Among CYP2D6 normal metabolizers after joint arthroplasty, hydrocodone yielded lower pain scores and significantly reduced opioid use compared with oxycodone, with no difference in function or mood outcomes. ja.ma/4bKdpqu

In pembrolizumab-treated advanced #CervicalCancer, cisplatin and carboplatin provided equivalent survival. Bevacizumab addition improved early overall survival but the benefit decreased over time. #Oncology ja.ma/44t10n4

Longer diagnosis-to-ablation time was associated with higher recurrence risk after ablation for atrial fibrillation; patients ablated ≥5 years post-diagnosis had double the 1-year recurrence risk vs those treated <1 year. #AFib #Cardiology ja.ma/4fooM8P

In randomized trials, text message outreach and small financial incentives increased enrollment of Black and Hispanic patients in a clinical biobank, but message source or framing did not. ja.ma/4wCRutm

In a Swedish screening pilot, women with lower socioeconomic status were less likely to participate in risk-selection, despite being at higher risk and more likely to be eligible for LDCT. ja.ma/4wa2zCy

Among patients hospitalized for acute #HeartFailure, advanced medical care at home yielded 30- and 60-day readmission, mortality, and therapy utilization rates comparable to brick-and-mortar care. Safety and quality were similar in both groups. ja.ma/3RBx3OM

Among US adults, higher digital health engagement—including clinician messaging and app use—was associated with higher psychological distress. Active engagement may reflect distress as well as patient activation. ja.ma/3RfJgbO

Among patients with advanced #HNSCC in early-phase trials, modest responses were seen with novel immunotherapies, with higher benefit for bispecific antibodies and lower benefit in tumors with PIK3CA or TP53 alterations. ja.ma/4w6tPlp

Multiple, intersecting WEF insecurities and their intermediates contribute to diverse health burdens in South Africa. Integrated approaches are required to address these overlapping risks. #PlanetaryHealth ja.ma/4poVRGg

Qualitative findings: Street-based HCV care improved health engagement among adults experiencing unsheltered homelessness. Strong relationships and tailored support helped overcome barriers to cure. #HepatitisC ja.ma/44t1k5g

Menopause forums highlight psychosocial and cognitive concerns far more often than EHR notes, which focus on vasomotor symptoms and treatments. Blending data sources could strengthen patient-centered care. ja.ma/4gGxf9M

RCT: In older adults at risk for cognitive decline, multidomain lifestyle intervention slowed MRI free water increase—a key early white matter injury marker—in those <70 years, with no effect in older participants. #Neuroimaging #Dementia ja.ma/4pobKwp

Combining implementation science and informatics infrastructure supported scalable and equitable delivery of genomic screening for CDC Tier 1 conditions. #PublicHealth #GeneticScreening ja.ma/44t0CoC

Among youth with #SickleCellDisease, stronger problem-focused coping and social support were independently associated with higher transition readiness for adult care. #hematology ja.ma/4aUqMEi

Tenecteplase was associated with shorter door-to-needle and door-in-door-out times than alteplase in acute ischemic stroke, supporting workflow efficiency in thrombolytic care. #Stroke #Neurology ja.ma/4gGx5PI

Continuation of #SSRI treatment during pregnancy was associated with transient neonatal adaptation symptoms but not with major anomalies or severe complications, compared with discontinuation. ja.ma/3RBwa8U

Annual vision screening rates were high, but American Indian or Alaska Native children had higher prevalence of amblyopia, astigmatism, hyperopia, and myopia, despite similar screening. #Pediatrics #VisionHealth ja.ma/4ytXeaQ

Social gatherings for grandchildren’s birthdays were associated with a nearly 10% increased hazard of #SARS-CoV-2 infection in grandparents during the #COVID-19 pandemic, especially after preschool-aged children's birthdays. ja.ma/4pqlu9C

Medically assisted reproduction was associated with small increases in hormone-related #cancer risk, but most excess risk could be explained by detection bias and unmeasured confounding. ja.ma/4gCtl1z

Plasma p-tau217 concentration was not associated with chronic traumatic encephalopathy, but reliably indicated beta-amyloid pathology and could help rule out #Alzheimer disease in at-risk individuals. ja.ma/3RdIImO

Among patients with #mCRPC, 43% did not receive bone-modifying agents, with use declining in recent years despite guideline recommendations. #Oncology ja.ma/3QOUMLb

About 19% of patients opted for home cervical cancer screening; 54% of those returned a sample. Participation was higher in older, White, and previously screened individuals. #CancerScreening ja.ma/4f7rnUq

Single-dose #psilocybin produced a rapid, sustained #antidepressant effect for more than 3 months in adults with #majordepressivedisorder vs placebo. 📖 Catch more details: ja.ma/4eVWkw7

Following policy changes, more #cancer patients learned of their #diagnosis via the portal, but three-quarters preferred #clinician-led communication, highlighting needs for flexible result release options. #Oncology ja.ma/4vTcT1D

Approximately 7.6% of suicide-related studies registered on ja.ma/4eVJtKj have been discontinued, a rate at the lower end of previously reported #disease-agnostic discontinuation estimates. ja.ma/4eWKTUU

