Check out this cool new paper from Mike Rogers lab @garvaninstitute.bsky.social out in @cp-immunity.bsky.social! Their new model of MKD deficiency (aka Hyper IgD syndrome) as a "prenylopathy": NK cell degranulation defect -> compensatory increase IFN gamma -> autoinflammation. Can Rx with JAKi!

Resistance of IgG–FcR interactions to shear stress can be engineered, establishing a separate parameter for optimizing antibody effector functions beyond affinity alone. www.cell.com/immunity/pdf... Congratulations to Dr. Bowie Cheng and the whole team 🎉.

My new comprehensive review of Immune Memory to Vaccines is out! It has an emphasis on human vaccines. It is also accompanied by a full video lecture. Enjoy! @lji.org @cp-immunity.bsky.social authors.elsevier.com/sd/article/S...

Excited to share our new paper in @cp-immunity.bsky.social showing that "Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques" A promisingstep toward an HIV vaccine advancing soon to human clinical testing! Immunity www.cell.com/immunity/ful...

Two new KI studies published in @cp-immunity.bsky.social have mapped immune gene variation across multiple global populations and shown how these variations affect the ability to form neutralising antibodies, for example against the #influenza virus 🧪 #Immunology #Genetics news.ki.se/large-mappin...

New paper reveals how the human immune system fights #malaria caused by Plasmodium vivax, opening new avenues to develop #vaccines against the most widespread form of malaria. Published in @cp-immunity.bsky.social @burnetinstitute.bsky.social @wehi-research.bsky.social doi.org/10.1016/j.im...

Those who know me, know I’m not someone who changes his preferences & behaviors lightly. As Ron Swanson said, “I regret nothing. The end.” Well, let me tell you about our new study, out from The Perry Lab @mskcancercenter.bsky.social in @cp-immunity.bsky.social, which is the exception. /1

Excited to share my paper published today in @cp-immunity.bsky.social! We find that when CTLs integrate antigen and cytokine signaling, the timing of these cues matters - shedding light on an old question: Why do NK cells sometimes behave like CD8+ T cells? www.sciencedirect.com/science/arti...

Commensal-derived trehalose monocorynomycolate triggers γδ T cell-driven protective ocular barrier immunity: Immunity www.cell.com/immunity/ful... @cp-immunity.bsky.social

State-specific enhancer landscapes govern microglial plasticity @cp-immunity.bsky.social www.cell.com/immunity/ful...

Thrilled to share our new paper on reactive microglial plasticity! Using long-term fate mapping and epigenetic profiling, we uncover the remarkable plasticity of reactive microglia across the lifespan and the enhancers and associated TFs that govern state transitions.

So excited to share with you our latest work, result of my PhD with Dr.Rejane Rua at the @ciml.bsky.social! 🍾 If you want to brainstorm about bone channels and skull’s contribution to meningeal immunity, have a look! 🔬🧠

We are #absolutely #thrilled to #present @cp-immunity.bsky.social - Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils: Immunity www.cell.com/immunity/ful...

Immunity is now on LinkedIn! Follow us if you love #immunology! And if you don't already love immunology, maybe we'll change your mind 😀https://www.linkedin.com/company/immunity-cellpress

Our new paper reveals that chronic active MS lesions feature CD8⁺ T cell niches with lipid-laden, inflamed microglia. IFN-γ drives cholesterol buildup, linking dysregulated lipid metabolism to inflammation and meurodeg. Check it out @cp-immunity.bsky.social www.sciencedirect.com/science/arti...

How is the persistence of compartmentalized inflammation sustained in MS? Our new study in @cp-immunity.bsky.social offers some hints. cell.com/immunity/ful... Thanks and congratulations to all contributors

For those of you joining us for the editors panel at #RTN2025, please bring your questions! We have more editors than I've ever seen at a single meeting, so this is your chance to get answers to all of your burning questions! @genelayinstitute.bsky.social @rtnconference.bsky.social

Looking forward to #RTN2025 today! Excited for some #neuroimmunology! If you'll be there, please look for me and say hello! @genelayinstitute.bsky.social @rtnconference.bsky.social genelayinstitute.org/rtn/#program

#CSNeuroimmune25 @danmucida.bsky.social talking about food allergy and neuroimmune response to helminth infection @cp-neuron.bsky.social

#CSNeuroimmune25 Come learn about a novel neuro immune niche that underpins touch! Littleton Tues P2.38 13:00-14:30 youtu.be/BAtzNKj4wxA?si…

Getting ready for #CSNeuroimmune25 tomorrow in NYC! Excited to see everyone, and looking forward to some cool #neuroimmunology! @cp-neuron.bsky.social @cp-immunity.bsky.social www.cell-symposia.com/neuroimmunol...

Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...

It was a privilege and a pleasure for both myself and @menezesnmaria.bsky.social‬ to preview a great upcoming article in @cp-immunity.bsky.social‬ by @kamphorstlab.bsky.social‬ showing an unexpected inhibitory role for ICOS in exhausted CD8+ T cells. www.cell.com/immunity/abs...

Thanks to Dr. Pinho-Ribeiro for previewing our latest work in the current issue of Immunity. @cp-immunity.bsky.social @kavithascranton.bsky.social Neural tuners of lung immunity: Immunity cell.com/immunity/ful... cell.com/immunity/ful...

