Ted Price
@tedpricethepainguy.bsky.social
π€ 2146
π₯ 1738
π 865
Dad, husband and pain scientist. Better guard me beyond the arc. Education should not cause debt
One of the all time greats
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3 days ago
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Cethan Leahy
4 days ago
Well, it's a little clearer now why billionaires are so invested in technology that produces better written emails.
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Looks like Nico is finally going to get the ax, but I hope the owners know that we will never forgive them for trading the favorite son of our fair city, Luka.
5 days ago
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The return of PKMzeta?
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5 days ago
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The New York Times
8 days ago
Breaking News: The company Merck said it had created a powerful new cholesterol pill that could be a more affordable alternative to other treatments.
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Merck PCSK9 Pill Results Point to Extremely Low Cholesterol Future
The drug targets the PCSK9 protein, and could give millions of people a more affordable option to reduce their heart disease risk.
https://nyti.ms/4p3JP3K
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He should be!
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8 days ago
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Robert Gereau
9 days ago
#NIHfunding
via the HEAL initiative for the PRECISION Human Pain Network has yielded a massive increase in data on human sensory neurons. One of the most amazing collaborations I've been part of. Data sharing across 4 centers, insights from experts across the network that really moved the needle.
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Totally agree with Rob. Being part of this has been a dream come true.
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9 days ago
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Seriously impressive effects of a prolactin blocking antibody treatment in endometriosis pain:
www.thelancet.com/journals/lan...
Now let's see a CGRP antibody trial to see which is better (and I want to see the prolactin antibody in a migraine trial too). The pain field is moving fast!
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Safety and efficacy of subcutaneous injection with HMI-115 versus placebo in endometriosis-associated pain in premenopausal women: a multicentre, double-blind, randomised, proof-of-concept phase 2 tri...
In this proof-of-concept phase 2 trial, blocking the prolactin receptor with HMI-115 showed an acceptable tolerability profile and promising efficacy in alleviating endometriosis-associated pain. Thes...
https://www.thelancet.com/journals/lanogw/article/PIIS3050-5038(25)00032-9/fulltext
9 days ago
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Also happy to see that our rat DRG dataset is now online at Journal of Pain.
www.jpain.org/article/S152...
Big thanks to Sydney Caparaso and Becky Wachs for leading this effort along with
@ish1789.bsky.social
and I. Rats and mice and humans are not the same, oh my!
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Single-nuclei RNA Sequencing Reveals Distinct Transcriptomic Signatures of Rat Dorsal Root Ganglia in a Chronic Discogenic Low Back Pain Model
Chronic low back pain (LBP), often correlated with intervertebral disc degeneration, is a leading source of disability worldwide, yet remains poorly understood. Current treatments often fail to provid...
https://www.jpain.org/article/S1526-5900(25)00817-X/fulltext?rss=yes
9 days ago
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This is the strategic mistake that will burn our economy for decades.
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10 days ago
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The BIG DRG paper is now up on
@biorxiv-neursci.bsky.social
www.biorxiv.org/content/10.1...
so many people worked so hard to make this happen. Props to the whole PRECISION Human Pain Network.
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A Reference Atlas of the Human Dorsal Root Ganglion
Somatosensory perception largely emerges from diverse peripheral sensory neurons whose cell bodies reside in dorsal root ganglia (DRG). Damage or dysfunction of DRG neurons is a major cause of chronic...
https://www.biorxiv.org/content/10.1101/2025.11.05.686654v1
10 days ago
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Journal of Experimental Medicine
15 days ago
Faust et al. show that type I IFN signaling contributes to
#arthritis
pathogenesis in
#obesity
through activation and expansion of CD8 T cells in visceral adipose tissue and synovium.
rupress.org/jem/article/...
π In
#Cytokines
collection
rupress.org/jem/collecti...
#Cytokines2025
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After some hangups in getting the data available on SPARC, our Nageotte nodule Visium data described in this paper:
www.nature.com/articles/s41...
is now freely available to download on SPARC:
discover.pennsieve.io/datasets/490
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Nageotte nodules in human dorsal root ganglia reveal neurodegeneration in diabetic peripheral neuropathy - Nature Communications
Nageotte nodules in the dorsal root ganglia were first described 100 years ago, but little is known about them. Here, the authors link Nageotte nodules to neurodegeneration in diabetic neuropathy in h...
https://www.nature.com/articles/s41467-025-59538-z
10 days ago
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Mark Peifer (He, him)
11 days ago
The 5th of 6 faculty positions in UNC Biology is posted. We're working with the
@ncbg.bsky.social
to fill a joint position as Director of the UNC Herbarium at
@ncbg.bsky.social
and as Associate Professor within the Department of Biology (BIOL). Please share 1/n
unc.peopleadmin.com/postings/308...
