Ariel Levine
@ariellevine.bsky.social
📤 1737
📥 1070
📝 145
Spinal cord and motor control scientist; PI at NINDS
reposted by
Ariel Levine
Andrew Pruszynski
24 days ago
Join us for Fall 2026. In our group, you can run studies from human behavior and neuroimaging, to large-scale NHP ephys, and join them up with a robust computational foundation. Bonus: you can help build the reading list.
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Ariel Levine
Enric Llorens
24 days ago
First paper from the lab is now online
@natneuro.nature.com
! We mapped injury induced enhancers in the mouse CNS and decoded their sequence architecture. Little 🧵
rdcu.be/eSQi1
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Hello 🇫🇷 I’ll be doing a mini-sabbatical in the lab of the amazing
@clairewyart.bsky.social
at the ICM in Paris. If you study motor control, spinal cord biology, evo/devo of behavior, let me know if you’d like to connect!
about 1 month ago
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Hello lab!! It’s been six weeks of shutdown, so much chaos and loss. But today, I am deeply happy to feel a slice of normal, to see my team and our community, and do some science
about 1 month ago
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@runewberg.bsky.social
congrats Rune and team! This looks really cool
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about 2 months ago
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Ariel Levine
Juan Gallego
about 2 months ago
🚨Job alert🚨 The lab has up to *3 postdoc openings* for comp systems neuroscientists interested in describing and manipulating neural population dynamics mediating behaviour This is part of a collaborative ARIA grant "4D precision control of cortical dynamics"
euraxess.ec.europa.eu/jobs/383909
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3 Postdoctoral Research Fellows
Champalimaud Foundation (Fundação D. Anna de Sommer Champalimaud e Dr.
https://euraxess.ec.europa.eu/jobs/383909
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Ariel Levine
Ted Price
about 2 months ago
The latest work from our PRECISION Human Pain Center project is now up on
@biorxivpreprint.bsky.social
led by Katherin Gabriel and
@oliviadavis.bsky.social
with a huge contribution from
@allanhpool.bsky.social
's lab and, of course, the Southwest Transplant Alliance:
www.biorxiv.org/content/10.1...
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A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences
The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-mot...
https://www.biorxiv.org/content/10.1101/2025.10.31.685953v1
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Ariel Levine
Giulia Boezio
2 months ago
Thrilled to share my main postdoc work with
@jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions 🧵👇
www.biorxiv.org/content/10.1...
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Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding
The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...
https://www.biorxiv.org/content/10.1101/2025.10.24.684328v1
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Kelsey Tyssowski
2 months ago
🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity! We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have: (1) more corticospinal neurons (CSNs) (2) better hand dexterity (3) more dexterous climbing, which is linked to CSN number🧵
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Ariel Levine
Jeff Markowitz
3 months ago
Our first preprint has been accepted for publication
www.science.org/doi/10.1126/...
!! tldr:
@ezeyulu00.bsky.social
,
@amartyapradhan.bsky.social
,
@dkoveal.bsky.social
and I developed a method using injectable nanoparticles to turn mice into…constellations in motion. 🧵⤵️
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High-resolution in vivo kinematic tracking with customized injectable fluorescent nanoparticles
Injectable fluorescent nanoparticles were used to track positions on and inside of freely moving animals at high resolution.
https://www.science.org/doi/10.1126/sciadv.adu9136
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Sabbatical question - which activities do you keep up and which do you pause? Eg reviewing new papers and grants, non-mentorship related service committee meetings, normal schedule of lab meetings…
3 months ago
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Does anyone have favorite colors for color blind friendly fluorescence images on a black background where the overlap combinations of 3 colors are important? Magenta/cyan/yellow overlaps are difficult to distinguish (lots of white) Thank you!
4 months ago
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Ariel Levine
Mehrdad Kashefi
4 months ago
Excited to share my latest work with
@jonathanamichaels.bsky.social
@diedrichsenjorn.bsky.social
&
@andpru.bsky.social
! We asked: How does the motor cortex account for arm posture when generating movement? Paper 👉
www.biorxiv.org/content/10.1...
