Petr Znamenskiy
@petrznam.bsky.social
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Neuroscientist at the Crick studying cortical microcircuits and cell types. www.znamlab.org
pinned post!
1/ Mapping synaptic connectivity between individual neurons is extremely laborious. We developed BRISC, a new method that makes it possible to map inputs onto 100s of neurons in the same animal in a matter of weeks! Led by Alex Becalick and
@antblot.bsky.social
. 🧵
www.biorxiv.org/content/10.1...
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Barcoded Rabies In Situ Connectomics for high-throughput reconstruction of neural circuits
Sequencing of oligonucleotide barcodes holds promise as a high-throughput approach for reconstructing synaptic connectivity at scale. Rabies viruses can act as a vehicle for barcode transmission, than...
https://www.biorxiv.org/content/10.1101/2025.07.16.665048v1
2 months ago
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We use high refresh rate "gaming" monitors to present closed-loop visual stimuli with low latency. They have various "gaming modes" and response time options that are poorly documented. So
@antblot.bsky.social
tested every possible setting to find out what they do.
znamlab.org/hardware-con...
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Which gaming mode will please my mice?
We use VR setups, see for instance this study, which require fast monitors. We recently got some cheap gaming monitors from MSI
https://znamlab.org/hardware-config/2025/08/08/msi-screen-settings.html
about 1 month ago
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How does the brain blend what we see with what we hear? In collaboration with
@flor-iacaruso.bsky.social
lab, we find new anatomical and functional rules that govern how auditory and visual cortices talk to each other. Led by
@alexegeaweiss.bsky.social
&
@bturner-bridger.bsky.social
.
add a skeleton here at some point
about 2 months ago
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1/ Mapping synaptic connectivity between individual neurons is extremely laborious. We developed BRISC, a new method that makes it possible to map inputs onto 100s of neurons in the same animal in a matter of weeks! Led by Alex Becalick and
@antblot.bsky.social
. 🧵
www.biorxiv.org/content/10.1...
loading . . .
Barcoded Rabies In Situ Connectomics for high-throughput reconstruction of neural circuits
Sequencing of oligonucleotide barcodes holds promise as a high-throughput approach for reconstructing synaptic connectivity at scale. Rabies viruses can act as a vehicle for barcode transmission, than...
https://www.biorxiv.org/content/10.1101/2025.07.16.665048v1
2 months ago
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reposted by
Petr Znamenskiy
James Briscoe
8 months ago
Agree. Cuts in UKRI funded PhD places, is about government funding and prioritisation. We need work force planning with joined up thinking A PhD is not about an academic career, its an apprenticeship for the knowledge economy. "Europe's Silicon Valley" will not exist without PhDs
add a skeleton here at some point
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reposted by
Petr Znamenskiy
Mark D Humphries
8 months ago
Save the date! UK Neural Computation 2025 will be at Imperial College London 9 July: ECR day 10-11 July: main meeting 9 invited speakers, 4 talks from abstracts and many posters Abstract & registration opening soon Pls share!
neuralcomputation.uk
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UKNC25 |
https://neuralcomputation.uk
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reposted by
Petr Znamenskiy
Dinu F Albeanu
8 months ago
Interested in understanding how things work? In particular the tools you use to study the brain? Join us at TENSS 2025 where we brainstorm ideas, build and debug microscopes, electrophysiology and behavior rigs amidst the picturesque Transylvanian hills!
tenss.ro
Apply by: February 16th!
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📢 If you are at
#SfN2023
, check out the lab's posters from Yiran He (Sun AM) and Alex Becalick (Mon PM)! I'll be around as well, so send me a message if you'd like to meet and catch up!
#SfN23
almost 2 years ago
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reposted by
Petr Znamenskiy
Jenny Bizley
almost 2 years ago
We're hiring - a lab tech and fully funded (UK rate) PhD student! Join us at to figure out how the brain constructs auditory space! Adverts here (tech :
shorturl.at/hmrFY
) and here (PhD studentship :
shorturl.at/adoJN
).
#neuroscience
#hearing
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🚀 Don't miss your chance join
@thecrick.bsky.social
PhD programme, including projects in my lab! Interested in how neuronal activity, connectivity and gene expression all relate to each other in vivo? Learn more and apply at
crick.ac.uk/careers-stud...
🗓️ Deadline Nov 9! Please repost!
almost 2 years ago
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Mouse cortical neurons have ~5,000 spines, but how many different presynaptic cells do they get input from? What is the average number of synaptic contacts between connected neurons in the mouse neocortex? I was hoping that there is a good estimate based on EM but I cannot find one.
almost 2 years ago
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reposted by
Petr Znamenskiy
Steve Shea
almost 2 years ago
ICYMI for neuro Twitter expats, a long standing mystery is solved.
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reposted by
Petr Znamenskiy
James Briscoe
almost 2 years ago
Delighted to see this in print from my @TheCrick colleagues in Jonny Kohl's lab How pregnancy (in mice) changes the behaviour of a population of hypothalamic neurons & initiates parental behaviour before birth
www.science.org/doi/10.1126/...
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Hormone-mediated neural remodeling orchestrates parenting onset during pregnancy
Work in mice suggests that hormonal remodeling of distinct hypothalamic neurons during pregnancy promotes parental behavior.
https://www.science.org/doi/10.1126/science.adi0576
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Multiple opportunities for PhD projects in my lab at the Francis Crick Institute starting in 2024! The Crick is an incredible place to do science! Please repost! (1) Mapping neocortical circuits using high throughput molecular connectomics and in vivo imaging:
www.crick.ac.uk/careers-stud...
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Znamenskiy Lab | Mapping the neocortical circuit diagram with high-throughput molecular connectomics
https://www.crick.ac.uk/careers-study/vacancies/2023-09-15-znamenskiy-lab-mapping-the-neocortical-circuit-diagram-with-high-throughput-molecular-connectomics
almost 2 years ago
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