Positive #MOG antibodies and steroid responsiveness don’t always tell the full story. This case of concurrent #MOGAD and spinal AVM highlights the importance of vascular imaging when presumed #myelitis recovery is incomplete. #Neurology #MOGAD #Neuroimmunology Paper 👇

mmune-checkpoint-inhibitors related CNS #neurotoxicity can mimic paraneoplastic and autoimmune encephalitis, making diagnosis challenging. High-risk anti-neuronal antibodies may predict poorer outcomes, while post-ICI meningoencephalitis responds well to corticosteroids. 👇👇

IRE1α/ASK1 signaling drives ER stress–mediated neuronal 🧠 apoptosis via the p38-CHOP pathway and caspase-3 activation.❌Blocking this pathway 😘➡️reduced infarct size & neurological damage: a promising therapeutic target for stroke. Check out the paper 👇 www.sciencedirect.com/science/arti...

High/moderate-efficacy DMTs cut sNfL ~40% and are associated with bigger gains in disability & relapse reduction; compared to first-line therapies. sNfL decline tracks EDSS/motor improvement (age-independent), but not psychiatric outcomes → biomarker potential. Paper below ⬇️⬇️

Persistent CNS inflammation in HIV continues despite ART. ↑ MMP-2 & MMP-9 in CSF point to localized brain inflammation. No differences across HIV subtypes or Tat variants. #HIV #NeuroHIV Check the paper below 👇 www.sciencedirect.com/science/arti...

1 in 5 neurosarcoidosis exhibit comorbid autoimmune disease, family history of autoimmunity, or nonspecific autoantibody seropositivity. These overlapping features represent potential sources of diagnostic ambiguity and may impact treatment strategies. Check the paper below 👇

FoxF2, a key regulator in remyelination in progressive MS 🧠 FoxF2+ Astrocyte links to TGFβ signaling and coordinates myelin repair, immune response, and metabolism. Its loss disrupts regenerative gene networks. #MultipleSclerosis #Neuroscience Check out the paper below 👇

Soluble c-Met ↑ in CSF & plasma, CSF c-Met links to NfL/GFAP, plasma ADAM10 ↓. Suggests compartment-specific c-Met shedding in early MS. #MultipleSclerosis #Biomarkers #Neuroinflammation Check the paper👇: www.sciencedirect.com/science/arti...

🧠👶🏻 Upcoming release of a special issue dedicated to Pediatric Neuroimmunology. Call for paper, check details below and submit your work: sciencedirect.com/special-issue/…

🧠🦠 Open Call: Gut–Brain Axis Special Issue Exploring microbiome and CNS communication & translational insights. Submit your work 👉 www.sciencedirect.com/special-issu... #GutBrainAxis #Microbiome #CallForPapers

An inspiring Welcome & Kenneth P. Johnson Memorial Lecture #ACTRIMS2026, beautifully presented by Chair Dr. Danny Reich. Moments like these remind us why academic community matters

Largest genetic study to date: the MTHFR C677T variant is associated with a 9% lower risk of multiple sclerosis, with no impact on disease severity 🧬 #MultipleSclerosis #genetics #cureMS Check out the paper below 👇 www.jni-journal.com/article/S016...

Diagnosing neurologic irAEs from ICIs is challenging. MRI is key to ruling out cancer spread and detecting indirect signs of neuroinflammation. This review 👇 highlights the essential imaging and diagnostic features of ICI-related neurotoxicities. www.jni-journal.com/article/S016...

Updated flow cytometric MOG-Ab cut-offs aligned with 2023 MOGAD criteria: Clear-positive: 90.7% PPV, in core demyelinating events: 100% PPV, High clear-positive: 100% specificity (lower sensitivity) MOGAD diagnosis accuracy in Korea. #MOGAD #Neuroimmunology Paper below 👇

Acupuncture eases neuropathic pain in lumbar disc herniation by blocking the CXCL12/CXCR4–ERK/NF-κB pathway, reducing glial activation and inflammation. #Neuroscience #PainResearch #Acupuncture Check the paper 👇 www.jni-journal.com/article/S016...

Hydrogen sulfide (H₂S) protects the brain from sepsis-induced injury by boosting HO-1 and blocking HMGB1. In mice, H₂S improved survival, cognition, and reduced brain damage - a potential therapy for sepsis-related injury. #Sepsis #Neuroinflam #H2S #HO1 #HMGB1 Paper 👇

Neoehrlichiosis, an emerging, underdiagnosed tick-borne infection. B-cell–depleting therapy increases risk and severity. #MS patients with fever, high CRP, or anemia may need further attention prior treatment initiation. #InfectiousDisease #MS #Neoehrlichiosis Paper below 👇

Fast-forward through our day in neuroimmunology 🔬 — where every pipette move brings us closer to the next discovery. #Neuroimmunology #LabWork #DataGeneration #PaperPrep #Pipetting #StainingHumanCells

Insight into stroke recovery! miR-126 worsens brain injury by suppressing LRP6 in the Wnt/β-catenin pathway. Blocking it restores signaling, reduces cell death, and improves outcomes - a promising new stroke therapy target. #StrokeResearch ##miR126 #WntPathway Check the paper 👇

It was an honor to sponsor the ISNI Young Session, Symposium 22 at #ISNI2025 in Chiba! 🌏 Congrats to our winner, @rosadelegadojimenez, and all speakers! Special thanks to @HeinzWeindl for making this session a success! 🙏 #Neuroimmunology #ISNI2025 #NextGenerationScientists

Hypoglycorrhachia shapes the landscape of encephalitis. Low CSF/serum glucose flags infectious causes, while its absence points to autoimmune disease with higher ICU burden. #NeuroID #Encephalitis #Neuroimmunology Check the paper below 👇 www.jni-journal.com/article/S016...