1/10
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Compositional neural dynamics during reaching
The complex mechanics of the arm make the neural control of reaching inherently posture dependent. Because previous reaching studies confound reach direction with final posture, it remains unknown how...
https://www.biorxiv.org/content/10.1101/2025.09.04.674069v1
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@petrznam.bsky.social
this is so cool!
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5 months ago
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Ariel Levine
Britton Sauerbrei
6 months ago
1/N How do neural dynamics in motor cortex interact with those in subcortical networks to flexibly control movement? I’m beyond thrilled to share our work on this problem, led by Eric Kirk
@eric-kirk.bsky.social
with help from Kangjia Cai!
www.biorxiv.org/content/10.1...
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Graziana Gatto
6 months ago
Paper is finally out on our experimentally-driven neuromechanical model to explain how spinal inhibition makes you do things faster!
www.cell.com/cell-reports...
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The spinal premotor network driving scratching flexor and extensor alternation
Yao et al. developed a neuromechanical model based on experimental perturbations, aligning theory-predicted with genetically labeled cell types. This work highlights the importance of inhibitory inter...
https://www.cell.com/cell-reports/fulltext/S2211-1247%2825%2900616-3
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reposted by
Ariel Levine
Claire Wyart
7 months ago
🧿 Excited about molecular biology & genetics 🧬🧬🧬? Wanna live in Paris? Join our team as a lab manager under the supervision of
@kevinfidelin.bsky.social
& myself! Personal development in professional environment is our mission. Inclusive space where proactive and playing collective people flourish 🧿
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Ariel Levine
Mark Histed
7 months ago
Despite some ups and downs at NIH, we do have an open position for a postbac and are considering candidates. Our work is at the intersection of neuroscience and AI, and we aim to understand how the brain's densely connected recurrent networks operate. 🧪
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Todd is a fantastic scientist, mentor, colleague and friend. Highly recommend!!
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8 months ago
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Ariel Levine
Christophe 🔬 L
8 months ago
Our PhD student Louis Romette is optimizing long-term live-cell imaging. He just casually dropped this 65-hour movie of a growing neuron (div 3 to 6) with knocked-in actin 🔥🕶️
#realtimemicroscopy
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Ariel Levine
Barriga Lab
9 months ago
REPOSTING this here just to officially leave "the other place" Our work on the role of endogenous electric fields in guiding collective cell migration during
#morphogenesis
is out
@naturematerials.bsky.social
nature.com/articles/s41...
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Stretch-induced endogenous electric fields drive directed collective cell migration in vivo - Nature Materials
Electric fields guide collective cell migration in developing embryos of Xenopus laevis via a voltage-sensitive phosphatase.
https://nature.com/articles/s41563-024-02060-2
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Ariel Levine
Nina Kudryashova
9 months ago
Excited to share our new pre-print on bioRxiv, in which we reveal that feedback-driven motor corrections are encoded in small, previously missed neural signals.
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What an elegant new assay for natural mouse behavior! Love this
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9 months ago
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Ariel Levine
HHMI
9 months ago
Igor Siwanowicz of
@hhmijanelia.bsky.social
captured these photos of pollen grains on the sigma of a morning glory flower. This is part of the early stage in creating a seed, it might also be the reason why you can’t stop sneezing!
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Ariel Levine
Victoria Abraira
9 months ago
Please register for this amazing meeting! Applications for this meeting must be submitted by June 8, 2025
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reposted by
Ariel Levine
Tayler Sheahan
9 months ago
Despite all of *waves around*, the Sheahan Lab is putting one foot in front of the other and is looking for a research technician. A great position for someone interested in gaining more neuroscience experience in itch & pain before applying for grad/med school:
shorturl.at/DW3fU
🧠
#PainResearch
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Research Technologist I
Medical College of Wisconsin - Research Technologist I - Milwaukee WI 53201
https://shorturl.at/DW3fU
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Gorgeous image and a wonderful thread from
@rbrianroome.bsky.social
on our new work 🥳
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9 months ago
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And science continues… check out our new work led by
@rbrianroome.bsky.social
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10 months ago
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Ariel Levine
Graziana Gatto
10 months ago
Registration started for the Janelia meeting on spinal cord and brainstem circuits for sensorimotor adaptation across species. Spinal cord is more than a hub, it does supercomputing!
www.janelia.org/you-janelia/...
