Check out our latest review on Basement Membranes! Including scaled representation of protein & glycan components 😊 @mcrcellmatrix.bsky.social

🥁 Check out our new preprint on OmniPath, the prior knowledge resource for #SystemsBiology, and its brand-new OmniPath Explorer web app! 🥳 📖 Preprint: www.biorxiv.org/content/10.1... 🔍 Explorer: explore.omnipathdb.org OmniPath integrates 160+ resources for multi-omics analysis & modeling. 🧶⬇️

Today 20 years after I started working in a scientific lab while still in 🇨🇱, my lab, the @cellcommlab.bsky.social has its 5th labversary. What a ride ! I'm thankful for the support of my family, friends, & so many great collabs & colleagues. Fig legend 👇🏽 + pending longer thread #PIlife #Science

Definitely the most unexpected @mesospim.bsky.social #lightsheet #microscopy application of the past years: Hunting dark matter with a lightsheet microscope! #astronomy 🔭🔬https://arxiv.org/abs/2503.20732

Want to acquire #ExM images like this and help us understand the true extent of cytoskeletal diversity across the tree of life? This position might be for you! embl.wd103.myworkdayjobs.com/en-US/EMBL/j... With @dudinlab.bsky.social @embl.org @biology-unige.bsky.social @moorefound.bsky.social

Nature research paper: Pathology-oriented multiplexing enables integrative disease mapping go.nature.com/3HdZxZG

Glad to contribute to this collaborative community platform. A case study shows MCP servers working together - combining BioContextAI Knowledgebase with our omnipath omnipathdb.org MCP (work in progress) to showcase interoperability. Looking forward to see how the ecosystem evolves!

Preprint alert 🚨 Do you use chatbots in your work or even build MCP servers and agentic systems yourself? Or would you like to find a way to use biomedical tools using natural language? Then check out biocontext.ai, now out on bioRxiv: www.biorxiv.org/content/10.1...

🚨Scaling multiplexed imaging 📈 We are excited to share Pathology-oriented multiPlexing (PathoPlex). Now out in @nature.com: www.nature.com/articles/s41... 🧵Walk-through thread below ⬇️

@puellesv.bsky.social @n-kaiser.bsky.social @tanevski.bsky.social @juliosaezrod.bsky.social @psl-schaefer.bsky.social @pjsaez.bsky.social @lucaspelkmans.bsky.social @costalab.bsky.social @m-schwerk.bsky.social and many others.

#HotFromThePress !! What if instead of analyzing 4-6 pathology markers you could check >100 in the *same* sample? @maltekuehl.com & co @puellesv.bsky.social lab introduce #PathoPlex, method that could even predict disease Full www.nature.com/articles/s41... @focalplane.bsky.social @nature.com 🧪🔬

Four more days to apply to our postdoctoral position 👇

🚨Join us! We're soon opening 3 postdoctoral positions in #AIDrivenBiology. Seeking biologists (especially microbiology and infection biology), computer scientists, and microscopy developers. Ideal candidates are those eager to use or develop next-gen tech for cell biology. Get in touch (DM/email)

🧾New paper now on ‪‪‪‪Nature Protocols ‬🎉The #ExSRRF protocol gives you all details on how to merge Expansion Microscopy technique with #eSSRF analysis. Developed by Dominik Kylies, @puellesv.bsky.social and @hannah-superres.bsky.social, @henriqueslab.bsky.social 🔗: www.nature.com/articles/s41...

It's here! ✨ The #ExSRRF protocol paper is out 😍. Full details for merging Expansion Microscopy with our eSRRF analysis. From cells to tissue. A partnership with @puellesv.bsky.social's lab. Lead by Dominik Kylies and @hannah-superres.bsky.social + colleagues. #ExM #eSRRF ➡️ Open link: rdcu.be/euvEw

Postdoc position in our group at @ebi.embl.org about analyzing single cell data sets to better understand and treat neurodegen diseases, in collab with A Bassett, M Lotfollahi, @bayraktarlab.bsky.social, M Strauss and others within Open Targets. Deadline 20/07. Please share tinyurl.com/87wj466m

🔬👨‍💻📰 #SReD is out! Automated structural detection for #ImageJ & #FIJI, from nano to macro ✨🐘. No training data, no bias - texture analysis with GPU acceleration!⚡️ Brainchild of @afonsomendes92.bsky.social and adventure w @christlet.bsky.social lab + friends. Check: www.nature.com/articles/s41...

🧑‍🔬📰🚀 #RxivMaker is here! A framework automating the creation of publication-ready scientific #preprints from simple Markdown. Goodbye manual formatting, and hello gorgeous manuscripts! A great adventure with @guijacquemet.bsky.social's lab 📜: zenodo.org/records/1575... 👨‍💻: github.com/HenriquesLab...

I wrote a short piece on how becoming an IgA Nephropathy patient has changed my perspective on biomedical research, developing an appreciation for the challenges in data interpretability & availability and the importance of patient engagement www.nature.com/articles/s41...

Integrated Organoid Atlas benchmarks new protocols, even more impressive as a Highly Variable Cohort for comparison against perturbation and disease models: nature.com/articles/s41... Lead by @quanxu.bsky.social, in collaboration with Lennard Halle and @fabiantheis.bsky.social

It was fun to learn about blood vessel organoids together with @marinanikolova.bsky.social and Barbara Treutlein! Thanks to Reiner Wimmer and @penningerlab.bsky.social for introducing us to this system! www.cell.com/cell/fulltex... Great support from editors and reviewers @cellpress.bsky.social!

