Largest genetic study to date: the MTHFR C677T variant is associated with a 9% lower risk of multiple sclerosis, with no impact on disease severity 🧬 #MultipleSclerosis #genetics #cureMS Check out the paper below 👇 www.jni-journal.com/article/S016...

Diagnosing neurologic irAEs from ICIs is challenging. MRI is key to ruling out cancer spread and detecting indirect signs of neuroinflammation. This review 👇 highlights the essential imaging and diagnostic features of ICI-related neurotoxicities. www.jni-journal.com/article/S016...

Updated flow cytometric MOG-Ab cut-offs aligned with 2023 MOGAD criteria: Clear-positive: 90.7% PPV, in core demyelinating events: 100% PPV, High clear-positive: 100% specificity (lower sensitivity) MOGAD diagnosis accuracy in Korea. #MOGAD #Neuroimmunology Paper below 👇

Acupuncture eases neuropathic pain in lumbar disc herniation by blocking the CXCL12/CXCR4–ERK/NF-κB pathway, reducing glial activation and inflammation. #Neuroscience #PainResearch #Acupuncture Check the paper 👇 www.jni-journal.com/article/S016...

Hydrogen sulfide (H₂S) protects the brain from sepsis-induced injury by boosting HO-1 and blocking HMGB1. In mice, H₂S improved survival, cognition, and reduced brain damage - a potential therapy for sepsis-related injury. #Sepsis #Neuroinflam #H2S #HO1 #HMGB1 Paper 👇

Neoehrlichiosis, an emerging, underdiagnosed tick-borne infection. B-cell–depleting therapy increases risk and severity. #MS patients with fever, high CRP, or anemia may need further attention prior treatment initiation. #InfectiousDisease #MS #Neoehrlichiosis Paper below 👇

Fast-forward through our day in neuroimmunology 🔬 — where every pipette move brings us closer to the next discovery. #Neuroimmunology #LabWork #DataGeneration #PaperPrep #Pipetting #StainingHumanCells

Insight into stroke recovery! miR-126 worsens brain injury by suppressing LRP6 in the Wnt/β-catenin pathway. Blocking it restores signaling, reduces cell death, and improves outcomes - a promising new stroke therapy target. #StrokeResearch ##miR126 #WntPathway Check the paper 👇

It was an honor to sponsor the ISNI Young Session, Symposium 22 at #ISNI2025 in Chiba! 🌏 Congrats to our winner, @rosadelegadojimenez, and all speakers! Special thanks to @HeinzWeindl for making this session a success! 🙏 #Neuroimmunology #ISNI2025 #NextGenerationScientists

Hypoglycorrhachia shapes the landscape of encephalitis. Low CSF/serum glucose flags infectious causes, while its absence points to autoimmune disease with higher ICU burden. #NeuroID #Encephalitis #Neuroimmunology Check the paper below 👇 www.jni-journal.com/article/S016...

CAR-T therapy has transformed hematologic cancers, but ICANS remains a major barrier. Diverse neurotoxicities, lack of biomarkers, and unclear mechanisms highlight an urgent unmet need. #CART #Neurotoxicity #crackingICANS Check out the paper below 👇 www.jni-journal.com/article/S016...

⏰ Starting soon Join this webinar to hear tips and strategies to promote your recently accepted or published work. @jnijournal.bsky.social Register now: https://neuronline.sfn.org/professional-development/communication-and-recognition

Join us at #ISNI international congress 5-8 October in Chiba, Japan. We are supporting the young investigator session.

Beyond the brain: Our review explores how peripheral monocyte-derived macrophages (MDMs) shape Alzheimer’s disease pathogenesis—revealing new therapeutic opportunities outside the blood-brain barrier. 🧠🧬 #Alzheimers #Neuroimmunology Check out the review below 👇 www.jni-journal.com/article/S016...

First reported case of AQP4+ NMOSD after golimumab for ulcerative colitis, presenting with intractable hiccups (Area Postrema Syndrome). Managed with plasmapheresis + rituximab, partial improvement. Check out the paper 👇 www.jni-journal.com/article/S016...

Autoimmune nodopathies mimic seronegative GBS or CIDP but have distinct biology and treatment response — often failing IVIg or steroids, yet improving with anti-CD20 therapy. Early recognition can be life-changing. #Neurology #RareDisease Check out this paper 👇 www.jni-journal.com/article/S016...

