Shingles vaccination prevents or delays dementia and slows the disease course among those already living with dementia @cellpress.bsky.social www.cell.com/cell/fulltex...

New preprint from @gocastelobranco.bsky.social lab!! We use MPRA & scCRISPRi/a to interrogate possible functions of GWAS-identified Multiple sclerosis risk SNPs in iPSC-derived oligodendrocytes. www.biorxiv.org/content/10.1...

📄🚨: Building off a stellar 2023 pub that engineered an hCSF1R variant, Sonia et al. now show how an mCSF1R variant not only confers inhibitor resistance and allows for efficient & non-toxic microglia replacement, but does so after vascular delivery into immunocompetent mice! 👏🧠 tinyurl.com/3wvmm8v3

How is the persistence of compartmentalized inflammation sustained in MS? Our new study in @cp-immunity.bsky.social offers some hints. cell.com/immunity/ful... Thanks and congratulations to all contributors

At least once per year I see someone with debilitating MS-related tremor, usually cerebellar or rubral. This is a study I was hoping would be done... journals.sagepub.com/doi/10.1177/...

A #huge win for @uvmvermont.bsky.social www.uvm.edu/larnermed/me...

Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis www.sciencedirect.com/science/arti...

Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions www.science.org/doi/10.1126/...

SV2A-PET imaging uncovers cortical synapse loss in multiple sclerosis | Science Translational Medicine www.science.org/doi/10.1126/...

Notch3+ Treg induced in the gut by microbiota translocate to CNS, outcompete protective NPY1R+-resident Treg, and degenerate into pathogenic Th17 in MS/EAE @cp-immunity.bsky.social @bostonchildrens.bsky.social www.cell.com/immunity/ful...

2024 MS McDonald criteria now published www.thelancet.com/journals/lan...

This is a really excellent review of the knowns and unknowns of the role of EBV in MS. Congrats @jsabatino37.bsky.social - this is fantastic www.neurology.org/doi/10.1212/...

PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia @nature.com www.nature.com/articles/s41...

#Throwback 🧪 PERSPECTIVE | The emerging role of protein l-lactylation in metabolic regulation and cell signalling H Ren, Y Tang & D Zhang

Emerging connections between myelin and Alzheimer’s disease www.nature.com/articles/s41...

New review from Carson Moseley and Scott Zamvil on B cell antigen presentation in CNS autoimmunity www.sciencedirect.com/science/arti...

Dysregulated cytokine networks have an important role in neuroinflammatory diseases such as multiple sclerosis. Read about progress and challenges in targeting these networks therapeutically in this review www.nature.com/articles/s41... rdcu.be/eBzvu

Systematic characterization of cell type-specific master metabolic regulators in Alzheimer's disease

Brain myelin as a deficient energy source in aging and disease www.cell.com/trends/endoc... Excellent discussion on how myelin fatty acid reserves may be reallocated during aging and neurodegeneration

#Throwback 🧪 COMMENT | A call for accessible tools to unlock single-cell immunometabolism research J Van den Bossche et al.

Review @jem.org Lipid metabolism and neuroinflammation: What is the link? rupress.org/jem/article/...

We’re excited to announce the Young Investigators Special Issue in the Journal of Neuroimmunology! We will spotlight early-career researchers and support the next generation of discovery. Submit your original research and let your work be seen and recognized. #CallForPaper

Two very cool back-to-back papers in @cp-cell.bsky.social on roles of meningeal dural mast cells in stroke and CSF dynamics 🤩😍👇🏻 cell.com/cell/fulltext/S0092-8674(25)00748-2 cell.com/cell/fulltext/S0092-8674(25)00747-0

New work from the lab - we found a surprising role for the glycolytic enzyme PGAM in Treg function. Whereas most glycolytic enzymes support inflammatory T cells, PGAM has the opposite effect by controlling serine synthesis to regulate the Treg-Th17 axis. #immunometabolism doi.org/10.7554/eLif...

It was such a pleasure to see this work unfold firsthand over the past few years as a member of Ruchita's thesis committee. She's a superstar with a fantastic mentor. Congrats to all - what a cool story www.cell.com/cell/fulltex...

A novel immunomodulatory compound that also acts by targeting the glycolytic enzyme GAPDH... www.science.org/doi/10.1126/...

Remyelination of chronic demyelinated lesions with directly induced neural stem cells url: academic.oup.com/brain/articl...

Excited to share this new story from the lab and led by the very talented @bendevlin.bsky.social! In collab with Anne Schaefer and grateful for funding from NIH and @curealzheimersfund.bsky.social. a brief 🧵

Emerging connections between myelin and Alzheimer’s disease www.nature.com/articles/s41...

Neuroinflammation across neurological diseases @science.org www.science.org/doi/10.1126/...

If we really want to understand and measure the distinct drivers of progression in MS, this is the sort of approach we need - accounting for both clinical relapse and MRI activity, rather than clinical relapse alone. www.frontiersin.org/journals/neu...

Our latest work: The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell www.cell.com/cell/fulltex...

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: @cellpress.bsky.social www.cell.com/cell/fulltex...

Our latest preprint showing alterations in the proteome of white matter EVs from MS patients compared to controls. www.biorxiv.org/content/10.1...

Very pleased to co-write this review with Bruce Cree and Steve Hauser on the future of #multiplesclerosis treatment onlinelibrary.wiley.com/doi/10.1002/...

What does the APOE 'lipid droplet-ome' look like??? Check out our new paper to find out! www.sciencedirect.com/science/arti... Thanks to first authors @cassifriday.bsky.social and @iostephens.bsky.social +help from Scott Gordon @morganti.bsky.social and @cohenlaboratory.bsky.social labs

The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour www.nature.com/articles/s41...

Nice progressive MS review by Volker Siffrin: Pathways to Progressive Disability in Multiple Sclerosis: The Role of Glial Cells in Chronic CNS Inflammation onlinelibrary.wiley.com/doi/10.1002/...

This is a succinct summary of the recent BTKi trials in MS that eloquently articulates the reasons for optimism and caution for their use in progressive MS, from Peter Calabresi www.nejm.org/doi/10.1056/...

Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. @cp-immunity.bsky.social All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...

Microglia & monocyte-derived cells were long assumed to have similar functions during remyelination. Our new paper @plosbiology.org shows non-redundant roles, with monocytes ultimately inhibiting remyelination. Team effort by Bianca Hill,Rebecca Holloway, Lindsey Forbes,Claire Davies plos.io/3RryCLF

With Butovsky Lab, we show that silencing TIM-3 in brain-resident immune cells prevents neurodegeneration in a mouse model of #Alzheimer’s disease. Deletion of TIM-3 in microglia enhance phagocytic clearance of toxic amyloid beta. #Immunosky🧪 www.nature.com/articles/s41...

Phase III trial data for #BTKi tolebrutinib in relapsing #multiplesclerosis and non-relapsing SP-MS out now. FDA decision for #tolebrutinib for SP-MS and disability progression more generally (PIRA) expected in September this year www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10....