#LLM-based note summarization in the emergency department did not significantly reduce #medical record review time, but most #physicians found it helpful and easy to use. #AI ja.ma/3RqyUG5

#Uninsured rates declined and #Medicaid coverage increased for US adults with #vision impairment, but their out-of-pocket spending ≥10% of income remained more than double that of those without VI in 2024. ja.ma/3R6WN5q

In a cohort study of nearly 3 million patients across 809 clinics, social risk indices calculated at the patient block group or tract were poorly correlated with indices using county or 3-digit ZCTA data. ja.ma/4pyT7Gx

#HPV-related #cancer risk in immunosuppressed groups varies by site, #immune status, organ type, and sociodemographic factors, underscoring the need for targeted prevention and management. #HIV ja.ma/4pyT5hT

Low-barrier clinic delivery of long-acting #injectable ART achieved 100% viral suppression in patients with #HIV experiencing homelessness, with high retention using a flexible outreach model. ja.ma/4vmQ4Cs

Analysis of national prescription claims from 2022 to 2024 found that LAI-CAB comprised a small fraction of US #PrEP use, accounting for 3% of users nationwide. ja.ma/4yhWgOJ

Among patients with #mCRPC, only 54% received second-line and 26% received third-line therapy. ARPIs dominated early lines; taxanes and Lu-177 use increased in later lines. #ProstateCancer ja.ma/3R6WBTK

Sex-specific optimal #hemoglobin curves in children diverged from World Health Organization #anemia thresholds, with curve-based lower limits often below current cutoffs, especially at younger ages. #Pediatrics ja.ma/4vXpMYn

RCT: Reusable #catheters were noninferior to single-use catheters for #UTIs, with similar safety but higher irritation and discontinuation rates. Patient preference and design improvements remain important. ja.ma/3TdCioa

Six ED #LLMs showed similar discrimination but different sensitivity and specificity for missed #diagnosis screening, underscoring the need for cohort-specific calibration in #clinical workflows. #AI #EmergencyMedicine ja.ma/44Yv6yS

Comprehensive #smoke-free laws were associated with sustained reductions in #cardiovascular mortality, particularly among older adults, male individuals, and non-Hispanic White populations. ja.ma/4ftLhKx

RCT: Among patients with AF-mediated #cardiomyopathy and normalized function after #ablation, phased #GDMT withdrawal led to heart failure deterioration in 13%, while drug adverse events were more common with continuation. ja.ma/4ygxcaW

Only 24% of individuals with hereditary #cancer variants had a family member pursue cascade #genetic testing, with lower uptake especially among racial and ethnic minority groups regardless of cost. ja.ma/4aHC9zu

Increasing severity of chronic kidney disease was associated with progressively higher ICU and 90-day mortality, greater risk of kidney replacement therapy, and longer hospital stays after ICU admission. ja.ma/44Xkwbq

Cost-growth benchmark programs were associated with a 2% reduction in per capita health care spending growth, driven by lower hospital and skilled nursing facility expenditures. ja.ma/4pi7FKv

Among older adults, high #diet quality—especially lower inflammatory diets—was associated with less #dementia risk, even for those with elevated #Alzheimer disease #biomarkers. ja.ma/44oji92

In a secondary analysis of the BALANCE randomized clinical trial, 7 days of antibiotics was not associated with increased mortality compared to 14 days among patients with uncomplicated bloodstream infection. ja.ma/4vTJNiz

Higher numbers of #nutrition security barriers were associated with greater risk of #cardiometabolic disease even among adults classified as nutrition secure, supporting tailored preventive approaches. ja.ma/4pfxmuR

The 2025-2026 #COVID19 vaccine was 50% effective against COVID-19-related ED/UC encounters and 55% effective against hospitalization in US adults, compared to no 2025-2026 vaccine. ja.ma/4wAxrMf

Cost-growth benchmark programs were associated with a 2% reduction in per capita #health care spending growth, driven by lower #hospital and skilled #nursing facility expenditures. ja.ma/4h7fLmX

Following the introduction of #respiratory #biologics in 2015, adults with #asthma experienced sustained population-level reductions in exacerbation events, especially those with severe #disease or elevated #eosinophils. ja.ma/4f9rMpw

Direct digital referrals and RDN #telehealth support increased #WIC program engagement in #pregnancy, supporting scalable EHR-integrated approaches for #nutrition support. ja.ma/4vX8oDb

Nearly 73% of infants discharged after #congenital #diaphragmatic #hernia repair were readmitted within 3 years, commonly for respiratory, gastrointestinal, and surgical complications. ja.ma/4w8YNco

Breast #cancer incidence rates have increased by >3% per year in nearly all Asian American, Native Hawaiian, and Pacific Islander groups, especially among #women <50 years and for aggressive subtypes. #BreastCancer ja.ma/3R6Wfwo

Only 3.8% of recommendations in recent US #clinical practice guidelines contained upfront economic or resource use statements, and 22.5% discussed cost or resource evidence. ja.ma/4eU4GEq