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Associate Professor & Director of NCBG Herbarium
This is a research, teaching, and public service position at the University of North Carolina at Chapel Hill, serving jointly as Herbarium Director at the North Carolina Botanical Garden (NCBG) and as...
https://unc.peopleadmin.com/postings/308835
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Another excellent position at UT Dallas, this time in the Biological Science Dept:
jobs.utdallas.edu/postings/30702
Our Neuroscience and Biological Sciences faculty are closely intertwined and collaborative creating a great place to launch your independent lab!
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Open Rank Faculty Position Artificial Intelligence in Biological Sciences
Position DescriptionThe School of Natural Sciences and Mathematics at The University of Texas at Dallas (UT Dallas) seeks to fill multiple open-rank (Full, Associate, or Assistant Professor) tenured/t...
https://jobs.utdallas.edu/postings/30702
11 days ago
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Excited for the next movie!
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12 days ago
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Wizard of Oz at The Sphere is astonishingly good. We were all totally blown away and I caught an apple!
12 days ago
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Reupping for the work week. Data should be up in
SPARC.science
this week
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13 days ago
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Mallory Harris, PhD
14 days ago
Tidmarsh gave a different explanation to NYT (gift link). I wonder whether he'll go back to being Board Chair of the "Journal" of the "Academy of Public Health." He was Board Chair, his son was Exec Editor, and several other Trump appointees were involved
www.nytimes.com/2025/11/02/h...
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F.D.A. Drug Unit Chief Is Placed on Leave, and Cites a βToxicβ Environment
https://www.nytimes.com/2025/11/02/health/fda-drug-unit-chief.html?unlocked_article_code=1.yE8.3qUo.tui3nEbvXwWp&smid=url-share
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We got to see the longest field goal in NFL history live today. That record might stand for a long time
14 days ago
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The latest work from our PRECISION Human Pain Center project is now up on
@biorxivpreprint.bsky.social
led by Katherin Gabriel and
@oliviadavis.bsky.social
with a huge contribution from
@allanhpool.bsky.social
's lab and, of course, the Southwest Transplant Alliance:
www.biorxiv.org/content/10.1...
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A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences
The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-mot...
https://www.biorxiv.org/content/10.1101/2025.10.31.685953v1
16 days ago
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Olivia Davis
16 days ago
Also huge props to
@allanhpool.bsky.social
and his lab at UTSW for helping optimise our single nuc prep and looking for species differences between human and mice. This paper builds on the foundation already set and increases our understanding of human spinal cord at an even higher resolution.
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Olivia Davis
16 days ago
Thrilled to share our latest preprint using single nuq sequencing and Xenium to define neuron organisation and sex differences in glia within human spinal cord. Truly a collaborative effort, with a big shoutout to Katherin Gabriel and
@tedpricethepainguy.bsky.social
www.biorxiv.org/content/10.1...
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A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences
The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-mot...
https://www.biorxiv.org/content/10.1101/2025.10.31.685953v1
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We are seeking a senior tenured professor in our Department working on affective and/or motivational neuroscience (defined in the ad, but pretty broad). The idea is that this person is going help lead our growth in this area alongside our excellent Centers.
jobs.utdallas.edu/postings/30693
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Associate/Full Professor - Affective Motivational Neuroscience
Position DescriptionThe Department of Neuroscience in the School of Behavioral and Brain Sciences at The University of Texas at Dallas seeks a late-stage Associate or Full Professor faculty member to ...
https://jobs.utdallas.edu/postings/30693
16 days ago
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17 days ago
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TrkA and its downstream signaling via MAPK (I think itβs mostly MNKs) remains a great target for pain in OA!
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19 days ago
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wonder if we could convince them to chant "Fire Nico"?
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20 days ago
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Olivia Davis
24 days ago
Sharing a figure from our recent paper showing excitatory synapses in the human spinal dorsal horn. Iβll never get over the awe of seeing these tiny dots, which underly such an important part of the human experience!
@tedpricethepainguy.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...
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Ted Price
Journal of Clinical Investigation
26 days ago
A test of nerves in diabetic peripheral neuropathy
@dianatavf.bsky.social
@tedpricethepainguy.bsky.social
& team identify regenerative and degenerative pathways and highlight axonal mRNA transport as a new mechanism in DPN:
www.jci.org/articles/vie...
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HUGE opportunity at Rutgers:
jobs.sciencecareers.org/job/675694/d...
