Manuel Friese
@manuelfriese.bsky.social
📤 187
📥 239
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Professor of Neurology | Director Institute of Neuroimmunology and Multiple Sclerosis, UKE
reposted by
Manuel Friese
Hertie Network (Hamburg site)
26 days ago
We’re excited to introduce the new Hamburg
#HertieNetwork
fellows for the 3rd funding period:
@felixfischbach.bsky.social
, Märit Jensen,
@brissiek.bsky.social
&
@janasonner.bsky.social
. Looking forward to inspiring projects, discussions & collaboration across sites!
#UKEHamburg
#HertieStiftung
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Check out our latest research on how a neuron-immune axis modulates peripheral immune responses during multiple sclerosis. We discovered it by exploring pregnancy-associated immune modulation in multiple sclerosis. Special thanks to Jana Sonner and Audrey Kahn:
www.nature.com/articles/s41...
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A GDF-15–GFRAL axis controls autoimmune T cell responses during neuroinflammation - Nature Immunology
Here the authors show that endogenous or therapeutically delivered GDF-15 activates brainstem neurons that trigger splenic β-adrenergic signaling. This, in turn, suppresses autoreactive T cells and re...
https://www.nature.com/articles/s41590-025-02406-1
about 1 month ago
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We are hiring dedicated and motivated new members to join our basic and clinical research team at INIMS (
www.inims.de
), Universitätsklinikum Hamburg-Eppendorf. - Medical Scientist (Postdoc) - Clinician Scientist (Neurology) Apply here:
www.uke.jobs/index.php?ac...
www.uke.jobs/index.php?ac...
about 2 months ago
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reposted by
Manuel Friese
The Lancet
3 months ago
👉 Register now:
hubs.li/Q03NdTNP0
📆 Nov 20, 2025 | 2pm GMT / 9am EST / 10pm CST Join our expert panel as they explore innate immunity’s role in neurological diseases, and therapies to prevent inflammation-driven neurodegeneration.
#neurology
#brainhealth
#lancetwebinar
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Our latest work: The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell
www.cell.com/cell/fulltex...
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The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis
Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative diseases. This study reveals that the interferon-induced immunoproteasome drastically decreases proteasomal ac...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2900616-6
8 months ago
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reposted by
Manuel Friese
Waggoner Lab
8 months ago
Interferon-induced immunoproteasome drastically decreases proteasomal activity in neurons, leading to a switch in neuronal metabolism with increased oxidative injury and ferroptosis
@cellcellpress.bsky.social
@manuelfriese.bsky.social
www.cell.com/cell/fulltex...
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reposted by
Manuel Friese
Sina Rosenkranz
8 months ago
We’re looking for a physician (f/m/d) with a strong interest in neuroimmunology and research in our MS outpatient clinic and day hospital team! Join us in advancing care and science in a dynamic, interdisciplinary environmentđź§
uke.jobs/index.php?ac...
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Arzt/Ärztin (all genders) in Weiterbildung - Neurologie mit Schwerpunkt Neuroimmunologie
https://uke.jobs/index.php?ac=jobad&id=4709
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reposted by
Manuel Friese
Pedro Friedmann Angeli
10 months ago
Important walkthrough for newcomers in the field
rdcu.be/eg58p
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Recommendations for robust and reproducible research on ferroptosis
Nature Reviews Molecular Cell Biology - Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in...
https://rdcu.be/eg58p
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reposted by
Manuel Friese
Seth Thomas Scanlon
12 months ago
This week in
#Science
#Immunology
: researchers @
@helsinki.fi
characterize
#immune
landscape of deep cervical
#LymphNodes
in newly diagnosed untreated patients w
#MultipleSclerosis
! Authors uncover several lines of evidence strengthening possible link btw
#MS
& Epstein–Barr virus (
#EBV
) infection!
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Altered immune landscape of cervical lymph nodes reveals Epstein-Barr virus signature in multiple sclerosis
Deep cervical lymph nodes of patients with MS have an altered B cell compartment that, in part, transcriptionally resembles an EBV infection.
https://www.science.org/doi/10.1126/sciimmunol.adl3604
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We are hiring (2 positions) one Postdoctoral fellow and one Clinician-Scientist (all genders) in neuroimmunological research | Universitätsklinikum Hamburg-Eppendorf
uke.jobs/index.php?ac...
uke.jobs/index.php?ac...
about 1 year ago
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Check out our results from an academic drug development program targeting TRPM4 to protect neurons from neurodegeneration. Many years of intense collaboration between UKE Hamburg, KU Leuven, Fraunhofer ITMP, Evotec:
www.cell.com/iscience/ful...
about 1 year ago
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