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Computing Cords: Sensorimotor Control by Nerve Cord Circuits Across Species
Organizers Salil Bidaye, Max Planck Florida Institute for Neuroscience Ansgar Büschges, University of Cologne Graziana Gatto, University of Cologne Abdel El Manira, Karolinska Institutet Julie
https://www.janelia.org/you-janelia/conferences/computing-cords-sensorimotor-control-by-nerve-cord-circuits-across-species
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reposted by
Ariel Levine
Stéphanie C Koch
10 months ago
Come join our lab as Postdoctoral Fellow! The project will investigate the maturation of spinal circuits and their plasticity within chronic widespread pain states. Apply here:
www.ucl.ac.uk/work-at-ucl/...
until 11th April.
@ucllifesciences.bsky.social
@uclnpp.bsky.social
@jobrxiv.bsky.social
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UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
https://www.ucl.ac.uk/work-at-ucl/search-ucl-jobs/details?jobId=32920&jobTitle=Research+Fellow
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What a treat to see this new paper from Anupama Sathyamurthy and her team! I couldn’t be more proud to have worked with her and see what she is up to now. Another important work in her efforts to understand how multiple motor control regions interact during reaching
www.cell.com/cell-reports...
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The superior colliculus directs goal-oriented forelimb movements
Goal-oriented reaching necessitates precise regulation of multiple movement parameters. Chaterji et al. demonstrate that excitatory neurons in the lateral superior colliculus (SC) control the directio...
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01448-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124724014487%3Fshowall%3Dtrue
11 months ago
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Ariel Levine
Tyler Sloan @Quorumetrix Studio
11 months ago
I was doing some research for a lecture I'm putting together and TIL that these may be the first ever drawings of
#neurons
by Otto Deiters published posthumously c1865. Anyone know of drawings that pre-date these?
#neuroscience
#history
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reposted by
Ariel Levine
Adrian Liston
12 months ago
Our paper on nurturing a
#PositiveResearchCulture
within your
#research
#team
published by
@wellcometrust.bsky.social
gives useful tips for your lab. As well as making you a good team leader, nurturing culture pays off in building your science: 1/11
wellcomeopenresearch.org/articles/9-3...
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https://wellcomeopenresearch.org/articles/9-341/v1/f3
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Ariel Levine
Seth Blackshaw
12 months ago
We begin the New Year with two preprints on hypothalamic development. The first, part of a long-term collaboration with Marysia Placzek’s group, investigates the organization of the developing forebrain, and show that current models are (mostly) incorrect./1
www.biorxiv.org/content/10.1...
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Resolving forebrain developmental organisation by analysis of differential growth patterns
The forebrain is the most complex region of the vertebrate CNS, and its developmental organisation is controversial. We fate-mapped the embryonic chick forebrain using lipophilic dyes and Cre-recombin...
https://www.biorxiv.org/content/10.1101/2025.01.10.632351v1
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Ariel Levine
Graziana Gatto
12 months ago
Our new preprint on how excitatory V2a and inhibitory V1 and V2b neurons cooperate to drive scratching rhythm, with a new neuromechanical model showing how CPG perturbations affect rhythm and phase of motoneuron firing and frequency of joint oscillations
www.biorxiv.org/content/10.1...
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The spinal premotor network driving scratching flexor and extensor alternation
Rhythmic motor behaviors are generated by neural networks termed central pattern generators (CPGs). Although locomotor CPGs have been extensively characterized, it remains unknown how the neuronal pop...
https://www.biorxiv.org/content/10.1101/2025.01.08.631866v1
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Ariel Levine
Kevin Mitchell
12 months ago
A reminder: for genotypes to produce phenotypes, they have to go through development
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Ariel Levine
Jonathan Eisen
12 months ago
And another 45 seconds
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Ariel Levine
David Schoppik
12 months ago
Big paper from
@paigel.bsky.social
in our lab: Sensory feedback is always crucial for proper development, right? Wrong! Crazier still, the motor system is the slowest part of a developing reflex circuit! Surprises abound in this bluetorial c’mon along….
www.science.org/doi/10.1126/...