#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!

A new function for an ancient innate immune stimulus. Zanoni et al report that oxidized lipids control IL-10 expression, impacting host defense and disease. Kudos to the authors on this important discovery www.sciencedirect.com/science/arti...

#ChromatinPower #WhatADay! After our paper @cp-immunity.bsky.social (free link 👉 authors.elsevier.com/a/1lS0g3qNrU-i…) happy for our tiny contribution to @xuzhoulab.bsky.social Medzhitov &co amazing paper @cp-cell.bsky.social showing pH controls inflammation via chromatin remodeling! Free link👇

Optogenetic vagal nerve stimulation attenuates heart failure by limiting the generation of monocyte-derived inflammatory CCRL2+ macrophages: @cp-immunity.bsky.social www.cell.com/immunity/ful...

Early discounted registration ends June 27th for #CSNeuroimmune25, Sept 7–9, NYC! Explore cutting-edge #neuroimmunology and engage with experts in the field. Keynotes: David Julius & Susan Kaech hubs.li/Q03qS95l0 @cp-neuron.bsky.social @kavithascranton.bsky.social @cellpress.bsky.social

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway @cp-immunity.bsky.social www.cell.com/immunity/ful...

Explore breakthroughs in #cancer #immunology with global leaders. #CellSymposia: The cancer-immunity cycle Keynotes: Ira Mellman & Carl June Abstract submission deadline: July 25 Sitges, Spain | Nov 2–4, 2025 http://dlvr.it/TLX7WS

So proud to share my first first-author paper from my postdoc in @liganlab.bsky.social out yesterday in @cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!

🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...

Meet the keynote speakers at #CSNeuroimmune25: David Julius (UCSF) & Susan Kaech (The Salk Institute) NYC | Sept 7–9, 2025 Early registration discount ends June 27! hubs.li/Q03sQJjj0 @tcellogic.bsky.social @cp-neuron.bsky.social @salkinstitute.bsky.social #neuroimmune

Our new Immunity paper is in print—and that an oil painting I made was chosen for the cover 😊 It visualizes “affinity birth,” the generative force of SHM creating new antibody specificities beyond V(D)J. #Immunology #AffinityBirth #SciArt #Bcells #SHM

Had a great time at the CSHL Senescence & Aging meeting this week #cshlsymp25 @cshlmeetings.bsky.social. Enjoyed a wonderful dinner last night with scientists and supporters of CSHL, including the amazing #SusanLucci!

Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis: @cp-immunity.bsky.social www.cell.com/immunity/ful...

Our latest work on how nerves safeguard lung fibrosis. Congrats to Dr. Hiroki and collaborators. @cp-immunity.bsky.social @kavithascranton.bsky.social @hotchkissbrain.bsky.social @ucalgary.bsky.social @ucalgarymed.bsky.social @libininstitute.bsky.social www.cell.com/immunity/abs...

Immunity editor @kavithascranton.bsky.social is at the CSHL Senescence & Aging meeting this week #cshlsymp25 Look for her and say hello! She's looking forward to hearing about your work!

Today is the final day to submit your abstract for Cell Symposia Neuro-immune axis: Charting the periphery (#CSNeuroimmune25) @alleninstitute.org @cp-immunity.bsky.social Don’t miss your opportunity to be part of this groundbreaking program! hubs.li/Q03nJ_gK0

Our Immunity @cp-immunity.bsky.social Cover was not selected but nothing can hold back the Microglia super-heroine when she has DGAT2-blocking beverage. #NotTheCover Read the full article in Immunity: www.cell.com/immunity/ful...

#notthecover, but it’s beautiful and captures the science so well! Thank you for sharing your creative vision with us!

Check out our special issue! The beautiful cover was designed by @ella-maru.bsky.social, working with @jonykipnis.bsky.social & Mitchell (Min Woo) Kim. A brain encased in a walnut shell that is cracking open symbolizes our growing understanding of #neuroimmunology www.cell.com/immunity/iss...

Why do the brain’s professional phagocytes stop clearing amyloid in Alzheimer’s disease? Can we restore microglial superpowers & rescue dying neurons in AD? YES, by stopping DGAT2-mediated lipid droplet formation! Checkout our latest manuscript @cp-immunity.bsky.social 👇🏼 www.cell.com/immunity/abs...

Microglial TMEM119 actively participates in the dynamic clearance of amyloid-beta in mice @cp-immunity.bsky.social www.cell.com/immunity/abs...

Review from @bethstevenslab.bsky.social Constanze Depp, Jordan Doman & co discusses how #microglia adapt to different brain contexts and how this shapes their states and function #neuroimmunology authors.elsevier.com/a/1l2Xo3qNrU...

Excited to see this collection out! Thank you to all the authors and reviewers who contributed!

Our special issue on #neuroimmunology is online! Check out the collection, with reviews from @jonykipnis.bsky.social @michellemonje.bsky.social @ugolinis.bsky.social @bethstevenslab.bsky.social @movahedilab.bsky.social Matteoli, Butovsky, Kim, Artis, & Prinz! www.cell.com/immunity/col... #AAI2025