Updated #Asthma diagnostic criteria from the Global Initiative for Asthma increased sensitivity by removing airflow limitation and including type 2 inflammatory biomarkers, but reduced specificity, raising overdiagnosis concerns. ja.ma/3RHILHf

Rates of hepatocellular carcinoma #Surveillance among patients with #Cirrhosis in US safety-net health systems declined after the COVID-19 pandemic and remained persistently low through early 2024. ja.ma/4tTIEpz

Among patients receiving #ImmuneCheckpointInhibitors, systemic glucocorticoid immunosuppression near initiation, at higher doses, and longer durations was associated with shorter overall survival, regardless of indication. ja.ma/4fIpNdo

Newborns with antenatal #Opioid exposure had reduced cerebral cortical sulcal depth and surface area, with greater reductions among those exposed to methadone or polysubstances, suggesting altered neonatal cortical folding. ja.ma/4v2mke6

Persons with #HIV had to travel farther to access #CAR-T clinical trials for #NonHodgkinLymphoma compared with the general population, with the greatest disparities in the South where HIV prevalence is highest. ja.ma/4f2vSBp

Meta-analysis indicates environmental exposure to #Arsenic, #Cadmium, and #Vanadium is associated with increased #UrologicCancer risk, while evidence for other nonessential elements and low-level exposures remains limited and heterogeneous. ja.ma/4wLIQtE

An FDA boxed warning for #Montelukast in 2020 was associated with decreased prescription rates for patients with #Asthma, a reduction observed across all age and severity groups in a national insurance cohort. ja.ma/4tToj3F

In a randomized trial, #Email recruitment increased research participant engagement more than patient portal messaging; message content (altruistic vs individualistic) had no significant overall effect. ja.ma/3Rp5eJ6

In simulated pediatric in-hospital #CardiacArrest, augmented reality decision support improved adherence to #PALS epinephrine dosing intervals, but did not shorten time to first epinephrine or affect other key performance metrics. ja.ma/4vpCCyf

The CMS payment reclassification modestly increased inpatient documentation of #homelessness, with accelerated coding for housing and other health-related social needs among Medicare beneficiaries. ja.ma/4wM2zta

In patients with #OvarianCancer, mirvetuximab soravtansine exposure was linked to higher odds of cataract surgery compared with age-matched controls, highlighting long-term ocular safety considerations. ja.ma/4u1LR6E

#EmergencyDepartment LWBS rates in California rose during the pandemic and remained highest at urban, government, and safety net hospitals, indicating persistent disparities in acute care access. ja.ma/4tW8itR

Among adults with newly identified #HFrEF, most did not undergo LVEF reassessment and GDMT use at 12 months was modest, even for those with persistent reduced ejection fraction or improved LVEF. ja.ma/4v4Ssy2

Few patients with advanced #RenalCellCarcinoma discontinued first-line axitinib-pembrolizumab due to adverse events, indicating improved AE management and prioritization of efficacy and safety. ja.ma/4uDsilS

Among very preterm newborns, prolonged #phototherapy was not associated with increased neonatal mortality, though longer exposure was linked to higher rates of severe morbidity. ja.ma/49hDPPq

Pediatric primary care visits for #MentalHealth diagnoses increased in Massachusetts from 2014 to 2023, especially for #Anxiety, while overall visit rates declined. ja.ma/4djeHKw

#Leucovorin prescriptions rose over 24-fold among US children with #Autism Spectrum Disorder after prominent media and political announcements, despite lack of large-scale efficacy data. ja.ma/3PfQBY1

This prospective observational study of breastfeeding problems finds no associations between distinct maxillary frenulum (upper-lip tie) findings and mother-reported breastfeeding problems. ja.ma/4dUebCN

Pharmacist-led outreach for patients with #Diabetes and #ChronicKidneyDisease was associated with doubled #SGLT2 inhibitor initiation vs usual care, but did not impact short-term clinical outcomes. ja.ma/49YgF0A

Among adolescents w/ major depressive disorder + suicidal ideation, dual-site accelerated intermittent theta burst stimulation targeting the prefrontal cortex and cerebellum was more effective for reducing suicidal ideation than single-site stimulation. ja.ma/4a28f8u

Among patients with HPV-positive #OropharyngealCancer, de-escalated adjuvant radiation therapy provided similar 2-year progression-free and overall survival on and off protocol, especially for intermediate-risk disease. ja.ma/42HVOLf

States with less alignment between trauma center designation criteria and #ACS-COT standards experienced greater expansion of for-profit #TraumaCenters, but this was not seen for nonprofit centers. ja.ma/4eTxb5v

High-dose vitamin D3 during pregnancy was associated with modestly better verbal and visual memory at age 10 vs standard dose, but no overall difference in intelligence or most other cognitive domains. ja.ma/4dTfceq

#Antibiotics did not reduce pain or disability compared with placebo at 12 months for chronic #LowBackPain with disc herniation, including in patients with Modic changes. ja.ma/4v0sbk7

A recall-based community immunization strategy using nirsevimab was associated with a 45% to 48% lower risk of all-cause bronchiolitis among infants, with greatest effectiveness found in those aged 2 to 3 months. ja.ma/4wLXiSw

