A new trial provides direct human evidence that the #placeboeffect can shape humoral #immunity and vaccine responses, opening new avenues for biomedical research. News & Views from Jonathan Kipnis & colleagues https://www.nature.com/articles/s41591-025-04168-7

Brain food on our brain drainage system to help keep you healthy, with @jonykipnis.bsky.social erictopol.substack.com/p/how-our-br...

Great podcast on the state of the science on brain fluid clearance and immune surveillance, by @jonykipnis.bsky.social discussing with @erictopol.bsky.social. They break down how sleep and our immune cells influence cognitive function and risk for dementia for 🧠 geek and lay audiences alike!👏

How Our Brain Drains Its Waste Products and its relevance to our sleep quality and risk of neurodegenerative diseases A podcast with @jonykipnis.bsky.social and illustrative text summary of 3 of his recent review articles erictopol.substack.com/p/how-our-br...

Smyth, Mehta, @jonykipnis.bsky.social et al. show that bridging veins accumulate amyloid in mouse models of #Alzheimers disease and human Alzheimer’s disease specimens, associated with impaired cerebrospinal fluid efflux. rupress.org/jem/article/... 🎥 See video summary: youtu.be/FsM6ontxHEI

My top 10 books for 2025

How do the metabolic waste products get cleared from our brain? And how does this process intersect with the brain's immune system? An exceptional review by @jonykipnis.bsky.social and colleagues cell.com/neuron/fullt...

Amyloidosis of bridging veins in AD mouse models and humans - clogged CSF exit routes. New in @jem.org from Smyth, Mehta, @jonykipnis.bsky.social @washumedicine.bsky.social and colleagues: rupress.org/jem/article/... #Neuroinflammation #Alzheimers

Amyloidosis of bridging veins in AD mouse models and humans - clogged CSF exit routes. New from Smyth, Mehta, @jonykipnis.bsky.social @washumedicine.bsky.social and colleagues: rupress.org/jem/article/... #Neuroinflammation #Alzheimers

Look Up! ✨ The Northern Lights lit up the skies above campus, captured beautifully by WashU student Hanyu Xiao! #WashU #northernlights #AuroraBorealis

We are proud to sponsor #ReThink Neuroimmunology 2025. A conference focusing on the biggest discoveries and breakthroughs in neuroimmunology, single cell genomics, immunology & neuroscience. The Gene Lay Institute of Immunology and Inflammation #RTN2025 RTN Conference Beth Stevens Jonathan Kipnis#ReThink

The 2025 Booker shortlist is made up of works by veteran authors, many of whom have several books under their belts — and a couple that have been on this list before.

Some thoughts on meningeal mast cells inspired by Xinzhong Dong and @jonykipnis.bsky.social recent (and AWESOME) papers. Lead: @fakesamir.bsky.social www.cell.com/trends/immun...

📅 Save the Date: Oxford 2026 Glymphatic Research Symposium! • Dates: March 30th, March 31st, April 1st 2026. • Keynote speakers: Maiken Nedergaard & Jonathan Kipnis. • Venue: Keble College, Oxford, UK. • Registration link to follow Looking forward to seeing you there! 🧠

#ReThinkNeuroimmunology! 3 days 27 speakers 7 selected talks 2 panel discussions >400 registered Submit your abstract by August 28th for #RTN2025. 🔗 genelayinstitute.org/rtn/ 🧪 @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua

Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com! Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab. www.nature.com/articles/s41...

In his “Neuroimmunology” lecture, @jonykipnis.bsky.social (@washumedicine.bsky.social) questioned what makes the CNS “immune privileged” if its antigens reach T cells via lymphatics and meningeal APCs—reshaping how we think about brain-immune interactions. #AAIcourses

Excited to share our new work, led by an exceptional graduate student, Tornike Mamuladze, on the role of meningeal mast cells in regulation of brain/dura access points, with implications to CSF flow dynamics and meningitis || www.cell.com/cell/fulltex...

Brilliant ⁦‪BIG center seminar by ex-postdoc fellow, now associate professor ⁦‪@MayoClinic‬⁩, @da-mesquita.bsky.social, who was our student-invited speaker. 👏👏👏

Here is another reason to come back to Twitter 😂

A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting @jonykipnis.bsky.social www.nature.com/articles/s41...

🔗 By @leonsmyth.bsky.social & @jonykipnis.bsky.social at Nature Reviews Immunology: www.nature.com/articles/s41... (10/11)

Dear all, come back to Twitter. It’s more exciting there!

Check out our special issue! The beautiful cover was designed by @ella-maru.bsky.social, working with @jonykipnis.bsky.social & Mitchell (Min Woo) Kim. A brain encased in a walnut shell that is cracking open symbolizes our growing understanding of #neuroimmunology www.cell.com/immunity/iss...

