Three studies that leverage blood-based gene expression data identify host response signatures in #sepsis and critical illnesses, opening a pathway to mechanism-anchored #precisiontherapy. News & Views from Robert Stevens and Carl Harris @jhu.edu https://www.nature.com/articles/s41591-025-04005-x#sepsis

Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE

📰 Please read this important news feature in @natmed.nature.com written by @marianneguenot.bsky.social It is impossible to reconcile this administration's alleged commitment to "Gold Standard Science" with their harmful actions against important biomedical research www.nature.com/articles/s41...

Ever since I learned about this study enrolling I have been eagerly awaiting the results. Researchers in Uganda took a centuries-old cultural practice mothers carrying babies on their backs in cloth wraps and turned it into a public health tool. You got to love it! www.nejm.org/doi/full/10....

SO the people actively sowing distrust in vaccines (i.e. many of the people in RFK's new ACIP) are also saying that we need to change safe and highly effective vaccine schedules because of this same lack of trust. Make it make sense!

ACIP voted 7-3 to NOT recommend MMRV combo vaccine for kids <4yo. Then in a confusing second vote (1 yes, 8 no, 3 abstentions - some citing confusion), they kept VFC coverage for the same vaccine they just said not to use. This chaos matters for every family. 1/8

Here's the upshot on hepatitis B vaccination at birth: - it's extremely safe - the earlier it's given, the better it protects against transmission from mother-to-child - screening fails to capture many cases and is not done at all in many cases - perinatal HBV infection is catastrophic

A horrible horrible decision with NO rationale.

On the Trump administration's cruel disbanding of the Pediatric Brain Tumor Consortium: my op-ed @statnews.com My 12-year-old son died from brain cancer. This research would have helped children like him www.statnews.com/2025/09/15/p...

Do NOT allow them to rewrite history with disinformation. #COVID vaccines worked remarkably well and allowed us to come out of a global pandemic. A picture is worth a thousand words.

🌟Proud to publish these exciting data in #NatureMedicine -- final results from a phase 1/2 trial + a case series show strong efficacy of GD2 CAR-T cells in children with high risk #Neuroblastoma #immunotherapy #OncSky #PedSky @natureportfolio.nature.com www.nature.com/articles/s41...

AAP's immunization recommendations are based only in the science, the needs of children, and the care that pediatricians have for the children in every community. If you have any questions about our recommended schedule, reach out to your pediatrician. aao.org

New and important #NatureMedicine correspondence on the health consequences of forced displacement in Gaza "These proposals are not humanitarian...Every effort must center on the health, humanity and rights of Palestinians, not their removal." www.nature.com/articles/d41...

🌟NEW in #NatureMedicine: Results from a phase 2 trial suggest that anti-PD-1 #immunotherapy should be the preferred treatment choice for patients with unresectable desmoplastic #melanoma -- complete response rate of 37% and a post hoc ORR of 89% (!!) #OncSky #MedSky www.nature.com/articles/s41...

I cannot emphasize enough that the playbook being used against mRNA vaccines (and vaccines in general) is IDENTICAL to the playbook used to restrict voting rights after the 2020 election: actively sow public distrust, then cite the distrust you sowed as an independent reason for your desired policy

⭐NEW in #NatureMedicine: final results from a phase 1 trial of an off-the-shelf, lymph node-targeted mKRAS peptide #vaccine for patients with #PancreaticCancer and #ColorectalCancer! Great efficacy results when T cell responses are strong 💪 AND signs of antigen spread! www.nature.com/articles/s41...

The mainstream media has already forgotten about this, of course. It's not convenient to explore the fact that the HHS secretary and his MAHA movement are quite literally jeopardizing the safety of healthcare workers by amplifying dangerous (and incorrect!) conspiracy theories.

Important to remember that Russell Vought has directly benefitted from NIH-funded research. His daughter, who has cystic fibrosis, takes Trikafta: www.motherjones.com/politics/202... Sadly, it seems that he is perfectly OK destroying innovative research that could benefit other families.

🤔I am curious about the ethics and logistics of demonstrating efficacy of an anti-measles antibody & about the strangely optimistic perspective that anti-vaccine/vaccine-hesitant parents would be willing to give their children a drug like this given their general attitudes towards modern medicine.

(1/2) "At the outset of his tenure, it seemed that Mr. Kennedy might not allow his skepticism of vaccines to influence national policy" Huh? Lots of people warned that this would happen... www.nytimes.com/2025/08/07/h...

My comments with @factcheck.org www.factcheck.org/2025/08/rfk-...

The mRNA vaccine platform has already been assessed across diverse clinical indications, many with remarkable progress: —cancer neoantigen vaccines [in patients with refractory disease (e.g. pancreatic)] —more than 15 infectious diseases —autoimmune diseases —rare disease for genome editing

Horrible decision but sadly par for the course for the HHS secretary.

NEW: Massive and confusing inconsistencies at NIH. New director says health disparities research is critical yet grants are being cut left and right. With @aniloza.bsky.social and @ericboodman.bsky.social. (Also my last story for STAT. 😢) www.statnews.com/2025/08/01/n...

Kevin Hall can now speak freely. He's the top nutrition scientist who is clashing with MAHA www.statnews.com/2025/07/30/k... via @statnews.com

Really, really bad. And really, really mystifying in its blatant disregard for science, medicine, health, education, etc. www.wsj.com/politics/pol...

