I don’t care whether Tesla gives Musk $1T or $100T. I do care that insanely rich people like Musk & Trump use their $$$ to accumulate power & use that power to kill kids. USAID may have had some flaws. But it was cheap($24/person) & effective. Its dismantling has already cost 600k lives-400k kids.

i hope one thing we take away from all these political prosecutions (and the deference given to government during them) is how easily people of color and low income folks can be wrongly incarcerated. so maybe we should do something about that

In vivo anti-inflammatory activity of sialylated IgG1 Fc engineered to have enhanced affinity for FcγRIIB via co-engagement of type I and II Fc receptors @science.org @rockefeller.edu www.science.org/doi/10.1126/...

Safety and Immunogenicity of an rVSV Lassa Fever Vaccine Candidate @nejm.org www.nejm.org/doi/full/10....

Independent of what PAHO ends up deciding, we don’t deserve elimination status given the state of things. Still, progress is rarely monotonic. Measles can be eliminated if we decide it’s worth eliminating.

I find this question odd. Creativity IMO is a statement about the process more than the outcome. I don't think it's simply about innovation. Insofar as there is no cognition involved here (we're basically dealing with a very fancy autocorrect), it's axiomatically not possible for AI to be creative.

PSA: It is very difficult to do chest auscultation when the stethoscope earpieces are not in your ears.

Influenza cases are climbing in Canada. Flu shots are widely available, and can help lower the chance of infection and hospitalization. Below are this year’s flu trends (arrow) vs. the past three years.

1/ Open enrollment for Obamacare (ACA) kicked off this weekend, during which more than 20 million families will shop for health insurance coverage. There's some sticker shock though: prices are up ~30% this year if tax credits aren’t extended. Here’s what else is happening in #publichealth 👇

RWJF: “Despite a common assumption that our country is more polarized than ever, new survey research shows that US adults agree broadly on their priorities for themselves, their families, & their communities, & in the day-to-day challenges they face”🧪🛟 *w/ gratitude to @meganranney.bsky.social

Misinformation about the COVID-19 vaccine spreads fast. Stay ahead of it with our tool kit, which has ready-to-share graphics, posts, and key messages that will help you foster vaccine confidence among your patients. See the tool kit and get resources to help you reach your patients: bit.ly/4ngleaw

harvard medical school got bombed yesterday and it barely made news

A friend of mine is doing the NYC marathon today. I've been watching her live on the website, and it is honestly baffling that human physiology is capable of this

The US funds the bulk of biomedical research globally by far. It's not like other countries can simply take up the slack. The more likely: people leave research, new people don't become researchers. There is no happy ending. www.pbs.org/newshour/sho...

“Furin cleavage site”, that is. Just casually, and naturally, sitting there in one of the most evolutionarily active parts of the genome. Mystery solved.

He has already chosen, what the fuck are we doing here www.theatlantic.com/politics/arc...

Pediatrics Corner: The AAP just released a statement regarding the use of leucovorin in patients with autism: "𝗔𝘁 𝘁𝗵𝗶𝘀 𝘁𝗶𝗺𝗲, 𝘁𝗵𝗲 𝗔𝗺𝗲𝗿𝗶𝗰𝗮𝗻 𝗔𝗰𝗮𝗱𝗲𝗺𝘆 𝗼𝗳 𝗣𝗲𝗱𝗶𝗮𝘁𝗿𝗶𝗰𝘀 (𝗔𝗔𝗣) 𝗱𝗼𝗲𝘀 𝗻𝗼𝘁 𝗿𝗲𝗰𝗼𝗺𝗺𝗲𝗻𝗱 𝘁𝗵𝗲 𝗿𝗼𝘂𝘁𝗶𝗻𝗲 𝘂𝘀𝗲 𝗼𝗳 𝗹𝗲𝘂𝗰𝗼𝘃𝗼𝗿𝗶𝗻 (𝗳𝗼𝗹𝗶𝗻𝗶𝗰 𝗮𝗰𝗶𝗱) 𝗳𝗼𝗿 𝗮𝘂𝘁𝗶𝘀𝘁𝗶𝗰 𝗰𝗵𝗶𝗹𝗱𝗿𝗲𝗻." www.aap.org/en/patient-c...

On halloween there’s nothing spookier than a future without CDC

It’s really odd that suddenly the people who embraced Nazi ideals into their ranks are appalled by having Nazis in their ranks

"Children born to mothers infected with covid-19 during pregnancy faced a higher risk of autism, along with other neurological differences" #MedSky + #PedSky + #ObGynSky - published in @greenjrnl.bsky.social. wapo.st/4hB1OvP

I can't decide whether fixing poorly done wikipedia articles is a good or poor use of my time

I keep seeing people say, oh, trans people must take a hit for the greater good and, first of all, no, you don't get to discard someone else's rights and second, we know from past experience that marginalized communities like theirs are merely the first to be targeted. They'll come for you next.

