Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch 🧪 www.science.org/doi/full/10....

www.nature.com/articles/s41... Peripheral infection wires T cells in the brain 🧪

www.cell.com/cell/abstrac... STAMP: Single-cell transcriptomics analysis and multimodal profiling through imaging 🧪

We are looking for a research technician to join our neuroimmunology group at the University of Pittsburgh. Please share to anyone who may be interested! Posting: cfopitt.taleo.net/careersectio...

www.nature.com/articles/s41... 🧪 A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting

Very pleased to co-write this review with Bruce Cree and Steve Hauser on the future of #multiplesclerosis treatment onlinelibrary.wiley.com/doi/10.1002/...

Prognostic Factors for Multiple Sclerosis Symptoms in Radiologically Isolated Syndrome jamanetwork.com/journals/jam...

Increased CSF drainage by non-invasive manipulation of cervical lymphatics 🧪 www.nature.com/articles/s41...

"If the proposal is enacted, Americans today and tomorrow will be sicker, poorer, and die younger” an $18 Billion cut Only 3 NIH Institutes will remain in place, and even they will have their funds markedly reduced www.statnews.com/2025/05/30/n...

Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development 🧪 www.nature.com/articles/s41...

Nice progressive MS review by Volker Siffrin: Pathways to Progressive Disability in Multiple Sclerosis: The Role of Glial Cells in Chronic CNS Inflammation onlinelibrary.wiley.com/doi/10.1002/...

Read our latest review article out in @thelancetneuro.bsky.social if you want to know more about CSF transport across the different compartments of the brain-meningeal border and its importance for neurological diseases with strong neuroimmune components 😉 authors.elsevier.com/a/1l7l75FFzL...

Insightful perspective from Dr. Calabresi @pcalabresi.bsky.social on recently published BTKi multiple sclerosis trials. Progress toward Mitigating Disability Progression in Multiple Sclerosis www.nejm.org/doi/full/10....

Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. @cp-immunity.bsky.social All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...

Inflammasome signaling in astrocytes modulates hippocampal plasticity 🧪 www.cell.com/immunity/ful...

Redefining CNS immune privilege - Nature Reviews Immunology www.nature.com/articles/s41...

Online now: Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease

Broad rim lesions are a new pathological and imaging biomarker for rapid disease progression in multiple sclerosis 🧪 www.nature.com/articles/s41...

T–B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity 🧪 www.science.org/doi/abs/10.1...

Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity. 🧪 rupress.org/jem/article/...

‼️BIG news ‼️ #ReThinkNeuroimmunology #RTN registration is open and live! The program is amazing! Hurry up to register while prices are low! See you in Boston in October! genelayinstitute.org/rtn/

In an attempt to reproduce stimulus-triggered acquisition of pluripotency (STAP) before those papers were retracted, this group stumbled upon a population of neural stem cells in the periphery. www.nature.com/articles/s41...

Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB www.cell.com/cell/fulltex...

Microglia heterogeneity, modeling and cell-state annotation in development and neurodegeneration Nice review on microglia states--figure 1 would be helpful if you ever have to annotate microglia single cell data, and they include a nice tool to automate the process. www.nature.com/articles/s41...

Brain sensing of metabolic state regulates circulating monocytes www.science.org/doi/full/10....

A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease www.nature.com/articles/s41... 🧪

Non-muscle myosin II inhibition at the site of axon injury increases axon regeneration 🧪 www.nature.com/articles/s41...

pubmed.ncbi.nlm.nih.gov/40138748/ 🧪

Super excited to be launching NimbusImage.com! Cloud-based image analysis to democratize machine learning! Documentation here! docs.nimbusimage.com

We are very concerned about the proposed budget cuts at the NIH and the DOD that could impact ALS research. Our Board of Trustees and staff are taking to Capitol Hill on Wednesday to urge Congress to continue to fund ALS research.

Great crowd in Pittsburgh Standing Up for Science. Thanks to all of the other great speakers sharing their stories!

SO MANY STAND UP FOR SCIENCE EVENTS TO CHOOSE FROM—153 and COUNTING! To get more information on our local events and to register your own, head to www.standupforscience2025.org/local-event-information/ ☀️⬇️🌎

Let's talk about this Nature piece in more detail. I've rarely read something so anti-scientific anywhere short of the National Review. www.nature.com/articles/d41...

Very happy to share the link to the full article of my recent work www.science.org/stoken/autho... Had fun visualizing this complex dataset! Excited to hear your thoughts and explore new insights or other creative ways to reuse the data!

Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates: Cell Reports www.cell.com/cell-reports...

CLEC16A in astrocytes promotes mitophagy and limits pathology in a multiple sclerosis mouse model @NatureNeuro www.nature.com/articles/s41...

🚨PA colleagues: "Senator Fetterman wants to hear from you about how the federal funding freeze is affecting Pennsylvania." "If your project has been impacted, please fill out our constituent impact form:" forms.office.com/g/mFv2JAPxpC Get out your Other Support and share that info!

We need more synesthetic computing. My backup files should smell like oak. Temporary files should glisten like melting snow.

It’s been buried in all the news today, but every scientist in the US should pay attention to this: Mike Lauer went out on a limb for us all, sending out a memo saying institutes should start awarding grants. And it looks like Trump/Musk fired him for that. 🧪

I wrote a book The Creative Destruction of Medicine (2013, title adopted after Schumpeter). This title of the book for what we are now seeing in the U.S. is just The Destruction of Medicine.

A tour de force review of the connections between between the nervous and immune systems www.nature.com/articles/s41...

Cool talk about magic squares—apparently sudoku is turtles all the way down: www.youtube.com/live/1lyIHew...

Check out this mind-blowing paper from a group of UCSF scientists. T-cells engineered with brain antigen specific receptors that can trigger any number of tissue-targeted effects (car-t activity, cytokine production...) www.science.org/doi/10.1126/...

Whoa! When a large language of life model generates a protein equivalent to ~500 million years of evolution. @science.org science.org/doi/10.1126/...

Excited to share our new work identifying PKC as a druggable target for modulating microglia in order to enhance myelin repair. 🧵 #remyelination #multiplesclerosis www.science.org/doi/10.1126/...

Fluid pathophysiology in the CNS following lymphatic dysfunction with implications for development of therapeutic strategies targeting lymphatics in neurological disease @jexpmed.bsky.social @jonykipnis.bsky.social doi.org/10.1084/jem....

Great perspective piece from Michal Schwartz's group 🧪: www.nature.com/articles/s41...

www.nature.com/articles/s41... 🧪

More people speak English today than any other language in human history. But what do we lose, psychologically and culturally, as a result? For this week's @newyorker.com, I explore how English shapes thought—from our conception of time to how we talk about the senses.