💉Our rundown of the changes in access to different vaccines under RFK Jr’s HHS: From @lenasun.bsky.social @laurenweberhp.bsky.social @rachelroubein.bsky.social gift link: wapo.st/4mau4q4

Gavi, the vaccine provider for the world’s poorest people, needs an extra US$3 billion to protect infants and other vulnerable groups. More donors must step up go.nature.com/4m0xFqG

🧠Check out our newest #NatureMedicine collection focused on the Global Neurodegeneration Proteomics Consortium, an international database using proteomics + clinical data to improve our understanding of neurodegenerative diseases! www.nature.com/collections/...

This is both embarrassing and very sad.

Really grateful @cidrap.bsky.social covered our volunteer project reviewing vaccine RCTs. We're up to 335 trials with >5.8 M participants and counting. "Essentially every childhood vaccine has been tested in placebo-controlled trials of some sort." cidrap.umn.edu/adult-non-fl...

After ruling the NIH grant cuts were illegal yesterday, Judge Young, a Reagan appointee on the bench since 1985, ended the hearing with a blistering 15-minute speech. I've cleaned up my notes — here are his remarks in full. 🧵

Nature Medicine reports how scientists are fighting back against malaria in urban areas of Africa with modified male mosquitoes. #medsky 🧪

Nature awards and Yakult have announced another round of 'Global Grants for Gut Health'. An excellent opportunity for gut microbiota researchers, at any career stage, to win $100,000 for a year to cover their interesting research! #MicrobiomeSky #MicroSky www.nature.com/immersive/gu...

Thanks for following along! My story from the hearing below "He can talk about freedom, but his own staff are decrying his censorship," @gavinyamey.bsky.social told me. "How he’s actually acting and what he says are not one in the same." Stay tuned for more live posting about NIH in court and more

Helen Chu is one of the ousted #ACIP members. She spoke to me today about her grave concerns for future vaccination policy and vaccine access in the United States. www.statnews.com/2025/06/10/c...

This will end up leading to more harm, more death. We are all less safe because of this decision. In particular, children and the elderly will pay the steepest price. “RFK Jr. removes all members of the CDC's vaccine advisory committee” www.npr.org/sections/sho...

The gutting of US biomedical research with loss of ~2,500 grants affecting research for cancer, Alzheimer’s, infectious disease, global health and much more www.nytimes.com/interactive/...

#NatMicroPicks Microbiome as marker of cancer 🦠⚕️ Pooled analysis of 3,741 stool metagenomes from 18 cohorts for cross-stage and strain-level reproducible microbial biomarkers of colorectal cancer #MicroSky www.nature.com/articles/s41...

Check out the earlier phase 1 trial results (that led to this larger study) in #NatureMedicine (interim results published in 2022, final results published in 2024): www.nature.com/articles/s41... cc: @natureportfolio.nature.com

I subscribe to the @newyorker.com, I was part of ACT UP, I knew Larry Kramer well and know Tony Fauci too. Daniel Immerwahr's piece on RFKJr, features this and other passages that need a reponse. 1/

Thank you for explicitly stating that this is a direct contradiction of the @nejm.org piece published last week by Makary and Prasad. It also contradicts CDC guidance. It would be nice if the related @nytimes.com article on this decision was corrected rather than retaining wishy washy phrasing...

ACOG is deeply disappointed by HHS’s move to drop COVID-19 vaccine recommendations in pregnancy. The science is clear: COVID-19 remains dangerous in pregnancy and vaccination protects both patients and newborns. The vaccine is safe and protects families. Read our full statement: buff.ly/OGue7sO

Too many don't appreciate just how awful vaccine-preventable diseases like measles can be -- we are fortunate to live in a time when routine infections aren't the norm. Worth reading and sharing with those who are vaccine hesitant. These are real lived experiences.

📣 #NatureMedicine is hiring a new editor with expertise in #AI, #DigitalMedicine and/or Health #Informatics! This job is open to applicants in NYC 🗽and Milano 🎭! Deadline is Fri, May 30th. Please share! springernature.wd3.myworkdayjobs.com/SpringerNatu... cc: @natureportfolio.nature.com

This week's genome editing triumph is a big deal. Here's why erictopol.substack.com/p/the-first-...

An incredible story -- base editing treatment for a rare disease! www.nytimes.com/2025/05/15/h... Read the paper in @nejm.org here: www.nejm.org/doi/full/10....

2.7Billion in NIH research funding cuts in the first three months of 2025. This is not abstract No NIH funding = fewer new treatments for cancer, fewer new vaccines, fewer discoveries for chronic diseases, lower retention of scientific talent, more brain drain. www.cnn.com/2025/05/13/h...

With NIH director Jayanta Bhattacharya dismissing my reporting as "false" and "spreading rumors" hours before releasing a policy that confirmed said "rumors," I feel compelled to respond. Here's an inside look into how this story was reported. It was a weird one. 🧵 www.nature.com/articles/d41...

< 72 h from launch → 48 placebo / active-controlled vaccine RCTs logged - now including all 5 COVID trials 1.43 M participants Crowd-powered, freely accessible evidence that buries the “never placebo-tested” myth. Browse or drop a PMID 👇 bit.ly/3EuYzqI cc @bradspellberg.bsky.social