📄🚨: Building off a stellar 2023 pub that engineered an hCSF1R variant, Sonia et al. now show how an mCSF1R variant not only confers inhibitor resistance and allows for efficient & non-toxic microglia replacement, but does so after vascular delivery into immunocompetent mice! 👏🧠 tinyurl.com/3wvmm8v3

Here's the thing. Do I believe the science? Yes. But would I sacrifice slightly better overall physical health for an (at minimum) 2x bump in mental health daily? There is literally no question. I don't need sun while sipping my coffee alone. I need it when I'm trying to have a social life post 5pm.

Let's be clear: no one should be taking medical advice from the man who told Americans to inject bleach. To moms worried about the Tylenol they took while pregnant: you deserve better than being RFK Jr's scapegoat. And to the autism community: you are loved exactly as you are.

Had the best time at the 17th annual @seattlechildrens.org Run of Hope benefiting pediatric cancer research! Over half a million dollars raised, and a lovely morning spent with friends, colleagues, and families who give meaning to everything we do. A very bright day in these not so bright times 🏃‍♀️ ☀️

My favorite training question.

Had a great time at my first #SeattleStorm game today with fellow @seattlechildrens.org Ben Towne Center scientists and friends! #EveryoneWatchesWomensSports

Congrats to the first graduating class of Invent at Seattle Children’s Postdoctoral Scholars! We’re so proud of what you’ve accomplished as Invent Scholars and can’t wait to see how you continue to advance pediatric biomedical research. #MedSky #BioTech

Given the recent and devastating cuts to the NIH, my colleagues and I from @seattlechildrens.org are running a 5k on 9/21 to raise money for pediatric cancer research. Please consider donating, joining our team, or simply sharing this post to help raise awareness! #EndDIPG runsignup.com/nemec

I thought this was a Magic Eye and spent an embarrassing amount of time trying to see the hidden figure before actually reading the caption of the post.

How does the human brain coordinate hierarchical cortical development? Our work in Nature Neuroscience identifies a role for thalamocortical structural connectivity in the expression of hierarchical periods of cortical plasticity & environmental receptivity in youth 🧵 www.nature.com/articles/s41...

Honeymooning in New Zealand when I got the notice that the final version of my thesis paper is out! Huge thank you to the @elife.bsky.social editors and reviewers for making this the smoothest review process I’ve ever had. Give it a read! #microglia #AGS 🤓🧠 elifesciences.org/reviewed-pre...

I am looking for a postdoc with an immunology background interested in joining a Yale neuroscience lab to study how the brain controls immunity. At Yale, we have a wonderful interdisciplinary & collaborative #neuroimmune community. Please reach out or share with anyone who might be interested!

We've launched the Armamentarium, a new toolkit for targeted gene delivery to the brain and spinal cord. This #OpenScience resource was made possible thanks to support from the NIH BRAIN Initiative and teamwork with our collaborators. 🧠📈 www.nih.gov/news-events/...

Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...

Had a great time at #SNOPeds2025 this weekend! Thanks to @neuroonc.bsky.social for putting on such a fun and informative conference, and for having it in a city that provided some much needed spring warmth ☀️ 🌴 ☺️

Breaking News: A baby with a rare disorder made medical history by receiving the first custom gene-editing treatment. The technique used has the potential to help people with thousands of other uncommon genetic diseases. nyti.ms/4j49xBy

Our May featured #FacultySpotlight is Dr. Ana Cristancho, CHOP neurologist. In her Q&A, Dr. Cristancho discusses her work investigating the mechanisms underlying the long-term effects of early-life brain injuries. http://ms.spr.ly/63325SZSdd

The #RunofHope is an annual fundraiser for the Seattle Children's #pediatriccancer & blood disorders research. Please consider joining us and/or making a donation. No amount is too small! All donations to our team will go to the Brain Tumor Research Program runsignup.com/cartforkids

The first photo was what I posted on my Instagram story last night. 18 hours later and I’ve signed up to run a 5k. Y’all I *hate* running. But I’m doing it to raise money for our center to fund pediatric cancer research. Plz considering supporting us! 🏃‍♀️🫣⬇️ www.runofhopeseattle.org/Race/93971/D...

Thrilled that @chopresearch.bsky.social highlighted our latest work published today in @cp-immunity.bsky.social www.chop.edu/news/preclin...

Very happy for having contributed to this amazing study led by Jonathan Bastos and Kia Movahedi. Super cool findings! @sotonbiosciences.bsky.social @cp-immunity.bsky.social @liambc.bsky.social www.sciencedirect.com/science/arti...

Amped to share this masterclass of a paper spearheaded by @waisenberg.bsky.social, out today in Immunity. Will et al. provide a deeply detailed look into microglia dysfunction in Krabbe disease & show that microglia replacement therapeutically improves disease outcomes! www.cell.com/immunity/ful...

Next up is NGG graduate Evan Gallagher’s work! Current NGG student Kara McGaughey @kara-mcgaughey.bsky.social explains how he investigated the novel positron emission tomography (PET) radioligand [18F]ROStrace as a possible in vivo biomarker for Parkinson's disease. www.upennglia.com/briefs/bib-p...

Incredible news from @nickvitanza.bsky.social et al! A timely reminder that what (the universal) we do is important and worth fighting for.

