Mammalian genome writing: Unlocking new length scales for genome engineering www.sciencedirect.com/science/arti...

Happy to share that our review on mammalian genome writing with Jack Atwater, Ran Brosh, Jef Boeke, @jshendure.bsky.social and Matt Maurano is now out in @cellpress.bsky.social! www.sciencedirect.com/science/arti...

🧬Sign up to our free online 2026 Genome Writing Workshop 🧬 www.thedarkmatterproject.org/2026-genome-...

www.biorxiv.org/content/10.6... Congrats to Dr. Noor Chalhoub who managed to defend her thesis and publish this paper on the same day!

Enhancer cooperativity in the folded genome www.sciencedirect.com/science/arti...

Structure and evolution-guided design of minimal RNA-guided nucleases www.biorxiv.org/content/10.6...

High-fidelity human chromosome transfer and elimination | Science www.science.org/doi/abs/10.1...

How could one engineer a mouse carrying a LETHAL allele? A thread 🧵

One step closer to an LLM that understands novel DNA🧬 𝗜𝘁𝗲𝗿𝗮𝘁𝗶𝘃𝗲 𝗶𝗺𝗽𝗿𝗼𝘃𝗲𝗺𝗲𝗻𝘁 𝗼𝗳 𝗱𝗲𝗲𝗽 𝗹𝗲𝗮𝗿𝗻𝗶𝗻𝗴 𝗺𝗼𝗱𝗲𝗹𝘀 𝘂𝘀𝗶𝗻𝗴 𝘀𝘆𝗻𝘁𝗵𝗲𝘁𝗶𝗰 𝗿𝗲𝗴𝘂𝗹𝗮𝘁𝗼𝗿𝘆 𝗴𝗲𝗻𝗼𝗺𝗶𝗰𝘀. pubmed.ncbi.nlm.nih.gov/41125441 Congrats Andre Ribeiro-Dos-Santos and Matt Maurano!

I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene. Read our two companion papers: 🔹 www.biorxiv.org/content/10.1... 🔹 www.biorxiv.org/content/10.1... 🧵 Highlights below!

We're thrilled to publish 2 exciting preprints today on the molecular pathology of X-linked Dystonia Parkinsonism! biorxiv.org/content/10.1... AND biorxiv.org/content/10.1... @nyulangone.bsky.social

Megabase-scale human genome rearrangement with programmable bridge recombinases | Science www.science.org/doi/10.1126/...

Structure of a polymorphic repeat at the CACNA1C schizophrenia locus | PNAS www.pnas.org/doi/10.1073/... Congrats to Raquel Moya and team!

we're slow to post, but we do have a great website! www.thedarkmatterproject.org