. They already have such a dynamic pain group there, and such a great history... really an amazing opportunity.
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Director of Rutgers Center on Research in Pain and Pain Therapeutics - Piscataway, New Jersey job with Rutgers University/RUTGERS BRAIN HEALTH INSTITUTE | 675694
The ideal candidate will be a leader in pain research with a strong, federally funded research program
https://jobs.sciencecareers.org/job/675694/director-of-rutgers-center-on-research-in-pain-and-pain-therapeutics/
27 days ago
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JCI insight
27 days ago
Do type I interferons increase pain perception or reduce it?
@uenzastiga.bsky.social
@tedpricethepainguy.bsky.social
& team interrogate human pain-sensing neurons, revealing IFN-I induces excitability & TRPV1 sensitization via MNK1/2 signaling:
insight.jci.org/articles/vie...
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Faculty position in Neuroscience at UT Austin:
apply.interfolio.com/175280
A great Department and an exceptional scientific community in Austin and across the UT System.
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Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
https://apply.interfolio.com/175280
28 days ago
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Not only not normal, but totally unprecedented in my lifetime.
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28 days ago
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The webinar that I did for Anabios is now available on youtube:
www.youtube.com/watch?v=llj2...
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Mechanisms of Neuropathic Pain: Lessons from Human DRG & Spinal Cord Studies by Dr. Ted Price
YouTube video by AnaBios
https://www.youtube.com/watch?v=llj2uWjO6Po
about 1 month ago
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New preprint from us: Detection of probable neuronal gene expression changes in skin biopsies from patients with paclitaxel-induced peripheral neuropathy
www.biorxiv.org/content/10.1...
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Detection of probable neuronal gene expression changes in skin biopsies from patients with paclitaxel-induced peripheral neuropathy
Our inability to obtain nerve samples from the vast majority of neuropathic pain patients impedes our ability to understand the disease, creates challenges in understanding mechanisms in specific pati...
https://www.biorxiv.org/content/10.1101/2025.10.15.682581v1
about 1 month ago
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huge news for T-type Ca channels:
ir.praxismedicines.com/news-release...
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https://ir.praxismedicines.com/news-releases/news-release-details/praxis-precision-medicines-announces-positive-topline-results-1
about 1 month ago
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Ted Price
bioRxiv Neuroscience
about 1 month ago
Detection of probable neuronal gene expression changes in skin biopsies from patients with paclitaxel-induced peripheral neuropathy
https://www.biorxiv.org/content/10.1101/2025.10.15.682581v1
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Derek Lowe
about 1 month ago
Never assume that you know all about what any drug molecule is doing in the body - where it's going, what it's binding to. A new example:
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Rapamycin's Secrets
https://www.science.org/content/blog-post/rapamycin-s-secrets
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Certain people just living in their home is now considered DEI in order to eliminate providing funds for basic safety of communities.
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about 1 month ago
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Ted Price
Ewan St. John Smith
about 1 month ago
If evolution, comparative
#neuroskyence
&
#PainResearch
are your thing, here's a great review from Terry Walters:
journals.biologists.com/jeb/article/...
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From nociception in aneural animals to human suffering: toward a comparative biology of pain
Summary: The biology of widely shared and unusual features of human pain is informed by functional and mechanistic comparisons of nociception and pain-like aversive states across vertebrate and invert...
https://journals.biologists.com/jeb/article/228/19/jeb251210/369505/From-nociception-in-aneural-animals-to-human
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I never would have believed such a graph could be possible.
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about 1 month ago
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Forrest Gump Point is for lovers
about 1 month ago
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Greetings from Goosenecks State Park Utah
about 1 month ago
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Hello from Natural Bridges National Monument
about 1 month ago
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Good morning from a rainy monument valley
about 1 month ago
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The vicious disassembly of American health and science leadership continues with no real resistance from congress
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about 1 month ago
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Ted Price
Jacob T. Levy
about 1 month ago
Four cheers for MIT.
orgchart.mit.edu/letters/rega...
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Regarding the Compact | MIT Organization Chart
https://orgchart.mit.edu/letters/regarding-compact
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Ted Price
SPARC
about 1 month ago
Check it out: π Paper:
doi.org/10.1093/brai...
π UTD Pain Center:
paincenter.utdallas.edu
π UTD Pain Center on SPARC:
sparc.science/about/projec...
#Neuroscience
#PainResearch
#HEAL
@tedpricethepainguy.bsky.social
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Validate User
https://doi.org/10.1093/brain/awaf370
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The graph and the short quote say it all!
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about 1 month ago
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