Review @cp-trendsimmuno.bsky.social Decoding brain border immunity to enable future therapeutic avenues www.cell.com/trends/immun...

Beautiful preprint by Maria Lehtinen's group on the impact of aging and Alzheimer's disease on the choroid plexus. www.biorxiv.org/content/10.6...

Thrilled to share our new paper on reactive microglial plasticity! Using long-term fate mapping and epigenetic profiling, we uncover the remarkable plasticity of reactive microglia across the lifespan and the enhancers and associated TFs that govern state transitions.

WE ARE HIRING! The Smyth Lab at Monash University is looking for a postdoc to join our team! Come join us if you are excited about neuroimmunology and the meninges. 📍 Melbourne, Australia 🇦🇺 Apply now: careers.pageuppeople.com/513/cw/en/jo... #Neuroimmunology #Meninges #PostdocJobs

So excited to share with you our latest work, result of my PhD with Dr.Rejane Rua at the @ciml.bsky.social! 🍾 If you want to brainstorm about bone channels and skull’s contribution to meningeal immunity, have a look! 🔬🧠

Remodeling of skull bone channels regulates immune infiltration into the meninges during neuroinflammation: Immunity www.cell.com/immunity/ful...

How Our Brain Drains Its Waste Products and its relevance to our sleep quality and risk of neurodegenerative diseases A podcast with @jonykipnis.bsky.social and illustrative text summary of 3 of his recent review articles erictopol.substack.com/p/how-our-br...

Smyth, Mehta, @jonykipnis.bsky.social et al. show that bridging veins accumulate amyloid in mouse models of #Alzheimers disease and human Alzheimer’s disease specimens, associated with impaired cerebrospinal fluid efflux. rupress.org/jem/article/... 🎥 See video summary: youtu.be/FsM6ontxHEI

Curiosity sparked it all, and that curiosity just earned one of science’s highest honors. In the Australian, rb.gy/cdwmki Yet government funding for curiosity-driven science is at an all-time low. Success rates are plummeting. If we don’t invest in curiosity, we risk losing the next big discovery.

@biorxivpreprint.bsky.social The circadian clock regulates scavenging of fluid-borne substrates by brain border-associated macrophages www.biorxiv.org/content/10.6... @harvard.edu @hhmi-science.bsky.social

Insights @jem.org Bridging veins in Alzheimer's disease: Decoding waste clearance failure rupress.org/jem/article/...

Thank you very much to Maiken and her team for writing this news and views article about our recent work on bridging vein amyloidosis! doi.org/10.1084/jem....

Amyloidosis of bridging veins in AD mouse models and humans - clogged CSF exit routes. New from Smyth, Mehta, @jonykipnis.bsky.social @washumedicine.bsky.social and colleagues: rupress.org/jem/article/... #Neuroinflammation #Alzheimers

Amyloidosis of bridging veins in AD mouse models and humans - clogged CSF exit routes. New in @jem.org from Smyth, Mehta, @jonykipnis.bsky.social @washumedicine.bsky.social and colleagues: rupress.org/jem/article/... #Neuroinflammation #Alzheimers

Excited to share our new preprint: “Local B cell maturation and mast cell regulation of choroid plexus function in early life” www.biorxiv.org/content/10.1... , initiated in the lab by Laetitia Travier and led by the one and only @fakesamir.bsky.social

Excited to share my final postdoc project published. We looked into the striking amyloidosis of important brain waste clearance sites (bridging veins) in mouse and human. A great collaborative project with Rupal Mehta at Rush who did all the human studies. Thanks to everyone who contributed!

Amyloidosis of bridging veins is a pathologic feature of Alzheimer’s disease @jem.org @jonykipnis.bsky.social @leonsmyth.bsky.social @washumedicine.bsky.social rupress.org/jem/article-...

Beautiful work on postnatal meningeal B cell proliferation and instruction by local fibroblasts!

Early-life stromal niches orchestrate B lymphopoiesis at the brain's borders https://www.biorxiv.org/content/10.1101/2025.11.27.690844v1

Microglial CLEC7A restrains amyloid beta plaque pathology in a mouse model of Alzheimer's disease alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social

I'm hiring! Come and work with me at UCL to try and understand how the brain's blood vessels go wrong and promote dementia: www.ucl.ac.uk/work-at-ucl/...

Resolving the mysteries of brain clearance and immune surveillance: @cp-neuron.bsky.social www.cell.com/neuron/fullt...

Nice overview on the knowns and unknowns about pathways and mechanisms governing brain immunity and clearance. 🫶🏻😃 “Resolving the mysteries of brain clearance and immune surveillance” Check it out 👇🏻 authors.elsevier.com/sd/article/S...

A great consensus review on brain washing from the groups doing some of the most important work in the field summarizing areas of agreement and open questions. www.cell.com/neuron/fullt...

