A new study of Medicaid & ACA formularies out in @jamanetworkopen.com finds substantial variation in utilization management requirements for antiemetics across insurance type & state as well as drug type, use & class ft @michaelannica.bsky.social @pennmehp.bsky.social jamanetwork.com/journals/jam...

Our new paper published in JAMA Network Open analyzes 15 years of U.S. sales data for oral tobacco and nicotine products. Check it out here: ja.ma/3Lgtlqg

Proud to coauthor this with my amazing friend and colleague, Dr. Tsion Firew. All over Africa, quick fixes can save lives, but real progress in emergency care needs full systems—training, diagnostics, and sustainable funding. Available at @jamanetworkopen.com. jamanetwork.com/journals/jam...

If I could go back in time 25 years, I’d have applied for this fellowship. Incredible mentorship and experience. @jamanetworkopen.com has a similar fellowship with applications opening soon.

💥In our new study published @jamanetworkopen.com, we found that cold is responsible for a substantially larger number of annual deaths, while the death toll from heat exposure rose sharply by 53% from 2000-2009 to 2010-2020, underscoring a growing threat in a warming climate.

🧵 JAMA, @jamainternalmed.com, and @jamanetworkopen.com conclude #KidneyWk with impactful findings: In stable AKI patients, indication-based dialysis enabled faster liberation from dialysis and reduced health care resource use compared to conventional thrice-weekly treatment. ja.ma/4nIK3Mo

Participant interviews from the Navigate-Kidney trial show that community health workers helped Latino patients manage complex health and social challenges tied to #dialysis care. #KidneyWk @asnkidney.bsky.social ja.ma/47so6wo

Of 950 FDA-cleared AI/ML-enabled medical devices since 1995, 76% were for radiology, with few undergoing prospective or clinical testing, and only 8% including a human-in-the-loop component. ja.ma/4hLirF4

In this national survey, 13.1% of US adolescents and young adults reported using generative #AI for mental health advice, with rates highest (22.2%) among those aged 18–21 years. ja.ma/3JJHEDd

Participants who identified as Asian, held a graduate degree, or were retired had higher odds of meeting American Cancer Society Guideline Scores for diet, physical activity, alcohol, and BMI, compared with other groups. ja.ma/3WMOtaa

Among women with prior gestational diabetes, higher adherence to the Planetary Health Diet was associated with lower risk of type 2 #diabetes and CV disease, and less weight gain. ja.ma/3LtqDxN

In this case series of over 54 million US deaths, both low and high temperatures were associated with increased mortality, with annual deaths from low temperatures estimated at 45,992 and from high temperatures at 3,414. ja.ma/47LujCm

RCT: Low-molecular-weight heparin plus insulin did not reduce the incidence of new-onset organ failure and/or mortality compared to insulin alone in patients with hypertriglyceridemic #pancreatitis. ja.ma/4osG4Vp

Nonopioid therapy for pain after third molar surgery provided superior pain control compared with opioid therapy during the first postoperative day for both males and females. ja.ma/4nEeN0Y

Fewer than 1 in 10 European Medicines Agency approvals from 2020 to 2023 incorporated real-world evidence, indicating its limited role in initial marketing authorization. ja.ma/3XcyYID

Among first-time US mothers, 1 in 27 used shared human milk, with no major demographic differences, and not linked to reduced formula feeding. ja.ma/4nGC9Do

In this economic evaluation across 12 countries, screening for MASH in adults with type 2 #diabetes followed by intensive lifestyle interventions was found to be cost-effective in all settings. ja.ma/3WJjpIn

Cord blood appetite hormone levels may influence early childhood growth and body composition trajectory, providing evidence for developmental origins of #obesity. ja.ma/49DxuyC

In patients with spontaneous #CervicalArteryDissection, the presence of fibromuscular dysplasia was associated with distinct correlates and a 2.75x higher rate of recurrent dissection. ja.ma/3LnLjqZ

In patients treated with molecularly targeted cancer medications, CDK4/6, EGFR, VEGFR & BRAF inhibitors were linked to higher rates of progressive kidney dysfunction vs controls. ja.ma/3WDFiJd

A cross-sectional survey in British Columbia, Canada, found 99% of reproductive-aged females lived within a 15-minute drive of a mifepristone-dispensing pharmacy, though 23% of pharmacies neither dispensed within 3 days nor provided a valid referral. ja.ma/3Li75MS

#MachineLearning models using self-report data predicted response to internet CBT for depression and generalized to antidepressant patients, but showed treatment-specificity only after retraining on patients receiving exclusively a single treatment. ja.ma/47VfPRL

In high-risk soft-tissue sarcoma, histopathological analysis after neoadjuvant chemotherapy showed that sclerohyalinosis >20% was associated with improved disease-free survival. ja.ma/3XbXj1h

In this randomized clinical trial of patients with acute peripheral vertigo, combination therapy provided better symptom relief than diphenhydramine alone. ja.ma/4nFmLaa

Daraja case management intervention for HIV care in Tanzania was more costly and also associated with improvements in disability-adjusted life-years, demonstrating cost-effective across various threshold estimates. ja.ma/4oZKzHb

