One of the all time greats

Well, it's a little clearer now why billionaires are so invested in technology that produces better written emails.

Looks like Nico is finally going to get the ax, but I hope the owners know that we will never forgive them for trading the favorite son of our fair city, Luka.

The return of PKMzeta?

Breaking News: The company Merck said it had created a powerful new cholesterol pill that could be a more affordable alternative to other treatments.

He should be!

#NIHfunding via the HEAL initiative for the PRECISION Human Pain Network has yielded a massive increase in data on human sensory neurons. One of the most amazing collaborations I've been part of. Data sharing across 4 centers, insights from experts across the network that really moved the needle.

Totally agree with Rob. Being part of this has been a dream come true.

Seriously impressive effects of a prolactin blocking antibody treatment in endometriosis pain: www.thelancet.com/journals/lan... Now let's see a CGRP antibody trial to see which is better (and I want to see the prolactin antibody in a migraine trial too). The pain field is moving fast!

Also happy to see that our rat DRG dataset is now online at Journal of Pain. www.jpain.org/article/S152... Big thanks to Sydney Caparaso and Becky Wachs for leading this effort along with @ish1789.bsky.social and I. Rats and mice and humans are not the same, oh my!

This is the strategic mistake that will burn our economy for decades.

The BIG DRG paper is now up on @biorxiv-neursci.bsky.social www.biorxiv.org/content/10.1... so many people worked so hard to make this happen. Props to the whole PRECISION Human Pain Network.

Faust et al. show that type I IFN signaling contributes to #arthritis pathogenesis in #obesity through activation and expansion of CD8 T cells in visceral adipose tissue and synovium. rupress.org/jem/article/... 📘 In #Cytokines collection rupress.org/jem/collecti... #Cytokines2025

After some hangups in getting the data available on SPARC, our Nageotte nodule Visium data described in this paper: www.nature.com/articles/s41... is now freely available to download on SPARC: discover.pennsieve.io/datasets/490

The 5th of 6 faculty positions in UNC Biology is posted. We're working with the @ncbg.bsky.social to fill a joint position as Director of the UNC Herbarium at @ncbg.bsky.social and as Associate Professor within the Department of Biology (BIOL). Please share 1/n unc.peopleadmin.com/postings/308...

Another excellent position at UT Dallas, this time in the Biological Science Dept: jobs.utdallas.edu/postings/30702 Our Neuroscience and Biological Sciences faculty are closely intertwined and collaborative creating a great place to launch your independent lab!

Excited for the next movie!

Wizard of Oz at The Sphere is astonishingly good. We were all totally blown away and I caught an apple!

Reupping for the work week. Data should be up in SPARC.science this week

Tidmarsh gave a different explanation to NYT (gift link). I wonder whether he'll go back to being Board Chair of the "Journal" of the "Academy of Public Health." He was Board Chair, his son was Exec Editor, and several other Trump appointees were involved www.nytimes.com/2025/11/02/h...

We got to see the longest field goal in NFL history live today. That record might stand for a long time

The latest work from our PRECISION Human Pain Center project is now up on @biorxivpreprint.bsky.social led by Katherin Gabriel and @oliviadavis.bsky.social with a huge contribution from @allanhpool.bsky.social's lab and, of course, the Southwest Transplant Alliance: www.biorxiv.org/content/10.1...

Also huge props to @allanhpool.bsky.social and his lab at UTSW for helping optimise our single nuc prep and looking for species differences between human and mice. This paper builds on the foundation already set and increases our understanding of human spinal cord at an even higher resolution.

Thrilled to share our latest preprint using single nuq sequencing and Xenium to define neuron organisation and sex differences in glia within human spinal cord. Truly a collaborative effort, with a big shoutout to Katherin Gabriel and @tedpricethepainguy.bsky.social www.biorxiv.org/content/10.1...

We are seeking a senior tenured professor in our Department working on affective and/or motivational neuroscience (defined in the ad, but pretty broad). The idea is that this person is going help lead our growth in this area alongside our excellent Centers. jobs.utdallas.edu/postings/30693

TrkA and its downstream signaling via MAPK (I think it’s mostly MNKs) remains a great target for pain in OA!

wonder if we could convince them to chant "Fire Nico"?

Sharing a figure from our recent paper showing excitatory synapses in the human spinal dorsal horn. I’ll never get over the awe of seeing these tiny dots, which underly such an important part of the human experience! @tedpricethepainguy.bsky.social onlinelibrary.wiley.com/doi/10.1002/...

A test of nerves in diabetic peripheral neuropathy @dianatavf.bsky.social @tedpricethepainguy.bsky.social & team identify regenerative and degenerative pathways and highlight axonal mRNA transport as a new mechanism in DPN: www.jci.org/articles/vie...

HUGE opportunity at Rutgers: jobs.sciencecareers.org/job/675694/d.... They already have such a dynamic pain group there, and such a great history... really an amazing opportunity.

Do type I interferons increase pain perception or reduce it? @uenzastiga.bsky.social @tedpricethepainguy.bsky.social & team interrogate human pain-sensing neurons, revealing IFN-I induces excitability & TRPV1 sensitization via MNK1/2 signaling: insight.jci.org/articles/vie...

Faculty position in Neuroscience at UT Austin: apply.interfolio.com/175280 A great Department and an exceptional scientific community in Austin and across the UT System.

Not only not normal, but totally unprecedented in my lifetime.

The webinar that I did for Anabios is now available on youtube: www.youtube.com/watch?v=llj2...

New preprint from us: Detection of probable neuronal gene expression changes in skin biopsies from patients with paclitaxel-induced peripheral neuropathy www.biorxiv.org/content/10.1...

huge news for T-type Ca channels: ir.praxismedicines.com/news-release...

Detection of probable neuronal gene expression changes in skin biopsies from patients with paclitaxel-induced peripheral neuropathy https://www.biorxiv.org/content/10.1101/2025.10.15.682581v1

Never assume that you know all about what any drug molecule is doing in the body - where it's going, what it's binding to. A new example:

Certain people just living in their home is now considered DEI in order to eliminate providing funds for basic safety of communities.

If evolution, comparative #neuroskyence & #PainResearch are your thing, here's a great review from Terry Walters: journals.biologists.com/jeb/article/...

I never would have believed such a graph could be possible.

Forrest Gump Point is for lovers

Greetings from Goosenecks State Park Utah

Hello from Natural Bridges National Monument

Good morning from a rainy monument valley

The vicious disassembly of American health and science leadership continues with no real resistance from congress

Four cheers for MIT. orgchart.mit.edu/letters/rega...

Check it out: 🔗 Paper: doi.org/10.1093/brai... 🔗 UTD Pain Center: paincenter.utdallas.edu 🔗 UTD Pain Center on SPARC: sparc.science/about/projec... #Neuroscience #PainResearch #HEAL @tedpricethepainguy.bsky.social

The graph and the short quote say it all!