Wonderful to see our work so clearly and professionally presented at #AIC2025 by co–first author and graduate student Kevin Telfer. www.nature.com/articles/s42...

Thrilled to share this last little bit of my thesis work w/ @siegenthalerlab.bsky.social! 🐭🧠 Generating the PDGFRa cKO line we use in this paper was no trivial task, spanning multiple years (& a pandemic!) We were extremely excited to see this phenotype & even more excited to share it with everyone!

Our work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀 Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!

PDGFRα is required for postnatal cerebral perivascular fibroblast development. Congrats @siegenthalerlab.bsky.social ! #cerebrovascular #fibroblasts #development

What are the fastest-growing areas in neuroscience? Survey respondents pointed to computational neuroscience, systems neuroscience, neuroimmunology and neuroimaging, among other subfields. www.thetransmitter.org/neuroscience... #neuroskyence #StateOfNeuroscience

Check out our recent preprint, "Live longitudinal imaging of meningeal cerebrovascular injury and its sequelae in adult zebrafish." lnkd.in/gN7z6th4

Australia’s first Centre of Research Excellence in #Lymphoedema and Lymphatic Regeneration has launched, led by Prof @benjhogan.bsky.social and Prof Natasha Harvey, it's been dubbed a global “paradigm shift” and a major step forward. Read more: www.petermac.org/about-us/new...

A new method uses high-resolution MRI to provide a noninvasive, granular view of cerebrospinal-fluid movement—even in the small spaces that surround blood vessels, which have not been studied before. By @claudia-lopez.bsky.social #neuroskyence www.thetransmitter.org/cerebrospina...

Attentional failures during wakefulness after sleep deprivation are tightly orchestrated in a series of brain–body changes, including neuronal shifts, pupil constriction and cerebrospinal fluid (CSF) flow pulsations @lauradata.bsky.social @ziy027.bsky.social www.nature.com/articles/s41...

Our B cell Keystone is getting closer! Short talk abstracts and scholarship applications are due on November 13 - get to it! www.keystonesymposia.org/conferences/...

Great work 👏 mapping how brain endothelial cells communicate with astrocyte endfeet at the blood–brain barrier in @natureportfolio.nature.com The study identifies ligand–receptor pairs conserved in humans and altered in MS and Alzheimer’s. Makes me also wonder how many could be druggable targets.

Lymphoid gene expression (CD28) in plaque-associated PU.1low microglia supports neuroprotective functions that mitigate the progression of Alzheimer’s disease www.nature.com/articles/s41... @nature.com

NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...

Excited to see the updated results from INDIGO confirming sustained benefit of mIDH inhibition for 1st line treatment in patients with G2 gliomas. Reduced seizure frequency aligns with our findings that mIDH inhibition modulates the glioma electrical microenvironment! 👇

‼️Lymphatic Education&Research Network-GRC Scholarships‼️ LE&RN is awarding 10 × $1,000 scholarships to early investigators to attend 2026 Lymphatics GRC March 1 – March 6, 2026, Lucca (Barga), Italy. 🗓 Apply by Dec 8, 2025! form.jotform.com/LERN/2026-gr...

Happy to share our latest work led by @kevincziegler.bsky.social and Aydan Askarova, examining cell type contributions of vascular cell types to dementia risk. Many thanks to the donors, and for support from @ukdri.ac.uk and @alzassociation.bsky.social. www.cell.com/neuron/fullt...

📣Registration is now open for the Gordon Research Seminar and Gordon Research Conference on Lymphatics 2026! Half of the talks will be selected from submitted abstracts. Don’t miss your chance to share your work! grc.org/lymphatics-g... grc.org/lymphatics-c...

Our paper on CSF, BOLD, pupil, and physiological measures in sleep deprivation and recovery sleep is finally out! 🎉 Congrats Zinong! www.nature.com/articles/s41...

#NZ Science in NZ has long been underfunded. Cuts to both staff and funding by the current coalition have cut into something already stretched thin. Winner of top science prize blames ‘batshit’ Budget for brain drain newsroom.co.nz/2025/10/29/w...

"Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government." AND the NZ government! www.nature.com/articles/d41...

Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? Read more! www.biorxiv.org/content/10.1...

A noninvasive, CSF-specific MRI technique that enables detailed in vivo measurement of CSF mobility in humans, down to the level of perivascular spaces located around penetrating vessels www.nature.com/articles/s41...

T-ALL exploits a neural proinflammatory pathway to colonize the meninges @jci.org www.jci.org/articles/vie...

Tertiary lymphoid structures in a subset of gliomas that show signs of functional adaptive immune activation and are associated with longer overall patient survival and an immune-permissive tumor microenvironment @cp-immunity.bsky.social www.cell.com/immunity/ful...

Excited to share new work from the lab showing that loss of AD risk gene Ms4a4a promotes abeta clearance and protects against amyloid plaque accumulation in a mouse model 🧠🐭 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...