Midlife hearing loss was associated with smaller brain volumes, accelerated worsening in executive function, and an increased risk of dementia, suggesting that it may be an early marker of brain aging and dementia risk. ja.ma/3Lh9veH

The frequency with which parents spoke to their children about sex and sexual health was associated with teens’ self-efficacy to seek sexual health information and services, as long as parents were informed and comfortable talking about these topics. ja.ma/3JywDos

Gestational diabetes and separate exposure to sub-clinical hyperglycemia during pregnancy were associated with increased risk of neurodevelopmental disorders in both a gestational timing- and sex-specific manner. ja.ma/4ouAmCA

In this survey of hospice-eligible patients with blood cancers, transfusion access had the highest importance compared to routine hospice services, highlighting the need for novel hospice models with access to palliative transfusions. ja.ma/3WHqdGt

In this cohort study, the 2013 change in neuroendocrine neoplasms classification had a prominent role in early-onset colorectal cancer incidence patterns. ja.ma/494st1Y

In this meta-analysis of RCTs, no molecular subgroup demonstrated a statistically significant OS benefit with first-line PARP inhibitor maintenance therapy in epithelial ovarian cancer and progression-free survival benefit may vary. ja.ma/4oiq5t4

RCT: In Black veterans with hypertension, enhanced texting intervention with video storytellers and narrative messages did not improve blood pressure compared with bidirectional text messaging alone. ja.ma/3WFTu4q

From 2016 to 2023, facility-based colorectal cancer screening in adults aged 45 to 49 rose nearly tenfold after the USPSTF lowered the screening age to 45, far outpacing growth in ages 50 to 75. ja.ma/47KRTPX

A large proportion of men with prostate had undergone PSA testing during the 5 years before diagnosis, including those with late-stage prostate cancer at diagnosis, finds this cohort study. ja.ma/4oMjjM6

Analysis of nationally representative data found persistent higher mean SBP among non-Hispanic Black adults compared to White adults, regardless of medication use. ja.ma/4qYjYfo

In a nationally representative survey, people with serious illness and those who were worried about serious illness were significantly more likely than those without to have discussed ACP with people close to them and clinicians. ja.ma/47Lm6hK

US veterans with metastatic hormone-sensitive prostate cancer receiving abiraterone and enzalutamide had similar estimated rates of tumor growth and overall survival, even after adjustment for confounders. ja.ma/4oXjF2D

D-dimer testing safely and efficiently ruled out pulmonary embolism in pregnant patients, enabling most to avoid advanced imaging; expanded use across all settings and trimesters may further reduce unnecessary imaging, costs, and risks. ja.ma/4oTtX3t

Traumatic spinal cord injury is associated with increased long-term risk of heart disease, endocrine and neuro/psychiatric disorders, underscoring the need for multidisciplinary care strategies. ja.ma/43SXIJE

Systematic review and meta-analysis: Outpatient follow-up within 30 days was associated with reduced 30-day readmissions, but the association varied by patient age and disease type. ja.ma/47p8vO7

Cladribine was associated with superior effectiveness in reducing disability progression over 25 months, likely due to reduced PIRA, despite comparable short-term NEDA-3 outcomes. ja.ma/47nNZ0n

While high school student current vaping declined from 2020-2024, daily use among vapers increased from 15% to 29%, and unsuccessful quit attempts increased from 28% to 53%, suggesting youth who vape is hardening. ja.ma/492cDF6

For premenopausal women with HR+ early-stage breast cancer, the BCI H/I was not predictive for incremental benefit of exemestane vs tamoxifen, but may support personalized adjuvant endocrine therapy selection for some patients. ja.ma/47BjnHt

In this study validating delirium risk stratification for ED patients ≥65 years old, the REDEEM and MDP tools accurately identified patients at high-risk for delirium, potentially improving ED delirium detection rates. ja.ma/3WEWNZx

In a nonrandomized clinical trial children with lymphatic malformations, the traditional Japanese (Kampo) herbal medicine eppikajyutsuto was associated with a ≥20% lesion volume reduction in 10 of 19 patients, with no serious adverse events. ja.ma/4nC3Flp

More than $7.5 million was spent on #Ozempic-related PPC ads targeting 15,000+ keywords, often including non–FDA-approved uses and competitor drugs. PPC ads led to 2.4 million website visits. ja.ma/47R31f5

This cross-sectional analysis of 90 million US individuals found that #tirzepatide and #semaglutide prescriptions grew fastest, but coverage gaps remain for people with obesity only—many of whom are not covered under Medicare. ja.ma/4hKX4UA

Although women made up the majority of board-certified academic pediatric neurologists between 2006 and 2020, men had more publications, higher h-index values, and greater likelihood of senior academic rank. ja.ma/3JF3Caz

Promotion delays in academic pediatrics cost physicians up to $3 million in lost earnings and widen pay gaps, highlighting the need for fair, timely advancement for a sustainable pediatric workforce. ja.ma/4nvdscM

In this 37-year study of women with #PCOS, those with polycystic ovarian morphology had a higher risk of type 2 diabetes, but no increase in mortality or other chronic diseases. ja.ma/4qCNuHa