Check out our latest paper: The Contribution of endocannabinoids to placebo analgesia www.biorxiv.org/content/10.6... This is an ongoing collaboration with David Finn & @laurenatlas.bsky.social Take away: beta-endorphins gate the contributions of endocannabinoids to placebo analgesia.

This is a dramatic update to the NIH Data Management and Sharing Plan template, effective for applications submitted for due dates on or after May 25, 2026. grants.nih.gov/grants/guide...

We are hiring a postdoc! If you love culturing neurons and are stellar at electrophysiological characterisation and imaging of sensory neurons, then come and work with us on this cool multi-lab project!🧑‍🎓 👩‍🎓 my.corehr.com/pls/uoxrecru...

Actually, it’s hurting children.

“Dr. Axel also announced that he had resigned as an investigator at the Howard Hughes Medical Institute“

glad to finally know that I am consistently creating lightening on the court www.nature.com/articles/d41... and maybe Kobe's are the best at doing this?

‘Caught lying’: Outrage mounts after ICE exposed for killing US citizen 11 months ago www.rawstory.com/ice-26752910...

US Citizen, Ruben Ray Martinez, was shot 3 times through the driver's side window & killed on South Padre Island in Texas by Homeland Security Investigators while celebrating his 23rd birthday on March 15th, 2025. This DHS & #ICELawlessness must stop. Remember his name: Ruben Ray Martinez 💔

An ICE agent shot and killed Ruben Ray Martinez, a US citizen and San Antonio resident, in March 2025. Then ICE and the Texas Department of Public Safety covered it up. He was 23 years old. I am calling for a full investigation into this shooting, including why there was an 8-month cover up.

BRIAN TYLER COHEN: Last question -- is Tupac alive? OBAMA: He's alive on my playlist

BOOM!

Imagine when The Terminator came out if you told someone that in 40 years the world’s richest weirdo would fill the sky with a communications net, embrace AI, and now promise to build an army of robots, and nobody seems inclined to stop him.

Can we get an expansion team in Plano with a guy named Luka?

I see no reason not to look at the online gambling and prediction market craze as a new opioids crisis. It will wreak havoc on lower-income Americans and leave a trail of destruction and despair in its wake. The companies are just Purdue Pharma 2.0 www.liberalcurrents.com/from-pill-mi...

In 1854, after watching the federal government deploy 2000 federal troops and spend $40,000 sending Anthony Burns back into slavery, Boston's Amos Adams Lawrence said “we went to bed one night old-fashioned, conservative, Compromise Union Whigs and waked up stark mad Abolitionists.”

"We can create rules that govern how industries may use AI. We have agency. It is possible to use society’s power—the consent of the governed—to establish laws...This seems like something the next Democrat who wants to be president should think about." open.substack.com/pub/thebulwa...

Just awful.

Good news keeps on coming in the pain and migraine space! endpoints.news/lundbeck-mig...

Had a great time walking around a magical place today with my Dad!

This is all so nuts.... and they have blocked Moderna's flu RNA vaccine from moving ahead for regulatory approval.

Yes, it is sabotage. Hopefully this decision will be overturned.

Trump: "I've cut hundreds of thousands of jobs"

The appearance of Ricky Martin elicited quite the response from my wife. Took me back to our days at Planeta Mexico in San Antonio when we were still dating.

More of this please

UNC-Duke is always great TV

Howard Lutnick went to Jeffrey Epstein's island 5 days before Lutnick and Epstein went into business together. 12/23/2012 — Lutnick goes to Epstein's island. 12/28/2012 — Lutnick and Epstein sign a stock purchase agreement.

#neuroskyence #neurosci #PainResearch 🧪💊 By @physoc.bsky.social A brilliant scientist and leader has left us. I taught about Dr. Dolphin's work on calcium channels and gabapentin in our pharmacology curriculum. Remembering Annette Dolphin (1951 – 2026)

give me the joyful world please, with more kids having fun at press conferences.

Goodbye Street Clothes. We hardly knew you. Dallas Blue Devils?

The US immigrant population generated more in taxes than they received in benefits from all levels of government every year from 1994 to 2023. The Cato study provides the first-ever 30-year analysis of the fiscal effects of immigration on government budgets. https://ow.ly/jy8a50Y8kM3

I just heard from the recipient of Hilari’s lungs. I am grateful that Hilari could continue giving of herself and that those gifts live on in someone else who can continue to make a difference in their family and community. Organ donation saves lives.

Likely also highly relevant for spinal dorsal horn excitability in neuropathic pain: www.biorxiv.org/content/10.6...

The greatest documentary ever is Hoop Dreams

"President Carter always said he wanted to outlast the last Guinea worm. While he didn't quite get his wish, he and Mrs. Carter would be proud to know there were only 10 human cases reported in 2025. And they would remind us that the work continues until we reach zero," said Carter Center CEO”

Register to vote Texans!! We just got our new registration cards in the mail this week.

Breaking: Democrat Taylor Rehmet wins solidly red Texas Senate seat in stunning special election upset.

So true. I would argue that most basic biomedical science does not depend on p-values yet almost everyone ignores this. For instance, pharmacology as a discipline is almost entirely independent of p-values at its core. A statistical test is unneeded for how a ligand interacts with receptors.

Full rights and citizenship actually means they’re not a “foreign labor class.” And that’s what he’s angry about. He’s mad citizenship is universal rather than restricted to white people like before the civil war bsky.app/profile/gbbr...

The kids love LaMelo

I know it is not really the point of the post, but I think the most important class I took as an ugrad was a film criticism class on classic Westerns, mostly John Ford films. I learned so much about writing and translating observations into words in that class.

Amen! I care not think of all I would lose from my wonderful life experiences that are directly tied to immigrants/immigration. Most importantly my wife who is the most wonderful person who I am so lucky to live this life with. Immigration makes America great!

Dallas this morning. Somehow our flight has not been cancelled. Thank goodness it was pretty warm the past few days. My wife took these photos while I was driving slowly to DFW.

Our latest preprint. More evidence that diabetic neuropathy is a neuro degenerative disease. Very proud of @ish1789.bsky.social and our whole PRECISION group who made this work possible. #HEALinitiative funded

This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again. www.nature.com/immersive/d4...

This visualization is excellent: www.nature.com/immersive/d4... This is what is happening to US science. We are becoming a shell of what we once were faster than I ever thought would be possible.

There was this event about 25 years ago... I think it was in September.

“.. foreign exporters absorbed only about 4% of the burden of last year’s U.S. tariff increases by lowering their prices, while American consumers and importers absorbed 96%.” 🤡 @wsj.com www.wsj.com/economy/trad...

Everyone should read this: www.nature.com/articles/s41... If you ask me, it is a stunning indictment of the despair spreading through society in the US. Our economy and society are sick and our politics are totally failing the common citizenry while feeding everything possible to the very rich.

We can neither confirm nor deny the existence of big pain relief news next week.