Homelessness was associated with lower antiretroviral therapy use among men who have sex with men living with #HIV, but this association was not present in states with higher per-person HOPWA funding. ja.ma/3PF92Fo

In this cross-sectional study of Medicare beneficiaries with diabetic lower-extremity (DLE) wounds, beyond social determinants of health, higher podiatrist supply was associated with fewer amputations. ja.ma/436ASOh

Achievable benchmarks of care for pediatric emergency departments demonstrated wide variation in vital sign documentation, pain reduction, and asthma management, with throughput metrics worsening over time across sites. ja.ma/4wO66av

Both the Canadian Syncope Risk Score and FAINT score identified emergency department patients at low risk for serious outcomes, with FAINT showing higher sensitivity than physicians for serious cardiac outcomes. ja.ma/3RBswLL

Among children with acute respiratory failure, an opioid- and benzodiazepine-only sedation strategy was associated with lower estimated IQ vs regimens that included dexmedetomidine, after controlling for confounders. ja.ma/3RcLQiu

Older adults with less favorable long-term memory trajectories spent less time in light physical activity and more time sedentary, suggesting cognitive decline may influence later-life activity patterns. ja.ma/4eZgrK6

Among adults who smoked daily, switching from cigarettes to a pod-based 5% nicotine EC was associated with reduced exposure to respiratory toxicants and increased smoking abstinence compared with a non-nicotine EC. ja.ma/49UCpuf

Most US state and federal health care committees had majority male membership, with female legislators less likely to serve on state-level health committees and some federal committees having no female members, finds this study. ja.ma/4nDn9ro

Among Aboriginal adults, #MentalHealth care pathways were fragmented, with Aboriginal mental health workers serving central, culturally important roles, but their presence during crises was inconsistent. ja.ma/49gFuoq

For #LungCancer, county-level structural racism indices were associated with larger disparities in early diagnosis and 2-year survival for Black vs White patients, with higher structural racism linked to lower survival among Black patients. ja.ma/42QBvey

In the Veterans Health Administration, 2021–2024, positive screening rates rose for depression and #PTSD, while rates for suicide risk and alcohol use disorder declined, with younger patients and those facing access barriers at higher risk. ja.ma/4wHIowr

Among patients with low-risk pancreatic cystic lesions, long-term pancreatic cancer risk was higher than the general population, with approximately one-quarter of cancers developing more than five years after cyst detection. ja.ma/4uzfo8s

Among patients with #MultipleSclerosis, live attenuated measles-mumps-rubella or varicella vaccination was not associated with increased risk of relapse, supporting current recommendations for vaccination before immunosuppressive therapy. ja.ma/42LG21S

Low-insulinemic and planetary health dietary patterns, lower in red and processed meats and higher in nuts, legumes, fruits, and whole grains, were associated with less weight gain and decreased obesity risk during menopause. ja.ma/4tXuLqw

In pediatric #EmergencyCare, higher hospital pediatric capability was associated with lower imaging rates but did not reduce differences in imaging by insurance or race, indicating continued gaps in quality and equity of radiology use. ja.ma/4dC5ifZ

In patients with #ParkinsonDisease and depression, ultra-brief intermittent theta-burst stimulation matched standard high-frequency rTMS in reducing depressive symptoms, suggesting a time-efficient and effective option for clinical management. ja.ma/4unzcM2

From 2017 to 2023, #PrEP prescribing rates among Black and Hispanic/Latino populations remained low relative to HIV incidence, despite modest increases and EHR-based monitoring efforts. ja.ma/3Ri5lGg

Medical learners supported restorative practices to address #MedicalRacism but identified concerns in preparation, personal and professional risk, and goal setting for implementation in healthcare settings. ja.ma/4nShLRD

Stool withholding was reported by 51.2% of primary and 71.4% of high school students in the Netherlands, primarily due to hygiene and privacy concerns. Improving school toilet facilities may reduce gastrointestinal symptoms and related physician visits. ja.ma/49QJ8p2

The 2020 California #MediCal expansion for noncitizens aged 19-25 was associated with significant increases in Medicaid and overall coverage, without reductions in private insurance coverage. ja.ma/4uLhVfI

Rural counties had stable or increased #LiverCancer (#HCC) incidence and mortality rates from 2001 to 2022, while urban counties experienced decreases, highlighting persistent rural-urban disparities. ja.ma/4nvw0ve

Among older adults with #dementia, residence in a Home Health Value-Based Purchasing state was associated with more therapy visits, fewer nursing visits, and smaller differences in home health service patterns by race, ethnicity, and dual eligibility. ja.ma/3RtJI5Q

In a diverse US primary care cohort, minoritized racial and ethnic groups had higher odds of screening but lower odds of receiving medications for #AlcoholUseDisorder or #OpioidUseDisorder compared with non-Hispanic White patients. ja.ma/4frsEHD

In US military families, first child maltreatment episodes were more likely in families with female or never-deployed service members, young parents, and larger family size, with risk highest in early childhood. ja.ma/4uTHfAc

This study using Japan’s Child Death Review data and forensic autopsies finds sudden unexpected infant deaths (SUIDs) finds SUIDs may be 3x higher than indicated by death certificates. ja.ma/4eQPRTx