New Article! iMUT-seq mapping of DSB-induced mutations with high sensitivity at single-nucleotide resolution

New Article! An assay to quantify sexual commitment and stage conversion in the human malaria parasite Plasmodium falciparum

Tired of "methods sections" lacking detail? Check out our new preprint: "Ten simple rules for writing a reusable step-by-step protocol" 📢 This is not only for lab work. Detailed protocols are essential for reproducibility across ALL research fields 🔗 osf.io/preprints/me...

New Article! High-throughput measurements of protein domain functions using magnetic separation

New Article! Inducing physiological polarity and performing gene editing using CRISPR–Cas9 in human trophoblast organoids

New Article! Photocatalytic low-temperature defluorination of PTFE

New Article! Yeast nuclei–mediated precise delivery of synthetic megabase-scale human DNA into mammalian embryos

New Article! Facilitating structure-based drug discovery with an artificial intelligence-driven virtual screening platform

New Article! Multimodal imaging and quantification of lanthanide chelate-labeled micro- and nanoplastics in plants

Check out our new Blog post, an interview with molecular biologist Dr. Steven Henikoff on the shaping of open science practices springernature.com/gp/researche...

New Article! Direct inoculation of bioreactor-controlled stirred suspension culture with cryopreserved human pluripotent stem cells

New Article! Whole-organ spatial transcriptional analysis at cellular resolution using TRISCO

New Article! Solid-phase synthesis of sterically hindered peptides via ribosome-mimicking molecular reactors

New Article! High-resolution single-cell sequencing of trans-spliced mRNA

New Article! An immunocompetent bone marrow-on-a-chip model for studying human hematological malignancies and preclinical therapeutic screening

New Article! Robust analytical methods for bis(monoacylglycero)phosphate profiling in health and disease

New Article! Three-dimensional direct neuronal reprogramming for modeling Alzheimer’s disease neuropathology

“My interest isn't really open science; it's high-quality, rigorous science..often that happens to be open.” Sense from @casey.greenelab.com that aligns with how serious scientists see research and the idea it should be "open as possible, closed as necessary" www.springernature.com/gp/researche...

New Article! Concurrent positional dynamics and activity mapping of DNA-binding proteins

New Article! On-resin assembly of cysteine-reactive linkers for controlled site-selective antibody bioconjugation

New Article! Structural variant calling using Sniffles2

We are 20!! A Milestone Birthday for Nature Protocols this month, which you can read about in our Editorial www.nature.com/articles/s41..., as well as hearing all about what our Authors think on our new Testimonials page www.nature.com/nprot/testim...!

New Article! Label-free interferometry platform for drug response profiling of bioprinted tumor organoids at single-organoid resolution

Happy 20th birthday, Nature Protocols! @natprot.nature.com Reading your editorial and author testimonials this morning is a great reminder of how a few kind words really can make such a difference. What a joy to read! www.nature.com/articles/s41... www.nature.com/nprot/testim...

New Article! Celebrating 20 years of Nature Protocols

New Article! Nonexhaustive microextraction as a step toward more sustainable chemical analysis in the field and the clinic

New Article! A generic, rapid and robust platform for personalized functional circuit-guided neuromodulation targeting

New Article! Synthesis and guest inclusion for molecular catcher-based structure determination

New Article! Targeted single-cell RNA and perturbation sequencing with TAP-seq

New Article! Chiral multimodal nanoprobes for sensing of biomarkers

New Article! SMAIS: a universal platform for the on-water surface synthesis of two-dimensional polymer crystals

New Article! Addendum: Detection of colinear blocks and synteny and evolutionary analyses based on utilization of MCScanX

New Article! Flexible high-resolution ECM micropatterning

New Article! Fabrication of focused electron beam induced deposition tips for high-speed atomic force microscopy using benchtop scanning electron microscopy

New Article! Quality assessment and control of unprocessed anatomical, functional and diffusion MRI of the human brain using MRIQC

New Article! Implementation of an adaptive-optics assisted isoSTED nanoscope

New Article! Fabrication of optically transparent ultrasound transducers to integrate light and sound in multimodal biomedical systems

New Article! A modular method for high-throughput measurement of ion channel currents in cardiac myocytes

New Article! Receptor discovery for nanomaterial soft and hard coronas via a biosensor-based Fishing strategy

New Article! Site-specific protein and peptide modification by redeploying an asparaginyl ligase for noncanonical reactions

Entries are now open for Nature’s 2026 #ScientistAtWork photo competition! Winners will receive a cash prize and have their images featured in Nature. Learn more: go.nature.com/48s7C7w See last year's winners in the quoted thread. #SciArt #Academicsky 🧪

New Article! Profiling large-scale protein occupancy on bacterial genomes using IPOD-HR

New Article! Preparation of C4′-modified nucleoside analogs

New Article! Whole-mouse immunolabeling at cellular resolution for comprehensive 3D atlases

New Article! Morphology-coupled formation and reversible gating of membrane channels in synthetic cells using reconfigurable DNA nanorafts

New Article! Discovery of candidate therapeutic targets with Geneformer

New Article! Differential protein expression analysis of quantitative mass spectrometry data using DEqMS

New Article! Peptide-centric local stability assay (PELSA) for sensitive identification of ligand-targeting proteins and binding sites at proteome scale

Rewiring an E3 #ligase enhances #cold resilience and #phosphate use in #maize www.nature.com/articles/s41... #PlantScience #PlantSci #SciComm @nature.com @natprot.nature.com @natplants.nature.com @planttreaty.bsky.social @plantoscope.bsky.social @plantevoeco.bsky.social @healthycrops.bsky.social

Check out this new @natprot.nature.com study! Dr. Chiara Lago and scientists at the University of Trento have enabled robust generation and drug testing of patient-derived pediatric brain tumor organoids. 📄 https://go.nature.com/4m6iTA3 🎧 https://bit.ly/425e7JH