Amit Agarwal (@agarwal-neurolab.bsky.social)

We identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth. Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...

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Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry Dereddi, Djannatian, and colleagues show that oligodendrocytes use mechanical cues to measure axon size. The stretch-activated channel TMEM63A converts membrane tension into calcium signals, which cal... https://www.cell.com/neuron/fulltext/S0896-6273%2825%2900856-6