NAADP production in activated T cells is stimulated by Ca2+ and two distinct protein kinases www.science.org/doi/10.1126/...

Last year, my group launched a project funded by the T. von Zastrow Foundation that truly took all of us into new territory: the establishment of our own #Nanobody Discovery Platform. We genuinely started from scratch – including setting up our own alpaca facility with five female alpacas…

Yesterday, our first immunization campaign finished. We started late (and finished at 2:00 am 🤯) but everything went well. Lots of PBMCs and good RNA yield 🥳. Big thx to our campaign front runners Gaby 🦙 and Justy 🦙

Fantastic study by Michelle Jäckstein and Jörg Heeren of #SFB1328. Only the inhibition of both - #P2X7 and #P2X4 - protects from BAT inflammation!!! It was a pleasure to collaborate! Hope this inspires others to check P2X4/P2X7 double inhibition in their models! www.embopress.org/doi/full/10....

Hey #IUIS2025 participants, check out our poster on Wednesday, August 20, 12:15 - 13:45 | Poster Area (Hall X5) #neuroimmunology. We brought data from our new "BrEndO" mouse model for cerebral vasculitis #CD8 #Tcells #immunology

Pretty certain running a lab is mostly about making signs to avoid inconveniences & minor catastrophes. 😊

Today, our blood sample preparation container arrived. Still needs to be filled with equipment 😊 then we are ready for the first blood samples in October #nanobodies #vhh #antibodies #immunology

Boost #1 of Campaign #1: done 🦙😊

Rest in peace Ozzy 🥲 www.youtube.com/watch?v=zY5n... one of my favorite Black Sabbath songs

#HotFromThePress !! What if instead of analyzing 4-6 pathology markers you could check >100 in the *same* sample? @maltekuehl.com & co @puellesv.bsky.social lab introduce #PathoPlex, method that could even predict disease Full www.nature.com/articles/s41... @focalplane.bsky.social @nature.com 🧪🔬

It’s hard being a scientist these days and I’ve captured that indescribable feeling that we are all facing in a new word!! open.substack.com/pub/profkap/...

Today, we startet our first #nanobody discovery campaign by immunizing two of our alpacas, one by s.c. protein injection and one by gene gun. Crossing our fingers for a good HcAb response 🤞🏻💪🏻

A warm welcome to our newest #nanobody discovery team member! “Occi” arrived this weekend and smothly joined the herd. Soon, she will help us generating new #nanobodies against antigen targets used in research and/or for medical application

Should I check this #alpaca for #nanobodies conferring resistance to electric shock? … or should I first check the electric fence energiser 😆 #vhh #antibody

Our alpaca mares have their summer coat since yesterday. Ethics are approved, antigen production is ongoing, and we hope to start the first round of immunization in July. Super excited!!! 🦙🧬🔬👨‍🔬

gift link www.nytimes.com/2025/05/13/o...

What does a science PhD really teach you? The ability to say “I don’t know, but I can find out.” open.substack.com/pub/profkap/...

Vaccines have saved 154 million lives in the past 50 years. A reminder of what is #HumanlyPossible. Science saves lives. #VaccinesWork bit.ly/wiw2025

It is always a pleasure to get young students enthusiastic about science! A few days ago we had a whole class in our department, showcasing #Nanobody research. What can I say - it was fun! Hope to see some of you around on campus some time! #sfb1328

I am happy to report that our chapter on "Flow Cytometric Analysis of Mouse Brain CD8+ T Cell Activation" is out now! It is part of a book on "T cell activation" curated and edited by Björn-Philipp Diercks of #sfb1328 link.springer.com/protocol/10....

Not good. 75% of US scientists who answered Nature poll consider leaving www.nature.com/articles/d41...

I received one of the 232 NIH grant "terminations" sent to scientists at Columbia last night. My research focuses on improving maternal and child health in the US. Also affected: ongoing clinical trials, research training programs, and research centers that aim to improve the health of Americans.

Texas measles outbreak update: 124 cases, 18 hospitalized, & now the first death of a child, who was not vaccinated. Tragic, preventable, & a direct consequence of the deadly lies spread by anti-vaxx grifters, one of whom is now the most powerful health official in the US.

Exciting special issue coming up in 2025: #purinergic signaling is a fascinating cellular communication hub in many different organ and tissue systems…including the immune system. The special issue is curated and edited by colleagues from #SFB1328. pubs.acs.org/doi/10.1021/...

Come and join our team at St. Jude Children's Research Hospital! We are seeking a Sr Scientist to advance our research on immune responses to infection/vaccination. This is a financially stable position offering a highly competitive salary and excellent benefits. talent.stjude.org/careers/jobs...

New approach: Nanobody inhibitors that target Ebolavirus are under development at Univ of Minnesota. Nanobodies are tiny antibodies from animals like alpacas allowing access to viral regions too small for larger antibodies. This one blocks EBV's ability to enter human cells phys.org/news/2025-01...

Our paper on nurturing a #PositiveResearchCulture within your #research #team published by @wellcometrust.bsky.social gives useful tips for your lab. As well as making you a good team leader, nurturing culture pays off in building your science: 1/11 wellcomeopenresearch.org/articles/9-3...

Excited to share our first paper of 2025, just published in @naturecomms.bsky.social 🧪🦠 Fantastic work by first author Zhao-Shan Chen and great collaboration with Qiyun Zhu and colleagues at Lanzhou Veterinary Research Institute. Short thread below 🧵 rdcu.be/d5JEL #ViroSky

2024 is ending ....and we are excited to start our own nanobody discovery campaigns in 2025! 👇👇👇👇

Very nice work using nanobodies, sortagging, click chemistry, and multivalent conjugates--right up my alley! Congrats to the authors www.cell.com/cell/fulltex...

Nanobodies: From High-Throughput Identification to Therapeutic Development. DOI: 10.1016/j.mcpro.2024.100865 https://pubmed.ncbi.nlm.nih.gov/39433212/

New Nanobodies against the human ecto-Enzyme ENPP1 are great tools to uncover ENPP1 expression on certain immune cell populations link.springer.com/article/10.1...

NAD-mediated cell death (NICD) kills kidney NKT cells during cell preparation. Great work by Nicola Wanner and colleagues! journals.lww.com/jasn/abstrac...