Wow 🤩 this image from the Hubble telescope as looks almost exactly like a dural sinus. I love when biology mirrors physics!

Yan et al. show that basal skull bridging vein–associated ACE structures enable #CSF flow from the SAS into the dura, whereas spinal meninges lack these gateways, defining compartmentalized clearance regulated by anatomical exit zones and parenchymal border #macrophages. rupress.org/jem/article/...

ICYMI: cDC1s license CD8+ T cell-mediated neurodegeneration

Streptococcal meningoencephalitis disrupts homeostatic, skull bone marrow–derived monocyte and macrophage trajectories in the dura @sciimmunology.bsky.social www.science.org/doi/10.1126/...

Now online! Persistent and transient senescent cells contribute to brain-barrier development

Final version of our paper on zebrafish pericytes and BBB function is now out in Elife! Congrats to Oz the first author and all contributors. elifesciences.org/articles/104...

Beautiful paper from Andrew Yang’s group. A whole suite of new tools for studying brain waste clearance. A few take home points: www.cell.com/cell/fulltex...

Macrophage-mediated refinement of the dural lymphatic regulates social behavior: Neuron www.cell.com/neuron/fullt...

EPAS1/HIF2α A530V (gain-of-function variant, oxygen-insensitive) #VascularMalformation 👉Human N=9 (16-63 y/o) Retinal capillary hemangioma Ocular/Spinal venous malformation Intracranial venous/cavernous malformation +Evidence of Epas1 A529V🐭 @insight.jci.org 2021 insight.jci.org/articles/vie...

Congrats to the newest PhD from the @siegenthalerlab.bsky.social, Dr. Sophia Kim! Beautiful thesis document & presentation! 🧠🦠🔬🎉 Sophia's thesis work on arachnoid barrier breakdown in meningitis is on bioRxiv - check it out! www.biorxiv.org/content/10.6...

Fibroblasts play an important role in the compartmentalization of the choroid plexus, according to new work in mice. By @claudia-lopez.bsky.social #neuroskyence www.thetransmitter.org/choroid-plex...

Some of my PhD work is now published in @mucosalimmunol.bsky.social!

Osteoclast-mediated skull bone channel remodeling influences meningeal immune infiltration upon challenge www.science.org/doi/10.1126/... @sciimmunology.bsky.social spotlight of @cp-immunity.bsky.social linkinghub.elsevier.com/retrieve/pii...

Microglia-glioblastoma crosstalk mediates glioblastoma invasion at the far infiltration zone @cp-immunity.bsky.social www.cell.com/immunity/ful...

Age-related NF-κB activation in fibroblasts remodels the lung resident immune system and promotes the emergence of pro-inflammatory Gzmk+ T cells @cp-immunity.bsky.social www.cell.com/immunity/ful...

New insights on brain macrophage repopulation by the Prinz group: Distinct origins and niches determine the cellular responsiveness of CNS macrophages after repopulation | @natimmunol.nature.com www.nature.com/articles/s41...

Immunology at the Allen Institute is looking for next generation leaders, particularly those working in neuroimmunology and creating AI models in human disease. Please apply if you are interested in collaborating with other scientists at the Allen Institute alleninstitute.org/about/people...

Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition: Neuron www.cell.com/neuron/fullt...

🚨 Our study is online @cp-neuron.bsky.social! A fun read for all you neuroimmunology aficionados! This study proposes that targeting innate immunity/lymphatics in female & male E4 carriers might lead to different cognitive outcomes, highlighting the need for immunotherapies tailored to each sex. 👇

@tcpotts.bsky.social paper is live. Happy to share #FishNAP, a new, non-invasive way to measure #BBB permeability in 96-well format with #zebrafish www.biorxiv.org/content/10.6...

🚨 Our search for a postdoctoral researcher is still on! Contact me if you feel passionate about investigating neuroimmune mechanisms in neurodegenerative disorders. Candidates should have proven experience with rodent models of neurodegenerative disorders.

Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties. @cp-neuron.bsky.social www.cell.com/neuron/fullt...

Integrative CSF profiling identifies disease-specific immune responses in leptomeningeal disease @cp-cellrepmed.bsky.social www.cell.com/cell-reports...

🚨 New preprint from our lab led by Sophia Kim w/ @kellydoran.bsky.social group @cuanschutz.bsky.social -- using neonatal 🐭 model of bacterial meningitis ➡️ arachnoid barrier is leaky, Cldn11 junctions are disrupted & cytokines are part of the problem. Lots of 🤩🧠🦠🔬 & compelling data, check it out! 1/5

Amyloidosis of bridging veins is a pathologic feature of #Alzheimers disease, from @leonsmyth.bsky.social, Rupal Mehta, @jonykipnis.bsky.social et al. rupress.org/jem/article/... 📘 In our #Lymphatics collection: rupress.org/jem/collecti...