Harvard has set an example for other higher-ed institutions - rejecting an unlawful and ham-handed attempt to stifle academic freedom, while taking steps to make sure students can benefit from an environment of intellectual inquiry, rigorous debate and mutual respect. Let’s hope others follow suit.

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.” A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world. www.cnn.com/2025/04/09/h...

Are you a woman who changed your name when you got married? Congress is considering a bill that could make it much harder for you to vote. Call your rep—this is not a drill. indivisible.org/resource/cal...

We're disappointed to see Ben Barres's powerful book "The Autobiography of a Transgender Scientist" among the ~400 titles removed from the Naval Academy Library. Needless to say, we're proud to have published his book and will keep it — and his memory — alive.

Lab (and life) is tough given The Current State of Things™️, but I persevere by knowing that what I do makes a genuine difference. But I just got yet another drop of bleach on a (dark green) pair of pants just below my lab coat, and I stg I'm about to absolutely lose it. Send help or snacks asap.

Not satisfied with purchasing a Presidential Election to become co-President, Sissy SpaceX now wants to buy himself a Supreme Court judge in Wisconsin. You can end his shopping spree, Wisconsinites! 🚫 💰 #VoteForJudgeSusanCrawford 🗳️ ✅ 👍 This is super important.

Tumor biologists! do we know that tumors produce mRNA (or RNA generally) more quickly than healthy tissues? maybe there are old papers on this? (pls reski)

The real March Madness! 8x champs and over Ohio State (again 😉) for that little bit of added sweetness 👐

Out now, the March 2025 cover of @natmedicine.bsky.social! Thank you @sahelisadanand.bsky.social & Nature Medicine team. It’s never been more important to advocate for children’s health, so thank you for bringing awareness to this terrible disease. #DIPG #DMG (Amazing cover artist: Katie Vicari)

Thanks to Dr. Syal & @nbcnews.com for visiting our #CARTcell program to highlight one of our courageous little patients with #DIPG #DMG. So much work left to do but thankful for the support of Seattle Children’s and our brave families. ❤️ www.nbcnews.com/now/video/ex...

Check out the NBC National News coverage of my superstar PI @nickvitanza.bsky.social regarding his recently published phase 1 clinical trial for children with DIPG. So very proud to be in this lab. Article: www.nbcnews.com/health/cance... Video: www.nbcnews.com/now/video/ex...

Hey @fetterman.senate.gov, please see the FY24 Economic Impact Report for @upenn.edu and @pennmedicine.bsky.social. 106,600 jobs and $37B in economic activity. Please fight for Penn’s funding. If not for morals and science, then for the good of the economy. penntoday.upenn.edu/news/fy24-ec...

We had an extremely important meeting at 1:59pm today. It was both impressive and delicious #PiDay

Absolute trash headline. If there is a shutdown, it's on the GOP for putting forth such a horrific (and partisan) bill, not on Dems for voting against it. The GOP controls the government; show their voters what they voted for #shutitdown WA: Our senators are Patty Murray (D) and Maria Cantwell (D)

The @philadelphiaeagles.bsky.social declined in 2018 but accepted in 2025? As if things are better now than they were then? Wtf guys. Super super disappointed to hear this. I expected more from a team from Philadelphia, a city of deep diversity and “brotherly love.”

At risk? Belong? Bias? Excluded? EXPRESSION? **EXPRESSION**?!?!?!

THIS IS HUGE! Researchers at Stanford University have developed a dual-antibody treatment that remains effective against ALL SARS-CoV-2 variants by targeting a less-mutable part of the virus. This breakthrough could lead to longer-lasting therapies that OUTPACE viral evolution. 🧪🧵⬇️

If you’re feeling depressed, go out and volunteer to educate the public/support the next generation of scientists. Between the rally yesterday and a HS science fair today, I’m feeling much better about our future, just knowing there will always be good people working and advocating for science 🧬✊

Seattle showed up to #standupforscience today. It has been really lonely in science lately. We've been facing flurries of changes, cuts, censorship, and all kinds of bad news and rumors of worse. And no clue what to do with all of it. 1/2

A beautiful day to #standupforscience. So proud of Seattle’s turnout today. Most of whom identified merely as “concerned citizens” with no scientific affiliation themselves. And that’s because #scienceisforeverybody.

SO MANY STAND UP FOR SCIENCE EVENTS TO CHOOSE FROM—153 and COUNTING! To get more information on our local events and to register your own, head to www.standupforscience2025.org/local-event-information/ ☀️⬇️🌎

I just logged in to Twatter for the first time since January and it’s even worse than I expected. It’s like when I occasionally go on Fox News just to see what folks are being fed. But infinitely worse because you can also see the horrible comments. Asdfghjk. Never again. Permanent account delete 🫡🦋

“I will need to prepare more parents for their child’s death, letting cures almost in hand slip through my fingers.” Hope to see you all out standing up for science on March 7th, nationwide #standupforscience

Republican congress members have introduced a bill to ban (nearly) all animal testing in federally funded labs. Please consider filling out this quick form to ask your local congress person to oppose this piece of legislation that is, at best, extremely misguided. speak4.app/lp/xe015ndd/

Join us on Friday, March 7th from 12-3PM at the Seattle Center Mural Ampitheater lawn for a rally to defend science as a public good and central pillar of social progress. Like. Share. Be there. STAND UP FOR SCIENCE. RSVP: www.eventbrite.com/e/stand-up-f...