What’s better than The Great Nerve by the amazing Kevin Tracey? Two copies of The Great Nerve 🤩 One for home and one for the lab! Amazing read and truly incredible science!

and how dysfunctional meningeal lymphatics regulate synaptic physiology in a microglia-dependent manner www.cell.com/cell/fulltex... @jonykipnis.bsky.social

The new issue is out! 👉 cell.com/cell/current On the cover, Beckwith and Brunner et al. uncover that chromosomes self-organize into their characteristic mitotic rod shape through the formation of large and extensively overlapping DNA loops 📷credit: Andreas Brunner.

May issue is online! Explore reviews on the #neuroimmune axis! The beautiful cover was designed by Ella Marushchenko, working with @jonykipnis.bsky.social. A brain encased in a walnut shell that is cracking open symbolizes our growing understanding of #neuroimmunology www.cell.com/immunity/iss...

Review @cp-immunity.bsky.social @jonykipnis.bsky.social Glymphatics and meningeal lymphatics unlock the brain-immune code www.cell.com/immunity/ful...

Our special issue on #neuroimmunology is online! Check out the collection, with reviews from @jonykipnis.bsky.social @michellemonje.bsky.social @ugolinis.bsky.social @bethstevenslab.bsky.social @movahedilab.bsky.social Matteoli, Butovsky, Kim, Artis, & Prinz! www.cell.com/immunity/col... #AAI2025

Excited having this review with Mitch Kim on glymphatic, brain clearance, and neuroimmunology published.

Online now: Glymphatics and meningeal lymphatics unlock the brain-immune code

The gylmphatics of our brain, which clear waste products, interact with our immune system and are key to preserving brain health, modulating its aging process, and propensity for neurodegenerative diseases A superb review @cp-immunity.bsky.social @jonykipnis.bsky.social

Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems. @jonykipnis.bsky.social www.nature.com/articles/s41...

#ReThinkNeuroimmunology 3 day think tank exploring the biggest discoveries & breakthroughs in neuroimmunology. Organized by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua Registrations 🔗 genelayinstitute.org/rtn/

Amazing talk on “New insights into the anatomy of ‘brainwashing’” by Jonathan Kipnis @jonykipnis.bsky.social from @washumedicinebsky.social at #CNIC today 🙇🏼‍♀️🙇🏼‍♀️👏🏻👏🏻👏🏻👏🏻

🚨Registrations now live! Check out this amazing line up of speakers at #RTN #ReThinkNeuroimmunology organised by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua Register here: genelayinstitute.org/rtn/

[email protected] @weizmanninstitute.bsky.social @genelayinstitute.bsky.social @massgenbrigham.bsky.social

‼️BIG news ‼️ #ReThinkNeuroimmunology #RTN registration is open and live! The program is amazing! Hurry up to register while prices are low! See you in Boston in October! genelayinstitute.org/rtn/

Harnessing microglia-based cell therapies for the treatment of neurodegenerative diseases www.sciencedirect.com/science/arti...

🔓🔓🔓🔓🔓🔓🔓🔓🔓🔓🔓🔓🔓🔓🔓🔓🔓🔓🔓🔓🔓🔓🔓🔓🔓 #UnlockDay #Edovo Education is a right—not a privilege. 1M incarcerated people lack access. Every 🔓 posted today = a day of free learning. Let’s change that: unlockday.org #UnlockDay #Edovo

Dysfunctional meningeal lymphatics interfere with the inhibitory synaptic inputs and disrupt excitatory/inhibitory balance on cortical neurons in a microglia-IL-6-dependent manner @cellcellpress.bsky.social @jonykipnis.bsky.social www.cell.com/cell/fulltex...

Meningeal lymphatics-microglia axis regulates synaptic physiology: @cellpress.bsky.social www.cell.com/cell/fulltex....

Very cool to see that the field has now (at least) one mechanism for the phenomena we reported in 2018 & 2021: www.nature.com/articles/s41... www.nature.com/articles/s41... Go @jonykipnis.bsky.social and team! 💪🏻👏🏻👍🏻 One step closer to understanding how meningeal lymphatics affect brain immunity! 😃

Excited to share our work by exceptional postdoc, Kyungdeok (KD) Kim. 2025 marks 10th anniversary of meningeal lymphatic discovery and I can’t be happier celebrating it with this work addressing how lymphatic dysfunction leads to cognitive deficits || www.sciencedirect.com/science/arti...

Check out this just-released Gustavo Gastão Davanzo & @jonykipnis.bsky.social News & Views piece in Nature Immunology covering recent research by @mmr2.bsky.social, Diane Mathis, & colleagues in Science Immunology! Marin-Rodero et al. Sci Immunol 2025 science.org/doi/10.1126/sciimmunol.adu2910

Our News&Views on the recent exciting paper from Diane Mathis & Christophe Benoist Lab || rdcu.be/eebrL

"Working with Gemma is great because, first of all, the quality of her editing is exceptional. In addition, Gemma is a very pleasant person, who greatly communicates and always meets the deadline. In short – highly recommended *****" @jonykipnis.bsky.social

The Ultimate Guide to Instant Noodles. You're welcome. www.eater.com/21299228/bes...