669013v1
about 2 months ago
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(1/3) Excited to introduce our new GRAB sensors for a series of steroid hormones! These tools enable real-time detection of steroid hormone dynamics in vivo🐭🧠. Happy to share these sensors and welcome any feedback! Please contact
[email protected]
for information.
2 months ago
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Excited to share our Science paper on HaloDA1.0-the first genetically encoded far-red dopamine sensor! 🥳It enables powerful multiplex imaging in neurons, brain slices, and live animals.🧠🔬
#GRABsensors
#Dopamine
www.science.org/doi/10.1126/...
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In vivo multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensors
Dopamine (DA) plays a crucial role in a variety of brain functions through intricate interactions with other neuromodulators and intracellular signaling pathways. However, studying these complex netwo...
https://www.science.org/doi/10.1126/science.adt7705
4 months ago
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reposted by
Yulong Li Lab
TouchscreenCognition
4 months ago
Deepest thanks to
@yulonglilab.bsky.social
and all those who attended his seminar on GRAB sensors in neuromodulator dynamics hosted by
@maximoprado.bsky.social
at
@westernu.bsky.social
.
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[email protected]
@westernubrainscan.bsky.social
@tridentpct.bsky.social
for inviting! Loved presenting our GRAB sensor work and the great discussions. Hope to visit again!
add a skeleton here at some point
4 months ago
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Join the "Genetically-Encoded and Chemigenetic Tools for Analysis and Control of Biological Systems" symposium at
#ChemPacific2025
! Explore cutting-edge tools alongside other world-class science in Hawaii. 🌴🌴
pacifichem.org
5 months ago
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Thrilled to share our latest research published in Nature Communications! Our new GRAB sensor of SNPF promotes discoveries in the dynamics and molecular regulation between neuropeptide and neurotransmitter release in vivo. Check out the full paper here:
www.nature.com/articles/s41...
8 months ago
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(1/6) Excited to introduce our first generation red acetylcholine sensors!
#acetylcholine
#GRAB
#RedSensors
www.biorxiv.org/content/10.1...
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Red-shifted GRAB acetylcholine sensors for multiplex imaging in vivo
The neurotransmitter acetylcholine (ACh) is essential in both the central and peripheral nervous systems. Recent studies highlight the significance of interactions between ACh and various neuromodulat...
https://www.biorxiv.org/content/10.1101/2024.12.22.627112v1
9 months ago
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First post on Bluesky!✨ (1/7) Far-red dopamine sensor is coming! Excited to introduce our chemigenetic DA sensor, HaloDA1.0!
#Dopamine
#FarRedSensors
,
#GRAB
www.biorxiv.org/content/10.1...
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https://www.biorxiv.org/content/10.1101/2024.12.22.629999v1
9 months ago
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