As our graduate program deadline approaches, we are recruiting motivated students to join our team. See details below:

Thrilled to share our new paper @cp-cell.bsky.social: “Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.” This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling. 🔗 www.cell.com/cell/fulltex... Faust et al., Cell 2025

On astrocyte-neuron interactions: Broad insights from the striatum: Neuron www.cell.com/neuron/fullt...

Check out this exciting study led by Anh-Tuan Trinh from our lab, where we investigated how thalamocortical-like circuits in the zebrafish pallium receive, represent, and integrate sensory information: 🔗 doi.org/10.1101/2025...

Circuit mechanisms governing endocannabinoid modulation of affective behaviour and stress adaptation — a Review by Niharika Loomba & Sachin Patel #neuroscience #neuroskyence www.nature.com/articles/s41...

Stoked to see this paper finally out! It answers two big questions: where visual objects are encoded in the brain, and how head-direction cells get oriented using visual landmarks. Super fun collaboration with @mace-lab.bsky.social and Stuart Trenholm. www.science.org/doi/10.1126/...

The best way to find typos in your grant proposal is to press submit.

After a break for summer we're back into the routine with a nice series of papers for lab Journal Club www.murphyroyallab.org/journal-club

Thanks! Preprint is here: doi.org/10.1101/2025...

L’impact du stress sur le cerveau dépendrait du sexe www.lapresse.ca/actualites/s...

This is an important rebuttal of government political pandering for animal research. Would have been great to see such a powerful statement from Ontario or U15 university leaders.

Thanks Bruno Geoffroy @crchum.bsky.social for the nice write up on our recent publication with @lewisholt.bsky.social nouvelles.umontreal.ca/en/article/2...

Great story in the @thetransmitter.bsky.social today by @callimcflurry.bsky.social. It was fun chatting about @melcooperphd.bsky.social's new research on astrocyte networks. Read the story here: www.thetransmitter.org/astrocytes/a... Read the preprint here: www.biorxiv.org/content/10.1...

Kathleen set the bar far too high for snacks at today’s lab meeting! 🤩

🚨Another PI job opening in the Neuroscience dept. at @umontreal.ca ! 🚨 www.nature.com/naturecareer...

Thrilled to share our new study showing microglia prune astrocyte processes in adult brain, to regulate synaptic transmission, hypothalamic neuron activity, and salt-induced hypertension in🐀. Huge team effort - congratulations to all🥂🍾🎉

Not yet #fluorescencefriday but too excited to wait to share this gorgeous #astrocyte image by student in the lab Camila Cabarcas Arrieta Astrocyte expressing eGFP in green. GFAP staining in magenta (labelling blood vessel in this case)

The cost of remembering: engram competition as a flexible mechanism of forgetting. Our new perspective piece in @cp-trendsneuro.bsky.social, lead by Ryan Lab alumni, Livia Autore. Also with Michael Drew from @utaustin.bsky.social Trends in Neurosciences www.cell.com/trends/neuro...

Excellent paper from @emreyaksi.bsky.social @manumameli.bsky.social labs. So much gold in the supplementary figures! www.nature.com/articles/s42...

Review now out in @npp-journal.bsky.social! Epigenetic regulation of brain development, plasticity, and response to early life stress rdcu.be/ezzYq

🆕 RESEARCH: Not all kids respond to early adversity the same way. We examined data from ~7,400 children for 4 years and found something notable about positive emotions & mental health outcomes... doi.org/10.1101/2025... A thread 🧵 #MentalHealth #ChildDevelopment #Resilience /1

Super psyched to help close out the #AstrocyteCafe on thursday!

Thank you to the Brain & Behavior Research Foundation (@bbrfoundation.bsky.social) for selecting me for a Young Investigator Award! I'm so excited to explore astrocyte networks in a new context.

The astroglial protein S100β regulates axon initial segment plasticity https://www.biorxiv.org/content/10.1101/2025.07.31.667937v1

#OCaMP is now on bioRxiv and reagents are available on #Addgene! 🧪 A sensitive orange fluorescent calcium ion indicator for imaging neural activity www.biorxiv.org/content/10.1...