How does inflammation kill neurons, and what can we do about it? Check out our latest paper where we consider this question: rdcu.be/e4nfP.

The Da Mesquita lab at Mayo Clinic (www.mayo.edu/research/lab...) is looking for a postdoctoral researcher to work on projects investigating the role(s) of the meningeal lymphatic vasculature in models of neurodegenerative diseases. Please spread the word and contact me in case you are interested! 😃

Base barrier cells provide compartmentalization of choroid plexus, brain and CSF | Nature Neuroscience www.nature.com/articles/s41...

Review @natrevdrugdiscov.nature.com Therapeutic targeting of neuroimmune mechanisms in neurodegeneration www.nature.com/articles/s41...

First proof-of-concept for engineered T cells as a potential treatment for Alzheimer's disease pnas.org/doi/10.1073/...

Cell is hiring! Do you have a background in #neuroscience or #immunology? Better still, #neuroimmunology? Cell has an opening for a full-time scientific editor. Role will be based out of any one of our offices in Medford, MA, UK, Spain, Netherlands, China tinyurl.com/4ma236xn @cp-cell.bsky.social

🙏🙏 to entire team esp co-lead Tim Bartels. So proud of @seppedeschepper.bsky.social brilliant first postdoc who now leads his own at VIB. 🙏🙏🙏to @chanzuckerberg.bsky.social for supporting the project from early pilot phase. Contact us if u want to explore next steps in PD gut/brain neuroimmunology!

Clonal CD8+ T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases www.nature.com/articles/s41...

We’re delighted to see this out today! Latest work from the lab reveals insights into the evolution of brain immunity and the developmental and evolutionary plasticity of lymphatic endothelial cells. www.nature.com/articles/s41...

Fibroblastic reticular cells direct the initiation of T cell responses via CD44 @nature.com @the-de-lab.bsky.social www.nature.com/articles/s41...

Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins @natneuro.nature.com Brioschi & Colonna www.nature.com/articles/s41...

Preprint: Type I IFN activates border-associated macrophages to drive MHC-I–dependent immune surveillance after stroke www.researchsquare.com/article/rs-8...

Macrophage immunosenescence prolongs intraocular inflammation in aged mice via impaired induction of regulatory T cells https://www.biorxiv.org/content/10.64898/2026.01.15.697975v1

Very common story from a follower👇 Even if you can avoid ARC’s ludicrously long time-scales & recruit via another country’s much more efficient system, you hit Australia’s immigration system. Barrier after barrier. It’s YEARS between idea & starting the research in Australia. The slooow country.

3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis cell.com/cell/fulltex... cell.com/cell/fulltex... www.cell.com/cell/fulltex...

A genetically encoded reporter reveals interferon responses in multiple cell lineages https://www.biorxiv.org/content/10.64898/2026.01.08.698513v1

Review @cp-trendsimmuno.bsky.social Decoding brain border immunity to enable future therapeutic avenues www.cell.com/trends/immun...

Beautiful preprint by Maria Lehtinen's group on the impact of aging and Alzheimer's disease on the choroid plexus. www.biorxiv.org/content/10.6...

Thrilled to share our new paper on reactive microglial plasticity! Using long-term fate mapping and epigenetic profiling, we uncover the remarkable plasticity of reactive microglia across the lifespan and the enhancers and associated TFs that govern state transitions.

WE ARE HIRING! The Smyth Lab at Monash University is looking for a postdoc to join our team! Come join us if you are excited about neuroimmunology and the meninges. 📍 Melbourne, Australia 🇦🇺 Apply now: careers.pageuppeople.com/513/cw/en/jo... #Neuroimmunology #Meninges #PostdocJobs

So excited to share with you our latest work, result of my PhD with Dr.Rejane Rua at the @ciml.bsky.social! 🍾 If you want to brainstorm about bone channels and skull’s contribution to meningeal immunity, have a look! 🔬🧠

Remodeling of skull bone channels regulates immune infiltration into the meninges during neuroinflammation: Immunity www.cell.com/immunity/ful...

How Our Brain Drains Its Waste Products and its relevance to our sleep quality and risk of neurodegenerative diseases A podcast with @jonykipnis.bsky.social and illustrative text summary of 3 of his recent review articles erictopol.substack.com/p/how-our-br...

Smyth, Mehta, @jonykipnis.bsky.social et al. show that bridging veins accumulate amyloid in mouse models of #Alzheimers disease and human Alzheimer’s disease specimens, associated with impaired cerebrospinal fluid efflux. rupress.org/jem/article/... 🎥 See video summary: youtu.be/FsM6ontxHEI