Curious about collagen?? There is an amazing program for the Collagen Gordon in New Hampshire this year. We have ample speaker slots reserved for abstract submissions. Come and join us! www.grc.org/collagen-con... July 6 - 11, 2025 www.grc.org/collagen-grs... July 5 - 6, 2025 Doug,Rachel,Alex

🤩 So many beautiful combinations of #ExM and #SuperResolution 🔬featured in this review!! 👇

🚨🔬💗Whether investigating cell organelles or mapping proteins, together with Victor Puelles's lab we lay a roadmap for selecting optimal #ExM and #SuperResolution #microscopy combinations. Daria Aristova and Dominik Kylies review with amazing co-authors pubs.aip.org/aip/apr/arti...

The self-driving multiscale microscope from @daetwylerstephan.bsky.social is out. It can image an entire zebrafish embryo longitudinally and follow a volume of interest over time with high resolution. We used it to study cancer-immune cell interactions. www.nature.com/articles/s41...

It is indeed my understanding that most research institutions won't survive if this is implemented. I know I will contact my congress and senate members. 5calls.org

NIH has announced a cut in the "indirect rate" to 15% across the board, in a move that appears to be retroactive to even existing grants. This is a bloodbath for research institutions throughout the country. Brief explainer for those not in this world: https://buff.ly/3EtML7D

#CellMigration for #FluorescenceFriday 🧪🔬 If a metastatic #cancer cell is offered 2 paths it decides very fast, bc it does matter where it goes... OTOH, if a non-cancer #cell is offered 2 options it takes some time to explore and decide. More in the paper: www.nature.com/articles/s41...

Please welcome our official #mesoSPIM channel on this platform, @mesospim.bsky.social. Repost is appreciated!

How cells decide where to go? #CellMigration Last year we published our 1st paper @cellcommlab.bsky.social, showing how actin-based membrane oscillations define a new direction ( #cancer & non-cancer #cells ) Full www.nature.com/articles/s41... @naturephysics.bsky.social @focalplane.bsky.social 🧪🔬

Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning - @erturklab.bsky.social @hendrikdietz.bsky.social go.nature.com/4gNLjeC

Warming up for the upcoming #GRCCellMigration For me the best video to explain adhesion-dependent #CellMigration by Felix Donghwi Son More in the website felixvis.artstation.com #sciart #scicomm #ScienceSky #SciSky #cytoskeleton #FocalAdhesion

Do you know about PIEZO receptors? We're learning more about their expansive role every day. A new podcast (with transcript and full video) with @ardemp.bsky.social, my friend and colleague @scripps.edu, who discovered these channels erictopol.substack.com/p/ardem-pata...

May your holidays sparkle as much as Alexa647 💖

How can we build an Al virtual cell that simulates all functions and interactions of a cell? How will it transform research and drive breakthroughs in programmable biology, drug discovery and personalized medicine? Take a look at our paper in @cellpress.bsky.social! www.cell.com/cell/fulltex...

Building Al virtual cells is no small feat! With a massive scientific undertaking and shared goals, we posit that a comprehensive understanding of cellular mechanisms is within reach. Stay tuned for exciting research coming out soon and consider joining my lab @icepfl.bsky.social! aimm.epfl.ch

... integrates extensive community discussions, resulting in an author list consisting of key leaders across different fields of Al and biology from @genentech.bsky.social, @chanzuckerberg.bsky.social , @msftresearch.bsky.social, @broadinstitute.org, @arcinstitute.org, @embl.org and more!

I could not be more thrilled to announce the Nature Methods @naturemethods.bsky.social Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue! www.nature.com/articles/s41...

Come see my talk =)

Dancing cells videoed under a microscope. Now the question is what music style is it? Probably salsa ;) 1st video of many that we will post about #CellMigration, which is at the center of our research @focalplane.bsky.social @pjsaez.bsky.social @the-node.bsky.social 🧪🔬

"E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains." -CEO Andrew Payne e11.bio/news/roadmap

Coding in Python and looking to perform bulk RNA sequencing analysis? With pytximport recently published in Bioinformatics and version 0.11.0 out today with many improvements, it’s time for my first Bluetorial! A thread 🧵 (1/12)

Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵Your weekend read👇 @cellpress.bsky.social cell.com/cell-host-mi...

New paper from our lab @erturklab.bsky.social www.cell.com/cell-host-mi...

You can read about our rationale and software package in Bioinformatics at: doi.org/10.1093/bioi... Thank you @puellesv.bsky.social and all the other co-authors without Bluesky (yet) for the great team effort. (6/12)

The SARS-CoV-2 spike protein can persist in the brain—in the skull bone marrow and meninges—to induce neurologic damage www.cell.com/cell-host-mi... open-access

Join us! It has an excellent lineup of speakers

🧪ECRs can now apply for a funded place at our Workshop 'Democratising Microscopy in Latin America: Imaging Across Scales and Regions' taking place in Ecuador in Oct 2025. Find out more at bit.ly/41646g5 #ECR #BiologistsWorkshops

Thanks for sharing! Looking forward to see what more options to use data from kallisto & others with scientific python and @scverse.bsky.social ecosystem tools will enable