Lewis Holt
@lewisholt.bsky.social
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Post-doctoral scientist Laboratory of Behavioural Genetics EPFL, Lausanne 🏴🇪🇺🇨🇭
reposted by
Lewis Holt
The Transmitter
8 days ago
“Based on astrocytic activity alone, you can tell whether a mouse is in its comfort zone,” a new study suggests. By Holly Barker
www.thetransmitter.org/spectrum/ast...
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Astrocytes in mouse amygdala encode emotional state
The glial cells’ activity reliably tracks with freezing, hesitancy and other behaviors reminiscent of anxiety.
https://www.thetransmitter.org/spectrum/astrocytes-in-mouse-amygdala-encode-emotional-state/?utm_source=bluesky&utm_medium=org-social&utm_campaign=20260324-news-sp-astrocytes-in-mouse-amygdala-encode-emo-state
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reposted by
Lewis Holt
Ciarán Murphy-Royal
8 days ago
Incredibly proud of this paper led by
@ossamaghenissa.bsky.social
and
@mathiasgua.bsky.social
titled Basolateral 'Amygdala Astrocytes Encode Anxiety States'.
www.cell.com/neuron/fullt...
🧵 below
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Basolateral amygdala astrocytes encode anxiety states
Ghenissa et al. provide evidence that basolateral amygdala astrocytes reliably encode anxiety states. Using simultaneous in vivo calcium recordings across an array of behavioral tasks, combined with g...
https://www.cell.com/neuron/fulltext/S0896-6273(26)00163-7
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First ride of the post-doc!! Change is always hard but these views defo help! 😍
about 1 month ago
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reposted by
Lewis Holt
Global Stress and Resilience Network (GSRNet)
about 1 month ago
🚨 Calls for Proposals are now open! Submit your ideas for: • Symposia • Panel discussions • Roundtables Be part of shaping the scientific program of GSRNet 2027. 📅 Deadline: April 15, 2026 🔗 Details:
stress-and-resilience-meeting27.epfl.ch/call-for-pro...
#GSRNet2027
#StressAndResilience
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add a skeleton here at some point
about 2 months ago
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🚨Great science in a stunning location!🚨 (Can confirm both are true)
add a skeleton here at some point
about 2 months ago
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reposted by
Lewis Holt
Ciarán Murphy-Royal
3 months ago
Delighted to share our first preprint of the year! A project that we're all really proud of in the lab led by
@ossamaghenissa.bsky.social
with
@mathiasgua.bsky.social
in which we set out to test the role of basolateral amygdala astrocytes in anxiety behaviour.
www.biorxiv.org/content/10.6...
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Astrocytic Encoding of Threat in the Basolateral Amygdala
The basolateral amygdala (BLA) has long been implicated in threat detection and the generation of anxiety states. While previous experiments have demonstrated the important role of BLA principal neuro...
https://www.biorxiv.org/content/10.64898/2026.01.07.697973v1
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reposted by
Lewis Holt
Ciarán Murphy-Royal
7 months ago
Thanks Bruno Geoffroy
@crchum.bsky.social
for the nice write up on our recent publication with
@lewisholt.bsky.social
nouvelles.umontreal.ca/en/article/2...
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After early-life stress, astrocytes affect behaviour
Canadian researchers show that stress modifies the morphology of brain cells in mice, directly influencing the rodents’ level of physical activity.
https://nouvelles.umontreal.ca/en/article/2025/09/04/after-early-life-stress-astrocytes-affect-behaviour/
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Super psyched to help close out the
#AstrocyteCafe
on thursday!
add a skeleton here at some point
8 months ago
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Absolutely thrilled to share the first half of my PhD work! Super proud to see it finally out!
www.nature.com/articles/s41...
Thread below for a quick (10 point) recap of what we found! 🧵🧪🧠
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A divergent astrocytic response to stress alters activity patterns via distinct mechanisms in male and female mice - Nature Communications
Early-life stress has lifelong impacts on neuronal function and behavior. Here, the authors show that astrocytic glucocorticoid receptor signaling drives stress-induced neuronal and behavioral change ...
https://www.nature.com/articles/s41467-025-61643-y
9 months ago
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reposted by
Lewis Holt
Ciarán Murphy-Royal
9 months ago
Final leg of the Tour de France done with an excellent
@gliameeting.bsky.social
! Amazing science in a great city, (despite some smoke!) and a nice travel award for
@lewisholt.bsky.social
🥳 Going to make sure we come back to this meeting again next time!