CAR-T therapy has transformed hematologic cancers, but ICANS remains a major barrier. Diverse neurotoxicities, lack of biomarkers, and unclear mechanisms highlight an urgent unmet need. #CART #Neurotoxicity #crackingICANS Check out the paper below 👇 www.jni-journal.com/article/S016...

⏰ Starting soon Join this webinar to hear tips and strategies to promote your recently accepted or published work. @jnijournal.bsky.social Register now: https://neuronline.sfn.org/professional-development/communication-and-recognition

Join us at #ISNI international congress 5-8 October in Chiba, Japan. We are supporting the young investigator session.

Beyond the brain: Our review explores how peripheral monocyte-derived macrophages (MDMs) shape Alzheimer’s disease pathogenesis—revealing new therapeutic opportunities outside the blood-brain barrier. 🧠🧬 #Alzheimers #Neuroimmunology Check out the review below 👇 www.jni-journal.com/article/S016...

First reported case of AQP4+ NMOSD after golimumab for ulcerative colitis, presenting with intractable hiccups (Area Postrema Syndrome). Managed with plasmapheresis + rituximab, partial improvement. Check out the paper 👇 www.jni-journal.com/article/S016...

Autoimmune nodopathies mimic seronegative GBS or CIDP but have distinct biology and treatment response — often failing IVIg or steroids, yet improving with anti-CD20 therapy. Early recognition can be life-changing. #Neurology #RareDisease Check out this paper 👇 www.jni-journal.com/article/S016...

We’re excited to announce the Young Investigators Special Issue in the Journal of Neuroimmunology! We will spotlight early-career researchers and support the next generation of discovery. Submit your original research and let your work be seen and recognized. #CallForPaper

CSF cell analysis is key to understanding neurological diseases but has been limited by cell fragility. Millet Wallisky et al. introduce a rapid, one-step method for efficient CSF immune profiling Check out the paper below 👇 www.jni-journal.com/article/S016...

Thinking about how seasons and environment affect myasthenia gravis. UV rays, humidity, and summer activity might play bigger roles than we know. More research ahead! #MyastheniaGravis #Science Check out the paper below 👇 www.jni-journal.com/article/S016...

Inflammation meets depression: Blocking hippocampal necroptosis eases depressive-like behavior in mice. Targeting RIPK3–MLKL could be a game-changer in depression. #Neuroscience #MentalHealth #DepressionResearch Check out the paper below 👇 www.jni-journal.com/article/S016...

TGFB1 is elevated in MS and correlates with IFNB1, which varies by disease phase but not IFN-β therapy. Check the paper below 👇 www.jni-journal.com/article/S016...

Stiff Person Syndrome Spectrum Disorders are under-recognized, immune-mediated conditions with diverse presentations—advances in treatment and understanding offer new hope! Check the paper below 👇 www.jni-journal.com/article/S016...

Don't miss this new case report on Neuro-Behçet's disease featured below 👇 www.jni-journal.com/article/S016...

High IL-10 and IL-12 serum levels in serum of Myasthenia Gravis patients could be used as potential biomarkers. Check the paper below 👇: www.jni-journal.com/article/S016...

CD4+ CD25+ T regs activated with MBP and rIL-2 ameliorate EAE and may serve as therapeutic agent for autoimmunity. Check out the paper below 👇: www.jni-journal.com/article/S016...

Brucella neurotype induces CNS damage via the QUIN/NMDAR/Ca²⁺/CaMKII/ROS pathway, highlighting a promising therapeutic target Check the paper below ⬇️ www.jni-journal.com/article/S016...

C-hype lectin protein derived from Toxocara canis larvae decreases disability scores in EAE, potentially through CD4+CD25+Foxp3+ Tregs Check this paper below 👇 www.jni-journal.com/article/S016...

A case report study: Thalidomide treatment is associated with RRMS Check out the details below ⬇️ www.jni-journal.com/article/S016...

The interplay between Rasmussen Encephalitis (RE) and localized Scleroderma (LS), a case report and literature review . Check out this newly published paper 👇 www.jni-journal.com/article/S016...

Interplay between peripheral & central nervous system inflammatory processes during major depressive disorder (MDD) Check out this new review 👇 www.jni-journal.com/article/S016...

Toxoplasma Gondii infection is linked with Astrocytic distinction, which could be linked to the progression of Schizophrenia Check this paper released today 👇 www.jni-journal.com/article/S016...

Resistance and endurance training differentially influence neuroinflammation during progressive vascular cognitive impairment. Check the paper below 👇 www.jni-journal.com/article/S016...

Remission from methamphetamine dependence is characterized by neuropsychiatric impairments, fatigue, sleep and memory perturbations as well as CD4+ and B cell losses. Check out the paper below👇 www.jni-journal.com/article/S016...

Examining Microglia in a 3D context following tissue clearing, with and without LPS treatment alongside detailed pathological analysis. Check out the paper below 👇

Glucose and fructose’s impact on Microglia and how it may influence on Alzheimer’s disease. Check out this newly published paper👇 www.jni-journal.com/article/S016...

miRNA profiling of naïve & effector memory CD4 T cell subsets are conserved in RRMS Check the paper below 👇 www.jni-journal.com/article/S016...

CSF T-tau protein, MCP1 & TNFa as Cerebrospinal fluid biomarkers associated wit NfL in untreated HIV* patients, as a result of CNS damage. While age & GFAP levels predict CSF NfL levels in HIV- patients. Check the link below 👇 www.jni-journal.com/article/S016...

Using sc-RNA-Seq to delineate T cell changes in AD, demonstrates an up regulation of exhaustion markers in CD8+ T RM cells within 5xFAD mouse brain. Check the link below 👇 jni-journal.com/article/S0165-…