Olivia Davis
@oliviadavis.bsky.social
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Interested in the neuroanatomy of pain and all things spinal cord.
reposted by
Olivia Davis
Ted Price
10 days ago
The latest work from our PRECISION Human Pain Center project is now up on
@biorxivpreprint.bsky.social
led by Katherin Gabriel and
@oliviadavis.bsky.social
with a huge contribution from
@allanhpool.bsky.social
's lab and, of course, the Southwest Transplant Alliance:
www.biorxiv.org/content/10.1...
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A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences
The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-mot...
https://www.biorxiv.org/content/10.1101/2025.10.31.685953v1
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Thrilled to share our latest preprint using single nuq sequencing and Xenium to define neuron organisation and sex differences in glia within human spinal cord. Truly a collaborative effort, with a big shoutout to Katherin Gabriel and
@tedpricethepainguy.bsky.social
www.biorxiv.org/content/10.1...
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A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences
The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-mot...
https://www.biorxiv.org/content/10.1101/2025.10.31.685953v1
10 days ago
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Sharing a figure from our recent paper showing excitatory synapses in the human spinal dorsal horn. I’ll never get over the awe of seeing these tiny dots, which underly such an important part of the human experience!
@tedpricethepainguy.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...
19 days ago
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reposted by
Olivia Davis
Ted Price
4 months ago
Our paper showing decreased KCC2 expression in the human spinal cord in people who died with a history of neuropathic pain is now published in PAIN:
journals.lww.com/pain/abstrac...
Great work from
@oliviadavis.bsky.social
and the teams of the De Koninck and Hildebrand labs. ❤️ 🇨🇦 collabs!
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Decreased KCC2 expression in the human spinal dorsal horn... : PAIN
date there is no evidence supporting or opposing this hypothesis in humans. Here, we demonstrate that KCC2 expression is decreased in superficial dorsal horn neurons of organ donors who died with a do...
https://journals.lww.com/pain/abstract/9900/decreased_kcc2_expression_in_the_human_spinal.956.aspx
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Highly, highly recommend working with Andy and the Spinal Cord Group!
add a skeleton here at some point
4 months ago
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reposted by
Olivia Davis
bioRxiv Neuroscience
7 months ago
Glutamatergic and GABAergic synapses in the human spinal dorsal horn revealed with immunohistochemistry
https://www.biorxiv.org/content/10.1101/2025.04.07.647666v1
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reposted by
Olivia Davis
Ted Price
10 months ago
Very excited to share our new preprint: "Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use" led by
@oliviadavis.bsky.social
and Samuel Ferland, a collab between us, Yves De Koninck and Mike Hildebrand labs
www.biorxiv.org/content/10.1...
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Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use
Loss of GABAergic and glycinergic inhibitory efficacy in the spinal dorsal horn is associated with neuropathic pain and opioid-induced hyperalgesia in rodent models. Downregulation of the KCC2 chlorid...
https://www.biorxiv.org/content/10.1101/2025.01.19.633733v1
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