#glia2025
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Was great to present at
@canglia.bsky.social
today! Cool to see all the glial research happening across Canada!
add a skeleton here at some point
11 months ago
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reposted by
Lewis Holt
Alex Chen
11 months ago
Excited to share that the astrocyte-centered half of my thesis work is now out
@science.org
! With
@mishaahrens.bsky.social
and
@marcduque.bsky.social
science.org/doi/10.1126/...
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Norepinephrine changes behavioral state through astroglial purinergic signaling
Both neurons and glia communicate through diffusible neuromodulators; however, how neuron-glial interactions in such neuromodulatory networks influence circuit computation and behavior is unclear. Dur...
https://science.org/doi/10.1126/science.adq5233
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reposted by
Lewis Holt
Papouin Lab @ WashU
11 months ago
Thought this would be a nice way to enter the bsky community👇Delighted for Katie (now in Chris Dulla's lab at Tufts). Thank you to our collaborators, to the reviewers and to Cagla Eroglu for the highlight!
www.science.org/doi/10.1126/...
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Norepinephrine signals through astrocytes to modulate synapses
Locus ceruleus (LC)–derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level...
https://www.science.org/doi/10.1126/science.adq5480
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Super cool that these are finally out!! Check out some of the protocols we've been using to investigate the role of astrocytes in stress!
add a skeleton here at some point
about 1 year ago
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Multinucleated astrocytes always look so cool!
#FluorescenceFriday
about 1 year ago
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Diversifying my portfolio with some Iba-1 staining.
#fluorescentfriday
about 1 year ago
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reposted by
Lewis Holt
Ciarán Murphy-Royal
about 1 year ago
Version of Record of our work at
@elife.bsky.social
has been published! Super proud of this one after all the hard work of the lab seeing it to the end. Make sure to click through figure supplements as there is so much good stuff in there - sex differences, etc.
elifesciences.org/articles/99988
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Early-life stress induces persistent astrocyte dysfunction associated with fear generalisation
Amygdala astrocytes play a critical role in mediating the effects of stress during infancy on neuronal excitability, synaptic plasticity, and memory.
https://elifesciences.org/articles/99988
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technical question. Can anyone recommend a good commercially available SOX9 antibody for fixed tissue IHC?
#astrosky
#astrocytes
about 1 year ago
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reposted by
Lewis Holt
Mackenzie Weygandt Mathis
over 1 year ago
What a year!
#DLC3🔥
is up tested by many of you (👀 watch out for a paper in 2025), we hit 750K downloads, and have over 120 contributors to the code!
@deeplabcut.bsky.social
❄️⛷just dropped: new human pose models & high perf. models!
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reposted by
Lewis Holt
Ciarán Murphy-Royal
over 1 year ago
Delighted to share an update to our preprint, reviewed at
@elife.bsky.social
, and now sent back for re-review. Colossal work by the team and driven home by
@mathiasgua.bsky.social
Quick 🧵 of what's new -
www.biorxiv.org/content/10.1...
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Early-life stress induces persistent astrocyte dysfunction associated with fear generalisation
Early-life stress can have lifelong consequences, enhancing stress susceptibility and resulting in behavioural and cognitive deficits. While the effects of early-life stress on neuronal function have ...
https://www.biorxiv.org/content/10.1101/2022.12.11.519598v4
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reposted by
Lewis Holt
Liisa Galea
over 1 year ago
Our latest review-with
@bonniee-leee.bsky.social
where we pour our ❤️🧠 & soul to outline our position on why we are so passionate about harnessing the power of sex differences & within sex diff to propel precision medicine forward let us know if we convince you
www.nature.com/articles/s41...
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Leveraging research into sex differences and steroid hormones to improve brain health - Nature Reviews Endocrinology
This Review outlines how the effects of steroid hormones on hippocampal neuroplasticity across the adult lifespan differ between the sexes, highlighting the importance of considering sex and steroid h...
https://www.nature.com/articles/s41574-024-01061-0
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reposted by
Lewis Holt
Shane Liddelow
over 1 year ago
There are lots of us missing, but so many joining so quickly Please do share, and comment below to be added
go.bsky.app/5f2V6L6
(microglia starter pack also here by
@mancusorenzo.bsky.social
-
bsky.app/starter-pack...
)
add a skeleton here at some point
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Not sure I have any good pictures in the back pocket to beat the calcium imaging from
@mathiasgua.bsky.social
Instead for my first post on Bluesky I want to share the CANglia webinar: trainee series!
over 1 year ago
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