We’re excited to announce the Young Investigators Special Issue in the Journal of Neuroimmunology! We will spotlight early-career researchers and support the next generation of discovery. Submit your original research and let your work be seen and recognized. #CallForPaper

CSF cell analysis is key to understanding neurological diseases but has been limited by cell fragility. Millet Wallisky et al. introduce a rapid, one-step method for efficient CSF immune profiling Check out the paper below 👇 www.jni-journal.com/article/S016...

Thinking about how seasons and environment affect myasthenia gravis. UV rays, humidity, and summer activity might play bigger roles than we know. More research ahead! #MyastheniaGravis #Science Check out the paper below 👇 www.jni-journal.com/article/S016...

Inflammation meets depression: Blocking hippocampal necroptosis eases depressive-like behavior in mice. Targeting RIPK3–MLKL could be a game-changer in depression. #Neuroscience #MentalHealth #DepressionResearch Check out the paper below 👇 www.jni-journal.com/article/S016...

TGFB1 is elevated in MS and correlates with IFNB1, which varies by disease phase but not IFN-β therapy. Check the paper below 👇 www.jni-journal.com/article/S016...

Stiff Person Syndrome Spectrum Disorders are under-recognized, immune-mediated conditions with diverse presentations—advances in treatment and understanding offer new hope! Check the paper below 👇 www.jni-journal.com/article/S016...

Don't miss this new case report on Neuro-Behçet's disease featured below 👇 www.jni-journal.com/article/S016...

High IL-10 and IL-12 serum levels in serum of Myasthenia Gravis patients could be used as potential biomarkers. Check the paper below 👇: www.jni-journal.com/article/S016...

CD4+ CD25+ T regs activated with MBP and rIL-2 ameliorate EAE and may serve as therapeutic agent for autoimmunity. Check out the paper below 👇: www.jni-journal.com/article/S016...

Brucella neurotype induces CNS damage via the QUIN/NMDAR/Ca²⁺/CaMKII/ROS pathway, highlighting a promising therapeutic target Check the paper below ⬇️ www.jni-journal.com/article/S016...

C-hype lectin protein derived from Toxocara canis larvae decreases disability scores in EAE, potentially through CD4+CD25+Foxp3+ Tregs Check this paper below 👇 www.jni-journal.com/article/S016...

A case report study: Thalidomide treatment is associated with RRMS Check out the details below ⬇️ www.jni-journal.com/article/S016...

The interplay between Rasmussen Encephalitis (RE) and localized Scleroderma (LS), a case report and literature review . Check out this newly published paper 👇 www.jni-journal.com/article/S016...

Interplay between peripheral & central nervous system inflammatory processes during major depressive disorder (MDD) Check out this new review 👇 www.jni-journal.com/article/S016...

Toxoplasma Gondii infection is linked with Astrocytic distinction, which could be linked to the progression of Schizophrenia Check this paper released today 👇 www.jni-journal.com/article/S016...

Resistance and endurance training differentially influence neuroinflammation during progressive vascular cognitive impairment. Check the paper below 👇 www.jni-journal.com/article/S016...

Remission from methamphetamine dependence is characterized by neuropsychiatric impairments, fatigue, sleep and memory perturbations as well as CD4+ and B cell losses. Check out the paper below👇 www.jni-journal.com/article/S016...

Examining Microglia in a 3D context following tissue clearing, with and without LPS treatment alongside detailed pathological analysis. Check out the paper below 👇

Glucose and fructose’s impact on Microglia and how it may influence on Alzheimer’s disease. Check out this newly published paper👇 www.jni-journal.com/article/S016...

miRNA profiling of naïve & effector memory CD4 T cell subsets are conserved in RRMS Check the paper below 👇 www.jni-journal.com/article/S016...

CSF T-tau protein, MCP1 & TNFa as Cerebrospinal fluid biomarkers associated wit NfL in untreated HIV* patients, as a result of CNS damage. While age & GFAP levels predict CSF NfL levels in HIV- patients. Check the link below 👇 www.jni-journal.com/article/S016...

Using sc-RNA-Seq to delineate T cell changes in AD, demonstrates an up regulation of exhaustion markers in CD8+ T RM cells within 5xFAD mouse brain. Check the link below 👇 jni-journal.com/article/S0165-…