1/19
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Sensation is dispensable for the maturation of the vestibulo-ocular reflex
Vertebrates stabilize gaze using a neural circuit that transforms sensed instability into compensatory counterrotation of the eyes. Sensory feedback tunes this vestibulo-ocular reflex throughout life....
https://www.science.org/doi/10.1126/science.adr9982
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Ariel Levine
Mark D Humphries
12 months ago
Cutting it a bit fine, but here’s my review of the year in neuroscience for 2024 The eighth of these, would you believe? We’ve got dark neurons, tiny monkeys, the most complete brain wiring diagram ever constructed, and much more… Published on The Spike Enjoy!
medium.com/the-spike/20...
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2024: A Review of the Year in Neuroscience
Feeling a bit wired
https://medium.com/the-spike/2024-a-review-of-the-year-in-neuroscience-84d343155146
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What’s the state of the art right now in robotic motor control? Eg. for overground locomotion w variable terrain, fine “dexterous” control. Boston Dynamics, da Vinci…?
about 1 year ago
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Ariel Levine
Schaeffer Somers
about 1 year ago
It’s impressive and humbling to see the scales of inner and outer space that have emerged in science this year.
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Ariel Levine
Jonathan A. Michaels
about 1 year ago
Can the motor system use sensory expectations to prepare for unexpected events? Excited to share my latest work with
@andpru.bsky.social
– where we establish that sensory expectations shape neural population dynamics in motor circuits! 🧵 and paper below 1/
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Rune W. Berg
about 1 year ago
New version of our preprint available. The supplementary information is also available. "Spatial and network principles behind neural generation of locomotion"
www.biorxiv.org/content/10.1...
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Spatial and network principles behind neural generation of locomotion
Generation of locomotion is a fundamental function of the spinal cord, yet the underlying principles remain unclear. In particular, the relationship between neuronal cell types, networks and functions...
https://www.biorxiv.org/content/10.1101/2024.10.03.616472v3
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I love this idea as an analogy and think it may explain a lot! I second
@neuralreckoning.bsky.social
’s recommendation. Research -> knowledge foraging
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about 1 year ago
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Ariel Levine
Marco Capogrosso
about 1 year ago
SfN 2023 “are those the guys that think GABA is excitatory? Ahahha” YES WE ARE BABY Finally out after a long process, GABA facilitates sensory inputs in the cervical spinal cord of NHPs
#GABA
#spinalcord
www.cell.com/cell-reports...
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Pharmacological blocking of spinal GABAA receptors in monkeys reduces sensory transmission to the spinal cord, thalamus, and cortex
Mahrous et al. examine the controversial role of GABAARs in sensory transmission in the monkey cervical spinal cord. They find that blocking spinal GABAARs reduces sensory input to both motoneurons and supraspinal centers. These findings suggest that GABAARs facilitate sensory transmission to modulate both movement and sensory perception in primates.
https://www.cell.com/cell-reports/fulltext/S2211-1247%2824%2901451-7
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Ariel Levine
Markus Meister
about 1 year ago
Have you had private doubts whether we'll ever understand the brain? Whether we'll be able explain psychological phenomena in an exhaustive way that ranges from molecules to membranes to synapses to cells to cell types to circuits to computation to perception and behavior?
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Welcome Jeff Diamond
@jsdiamond.bsky.social
! Nice to finally see you on science social media 🥳 If anyone has the retina/vision science starter packs or feeds handy, please share!
about 1 year ago
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Ariel Levine
Stéphanie C Koch
about 1 year ago
We have an exciting postdoc opportunity to study the spinal circuits involved in spatial restriction of pain. Please spread the word and get in touch if you’re interested in joining our team. Application details to follow!
@uclnpp.bsky.social
@ucllifesciences.bsky.social
#painscience
#neuroskyence
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reposted by
Ariel Levine
Shari Wiseman
about 1 year ago
The December issue of Nature Neuroscience is now live, featuring our Focus on Single-Cell Genomics! We hope that these consensus reviews from experts in the field will serve as a useful guide for neuroscientists regarding best practices for these approaches.
www.nature.com/neuro/volume...
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Nature Neuroscience - Focus on single-cell genomics in neuroscience
Single-cell and single-nucleus genomics pave the way for a comprehensive understanding of the nervous system and its diverse cell populations. Realizing this...
https://www.nature.com/neuro/volumes/27/issues/12
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