👀 might need to give this a shot in astrocytes!

New lab paper by @merridee.bsky.social identifying a novel role for VTA GABA neurons in behavioral flexibility GABA, but not dopamine, neuron activation correlates with behavior when cues unexpectedly shift from predicting punishment to predicting reward www.sciencedirect.com/science/arti...

As chair of the @acnporg.bsky.social Global Outreach Committee, I am happy to answer any questions about the Global Scholarship! Please share with your networks! Excellent opportunity to attend what might be the best science meeting in this space!

Huge congrats to Katarzyna, excellent PhD defense yesterday!! She clearly got fantastic training (job well done Caroline) and will continue to do great work in the future.

Now on bioRxiv! Astrocytes in one brain region (cyan) communicate in expansive networks (magenta). Through tool development, tissue clearing, and many hours on our @zeiss-microscopy.bsky.social Z1, we now know these networks are repeatable across mice, plastic, and specific. doi.org/10.1101/2025...

I love this: “The question isn't whether we can afford to invest in research. It's whether we can afford not to.” Keep that on repeat.

Absolutely thrilled to share the first half of my PhD work! Super proud to see it finally out! www.nature.com/articles/s41... Thread below for a quick (10 point) recap of what we found! 🧵🧪🧠

Was a lot of fun working on this piece with Ben Clayton for @annualreviews.bsky.social Reactive astrocyte heterogeneity is a thoroughly exciting and complicated problem... lots of exciting discoveries in recent years. www.annualreviews.org/content/jour...

New publication out Led by Enrica Montalban, who did a fantastic work, our new paper demonstrate a role for striatal astrocytes in the context of diet-induced obesity in both metabolic and cognitive processes. Thanks to all the collaborators for their work! www.nature.com/articles/s41...

🚨New lab publication is out!! 🚨 In this work we reveal that astrocytes, the most abundant glial cell type, are responsible for the effects of stress and that targeting these cells completely rescued the effects of stress on neuronal activity and behaviour! Huge congrats to Lewis!! See his 🧵below

Final leg of the Tour de France done with an excellent @gliameeting.bsky.social ! Amazing science in a great city, (despite some smoke!) and a nice travel award for @lewisholt.bsky.social 🥳 Going to make sure we come back to this meeting again next time! #glia2025

Really excited for this lineup today! Can’t wait to see and share lots of great astrocyte work!

Part 2 of France trip done. Fantastic @ebbsociety.bsky.social meeting with PhD students from the lab! Topping it off with a presentation prize for @mathiasgua.bsky.social !! 🥳

Looking forward to this! Thanks for organising @bgarcialab.bsky.social and Sílvia!

Fantastic in-depth review on early life stress! 🤩

Part 1 of the French trip done! Lots of fun exploring Paris, hanging out with Jun Nagai, and having a mini astrocyte day at Serge Luquet’s lab in Université Paris Cité.

This was a really fun project: We blocked obesity in mice by making them do a tiny bit of work for their food. www.sciencedirect.com/science/arti...

#RECRUITMENT "We are well-positioned to welcome top minds who are seeking to thrive in an open, dynamic environment where science can flourish freely," says @vpoitout.bsky.social. #U.S. #academia #funding #Canada @usherbrooke.bsky.social @ulaval.ca @mcgill.ca nouvelles.umontreal.ca/en/article/2...

Calling all Neuroscience postdocs! 🧠 Share your research through SPiNES (Seminars from Postdocs in Neuroscience: Extramural Series) from the NYUGSoM Department of Neuroscience. Applications close 08/20/25. Apply today! 👉 nyumc.qualtrics.com/jfe/form/SV_... #Neuroscience #Postdoc #ResearchOpportunity

A ventral hippocampal-lateral septum pathway regulates social novelty preference. Version of record - now available on @elife.bsky.social check it out doi.org/10.7554/eLif...