I don't think I've ever seen a lymphocyte gate quite like this one

NEW @nejm.org: We synthesized 511 recent studies on Covid-19, RSV & flu vaccines for 2025-26. With federal advisory processes disrupted, clinicians & the public need rigorous, independent evidence synthesis. Here's what we found: 🧵 www.nejm.org/doi/full/10....

I feel like whoever named the kinase that phosphorylates MAP kinase "MAP kinase kinase" and the kinase that phosphorylates that one "MAP kinase kinase kinase" would be a really interesting person to speak with

Let me be very clear. It is not enough that RFK Jr. was forced to admit today that no causal relationship between Tylenol and autism has been shown. We know that while disinformation spreads like wildfire on social media, corrections most often die on the vine.

this figure would be such a good inclusion for an introduction to immunology

Updated peer-reviewed evidence supports the safety and effectiveness of immunizations against Covid-19, RSV, and influenza during the 2025–2026 season @nejm.org @jakescottmd.bsky.social @stanforddeptmed.bsky.social www.nejm.org/doi/full/10....

The MAHA plan was ALWAYS intended to undermine vaccines. - Rolling back access - Seeding doubt on vaccine effectiveness - Pushing false narratives about vaccine harms - Crippling the infrastructure for vaccine approval and guidelines www.theguardian.com/us-news/2025...

Review @natrevcancer.nature.com @stjuderesearch.bsky.social Epigenetic regulation of T cell exhaustion in cancer www.nature.com/articles/s41...

NEW: The entire staff supporting ACIP was laid off, and most working groups haven't met in months. That means the US may not make routine vaccine recommendations for more than half of children in 2026, and it could halt new vaccines in the pipeline. My latest: www.theguardian.com/us-news/2025...

credible modeling from impactcounter.com shows that trump and musk have killed nearly 600,000 people with their illegal cuts to date. nearly 400,000 of them were children.

Sorry to sound like a stuck record, but this is yet another reason why I believe that the physicians who are working for MAGA & MAHA—like Drs Oz, Makary, Bhattacharya, & Prasad—& the physician organizations who are collaborating with Team Trump are complicit in causing pain, harm, suffering & death

"Blindly defending?" They literally review it it, regularly and publicly, with the data freely available for anyone to see. Or at least they did before RFKJr blew up the process. It was the opposite of blind.

Okay so as promised... let's go through this paper and why it matters 🧵 #medsky #immunosky #idsky

Try to find a moment of bliss in the cheese aisle, and the universe just slaps you right back down.

A short history of children's hospitals in case anyone you know thinks like Rob Schneider: open.substack.com/pub/epiellie...

12% of Americans will lose access to food resources when SNAP benefits expire in 8 days

I'd like to highlight this passage in particular, since the New ACIP loves to pat themselves on the back for their supposed radical transparency and excuse their extremist, unscientific anti-vax views as academic dissent. THIS is academic dissent: opposition to quackery

Hot off the press at Vaccine, the former (competent) ACIP used a standardized tool for evaluating vaccine advisory committee performance to deliver a solid evidence-based ass-whupping on the quacks that RFK, Jr replaced them with. I'll briefly explain why 🧵 www.sciencedirect.com/science/arti...

It's hard to overstate how grievous a mistake this is for any state that cares about the health of its people.

I want to hear from all the people who said RFK Jr. has good ideas on nutrition

Is anyone aware of any clinical trials looking at intravenous BCG for pulmonary tuberculosis? I did a cursory skim and didn't find anything, but figured I'd ask #idsky #immunosky #episky

Public health is under attack by a deluge of misinformation. We offer a consensus report from the American Psychological Association summarizing what we know & what interventions are effective in countering it. We provide 8 concrete recommendations. Open-access - awspntest.apa.org/fulltext/202...

Oh, to have a functioning NIH, labs around the country studying...we'd have more of this! 👇 #fundscience

I will try to do a tweetorial about this paper when I have more energy but this is really important data. It looks (tentatively, preliminarily) that COVID-19 mRNA vaccines might significantly enhance the effectiveness of cancer immunotherapy (subject to many caveats).

"I'll just research it using AI" is something I see a fair bit today. But AI just isn't there yet. You *must* check what it tells you. Which takes time & effort. In the mean time, reading source material, asking questions, listening to experts & being able to adjust your thinking remain essential

Unfortunately, not surprising. Preventing herpesvirus *infections* is a very high bar in general, and cytomegalovirus immunity is particularly complicated even relative to other herpesviruses. That said, I do think mRNA approaches could be advantageous for other herpesviruses.

I am so tired of hearing the opinions on the origins of COVID-19 from people who have literally no germane expertise to opine on it. The authors claim not to have a strong opinion. Fine, but it’s clear that they favor lab leak over spillover and their focus on lab leakers as the real victims…